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Volumn 7, Issue 12, 2012, Pages

Regionally Distinct Responses of Microglia and Glial Progenitor Cells to Whole Brain Irradiation in Adult and Aging Rats

Author keywords

[No Author keywords available]

Indexed keywords

CD38 ANTIGEN;

EID: 84871572292     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0052728     Document Type: Article
Times cited : (45)

References (78)
  • 1
    • 0003037094 scopus 로고    scopus 로고
    • Metastatic brain cancer
    • In: DeVita V, Hellman S, Rosenberg SA, editors, 6th ed. Philadelphia, PA: Lippincott,Williams & Wilkins
    • Wen PY, Black PM, Loeffler JS (2001) Metastatic brain cancer. In: DeVita V, Hellman S, Rosenberg SA, editors. Cancer: Principles and practice of oncology. 6th ed. Philadelphia, PA: Lippincott,Williams & Wilkins. p. 2655-2670.
    • (2001) Cancer: Principles and practice of oncology , pp. 2655-2670
    • Wen, P.Y.1    Black, P.M.2    Loeffler, J.S.3
  • 2
    • 33644850757 scopus 로고    scopus 로고
    • Whole-brain radiotherapy in the management of brain metastasis
    • Khuntia D, Brown P, Li J, Mehta MP, (2006) Whole-brain radiotherapy in the management of brain metastasis. J Clin Oncol 24: 1295-1304.
    • (2006) J Clin Oncol , vol.24 , pp. 1295-1304
    • Khuntia, D.1    Brown, P.2    Li, J.3    Mehta, M.P.4
  • 4
    • 0028356814 scopus 로고
    • Neurobehavioral sequelae of cranial irradiation in adults: a review of radiation-induced encephalopathy
    • Crossen JR, Garwood D, Glatstein E, Neuwelt EA, (1994) Neurobehavioral sequelae of cranial irradiation in adults: a review of radiation-induced encephalopathy. J Clin Oncol 12: 627-642.
    • (1994) J Clin Oncol , vol.12 , pp. 627-642
    • Crossen, J.R.1    Garwood, D.2    Glatstein, E.3    Neuwelt, E.A.4
  • 5
    • 0028914873 scopus 로고
    • Neuropsychological effects of cranial radiation: Current knowledge and future directions
    • Roman DD, Sperduto PW, (1995) Neuropsychological effects of cranial radiation: Current knowledge and future directions. Int J Radiat Oncol Biol Phys 31: 983-998.
    • (1995) Int J Radiat Oncol Biol Phys , vol.31 , pp. 983-998
    • Roman, D.D.1    Sperduto, P.W.2
  • 7
    • 1342287206 scopus 로고    scopus 로고
    • Delayed radiation toxicity after focal or whole brain radiotherapy for low-grade glioma
    • Swennen MH, Bromberg JE, Witkamp TD, Terhaard CH, Postma TJ, et al. (2004) Delayed radiation toxicity after focal or whole brain radiotherapy for low-grade glioma. J Neurooncol 66: 333-339.
    • (2004) J Neurooncol , vol.66 , pp. 333-339
    • Swennen, M.H.1    Bromberg, J.E.2    Witkamp, T.D.3    Terhaard, C.H.4    Postma, T.J.5
  • 9
    • 0034126973 scopus 로고    scopus 로고
    • The radioresponse of the central nervous system: a dynamic process
    • Tofilon PJ, Fike JR, (2000) The radioresponse of the central nervous system: a dynamic process. Radiat Res 153: 357-370.
    • (2000) Radiat Res , vol.153 , pp. 357-370
    • Tofilon, P.J.1    Fike, J.R.2
  • 10
    • 2942552909 scopus 로고    scopus 로고
    • Chronic oxidative stress and radiation-induced late normal tissue injury: a review
    • Robbins ME, Zhao W, (2004) Chronic oxidative stress and radiation-induced late normal tissue injury: a review. Int J Radiat Biol 80: 251-259.
    • (2004) Int J Radiat Biol , vol.80 , pp. 251-259
    • Robbins, M.E.1    Zhao, W.2
  • 13
    • 3843075154 scopus 로고    scopus 로고
    • Radiation-induced cognitive impairments are associated with changes in indicators of hippocampal neurogenesis
    • Raber J, Rola R, LeFevour A, Morhardt D, Curley J, et al. (2004) Radiation-induced cognitive impairments are associated with changes in indicators of hippocampal neurogenesis. Radiat Res 162: 39-47.
    • (2004) Radiat Res , vol.162 , pp. 39-47
    • Raber, J.1    Rola, R.2    LeFevour, A.3    Morhardt, D.4    Curley, J.5
  • 14
    • 3042799716 scopus 로고    scopus 로고
    • Radiation-induced impairment of hippocampal neurogenesis is associated with cognitive deficits in young mice
    • Rola R, Raber J, Rizk A, Otsuka S, VandenBerg SR, et al. (2004) Radiation-induced impairment of hippocampal neurogenesis is associated with cognitive deficits in young mice. Exp Neurol 188: 316-330.
