The neuroscience and context of adolescent depression

Acta Paediatrica, International Journal of Paediatrics

Volumn 105, Issue 4, 2016, Pages 358-365

  Henje Blom, Eva ^a,b   Ho, Tiffany C ^a   Connolly, Colm G ^a   LeWinn, Kaja Z ^a   Sacchet, Matthew D ^a,c   Tymofiyeva, Olga ^d   Weng, Helen Y ^d   Yang, Tony T ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b KAROLINSKA INSTITUTE   (Sweden)

^c STANFORD UNIVERSITY   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Adolescent depression; Contextual factors; Neuroscience; Review; Sustained threat

Indexed keywords

ADOLESCENT DEPRESSION; AMYGDALOID NUCLEUS; BRAIN DEVELOPMENT; DEPRESSION; EMOTIONALITY; ENDOCRINE SYSTEM; EPIGENETICS; FAMILY THERAPY; FUNCTIONAL MAGNETIC RESONANCE IMAGING; GENETIC ASSOCIATION; HUMAN; IMMUNE SYSTEM; LIFE STRESS; METABOLISM; NERVE CELL NETWORK; NEUROSCIENCE; PATHOPHYSIOLOGY; PREVALENCE; PRIORITY JOURNAL; PSYCHOTHERAPY; PUBLIC HEALTH PROBLEM; REVIEW; SUICIDE; ADOLESCENT; CHILD PSYCHOLOGY; DIAGNOSTIC IMAGING; GENETIC EPIGENESIS; MENTAL STRESS;

ADOLESCENT; DEPRESSION; EPIGENESIS, GENETIC; HUMANS; PSYCHOLOGY, ADOLESCENT; STRESS, PSYCHOLOGICAL;

EID: 84956600700     PISSN: 08035253     EISSN: 16512227     Source Type: Journal    
DOI: 10.1111/apa.13299     Document Type: Review

References (80)

