-
1
-
-
77956457439
-
Resveratrol and derivatives for the prevention and treatment of cancer
-
Fulda, S. Resveratrol and derivatives for the prevention and treatment of cancer. Drug Discov Today 15, 757-765 (2010).
-
(2010)
Drug Discov Today
, vol.15
, pp. 757-765
-
-
Fulda, S.1
-
2
-
-
84899463978
-
Resveratrol and cancer: Focus on in vivo evidence
-
Carter, L. G., D'Orazio, J. A., Pearson, K. J. Resveratrol and cancer: focus on in vivo evidence. Endocr Relat Cancer 21, R209-225 (2014).
-
(2014)
Endocr Relat Cancer
, vol.21
, pp. R209-225
-
-
Carter, L.G.1
D'Orazio, J.A.2
Pearson, K.J.3
-
3
-
-
6944250259
-
Role of resveratrol in prevention and therapy of cancer: Preclinical and clinical studies
-
Aggarwal, B. B. et al. Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies. Anticancer Res 24, 2783-2840 (2004).
-
(2004)
Anticancer Res
, vol.24
, pp. 2783-2840
-
-
Aggarwal, B.B.1
-
4
-
-
67650297506
-
Cancer prevention and treatment with resveratrol: From rodent studies to clinical trials
-
Bishayee, A. Cancer prevention and treatment with resveratrol: from rodent studies to clinical trials. Cancer Prev Res (Phila) 2, 409-418 (2009).
-
(2009)
Cancer Prev Res (Phila)
, vol.2
, pp. 409-418
-
-
Bishayee, A.1
-
5
-
-
0031561513
-
Cancer chemopreventive activity of resveratrol, a natural product derived from grapes
-
Jang, M. et al. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science 275, 218-220 (1997).
-
(1997)
Science
, vol.275
, pp. 218-220
-
-
Jang, M.1
-
6
-
-
0035933774
-
Specific structural determinants are responsible for the antioxidant activity and the cell cycle effects of resveratrol
-
Stivala, L. A. et al. Specific structural determinants are responsible for the antioxidant activity and the cell cycle effects of resveratrol. J Biol Chem 276, 22586-22594 (2001).
-
(2001)
J Biol Chem
, vol.276
, pp. 22586-22594
-
-
Stivala, L.A.1
-
7
-
-
2542445157
-
Resveratrol is a peroxidase-mediated inactivator of COX-1 but not COX-2: A mechanistic approach to the design of COX-1 selective agents
-
Szewczuk, L. M., Forti, L., Stivala, L. A., Penning, T. M. Resveratrol is a peroxidase-mediated inactivator of COX-1 but not COX-2: a mechanistic approach to the design of COX-1 selective agents. J Biol Chem 279, 22727-22737 (2004).
-
(2004)
J Biol Chem
, vol.279
, pp. 22727-22737
-
-
Szewczuk, L.M.1
Forti, L.2
Stivala, L.A.3
Penning, T.M.4
-
8
-
-
84920187663
-
Anti-inflammatory effects of a triple-bond resveratrol analog: Structure and function relationship
-
Antus, C. et al. Anti-inflammatory effects of a triple-bond resveratrol analog: structure and function relationship. Eur J Pharmacol 748, 61-67 (2015).
-
(2015)
Eur J Pharmacol
, vol.748
, pp. 61-67
-
-
Antus, C.1
-
9
-
-
70350346843
-
The resveratrol analogue 4,4-dihydroxy-trans-stilbene inhibits cell proliferation with higher efficiency but different mechanism from resveratrol
-
Savio, M. et al. The resveratrol analogue 4,4-dihydroxy-trans-stilbene inhibits cell proliferation with higher efficiency but different mechanism from resveratrol. Int J Biochem Cell Biol 41, 2493-2502 (2009).
-
(2009)
Int J Biochem Cell Biol
, vol.41
, pp. 2493-2502
-
-
Savio, M.1
-
10
-
-
17844388310
-
Antiangiogenic and vascular-targeting activity of the microtubule-destabilizing trans-resveratrol derivative 3,5,4-trimethoxystilbene
-
Belleri, M. et al. Antiangiogenic and vascular-targeting activity of the microtubule-destabilizing trans-resveratrol derivative 3,5,4-trimethoxystilbene. Mol Pharmacol 67, 1451-1459 (2005).