    • (2004) Exp Neurol , vol.188 , pp. 316-330
    • Rola, R.1    Raber, J.2    Rizk, A.3    Otsuka, S.4    VandenBerg, S.R.5
  • 15
    • 0038182466 scopus 로고    scopus 로고
    • Arrested neuronal proliferation and impaired hippocampal function following fractionated brain irradiation in the adult rat
    • Madsen TM, Kristjansen PE, Bolwig TG, Wortwein G, (2003) Arrested neuronal proliferation and impaired hippocampal function following fractionated brain irradiation in the adult rat. Neuroscience 119: 635-642.
    • (2003) Neuroscience , vol.119 , pp. 635-642
    • Madsen, T.M.1    Kristjansen, P.E.2    Bolwig, T.G.3    Wortwein, G.4
  • 16
    • 34247895760 scopus 로고    scopus 로고
    • Neural stem cells: implications for the conventional radiotherapy of central nervous system malignancies
    • Barani IJ, Benedict SH, Lin PS, (2007) Neural stem cells: implications for the conventional radiotherapy of central nervous system malignancies. Int J Radiat Oncol Biol Phys 68: 324-333.
    • (2007) Int J Radiat Oncol Biol Phys , vol.68 , pp. 324-333
    • Barani, I.J.1    Benedict, S.H.2    Lin, P.S.3
  • 17
    • 34548507015 scopus 로고    scopus 로고
    • Whole brain radiotherapy with hippocampal avoidance and simultaneously integrated brain metastases boost: a planning study
    • Gutiérrez AN, Westerly DC, Tomé WA, Jaradat HA, Mackie TR, et al. (2007) Whole brain radiotherapy with hippocampal avoidance and simultaneously integrated brain metastases boost: a planning study. Int J Radiat Oncol Biol Phys 69: 589-597.
    • (2007) Int J Radiat Oncol Biol Phys , vol.69 , pp. 589-597
    • Gutiérrez, A.N.1    Westerly, D.C.2    Tomé, W.A.3    Jaradat, H.A.4    Mackie, T.R.5
  • 18
    • 77957192286 scopus 로고    scopus 로고
    • Sparing of the neural stem cell compartment during whole-brain radiation therapy: a dosimetric study using helical tomotherapy
    • Marsh JC, Godbole RH, Herskovic AM, Gielda BT, Turian JV, (2010) Sparing of the neural stem cell compartment during whole-brain radiation therapy: a dosimetric study using helical tomotherapy. Int J Radiat Oncol Biol Phys 78: 946-954.
    • (2010) Int J Radiat Oncol Biol Phys , vol.78 , pp. 946-954
    • Marsh, J.C.1    Godbole, R.H.2    Herskovic, A.M.3    Gielda, B.T.4    Turian, J.V.5
  • 19
    • 0024504664 scopus 로고
    • Effects of radiation therapy on neuropsychological functioning in patients with nasopharyngeal carcinoma
    • Lee PW, Hung BK, Woo EK, Tai PT, Choi DT, (1989) Effects of radiation therapy on neuropsychological functioning in patients with nasopharyngeal carcinoma. J Neurol Neurosurg Psychiatry 52: 488-492.
    • (1989) J Neurol Neurosurg Psychiatry , vol.52 , pp. 488-492
    • Lee, P.W.1    Hung, B.K.2    Woo, E.K.3    Tai, P.T.4    Choi, D.T.5
  • 20
    • 27944507295 scopus 로고    scopus 로고
    • Cognitive sequelae of brain tumor treatment
    • Byrne TN, (2005) Cognitive sequelae of brain tumor treatment. Curr Opin Neurol 18: 662-666.
    • (2005) Curr Opin Neurol , vol.18 , pp. 662-666
    • Byrne, T.N.1
  • 21
    • 33750723795 scopus 로고    scopus 로고
    • Managing the cognitive effects of brain tumor radiation therapy
    • Butler JM, Rapp SR, Shaw EG, (2006) Managing the cognitive effects of brain tumor radiation therapy. Curr Treat Options Oncol 7: 517-523.
    • (2006) Curr Treat Options Oncol , vol.7 , pp. 517-523
    • Butler, J.M.1    Rapp, S.R.2    Shaw, E.G.3
  • 22
    • 33745293505 scopus 로고    scopus 로고
    • Cognitive impairment in patients with brain tumors: assessment and intervention in the clinic setting
    • Fox SW, Mitchell SA, Booth-Jones M, (2006) Cognitive impairment in patients with brain tumors: assessment and intervention in the clinic setting. Clin J Oncol Nurs 10: 169-176.
    • (2006) Clin J Oncol Nurs , vol.10 , pp. 169-176
    • Fox, S.W.1    Mitchell, S.A.2    Booth-Jones, M.3
  • 23
    • 33645456265 scopus 로고    scopus 로고
    • Phase II study of donepezil in irradiated brain tumor patients: effect on cognitive function, mood, and quality of life
    • Shaw EG, Rosdhal R, D'Agostino RB Jr, Lovato J, Naughton MJ, et al. (2006) Phase II study of donepezil in irradiated brain tumor patients: effect on cognitive function, mood, and quality of life. J Clin Oncol 24: 1415-1420.