1. Perou R, Bitsko RH, Blumberg SJ, Pastor P, Ghandour RM, Gfroerer JC, et al., Mental health surveillance among children-United States, 2005-2011. Morbidity and mortality weekly report. MMWR Surveill Summ 2013; 62 (Suppl 2): 1-35.
2. The Swedish National Board of Health and Welfare. F. Folkhälsorapporten 2009. 2009.
3. Avenevoli S, Swendsen J, He JP, Burstein M, Merikangas KR,. Major depression in the national comorbidity survey-adolescent supplement: prevalence, correlates, and treatment. J Am Acad Child Adolesc Psychiatry 2015; 54: 37-44.e2.
4. Korczak DJ, Goldstein BI,. Childhood onset major depressive disorder: course of illness and psychiatric comorbidity in a community sample. J Pediatr 2009; 155: 118-23.
5. Birmaher B, Arbelaez C, Brent D,. Course and outcome of child and adolescent major depressive disorder. Child Adolesc Psychiatr Clin N Am 2002; 11: 619-37.
6. Birmaher B, Ryan ND, Williamson DE, Brent DA, Kaufman J, Dahl RE, et al., Childhood and adolescent depression: a review of the past 10 years. Part I. J Am Acad Child Adolesc Psychiatry 1996; 35: 1427-39.
7. Wolkowitz OM, Reus VI, Mellon SH,. Of sound mind and body: depression, disease, and accelerated aging. Dialogues Clin Neurosci 2011; 13: 25-39.
8. Mulder RT,. An epidemic of depression or the medicalization of distress? Perspect Biol Med 2008; 51: 238-50.
9. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders DSM-IV-TR Fourth Edition: American Psychiatric Association; 2000.
10. Henje Blom E, Forsman M, Yang TT, Serlachius E, Larsson JO,. Latent classes of symptoms related to clinically depressed mood in adolescents. Scand J Child Adolesc Psychiatr Psychol 2014; 2: 19-28.
11. Insel T, Cuthbert B, Garvey M, Heinssen R, Pine DS, Quinn K, et al., Research domain criteria (RDoC): toward a new classification framework for research on mental disorders. Am J Psychiatry 2010; 167: 748-51.
12. Casey BJ, Oliveri ME, Insel T,. A neurodevelopmental perspective on the research domain criteria (RDoC) framework. Biol Psychiatry 2014; 76: 350-3.
13. Cox GR, Callahan P, Churchill R, Hunot V, Merry SN, Parker AG, et al., Psychological therapies versus antidepressant medication, alone and in combination for depression in children and adolescents. Cochrane Database Syst Rev 2014; 11: CD008324.
14. Reinecke MA, Curry JF, March JS,. Findings from the Treatment for Adolescents with Depression Study (TADS): what have we learned? What do we need to know? J Clin Child Adolesc Psychol 2009; 38: 761-7.
15. Henje Blom E, Duncan LG, Ho TC, Connolly CG, LeWinn KZ, Chesney M, et al., The development of an RDoC-based treatment program for adolescent depression: "Training for Awareness, Resilience, and Action" (TARA). Front Hum Neurosci 2014; 8: 630.
16. Rice F, Rawal A, Riglin L, Lewis G, Lewis G, Dunsmuir S,. Examining reward-seeking, negative self-beliefs and over-general autobiographical memory as mechanisms of change in classroom prevention programs for adolescent depression. J Affect Disord 2015; 186: 320-7.
17. Cousins L, Goodyer IM,. Antidepressants and the adolescent brain. J Psychopharmacol 2015; 29: 545-55.
18. Ferguson JM,. SSRI antidepressant medications: adverse effects and tolerability. Prim Care Companion J Clin Psychiatry 2001; 3: 22-7.
19. Jaycox LH, Stein BD, Paddock S, Miles JN, Chandra A, Meredith LS, et al., Impact of teen depression on academic, social, and physical functioning. Pediatrics 2009; 124: e596-605.
20. Popovic D, Vieta E, Fornaro M, Perugi G,. Cognitive tolerability following successful long term treatment of major depression and anxiety disorders with SSRi antidepressants. J Affect Disord 2015; 173: 211-5.
21. Sansone RA, Sansone LA,. SSRI-induced indifference. Psychiatry 2010; 7: 14-8.
22. Molero Y, Lichtenstein P, Zetterqvist J, Gumpert CH, Fazel S,. Selective serotonin reuptake inhibitors and violent crime: a cohort study. PLoS Med 2015; 12: e1001875.
23. Fava GA, Offidani E,. The mechanisms of tolerance in antidepressant action. Prog Neuropsychopharmacol Biol Psychiatry 2011; 35: 1593-602.
24. Varigonda AL, Jakubovski E, Taylor MJ, Freemantle N, Coughlin C, Bloch MH,. Systematic review and meta-analysis: early treatment responses of selective serotonin reuptake inhibitors in pediatric major depressive disorder. J Am Acad Child Adolesc Psychiatry 2015; 54: 557-64.
25. Kirsch I, Deacon BJ, Huedo-Medina TB, Scoboria A, Moore TJ, Johnson BT,. Initial severity and antidepressant benefits: a meta-analysis of data submitted to the food and drug administration. PLoS Med 2008; 5: e45.
26. Le Noury J, Nardo JM, Healy D, Jureidini J, Raven M, Tufanaru C, et al., Restoring study 329: efficacy and harms of paroxetine and imipramine in treatment of major depression in adolescence. BMJ 2015; 351: h4320.
27. Silva LJ, Pereira AM, Meisel LM, Lino CM, Pena A,. Reviewing the serotonin reuptake inhibitors (SSRIs) footprint in the aquatic biota: uptake, bioaccumulation and ecotoxicology. Environ Pollut 2015; 197: 127-43.