-
(2005)
Mol Pharmacol
, vol.67
, pp. 1451-1459
-
-
Belleri, M.1
-
11
-
-
77952423813
-
3,3 ,4,4 ,5,5-hexahydroxystilbene impairs melanoma progression in a metastatic mouse model
-
Paulitschke, V. et al. 3,3 ,4,4 ,5,5-hexahydroxystilbene impairs melanoma progression in a metastatic mouse model. J Invest Dermatol 130, 1668-1679 (2010).
-
(2010)
J Invest Dermatol
, vol.130
, pp. 1668-1679
-
-
Paulitschke, V.1
-
12
-
-
57749087561
-
Identification of molecular pathways affected by pterostilbene, a natural dimethylether analog of resveratrol
-
Pan, Z. et al. Identification of molecular pathways affected by pterostilbene, a natural dimethylether analog of resveratrol. BMC Med Genomics 1, 7-20 (2008).
-
(2008)
BMC Med Genomics
, vol.1
, pp. 7-20
-
-
Pan, Z.1
-
13
-
-
84868613224
-
The resveratrol analog 4,4-dihydroxy-trans-stilbene suppresses transformation in normal mouse fibroblasts and inhibits proliferation and invasion of human breast cancer cells
-
Maccario, C. et al. The resveratrol analog 4,4-dihydroxy-trans-stilbene suppresses transformation in normal mouse fibroblasts and inhibits proliferation and invasion of human breast cancer cells. Carcinogenesis 33, 2172-80 (2012).
-
(2012)
Carcinogenesis
, vol.33
, pp. 2172-2180
-
-
MacCario, C.1
-
14
-
-
0014446525
-
Metabolic hydroxylations of trans-stilbene
-
Sinsheimer, J. E., Smith, R. V. Metabolic hydroxylations of trans-stilbene. Biochem J 111, 35-41 (1969).
-
(1969)
Biochem J
, vol.111
, pp. 35-41
-
-
Sinsheimer, J.E.1
Smith, R.V.2
-
15
-
-
0036512863
-
Cytochrome P450 1A1/2 mediated metabolism of trans-stilbene in rats and humans
-
Sanoh, S., Kitamura, S., Sugihara, K., Ohta, S. Cytochrome P450 1A1/2 mediated metabolism of trans-stilbene in rats and humans. Biol Pharm Bull 25, 397-400 (2002).
-
(2002)
Biol Pharm Bull
, vol.25
, pp. 397-400
-
-
Sanoh, S.1
Kitamura, S.2
Sugihara, K.3
Ohta, S.4
-
16
-
-
0034663297
-
Metabolic activation of the proestrogens trans-stilbene and trans-stilbene oxide by rat liver microsomes
-
Sugihara, K. et al. Metabolic activation of the proestrogens trans-stilbene and trans-stilbene oxide by rat liver microsomes. Toxicol Appl Pharmacol 167, 46-54 (2000).
-
(2000)
Toxicol Appl Pharmacol
, vol.167
, pp. 46-54
-
-
Sugihara, K.1
-
17
-
-
0141794455
-
Antioxidant and insect growth regulatory activities of stilbenes and extracts from Yucca periculosa
-
Torres, P. et al. Antioxidant and insect growth regulatory activities of stilbenes and extracts from Yucca periculosa. Phytochemistry 64, 463-473 (2003).
-
(2003)
Phytochemistry
, vol.64
, pp. 463-473
-
-
Torres, P.1
-
18
-
-
0035085038
-
Structure-activity relationships for a large diverse set of natural, synthetic, and environmental estrogens
-
Fang, H. et al. Structure-activity relationships for a large diverse set of natural, synthetic, and environmental estrogens. Chem Res Toxicol 14, 280-294 (2001).
-
(2001)
Chem Res Toxicol
, vol.14
, pp. 280-294
-
-
Fang, H.1
-
19
-
-
33746734173
-
Proteasome-independent down-regulation of estrogen receptor-alpha (ERalpha) in breast cancer cells treated with 4,4-dihydroxy-trans-stilbene
-
Balan, K. V. et al. Proteasome-independent down-regulation of estrogen receptor-alpha (ERalpha) in breast cancer cells treated with 4,4-dihydroxy-trans-stilbene. Biochem Pharmacol 72, 573-581 (2006).