    • (2006) J Clin Oncol , vol.24 , pp. 1415-1420
    • Shaw, E.G.1    Rosdhal, R.2    D'Agostino Jr., R.B.3    Lovato, J.4    Naughton, M.J.5
  • 24
    • 36148955544 scopus 로고    scopus 로고
    • Long-term impact of radiation on the stem cell and oligodendrocyte precursors in the brain
    • Panagiotakos G, Alshamy G, Chan B, Abrams R, Greenberg E, et al. (2007) Long-term impact of radiation on the stem cell and oligodendrocyte precursors in the brain. PLoS One 2: e588.
    • (2007) PLoS One , vol.2
    • Panagiotakos, G.1    Alshamy, G.2    Chan, B.3    Abrams, R.4    Greenberg, E.5
  • 25
    • 0032033535 scopus 로고    scopus 로고
    • Late behavioural and neuropathological effects of local brain irradiation in the rat
    • Hodges H, Katzung N, Sowinski P, Hopewell JW, Wilkinson JH, et al. (1998) Late behavioural and neuropathological effects of local brain irradiation in the rat. Behav Brain Res 91: 99-114.
    • (1998) Behav Brain Res , vol.91 , pp. 99-114
    • Hodges, H.1    Katzung, N.2    Sowinski, P.3    Hopewell, J.W.4    Wilkinson, J.H.5
  • 26
    • 0035798440 scopus 로고    scopus 로고
    • Radiation induced CNS toxicity-molecular and cellular mechanisms
    • Belka C, Budach W, Kortmann RD, Bamberg M, (2001) Radiation induced CNS toxicity-molecular and cellular mechanisms. Br J Cancer 85: 1233-1239.
    • (2001) Br J Cancer , vol.85 , pp. 1233-1239
    • Belka, C.1    Budach, W.2    Kortmann, R.D.3    Bamberg, M.4
  • 27
    • 69549130709 scopus 로고    scopus 로고
    • Maintenance of white matter integrity in a rat model of radiation-induced cognitive impairment
    • Shi L, Linville MC, Iversen E, Molina DP, Yester J, et al. (2009) Maintenance of white matter integrity in a rat model of radiation-induced cognitive impairment. J Neurol Sci 285: 178-184.
    • (2009) J Neurol Sci , vol.285 , pp. 178-184
    • Shi, L.1    Linville, M.C.2    Iversen, E.3    Molina, D.P.4    Yester, J.5
  • 28
    • 29644445235 scopus 로고    scopus 로고
    • NG2-expressing cells as oligodendrocyte progenitors in the normal and demyelinated adult central nervous system
    • Polito A, Reynolds R, (2005) NG2-expressing cells as oligodendrocyte progenitors in the normal and demyelinated adult central nervous system. J Anat 207: 707-716.
    • (2005) J Anat , vol.207 , pp. 707-716
    • Polito, A.1    Reynolds, R.2
  • 29
    • 55249102238 scopus 로고    scopus 로고
    • Progeny of Olig2-expressing progenitors in the gray and white matter of the adult mouse cerebral cortex
    • Dimou L, Simon C, Kirchhoff F, Takebayashi H, Götz M, (2008) Progeny of Olig2-expressing progenitors in the gray and white matter of the adult mouse cerebral cortex. J Neurosci 28: 10434-10442.
    • (2008) J Neurosci , vol.28 , pp. 10434-10442
    • Dimou, L.1    Simon, C.2    Kirchhoff, F.3    Takebayashi, H.4    Götz, M.5
  • 30
    • 75949085273 scopus 로고    scopus 로고
    • NG2+/Olig2+ Cells Are the Major Cycle-Related Cell Population of the Adult Human Normal Brain
    • Geha S, Pallud J, Junier MP, Devaux B, Leonard N, et al. (2009) NG2+/Olig2+ Cells Are the Major Cycle-Related Cell Population of the Adult Human Normal Brain. Brain Pathol 20: 399-411.
    • (2009) Brain Pathol , vol.20 , pp. 399-411
    • Geha, S.1    Pallud, J.2    Junier, M.P.3    Devaux, B.4    Leonard, N.5
  • 31
    • 69449102250 scopus 로고    scopus 로고
    • Adult-onset deficiency in growth hormone and insulin-like growth factor-I alters oligodendrocyte turnover in the corpus callosum
    • Hua K, Forbes ME, Lichtenwalner RJ, Sonntag WE, Riddle DR, (2009) Adult-onset deficiency in growth hormone and insulin-like growth factor-I alters oligodendrocyte turnover in the corpus callosum. Glia 57: 1062-1071.
