Radiation-induced c-Jun activation depends on MEK1-ERK1/2 signaling pathway in microglial cells

PLoS ONE

Volumn 7, Issue 5, 2012, Pages

  Deng, Zhiyong ^a   Sui, Guangchao ^a   Rosa, Paulo Mottin ^a   Zhao, Weiling ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOOXYGENASE 2; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; PROTEIN C JUN; REACTIVE OXYGEN METABOLITE; SERINE; SERINE 63; SERINE 73; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; 1,3 BUTADIENE DERIVATIVE; 1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; HYBRID PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; NITRILE; PRIMER DNA; PROTEIN KINASE INHIBITOR;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; IONIZING RADIATION; MICROGLIA; MOLECULAR MECHANICS; MOUSE; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; PHARMACOLOGICAL BLOCKING; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEINASE INHIBITION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; UPREGULATION; ANIMAL; BRAIN INJURY; CELL LINE; DRUG EFFECT; ENZYME ACTIVATION; ENZYMOLOGY; GENETIC TRANSCRIPTION; GENETICS; INFLAMMATION; METABOLISM; NUCLEOTIDE SEQUENCE; PHOSPHORYLATION; RADIATION EXPOSURE; RADIATION INJURY;

MURINAE;

ANIMALS; BASE SEQUENCE; BRAIN INJURIES; BUTADIENES; CELL LINE; DNA PRIMERS; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; INFLAMMATION; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE SIGNALING SYSTEM; MICE; MICROGLIA; NITRILES; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; RADIATION INJURIES, EXPERIMENTAL; REACTIVE OXYGEN SPECIES; RECOMBINANT FUSION PROTEINS; TRANSCRIPTION, GENETIC;

EID: 84860992169     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0036739     Document Type: Article

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