Brain radiation injury leads to a dose- and time-dependent recruitment of peripheral myeloid cells that depends on CCR2 signaling

Journal of Neuroinflammation

Volumn 13, Issue 1, 2016, Pages

  Moravan, Michael J ^a   Olschowka, John A ^a   Williams, Jacqueline P ^a   O'Banion, M Kerry ^a  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

Author keywords

CCR2; Cell infiltration; Chimeric mice; Ionizing radiation; Late CNS radiation injury; Myeloid cells

Indexed keywords

CD11B ANTIGEN; CD3 ANTIGEN; CHEMOKINE RECEPTOR CCR2; ENHANCED GREEN FLUORESCENT PROTEIN; GLYCOPROTEIN P 15095; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; ACTIN BINDING PROTEIN; AIF1 PROTEIN, MOUSE; CALCIUM BINDING PROTEIN; CCR2 PROTEIN, MOUSE; CYTOKINE; GREEN FLUORESCENT PROTEIN; MYOSIN HEAVY CHAIN;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; BRAIN INJURY; BRAIN RADIATION; C57BL 6 MOUSE; CELL INFILTRATION; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DOSE RESPONSE; IMMUNOCOMPETENT CELL; IMMUNOFLUORESCENCE MICROSCOPY; MALE; MOUSE; NONHUMAN; RADIATION EXPOSURE; RADIATION INJURY; RADIATION RESPONSE; SIGNAL TRANSDUCTION; YOUNG ADULT; ANIMAL; BONE MARROW TRANSPLANTATION; BRAIN INJURIES; C57BL MOUSE; COMPLICATION; DISEASE MODEL; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; NEUTROPHIL CHEMOTAXIS; PATHOLOGY; PHYSIOLOGY; RADIATION CHIMERA; TIME FACTOR; TRANSGENIC MOUSE;

ANIMALS; BONE MARROW TRANSPLANTATION; BRAIN INJURIES; CALCIUM-BINDING PROTEINS; CYTOKINES; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, RADIATION; GENE EXPRESSION REGULATION; GREEN FLUORESCENT PROTEINS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MICROFILAMENT PROTEINS; MYELOID CELLS; MYOSIN HEAVY CHAINS; NEUTROPHIL INFILTRATION; RADIATION CHIMERA; RADIATION INJURIES; RECEPTORS, CCR2; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 84956603558     PISSN: None     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/s12974-016-0496-8     Document Type: Article

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