    • (2009) Glia , vol.57 , pp. 1062-1071
    • Hua, K.1    Forbes, M.E.2    Lichtenwalner, R.J.3    Sonntag, W.E.4    Riddle, D.R.5
  • 32
    • 58749089099 scopus 로고    scopus 로고
    • Clinical patterns and biological correlates of cognitive dysfunction associated with cancer therapy
    • Dietrich J, Monje M, Wefel J, Meyers C, (2008) Clinical patterns and biological correlates of cognitive dysfunction associated with cancer therapy. Oncologist 13: 1285-1295.
    • (2008) Oncologist , vol.13 , pp. 1285-1295
    • Dietrich, J.1    Monje, M.2    Wefel, J.3    Meyers, C.4
  • 33
    • 68249131500 scopus 로고    scopus 로고
    • Cognitive and radiological effects of radiotherapy in patients with low-grade glioma: long-term follow-up
    • Douw L, Klein M, Fagel SS, van den Heuvel J, Taphoorn MJ, et al. (2009) Cognitive and radiological effects of radiotherapy in patients with low-grade glioma: long-term follow-up. Lancet Neurol 8: 810-818.
    • (2009) Lancet Neurol , vol.8 , pp. 810-818
    • Douw, L.1    Klein, M.2    Fagel, S.S.3    van den Heuvel, J.4    Taphoorn, M.J.5
  • 34
    • 0034718139 scopus 로고    scopus 로고
    • X-irradiation causes a prolonged reduction in cell proliferation in the dentate gyrus of adult rats
    • Tada E, Parent JM, Lowenstein DH, Fike JR, (2000) X-irradiation causes a prolonged reduction in cell proliferation in the dentate gyrus of adult rats. Neuroscience 99: 33-41.
    • (2000) Neuroscience , vol.99 , pp. 33-41
    • Tada, E.1    Parent, J.M.2    Lowenstein, D.H.3    Fike, J.R.4
  • 35
    • 0041672477 scopus 로고    scopus 로고
    • Extreme sensitivity of adult neurogenesis to low doses of X-irradiation
    • Mizumatsu S, Monje ML, Morhardt DR, Rola R, Palmer TD, et al. (2003) Extreme sensitivity of adult neurogenesis to low doses of X-irradiation. Cancer Res 63: 4021-4027.
    • (2003) Cancer Res , vol.63 , pp. 4021-4027
    • Mizumatsu, S.1    Monje, M.L.2    Morhardt, D.R.3    Rola, R.4    Palmer, T.D.5
  • 36
    • 0345189366 scopus 로고    scopus 로고
    • Inflammatory blockade restores adult hippocampal neurogenesis
    • Monje ML, Toda H, Palmer TD, (2003) Inflammatory blockade restores adult hippocampal neurogenesis. Science 302: 1760-1765.
    • (2003) Science , vol.302 , pp. 1760-1765
    • Monje, M.L.1    Toda, H.2    Palmer, T.D.3
  • 37
    • 0029814114 scopus 로고    scopus 로고
    • Microglial responses after focal radiation-induced injury are affected by alpha-difluoromethylornithine
    • Nakagawa M, Bellinzona M, Seilhan TM, Gobbel GT, Lamborn KR, et al. (1996) Microglial responses after focal radiation-induced injury are affected by alpha-difluoromethylornithine. Int J Radiat Oncol Biol Phys 36: 113-123.
    • (1996) Int J Radiat Oncol Biol Phys , vol.36 , pp. 113-123
    • Nakagawa, M.1    Bellinzona, M.2    Seilhan, T.M.3    Gobbel, G.T.4    Lamborn, K.R.5
  • 38
    • 0030272846 scopus 로고    scopus 로고
    • Cellular and secretory mechanisms related to delayed radiation-induced microvessel dysfunction in the spinal cord of rats
    • Siegal T, Pfeffer MR, Meltzer A, Shezen E, Nimrod A, et al. (1996) Cellular and secretory mechanisms related to delayed radiation-induced microvessel dysfunction in the spinal cord of rats. Int J Radiat Oncol Biol Phys 36: 649-659.
    • (1996) Int J Radiat Oncol Biol Phys , vol.36 , pp. 649-659
    • Siegal, T.1    Pfeffer, M.R.2    Meltzer, A.3    Shezen, E.4    Nimrod, A.5
  • 39
    • 0032736126 scopus 로고    scopus 로고
    • Quantification of microglial late reaction to stereotactic irradiation of the rat brain using computer-aided image analysis
    • Reinacher PC, Blum C, Gass P, Karger CP, Debus J, (1999) Quantification of microglial late reaction to stereotactic irradiation of the rat brain using computer-aided image analysis. Exp Neurol 160: 117-123.
    • (1999) Exp Neurol , vol.160 , pp. 117-123
    • Reinacher, P.C.1    Blum, C.2    Gass, P.3    Karger, C.P.4    Debus, J.5
  • 40
    • 0036735783 scopus 로고    scopus 로고
    • Irradiation induces neural precursor-cell dysfunction
    • Monje ML, Mizumatsu S, Fike JR, Palmer TD, (2002) Irradiation induces neural precursor-cell dysfunction. Nat Med 8: 955-962.