-
(2006)
Biochem Pharmacol
, vol.72
, pp. 573-581
-
-
Balan, K.V.1
-
20
-
-
27244461732
-
Efficiency and mechanism of the antioxidant action of trans-resveratrol and its analogues in the radical liposome oxidation
-
Stojanovi, S., Sprinz, H., Brede, O. Efficiency and mechanism of the antioxidant action of trans-resveratrol and its analogues in the radical liposome oxidation. Arch Biochem Biophys 391, 79-89 (2001).
-
(2001)
Arch Biochem Biophys
, vol.391
, pp. 79-89
-
-
Stojanovi, S.1
Sprinz, H.2
Brede, O.3
-
21
-
-
0037120157
-
Antioxidant effects of resveratrol and its analogues against the free-radical-induced peroxidation of linoleic acid in micelles
-
Fang, J. G. et al. Antioxidant effects of resveratrol and its analogues against the free-radical-induced peroxidation of linoleic acid in micelles. Chemistry 8, 4191-4198 (2002).
-
(2002)
Chemistry
, vol.8
, pp. 4191-4198
-
-
Fang, J.G.1
-
22
-
-
0037454754
-
Inhibition of free radical-induced peroxidation of rat liver microsomes by resveratrol and its analogues
-
Cai, Y. J., Fang, J. G., Ma, L. P., Yang, L., Liu, Z. L. Inhibition of free radical-induced peroxidation of rat liver microsomes by resveratrol and its analogues. Biochim Biophys Acta 1637, 31-38 (2003).
-
(2003)
Biochim Biophys Acta
, vol.1637
, pp. 31-38
-
-
Cai, Y.J.1
Fang, J.G.2
Ma, L.P.3
Yang, L.4
Liu, Z.L.5
-
23
-
-
0037180989
-
Antioxidant properties of trans-epsilon-viniferin as compared to stilbene derivatives in aqueous and nonaqueous media
-
Privat, C. et al. Antioxidant properties of trans-epsilon-viniferin as compared to stilbene derivatives in aqueous and nonaqueous media. J Agric Food Chem 50, 1213-1217 (2002).
-
(2002)
J Agric Food Chem
, vol.50
, pp. 1213-1217
-
-
Privat, C.1
-
24
-
-
62149135338
-
4,4-Dihydroxy-trans-stilbene, a resveratrol analogue, exhibited enhanced antioxidant activity and cytotoxicity
-
Fan, G. J. et al. 4,4-Dihydroxy-trans-stilbene, a resveratrol analogue, exhibited enhanced antioxidant activity and cytotoxicity. Bioorg Med Chem 17, 2360-2365 (2009).
-
(2009)
Bioorg Med Chem
, vol.17
, pp. 2360-2365
-
-
Fan, G.J.1
-
25
-
-
79955465574
-
Finding more active antioxidants and cancer chemoprevention agents by elongating the conjugated links of resveratrol
-
Tang, J. J. et al. Finding more active antioxidants and cancer chemoprevention agents by elongating the conjugated links of resveratrol. Free Radic Biol Med 50, 1447-1457 (2011).
-
(2011)
Free Radic Biol Med
, vol.50
, pp. 1447-1457
-
-
Tang, J.J.1
-
26
-
-
54949114722
-
Antitumor activities of synthetic and natural stilbenes through antiangiogenic action
-
Kimura, Y., Sumiyoshi, M., Baba, K. Antitumor activities of synthetic and natural stilbenes through antiangiogenic action. Cancer Sci 99, 2083-2096 (2008).
-
(2008)
Cancer Sci
, vol.99
, pp. 2083-2096
-
-
Kimura, Y.1
Sumiyoshi, M.2
Baba, K.3
-
27
-
-
84886461893
-
Resveratrol and clinical trials: The crossroad from in vitro studies to human evidence
-
Tomé-Carneiro, J. et al. Resveratrol and clinical trials: the crossroad from in vitro studies to human evidence. Curr Pharm Des 19, 6064-6093 (2013).