28. Dannlowski U, Stuhrmann A, Beutelmann V, Zwanzger P, Lenzen T, Grotegerd D, et al., Limbic scars: long-term consequences of childhood maltreatment revealed by functional and structural magnetic resonance imaging. Biol Psychiatry 2012; 71: 286-93.
29. Sisk CL, Zehr JL,. Pubertal hormones organize the adolescent brain and behavior. Front Neuroendocrinol 2005; 26: 163-74.
30. Yang TT, Simmons AN, Matthews SC, Tapert SF, Frank GK, Max JE, et al., Adolescents with major depression demonstrate increased amygdala activation. J Am Acad Child Adolesc Psychiatry 2010; 49: 42-51.
31. Yang TT, Simmons AN, Matthews SC, Tapert SF, Frank GK, Bischoff-Grethe A, et al., Depressed adolescents demonstrate greater subgenual anterior cingulate activity. NeuroReport 2009; 20: 440-4.
32. Ho TC, Yang G, Wu J, Cassey P, Brown SD, Hoang N, et al., Functional connectivity of negative emotional processing in adolescent depression. J Affect Disord 2014; 155: 65-74.
33. Michl LC, McLaughlin KA, Shepherd K, Nolen-Hoeksema S,. Rumination as a mechanism linking stressful life events to symptoms of depression and anxiety: longitudinal evidence in early adolescents and adults. J Abnorm Psychol 2013; 122: 339-52.
34. Kerestes R, Davey CG, Stephanou K, Whittle S, Harrison BJ,. Functional brain imaging studies of youth depression: a systematic review. Neuroimage Clin 2013; 4: 209-31.
35. Davey CG, Whittle S, Harrison BJ, Simmons JG, Byrne ML, Schwartz OS, et al., Functional brain-imaging correlates of negative affectivity and the onset of first-episode depression. Psychol Med 2015; 45: 1001-9.
36. Cullen KR, Westlund MK, Klimes-Dougan B, Mueller BA, Houri A, Eberly LE, et al., Abnormal amygdala resting-state functional connectivity in adolescent depression. JAMA Psychiatry 2014; 71: 1138-47.
37. Forbes EE, Dahl RE,. Research review: altered reward function in adolescent depression: what, when and how? J Child Psychol Psychiatry 2012; 53: 3-15.
38. Hulvershorn LA, Cullen K, Anand A,. Toward dysfunctional connectivity: a review of neuroimaging findings in pediatric major depressive disorder. Brain Imaging Behav 2011; 5: 307-28.
39. Andrews-Hanna JR, Mackiewicz Seghete KL, Claus ED, Burgess GC, Ruzic L, Banich MT,. Cognitive control in adolescence: neural underpinnings and relation to self-report behaviors. PLoS One 2011; 6: e21598.
40. Levinson DF,. The genetics of depression: a review. Biol Psychiatry 2006; 60: 84-92.
41. Kim DR, Bale TL, Epperson CN,. Prenatal programming of mental illness: current understanding of relationship and mechanisms. Curr Psychiatry Rep 2015; 17: 5.
42. Harris A, Seckl J,. Glucocorticoids, prenatal stress and the programming of disease. Horm Behav 2011; 59: 279-89.
43. Henje Blom E, Lekander M, Ingvar M, Asberg M, Mobarrez F, Serlachius E,. Pro-inflammatory cytokines are elevated in adolescent females with emotional disorders not treated with SSRIs. J Affect Disord 2012; 136: 716-23.
44. Taylor SE, Way BM, Seeman TE,. Early adversity and adult health outcomes. Dev Psychopathol 2011; 23: 939-54.
45. Andersen SL, Teicher MH,. Stress, sensitive periods and maturational events in adolescent depression. Trends Neurosci 2008; 31: 183-91.
46. Colich NL, Kircanski K, Foland-Ross LC, Gotlib IH,. HPA-axis reactivity interacts with stage of pubertal development to predict the onset of depression. Psychoneuroendocrinology 2015; 55: 94-101.
47. Galvao TF, Silva MT, Zimmermann IR, Souza KM, Martins SS, Pereira MG,. Pubertal timing in girls and depression: a systematic review. J Affect Disord 2014; 155: 13-9.
48. Mouritsen A, Aksglaede L, Sorensen K, Mogensen SS, Leffers H, Main KM, et al., Hypothesis: exposure to endocrine-disrupting chemicals may interfere with timing of puberty. Int J Androl 2010; 33: 346-59.
49. Perlman G, Simmons AN, Wu J, Hahn KS, Tapert SF, Max JE, et al., Amygdala response and functional connectivity during emotion regulation: a study of 14 depressed adolescents. J Affect Disord 2012; 139: 75-84.
50. Malik S, Wells A, Wittkowski A,. Emotion regulation as a mediator in the relationship between attachment and depressive symptomatology: a systematic review. J Affect Disord 2014; 172C: 428-44.
51. Mandelli L, Petrelli C, Serretti A,. The role of specific early trauma in adult depression: a meta-analysis of published literature. Childhood trauma and adult depression. Eur Psychiatry 2015; 30: 665-80.
52. Gilbert R, Widom CS, Browne K, Fergusson D, Webb E, Janson S,. Burden and consequences of child maltreatment in high-income countries. Lancet 2009; 373: 68-81.
53. Moskowitz D, Vittinghoff E, Schmidt L,. Reconsidering the effects of poverty and social support on health: a 5-year longitudinal test of the stress-buffering hypothesis. J Urban Health 2013; 90: 175-84.