    • (2002) Nat Med , vol.8 , pp. 955-962
    • Monje, M.L.1    Mizumatsu, S.2    Fike, J.R.3    Palmer, T.D.4
  • 41
    • 73349128110 scopus 로고    scopus 로고
    • Effects of the AT1 receptor antagonist L-158,809 on microglia and neurogenesis after fractionated whole-brain irradiation
    • Conner KR, Payne VS, Forbes ME, Robbins ME, Riddle DR, (2010) Effects of the AT1 receptor antagonist L-158,809 on microglia and neurogenesis after fractionated whole-brain irradiation. Radiat Res 173: 49-61.
    • (2010) Radiat Res , vol.173 , pp. 49-61
    • Conner, K.R.1    Payne, V.S.2    Forbes, M.E.3    Robbins, M.E.4    Riddle, D.R.5
  • 42
    • 4544340146 scopus 로고    scopus 로고
    • Cytokines and the aging brain - what we don't know might help us
    • Bodles AM, Barger SW, (2004) Cytokines and the aging brain- what we don't know might help us. Trends Neurosci 27: 621-626.
    • (2004) Trends Neurosci , vol.27 , pp. 621-626
    • Bodles, A.M.1    Barger, S.W.2
  • 43
    • 2542526131 scopus 로고    scopus 로고
    • Increased IL-1beta in cortex of aged rats is accompanied by downregulation of ERK and PI-3 kinase
    • Maher FO, Martin DS, Lynch MA, (2004) Increased IL-1beta in cortex of aged rats is accompanied by downregulation of ERK and PI-3 kinase. Neurobiol Aging 25: 795-806.
    • (2004) Neurobiol Aging , vol.25 , pp. 795-806
    • Maher, F.O.1    Martin, D.S.2    Lynch, M.A.3
  • 44
    • 33750480549 scopus 로고    scopus 로고
    • The age-related attenuation in long-term potentiation is associated with microglial activation
    • Griffin R, Nally R, Nolan Y, McCartney Y, Linden J, et al. (2006) The age-related attenuation in long-term potentiation is associated with microglial activation. J Neurochem 99: 1263-1272.
    • (2006) J Neurochem , vol.99 , pp. 1263-1272
    • Griffin, R.1    Nally, R.2    Nolan, Y.3    McCartney, Y.4    Linden, J.5
  • 45
    • 57149094857 scopus 로고    scopus 로고
    • Neuroinflammation associated with aging sensitizes the brain to the effects of infection or stress
    • Sparkman NL, Johnson RW, (2008) Neuroinflammation associated with aging sensitizes the brain to the effects of infection or stress. Neuroimmunomodulation 15: 323-330.
    • (2008) Neuroimmunomodulation , vol.15 , pp. 323-330
    • Sparkman, N.L.1    Johnson, R.W.2
  • 46
    • 64649100658 scopus 로고    scopus 로고
    • Age and neuroinflammation: a lifetime of psychoneuroimmune consequences
    • Godbout JP, Johnson RW, (2009) Age and neuroinflammation: a lifetime of psychoneuroimmune consequences. Immunol Allergy Clin North Am 29: 321-337.
    • (2009) Immunol Allergy Clin North Am , vol.29 , pp. 321-337
    • Godbout, J.P.1    Johnson, R.W.2
  • 47
    • 71749095117 scopus 로고    scopus 로고
    • Regulation of cytokine signaling and T-cell recruitment in the aging mouse brain in response to central inflammatory challenge
    • Xu YZ, Nygård M, Kristensson K, Bentivoglio M, (2010) Regulation of cytokine signaling and T-cell recruitment in the aging mouse brain in response to central inflammatory challenge. Brain Behav Immun 24: 138-152.
    • (2010) Brain Behav Immun , vol.24 , pp. 138-152
    • Xu, Y.Z.1    Nygård, M.2    Kristensson, K.3    Bentivoglio, M.4
  • 48
    • 72049100387 scopus 로고    scopus 로고
    • Role of intercellular adhesion molecule-1 in radiation-induced brain injury
    • Wu KL, Tu B, Li YQ, Wong CS, (2010) Role of intercellular adhesion molecule-1 in radiation-induced brain injury. Int J Radiat Oncol Biol Phys 76: 220-228.
    • (2010) Int J Radiat Oncol Biol Phys , vol.76 , pp. 220-228
    • Wu, K.L.1    Tu, B.2    Li, Y.Q.3    Wong, C.S.4
  • 49
    • 73149111251 scopus 로고    scopus 로고
    • Rescue of radiation-induced cognitive impairment through cranial transplantation of human embryonic stem cells
    • Acharya MM, Christie LA, Lan ML, Donovan PJ, Cotman CW, et al. (2009) Rescue of radiation-induced cognitive impairment through cranial transplantation of human embryonic stem cells. Proc Natl Acad Sci U S A 106: 19150-19155.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 19150-19155
    • Acharya, M.M.1    Christie, L.A.2    Lan, M.L.3    Donovan, P.J.4    Cotman, C.W.5
  • 50
    • 79960436555 scopus 로고    scopus 로고
    • Human neural stem cell transplantation ameliorates radiation-induced cognitive dysfunction
    • Acharya MM, Christie LA, Lan ML, Giedzinski E, Fike JR, et al. (2011) Human neural stem cell transplantation ameliorates radiation-induced cognitive dysfunction. Cancer Res 71: 4834-4845.