-
(2013)
Curr Pharm des
, vol.19
, pp. 6064-6093
-
-
Tomé-Carneiro, J.1
-
28
-
-
79957444495
-
Ant i-tumor act ivity and mechanisms of a novel vascular disrupting agent, (Z)-3,4 ,5-trimethoxylstilbene-3-O-phosphate disodium ( M410
-
Cai, Y. C. et al. Ant i-tumor act ivity and mechanisms of a novel vascular disrupting agent, (Z)-3,4 ,5-trimethoxylstilbene-3-O-phosphate disodium (M410). Invest New Drugs 29, 300-311 (2011).
-
(2011)
Invest New Drugs
, vol.29
, pp. 300-311
-
-
Cai, Y.C.1
-
29
-
-
84939986664
-
3,4 ,5-trans-Trimethoxystilbene; A natural analogue of resveratrol with enhanced anticancer potency
-
Aldawsari, F. S., Velázquez-Martínez, C. A. 3,4 ,5-trans-Trimethoxystilbene; a natural analogue of resveratrol with enhanced anticancer potency. Invest New Drugs 33, 775-786 (2015).
-
(2015)
Invest New Drugs
, vol.33
, pp. 775-786
-
-
Aldawsari, F.S.1
Velázquez-Martínez, C.A.2
-
30
-
-
0028195052
-
Proliferating cell nuclear antigen (PCNA): A new marker to study human colonic cell proliferation
-
Kubben, F. J. et al. Proliferating cell nuclear antigen (PCNA): a new marker to study human colonic cell proliferation. Gut 35, 530-535 (1994).
-
(1994)
Gut
, vol.35
, pp. 530-535
-
-
Kubben, F.J.1
-
31
-
-
84866693927
-
Controlling escape from angiogenesis inhibitors
-
Sennino, B., McDonald, D. M. Controlling escape from angiogenesis inhibitors. Nat Rev Cancer 12, 699-709 (2012).
-
(2012)
Nat Rev Cancer
, vol.12
, pp. 699-709
-
-
Sennino, B.1
McDonald, D.M.2
-
32
-
-
0034991938
-
Resveratrol isolated from Polygonum cuspidatum root prevents tumor growth and metastasis to lung and tumor-induced neovascularization in Lewis lung carcinoma-bearing mice
-
Kimura, Y., Okuda, H. Resveratrol isolated from Polygonum cuspidatum root prevents tumor growth and metastasis to lung and tumor-induced neovascularization in Lewis lung carcinoma-bearing mice. J Nutr 131, 1844-1849 (2001).
-
(2001)
J Nutr
, vol.131
, pp. 1844-1849
-
-
Kimura, Y.1
Okuda, H.2
-
33
-
-
84929693088
-
Determination of naturally occurring resveratrol analog trans-4,4-dihydroxystilbene in rat plasma by liquid chromatography-tandem mass spectrometry: Application to a pharmacokinetic study
-
Chen, W., Yeo, S. C., Elhennawy, M. G., Xiang, X., Lin, H. S. Determination of naturally occurring resveratrol analog trans-4,4-dihydroxystilbene in rat plasma by liquid chromatography-tandem mass spectrometry: application to a pharmacokinetic study. Anal Bioanal Chem 407, 5793-5801 (2015).
-
(2015)
Anal Bioanal Chem
, vol.407
, pp. 5793-5801
-
-
Chen, W.1
Yeo, S.C.2
Elhennawy, M.G.3
Xiang, X.4
Lin, H.S.5
-
34
-
-
82255182998
-
Determination of resveratrol and its sulfate and glucuronide metabolites in plasma by LC-MS/MS and their pharmacokinetics in dogs
-
Muzzio, M. et al. Determination of resveratrol and its sulfate and glucuronide metabolites in plasma by LC-MS/MS and their pharmacokinetics in dogs. J Pharm Biomed Anal 59, 201-208 (2012).
-
(2012)
J Pharm Biomed Anal
, vol.59
, pp. 201-208
-
-
Muzzio, M.1
-
35
-
-
0142243190
-
Relationship between mechanisms, bioavailibility, and preclinical chemopreventive efficacy of resveratrol: A conundrum
-
Gescher, A. J., Steward, W. P. Relationship between mechanisms, bioavailibility, and preclinical chemopreventive efficacy of resveratrol: a conundrum. Cancer Epidemiol Biomarkers Prev 12, 953-957 (2003).
