Metabolic activation of the proestrogens trans-stilbene and trans-stilbene oxide by rat liver microsomes

Toxicology and Applied Pharmacology

Volumn 167, Issue 1, 2000, Pages 46-54

  Sugihara, Kazumi ^a   Kitamura, Shigeyuki ^a   Sanoh, Seigo ^a   Ohta, Shigeru ^a   Fujimoto, Nariaki ^b   Maruyama, Satoshi ^b   Ito, Akihiro ^b  

^a HIROSHIMA UNIV SCHOOL OF MEDICINE   (Japan)

^b HIROSHIMA UNIVERSITY   (Japan)

Author keywords

Estrogenic activity; Human breast cancer cell line MCF 7; Metabolic activation; Rat liver microsomes; Rat pituitary tumor cell line MtT E 2; trans 4,4' dihydroxystilbene; trans 4 hydroxystilbene; trans stilbene; trans stilbene oxide

Indexed keywords

HORMONE PRECURSOR; STILBENE; TRANS STILBENE OXIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; ESTROGEN ACTIVITY; LIVER MICROSOME; LIVER MICROSOME METABOLISM; MALE; METABOLIC ACTIVATION; NONHUMAN; RAT;

ANIMALIA; MINK CELL FOCUS-FORMING VIRUS;

EID: 0034663297     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.2000.8979     Document Type: Article

References (35)

1. Synthesis and nematocidal activity of hydroxystilbenes
2. Transcriptional activation of the human estrogen receptor by DDT isomers and metabolites in yeast and MCF-7 cells
3. Hydroxylated polychlorinated biphenyls (PCBs) as estrogens and antiestrogens: Structure-activity relationships
4. Estrogenic activity of some hydrocarbon derivatives of ethylene
5. Untersuchungen uber Stilbene.II.Mitt. Die Darstellung von Stilbenderivaten der Adrenalin-Reihe
6. Metabolism of insecticides by reductive systems
7. Metabolism of nitro-polycyclic aromatic hydrocarbons
8. Establishment of an estrogen responsive rat pituitary cell sub-line MtT/E-2
9. In vitro estrogenicity of the catechol metabolitea of selected polychlorinated biphenyls
10. Artifical estrogens
11. Adenocarcinoma of the vagina: Association of maternal stilbestrol therapy with tumor appearance in young women
12. Some hypocholesteremic 2,3-diphenylacrylonitriles
13. Persistent DDT metabolite p, p'- DDE is a potent androgen receptor antagonist
14. Reductive metabolism of stilbene oxide and styrene oxide to the olefins in rats
15. Reduction of stilbene oxide and styrene oxide to the corresponding alkenes by intestinal bacteria
16. Reductive dechlorination of p, p'-DDT mediated by hemoproteins in the hepatopancreas and blood of goldfish, Carassius auratus
17. Estrogen receptor-binding activity of polychlorinated hydroxybiphenyls: Conformationally restricted structural probes
18. Metabolic activation of pesticides with proestrogenic activity
19. Protein measurement with the Folin phenol reagent
20. Growth stimulation of a rat pituitary cell line MtT/E-2 by environmental estrogens in vitro and in vivo
21. Purification and characterization of the major microsomal cytochrome P-450 from induced by trans-stilbene oxide in rat liver
22. Coordinate- and elicitor-dependent expression of stilbene synthase and phenylalanine ammona-lyase genes in Vitis cv
23. Biochemical toxicology of diethylstilbestrol
24. Hepatic epoxide hydrase. Structure-activity relationships for substrates and inhibitors
25. Catalysis of the oxidation and reduction reactions of steroid and stilbene estrogens by nuclear enzymes
26. Polyhydroxylated metabolites of trans-stilbene in the rat
27. Molecular analysis of resveratrol synthase. CDNA, genomic clones and relationship with chalcone synthase
28. 4,4'-Dihydroxybibenzyl, a reduction metabolite of trans-stilbene
29. Metabolic hydroxylation of trans-stilbene
30. Diethylstilbestrol in the prevention and treatment of complications of pregnancy
31. Hum cytochrome P450-catalyzed conversion of the proestrogenic pesticide methoxychlor into an estrogen. Role of CYP2C19 and CYP1A2 in O-demethylation
32. Preliminary investigation of the metabolism of stilbene
33. The metabolism of the parent compounds of some of the simpler synthetic oestrogenic hydrocarbons
34. Rat liver DT-diaphorase: Regulation of functional mRNA levels by 3-methylcholanthrene, trans-stilbene oxide, and phenobarbital
35. Boron trihalide-methyl sulfide complex as convenient reagents for dealkylation of aryl ether