    • (2011) Cancer Res , vol.71 , pp. 4834-4845
    • Acharya, M.M.1    Christie, L.A.2    Lan, M.L.3    Giedzinski, E.4    Fike, J.R.5
  • 52
    • 0035965708 scopus 로고    scopus 로고
    • Intracerebroventricular infusion of insulin-like growth factor-I ameliorates the age-related decline in hippocampal neurogenesis
    • Lichtenwalner RJ, Forbes ME, Bennett SA, Lynch CD, Sonntag WE, et al. (2001) Intracerebroventricular infusion of insulin-like growth factor-I ameliorates the age-related decline in hippocampal neurogenesis. Neuroscience 107: 603-613.
    • (2001) Neuroscience , vol.107 , pp. 603-613
    • Lichtenwalner, R.J.1    Forbes, M.E.2    Bennett, S.A.3    Lynch, C.D.4    Sonntag, W.E.5
  • 53
    • 0023760665 scopus 로고
    • The new stereological tools: disector, fractionator, nucleator and point sampled intercepts and their use in pathological research and diagnosis
    • Gundersen HJ, Bagger P, Bendtsen TF, Evans SM, Korbo L, et al. (1988) The new stereological tools: disector, fractionator, nucleator and point sampled intercepts and their use in pathological research and diagnosis. APMIS 96: 857-881.
    • (1988) APMIS , vol.96 , pp. 857-881
    • Gundersen, H.J.1    Bagger, P.2    Bendtsen, T.F.3    Evans, S.M.4    Korbo, L.5
  • 54
    • 0032080116 scopus 로고    scopus 로고
    • Experience-induced neurogenesis in the senescent dentate gyrus
    • Kempermann G, Kuhn HG, Gage FH, (1998) Experience-induced neurogenesis in the senescent dentate gyrus. J Neurosci 18: 3206-3212.
    • (1998) J Neurosci , vol.18 , pp. 3206-3212
    • Kempermann, G.1    Kuhn, H.G.2    Gage, F.H.3
  • 55
    • 51349096586 scopus 로고    scopus 로고
    • Age and region-specific responses of microglia, but not astrocytes, suggest a role in selective vulnerability of dopamine neurons after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure in monkeys
    • Kanaan NM, Kordower JH, Collier TJ, (2008) Age and region-specific responses of microglia, but not astrocytes, suggest a role in selective vulnerability of dopamine neurons after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure in monkeys. Glia 56: 1199-1214.
    • (2008) Glia , vol.56 , pp. 1199-1214
    • Kanaan, N.M.1    Kordower, J.H.2    Collier, T.J.3
  • 56
    • 58149271022 scopus 로고    scopus 로고
    • Irradiation-induced loss of microglia in the young brain
    • Kalm M, Lannering B, Bjork-Eriksson T, Blomgren K, (2009) Irradiation-induced loss of microglia in the young brain. J Neuroimmunol 206 (1-2):: 70-75.
    • (2009) J Neuroimmunol , vol.206 , Issue.1-2 , pp. 70-75
    • Kalm, M.1    Lannering, B.2    Bjork-Eriksson, T.3    Blomgren, K.4
  • 57
    • 35548986304 scopus 로고    scopus 로고
    • Microglia: active sensor and versatile effector cells in the normal and pathologic brain
    • Hanisch UK, Kettenmann H, (2007) Microglia: active sensor and versatile effector cells in the normal and pathologic brain. Nat Neurosci 10: 1387-1394.
    • (2007) Nat Neurosci , vol.10 , pp. 1387-1394
    • Hanisch, U.K.1    Kettenmann, H.2
  • 58
    • 73049110767 scopus 로고    scopus 로고
    • The multifaceted profile of activated microglia
    • Lynch MA, (2009) The multifaceted profile of activated microglia. Mol Neurobiol 40 (2):: 139-156.
    • (2009) Mol Neurobiol , vol.40 , Issue.2 , pp. 139-156
    • Lynch, M.A.1
  • 59
    • 0030480897 scopus 로고    scopus 로고
    • Oligodendrocytes in the adult rat spinal cord undergo radiation-induced apoptosis
    • Li YQ, Jay V, Wong CS, (1996) Oligodendrocytes in the adult rat spinal cord undergo radiation-induced apoptosis. Cancer Res 56: 5417-5422.