-
(2003)
Cancer Epidemiol Biomarkers Prev
, vol.12
, pp. 953-957
-
-
Gescher, A.J.1
Steward, W.P.2
-
36
-
-
1242336775
-
Urinary and plasma levels of resveratrol and quercetin in humans, mice, and rats after ingestion of pure compounds and grape juice
-
Meng, X., Maliakal, P., Lu, H., Lee, M. J., Yang, C. S. Urinary and plasma levels of resveratrol and quercetin in humans, mice, and rats after ingestion of pure compounds and grape juice. J Agric Food Chem 52, 935-942 (2004).
-
(2004)
J Agric Food Chem
, vol.52
, pp. 935-942
-
-
Meng, X.1
Maliakal, P.2
Lu, H.3
Lee, M.J.4
Yang, C.S.5
-
37
-
-
9444296057
-
High absorption but very low bioavailability of oral resveratrol in humans
-
Walle, T., Hsieh, F., DeLegge, M. H., Oatis, J. E., Walle, U. K. High absorption but very low bioavailability of oral resveratrol in humans. Drug Metab Dispos 32, 1377-1382 (2004).
-
(2004)
Drug Metab Dispos
, vol.32
, pp. 1377-1382
-
-
Walle, T.1
Hsieh, F.2
DeLegge, M.H.3
Oatis, J.E.4
Walle, U.K.5
-
38
-
-
84918551405
-
Metabolism of skin-absorbed resveratrol into its glucuronized form in mouse skin
-
Murakami, I. et al. Metabolism of skin-absorbed resveratrol into its glucuronized form in mouse skin. PLoS One 9, e115359 (2014).
-
(2014)
PLoS One
, vol.9
, pp. e115359
-
-
Murakami, I.1
-
39
-
-
33748916241
-
Methylated flavonoids have greatly improved intestinal absorption and metabolic stability
-
Wen, X., Walle, T. Methylated flavonoids have greatly improved intestinal absorption and metabolic stability. Drug Metab Dispos 34 1786-1792 (2006).
-
(2006)
Drug Metab Dispos
, vol.34
, pp. 1786-1792
-
-
Wen, X.1
Walle, T.2
-
40
-
-
84858291668
-
Pterostilbene and cancer: Current review
-
McCormack, D., McFadden, D. Pterostilbene and cancer: current review. J Surg Res 173, e53-61 (2012).
-
(2012)
J Surg Res
, vol.173
, pp. e53-61
-
-
McCormack, D.1
McFadden, D.2
-
41
-
-
0037023981
-
Cancer chemopreventive and antioxidant activities of pterostilbene, a naturally occurring analogue of resveratrol
-
Rimando, A. M. et al. Cancer chemopreventive and antioxidant activities of pterostilbene, a naturally occurring analogue of resveratrol. J Agric Food Chem 50, 3453-3457 (2002).
-
(2002)
J Agric Food Chem
, vol.50
, pp. 3453-3457
-
-
Rimando, A.M.1
-
42
-
-
80054014686
-
Pharmacokinetics oral bioavailability, and metabolic profile of resveratrol and its dimethylether analog, pterostilbene, in rats
-
Kapetanovic, I. M., Muzzio, M., Huang, Z., Thompson, T. N., McCormick, D. L. Pharmacokinetics, oral bioavailability, and metabolic profile of resveratrol and its dimethylether analog, pterostilbene, in rats. Cancer Chemother Pharmacol 68, 593-601 (2011).
-
(2011)
Cancer Chemother Pharmacol
, vol.68
, pp. 593-601
-
-
Kapetanovic, I.M.1
Muzzio, M.2
Huang, Z.3
Thompson, T.N.4
McCormick, D.L.5
-
43
-
-
53849145999
-
The impact of aqueous solubility and dose on the pharmacokinetic profiles of resveratrol
-
Das, S., Lin, H. S., Ho, P. C., Ng, K. Y. The impact of aqueous solubility and dose on the pharmacokinetic profiles of resveratrol. Pharm Res 25, 2593-2600 (2008).
