Obesity weighs down memory through a mechanism involving the neuroepigenetic dysregulation of Sirt1

Journal of Neuroscience

Volumn 36, Issue 4, 2016, Pages 1324-1335

  Heyward, Frankie D ^a   Gilliam, Daniel ^a   Coleman, Mark A ^a   Gavin, Cristin F ^a   Wang, Jing ^a   Kaas, Garrett ^a   Trieu, Richard ^a   Lewis, John ^a   Moulden, Jerome ^a   David Sweatt, J ^a  

^a University of Alabama at Birmingham   (United States)

Author keywords

DNA methylation; Epigenetics; High fat diet; Memory; Obesity; Sirt1

Indexed keywords

AFIMOXIFENE; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; RESVERATROL; SIRTUIN 1; TAMOXIFEN; ANTIOXIDANT; INSULIN; SIRT1 PROTEIN, MOUSE; STILBENE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEHAVIOR ASSESSMENT; BLOOD ANALYSIS; CONTROLLED STUDY; DIET INDUCED OBESITY; DIET SUPPLEMENTATION; DNA ISOLATION; DNA METHYLATION; DNA MODIFICATION; EPIGENETICS; FOOD INTAKE; GENE EXPRESSION; GENETIC TRANSCRIPTION; IMMUNOPRECIPITATION; LIPID DIET; MALE; MEMORY ASSESSMENT; MEMORY DISORDER; MOUSE; NERVE CELL PLASTICITY; NERVOUS SYSTEM ELECTROPHYSIOLOGY; NONHUMAN; OBESITY; OBJECT LOCATION MEMORY; OBJECT RECOGNITION MEMORY; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; RNA ISOLATION; SEQUENCE ANALYSIS; SPATIAL MEMORY; SYNAPTIC TRANSMISSION; WESTERN BLOTTING; ADVERSE EFFECTS; ANIMAL; C57BL MOUSE; CHEMICALLY INDUCED; COMPLICATION; DIET THERAPY; DIETARY SUPPLEMENT; DISEASE MODEL; DRUG EFFECTS; EXCITATORY POSTSYNAPTIC POTENTIAL; EXPLORATORY BEHAVIOR; FOREBRAIN; GENE EXPRESSION REGULATION; GENETICS; HIPPOCAMPUS; MEMORY DISORDERS; METABOLISM; NERVE CELL; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; RADIATION RESPONSE; RECOGNITION; TIME FACTOR; TRANSGENIC MOUSE;

ANIMALS; ANTIOXIDANTS; DIET, HIGH-FAT; DIETARY SUPPLEMENTS; DISEASE MODELS, ANIMAL; DNA METHYLATION; EXCITATORY POSTSYNAPTIC POTENTIALS; EXPLORATORY BEHAVIOR; GENE EXPRESSION REGULATION; HIPPOCAMPUS; INSULIN; MALE; MEMORY DISORDERS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NEURONS; OBESITY; PROSENCEPHALON; RECOGNITION (PSYCHOLOGY); SIRTUIN 1; SPATIAL MEMORY; STILBENES; TIME FACTORS;

EID: 84956715114     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.1934-15.2016     Document Type: Article

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