    • (1996) Cancer Res , vol.56 , pp. 5417-5422
    • Li, Y.Q.1    Jay, V.2    Wong, C.S.3
  • 60
    • 36448994709 scopus 로고    scopus 로고
    • Local self-renewal can sustain CNS microglia maintenance and function throughout adult life
    • Ajami B, Bennett JL, Krieger C, Tetzlaff W, Rossi FM, (2007) Local self-renewal can sustain CNS microglia maintenance and function throughout adult life. Nat Neurosci 10: 1538-1543.
    • (2007) Nat Neurosci , vol.10 , pp. 1538-1543
    • Ajami, B.1    Bennett, J.L.2    Krieger, C.3    Tetzlaff, W.4    Rossi, F.M.5
  • 61
    • 84861913141 scopus 로고    scopus 로고
    • High-resolution in-vivo analysis of normal brain response to cranial irradiation
    • Burrell K, Hill RP, Zadeh G, (2012) High-resolution in-vivo analysis of normal brain response to cranial irradiation. PLoS ONE 7: e38366.
    • (2012) PLoS ONE , vol.7
    • Burrell, K.1    Hill, R.P.2    Zadeh, G.3
  • 62
    • 50249153471 scopus 로고    scopus 로고
    • Intact neurogenesis is required for benefits of exercise on spatial memory but not motor performance or contextual fear conditioning in C57BL/6J mice
    • Clark PJ, Brzezinska WJ, Thomas MW, Ryzhenko NA, Toshkov SA, et al. (2008) Intact neurogenesis is required for benefits of exercise on spatial memory but not motor performance or contextual fear conditioning in C57BL/6J mice. Neuroscience 155: 1048-1058.
    • (2008) Neuroscience , vol.155 , pp. 1048-1058
    • Clark, P.J.1    Brzezinska, W.J.2    Thomas, M.W.3    Ryzhenko, N.A.4    Toshkov, S.A.5
  • 63
    • 70349560028 scopus 로고    scopus 로고
    • The PPARalpha agonist fenofibrate preserves hippocampal neurogenesis and inhibits microglial activation after whole-brain irradiation
    • Ramanan S, Kooshki M, Zhao W, Hsu FC, Riddle DR, et al. (2009) The PPARalpha agonist fenofibrate preserves hippocampal neurogenesis and inhibits microglial activation after whole-brain irradiation. Int J Radiat Oncol Biol Phys 75: 870-877.
    • (2009) Int J Radiat Oncol Biol Phys , vol.75 , pp. 870-877
    • Ramanan, S.1    Kooshki, M.2    Zhao, W.3    Hsu, F.C.4    Riddle, D.R.5
  • 64
    • 0038206578 scopus 로고    scopus 로고
    • Gene microarrays in hippocampal aging: statistical profiling identifies novel processes correlated with cognitive impairment
    • Blalock EM, Chen K-C, Sharrow K, Herman JP, Porter NM, et al. (2003) Gene microarrays in hippocampal aging: statistical profiling identifies novel processes correlated with cognitive impairment. J Neurosci 23 (9):: 3807-3819.
    • (2003) J Neurosci , vol.23 , Issue.9 , pp. 3807-3819
    • Blalock, E.M.1    Chen, K.-C.2    Sharrow, K.3    Herman, J.P.4    Porter, N.M.5
  • 65
    • 63549116173 scopus 로고    scopus 로고
    • Age-related myelin dynamics revealed by increased oligodendogenesis and short internodes
    • Lasiene J, Matsui A, Sawa Y, Wong F, Horner PJ, (2009) Age-related myelin dynamics revealed by increased oligodendogenesis and short internodes. Aging Cell 8 (2):: 201-213.
    • (2009) Aging Cell , vol.8 , Issue.2 , pp. 201-213
    • Lasiene, J.1    Matsui, A.2    Sawa, Y.3    Wong, F.4    Horner, P.J.5
  • 66
    • 0031425302 scopus 로고    scopus 로고
    • Microglial cytokine gene induction after irradiation is affected by morphologic differentiation
    • Hayakawa K, Borchardt PE, Sakuma S, Ijichi A, Niibe H, et al. (1997) Microglial cytokine gene induction after irradiation is affected by morphologic differentiation. Radiat Med 15: 405-410.
    • (1997) Radiat Med , vol.15 , pp. 405-410
    • Hayakawa, K.1    Borchardt, P.E.2    Sakuma, S.3    Ijichi, A.4    Niibe, H.5
  • 67
    • 53149110451 scopus 로고    scopus 로고
    • Glial responses, neuron death and lesion resolution after intracerebral hemorrhage in young vs. aged rats
    • Wasserman JK, Yang H, Schlichter LC, (2008) Glial responses, neuron death and lesion resolution after intracerebral hemorrhage in young vs. aged rats. Eur J Neurosci 28: 1316-1328.
    • (2008) Eur J Neurosci , vol.28 , pp. 1316-1328
    • Wasserman, J.K.1    Yang, H.2    Schlichter, L.C.3
  • 68
    • 33747877627 scopus 로고    scopus 로고
    • Microglial senescence: does the brain's immune system have an expiration date
    • Streit WJ, (2006) Microglial senescence: does the brain's immune system have an expiration date? Trends Neurosci 29: 506-510.