-
(2008)
Pharm Res
, vol.25
, pp. 2593-2600
-
-
Das, S.1
Lin, H.S.2
Ho, P.C.3
Ng, K.Y.4
-
44
-
-
33749558110
-
Potent inhibition of Lewis lung cancer growth by heyneanol A from the roots of Vitis amurensis through apoptotic and anti-angiogenic activities
-
Lee, E. O. et al. Potent inhibition of Lewis lung cancer growth by heyneanol A from the roots of Vitis amurensis through apoptotic and anti-angiogenic activities. Carcinogenesis 27, 2059-2069 (2006).
-
(2006)
Carcinogenesis
, vol.27
, pp. 2059-2069
-
-
Lee, E.O.1
-
45
-
-
0035430177
-
Suppression of angiogenesis, tumor growth, and wound healing by resveratrol, a natural compound in red wine and grapes
-
Brakenhielm, E., Cao, R., Cao, Y. Suppression of angiogenesis, tumor growth, and wound healing by resveratrol, a natural compound in red wine and grapes. FASEB J 15, 1798-1800 (2001).
-
(2001)
FASEB J
, vol.15
, pp. 1798-1800
-
-
Brakenhielm, E.1
Cao, R.2
Cao, Y.3
-
46
-
-
22544463089
-
Inhibition of mammalian DNA polymerases by resveratrol: Mechanism and structural determinants
-
Locatelli, G. A. et al. Inhibition of mammalian DNA polymerases by resveratrol: mechanism and structural determinants. Biochem J 389, 259-268 (2005).
-
(2005)
Biochem J
, vol.389
, pp. 259-268
-
-
Locatelli, G.A.1
-
47
-
-
80054073689
-
Structure-activity relationship of resveratrol and its analogue, 4,4-dihydroxy-trans-stilbene, toward the endothelin axis in human endothelial cells
-
Coppa, T. et al. Structure-activity relationship of resveratrol and its analogue, 4,4-dihydroxy-trans-stilbene, toward the endothelin axis in human endothelial cells. J Med Food 14, 1173-1180 (2011).
-
(2011)
J Med Food
, vol.14
, pp. 1173-1180
-
-
Coppa, T.1
-
48
-
-
68949092046
-
Study of the effects of a new pyrazolecarboxamide: Changes in mitochondria and induction of apoptosis
-
Giansanti, V. et al. Study of the effects of a new pyrazolecarboxamide: changes in mitochondria and induction of apoptosis. Int J Biochem Cell Biol 41, 1890-1898 (2009).
-
(2009)
Int J Biochem Cell Biol
, vol.41
, pp. 1890-1898
-
-
Giansanti, V.1
-
49
-
-
4344703256
-
Anthocyanins induce cell cycle perturbations and apoptosis in different human cell lines
-
Lazze, M. C. et al. Anthocyanins induce cell cycle perturbations and apoptosis in different human cell lines. Carcinogenesis 25, 1427-1433 (2004).
-
(2004)
Carcinogenesis
, vol.25
, pp. 1427-1433
-
-
Lazze, M.C.1
-
50
-
-
84923649395
-
Renal fibrogenesis and platinum compounds in a rat model: A novel Pt (II) complex vs. Cisplatin
-
Fenoglio, C. et al. Renal fibrogenesis and platinum compounds in a rat model: a novel Pt (II) complex vs. cisplatin. Anticancer Res 35, 739-751 (2015).
-
(2015)
Anticancer Res
, vol.35
, pp. 739-751
-
-
Fenoglio, C.1
-
51
-
-
79952769787
-
Antiangiogenic agents significantly improve survival in tumor-bearing mice by increasing tolerance to chemotherapy-induced toxicity
-
Zhang, D. et al. Antiangiogenic agents significantly improve survival in tumor-bearing mice by increasing tolerance to chemotherapy-induced toxicity. Proc Natl Acad Sci USA 108, 4117-4122 (2011).
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 4117-4122
-
-
Zhang, D.1
-
52
-
-
84930941341
-
VEGF-B promotes cancer metastasis through a VEGF-A-independent mechanism and serves as a marker of poor prognosis for cancer patients
-
Yang, X. et al. VEGF-B promotes cancer metastasis through a VEGF-A-independent mechanism and serves as a marker of poor prognosis for cancer patients. Proc Natl Acad Sci USA 112, E2900-2909 (2015).
-
(2015)
Proc Natl Acad Sci USA
, vol.112
, pp. E2900-2909
-
-
Yang, X.1
|