54. Mikulincer M, Shaver PR,. An attachment perspective on psychopathology. World Psychiatry 2012; 11: 11-5.
55. Roberts DF,. Media and youth: access, exposure, and privatization. J Adolesc Health 2000; 27: 8-14.
56. Primack BA, Swanier B, Georgiopoulos AM, Land SR, Fine MJ,. Association between media use in adolescence and depression in young adulthood: a longitudinal study. Arch Gen Psychiatry 2009; 66: 181-8.
57. Bailin A, Milanaik R, Adesman A,. Health implications of new age technologies for adolescents: a review of the research. Curr Opin Pediatr 2014; 26: 605-19.
58. Rosen LD, Lim AF, Felt J, Carrier LM, Cheever NA, Lara-Ruiz JM, et al., Media and technology use predicts ill-being among children, preteens and teenagers independent of the negative health impacts of exercise and eating habits. Comput Hum Behav 2014; 35: 364-75.
59. Stice E, Hayward C, Cameron RP, Killen JD, Taylor CB,. Body-image and eating disturbances predict onset of depression among female adolescents: a longitudinal study. J Abnorm Psychol 2000; 109: 438-44.
60. Dittmar H, Bond R, Hurst M, Kasser T,. The relationship between materialism and personal well-being: a meta-analysis. J Pers Soc Psychol 2014; 107: 879-924.
61. van Geel M, Vedder P, Tanilon J,. Relationship between peer victimization, cyberbullying, and suicide in children and adolescents: a meta-analysis. JAMA Pediatr 2014; 168: 435-42.
62. Aboujaoude E, Savage MW, Starcevic V, Salame WO,. Cyberbullying: review of an old problem gone viral. J Adolesc Health 2015; 57: 10-8.
63. Slavich GM, Irwin MR,. From stress to inflammation and major depressive disorder: a social signal transduction theory of depression. Psychol Bull 2014; 140: 774-815.
64. Toseeb U, Inkster B,. Online social networking sites and mental health research. Front Psychiatry 2015; 6: 36.
65. Shaftel HJA, (editor). Global Climate Change, Vital Signs of the Planet. California Institute of Technology, Pasadena, CA: The Earth Science Communications Team at NASA's Jet Propulsion Laboratory, 2015.
66. Clayton S, Manning C, Hodge C,. Beyond storms and droughts: The psychological impacts of climate change momentus. Available from URL http://ecoamerica.org/wp-content/uploads/2014/06/eA-Beyond-Storms-and-Droughts-Psych-Impacts-of-Climate-Change.pdf2014.
67. Kowalski RM, Giumetti GW, Schroeder AN, Lattanner MR,. Bullying in the digital age: a critical review and meta-analysis of cyberbullying research among youth. Psychol Bull 2014; 140: 1073-137.
68. Wirtén HK, Klum M, Lakso J, Nyberg H, Holmgren P,. 80 procent av Sveriges unga har klimatångest. Svenska Dagbladet, 2014.
69. Spinhoven P, Drost J, de Rooij M, van Hemert AM, Penninx BW,. A longitudinal study of experiential avoidance in emotional disorders. Behav Ther 2014; 45: 840-50.
70. Ewing ES, Diamond G, Levy S,. Attachment-based family therapy for depressed and suicidal adolescents: theory, clinical model and empirical support. Attach Hum Dev 2015; 17: 136-56.
71. Mufson L, Dorta KP, Wickramaratne P, Nomura Y, Olfson M, Weissman MM,. A randomized effectiveness trial of interpersonal psychotherapy for depressed adolescents. Arch Gen Psychiatry 2004; 61: 577-84.
72. Hayes L, Boyd CP, Sewell J,. Acceptance and commitment therapy for the treatment of adolescent depression: a pilot study in a psychiatric outpatient setting. Mindfulness 2011; 2: 86-94.
73. Li J, Theng YL, Foo S,. Game-based digital interventions for depression therapy: a systematic review and meta-analysis. Cyberpsychol Behav Soc Netw 2014; 17: 519-27.
74. Ebert DD, Zarski AC, Christensen H, Stikkelbroek Y, Cuijpers P, Berking M, et al., Internet and computer-based cognitive behavioral therapy for anxiety and depression in youth: a meta-analysis of randomized controlled outcome trials. PLoS One 2015; 10: e0119895.
75. Catalano RF, Fagan AA, Gavin LE, Greenberg MT, Irwin CE Jr, Ross DA, et al., Worldwide application of prevention science in adolescent health. Lancet 2012; 379: 1653-64.
76. McEwen BS,. Brain on stress: how the social environment gets under the skin. Proc Natl Acad Sci U S A 2012; 109 (Suppl 2): 17180-5.
77. Evans R, Murphy S, Scourfield J,. Implementation of a school-based social and emotional learning intervention: understanding diffusion processes within complex systems. Prev Sci 2015; 16: 754-64.
78. Greenberg MT, Lippold MA,. Promoting healthy outcomes among youth with multiple risks: innovative approaches. Annu Rev Public Health 2013; 34: 253-70.
79. Atkins MS, Rusch D, Mehta TG, Lakind D,. Future directions for dissemination and implementation science: aligning ecological theory and public health to close the research to practice gap. J Clin Child Adolesc Psychol 2015; 53: 1-12.
80. Norris FH, Stevens SP, Pfefferbaum B, Wyche KF, Pfefferbaum RL,. Community resilience as a metaphor, theory, set of capacities, and strategy for disaster readiness. Am J Community Psychol 2008; 41: 127-50.