    • (2006) Trends Neurosci , vol.29 , pp. 506-510
    • Streit, W.J.1
  • 69
    • 42649097901 scopus 로고    scopus 로고
    • The effects of aging, injury and disease on microglial function: a case for cellular senescence
    • Miller KR, Streit WJ, (2007) The effects of aging, injury and disease on microglial function: a case for cellular senescence. Neuron Glia Biol 3: 245-253.
    • (2007) Neuron Glia Biol , vol.3 , pp. 245-253
    • Miller, K.R.1    Streit, W.J.2
  • 71
    • 77956179288 scopus 로고    scopus 로고
    • Differential effects of radiation and age on diffusion tensor imaging in rats
    • Peiffer AM, Shi L, Olson J, Brunso-Bechtold JK, (2010) Differential effects of radiation and age on diffusion tensor imaging in rats. Brain Res 1351: 23-31.
    • (2010) Brain Res , vol.1351 , pp. 23-31
    • Peiffer, A.M.1    Shi, L.2    Olson, J.3    Brunso-Bechtold, J.K.4
  • 72
    • 0033566927 scopus 로고    scopus 로고
    • Cycling cells in the adult rat neocortex preferentially generate oligodendroglia
    • Levison SW, Young GM, Goldman JE, (1999) Cycling cells in the adult rat neocortex preferentially generate oligodendroglia. J Neurosci Res 57: 435-446.
    • (1999) J Neurosci Res , vol.57 , pp. 435-446
    • Levison, S.W.1    Young, G.M.2    Goldman, J.E.3
  • 73
    • 18944384786 scopus 로고    scopus 로고
    • Apoptosis and proliferation of oligodendrocyte progenitor cells in the irradiated rodent spinal cord
    • Atkinson SL, Li YQ, Wong CS, (2005) Apoptosis and proliferation of oligodendrocyte progenitor cells in the irradiated rodent spinal cord. Int J Radiat Oncol Biol Phys 62: 535-544.
    • (2005) Int J Radiat Oncol Biol Phys , vol.62 , pp. 535-544
    • Atkinson, S.L.1    Li, Y.Q.2    Wong, C.S.3
  • 74
    • 77952423805 scopus 로고    scopus 로고
    • NG2 cells: Properties, progeny and origin
    • Trotter J, Karram K, Nishiyama A, (2010) NG2 cells: Properties, progeny and origin. Brain Res Rev 63: 72-82.
    • (2010) Brain Res Rev , vol.63 , pp. 72-82
    • Trotter, J.1    Karram, K.2    Nishiyama, A.3
  • 75
    • 57749172539 scopus 로고    scopus 로고
    • Polydendrocytes (NG2 cells): multifunctional cells with lineage plasticity
    • Nishiyama A, Komitova M, Suzuki R, Zhu X, (2009) Polydendrocytes (NG2 cells): multifunctional cells with lineage plasticity. Nat Rev Neurosci 10: 9-22.
    • (2009) Nat Rev Neurosci , vol.10 , pp. 9-22
    • Nishiyama, A.1    Komitova, M.2    Suzuki, R.3    Zhu, X.4
  • 76
    • 0033982253 scopus 로고    scopus 로고
    • Target cells of apoptosis in the adult murine dentate gyrus and O4 immunoreactivity after ionizing radiation
    • Sasaki R, Matsumoto A, Itoh K, Kawabe T, Ota Y, et al. (2000) Target cells of apoptosis in the adult murine dentate gyrus and O4 immunoreactivity after ionizing radiation. Neurosci Lett 279: 57-60.
    • (2000) Neurosci Lett , vol.279 , pp. 57-60
    • Sasaki, R.1    Matsumoto, A.2    Itoh, K.3    Kawabe, T.4    Ota, Y.5
  • 77
    • 79953036457 scopus 로고    scopus 로고
    • Gray matter NG2 cells display multiple CA2+-signaling pathways and highly motile processes
    • Haberlandt C, Derouiche A, Wyczynski A, Haseleu J, Pohle J, et al. (2011) Gray matter NG2 cells display multiple CA2+-signaling pathways and highly motile processes. PLoS One 6 (3):: e17575.
    • (2011) PLoS One , vol.6 , Issue.3
    • Haberlandt, C.1    Derouiche, A.2    Wyczynski, A.3    Haseleu, J.4    Pohle, J.5
  • 78
    • 64549125545 scopus 로고    scopus 로고
    • NG2 cells generate oligodendrocytes and gray matter astrocytes in the spinal cord
    • Zhu X, Hill RA, Nishiyama A, (2008) NG2 cells generate oligodendrocytes and gray matter astrocytes in the spinal cord. Neuron Glia Biol 4 (1):: 19-26.
    • (2008) Neuron Glia Biol , vol.4 , Issue.1 , pp. 19-26
    • Zhu, X.1    Hill, R.A.2    Nishiyama, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.