Psychological therapies versus antidepressant medication, alone and in combination for depression in children and adolescents

Cochrane Database of Systematic Reviews

Volumn 2014, Issue 11, 2014, Pages

  Cox, Georgina R ^a   Callahan, Patch ^a   Churchill, Rachel ^b   Hunot, Vivien ^b   Merry, Sally N ^c   Parker, Alexandra G ^a   Hetrick, Sarah E ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

^c UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDEPRESSANT AGENT;

ADOLESCENT; ADVERSE EVENT; ANXIETY; CHILD; CLINICAL OUTCOME; COMPARATIVE EFFECTIVENESS; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; DISEASE SEVERITY; DRUG DEPENDENCE; HUMAN; INTERNATIONAL CLASSIFICATION OF DISEASES; INTERVENTION STUDY; MAJOR DEPRESSION; META ANALYSIS; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PSYCHOTHERAPY; REMISSION; REVIEW; SUICIDAL IDEATION; SYMPTOM; SYSTEMATIC REVIEW; THERAPY EFFECT; ADDICTION; DEPRESSION; METHODOLOGY; MULTIMODALITY CANCER THERAPY; RANDOMIZED CONTROLLED TRIAL (TOPIC); DEPRESSIVE DISORDER, MAJOR; PROCEDURES; SUBSTANCE-RELATED DISORDERS;

ADOLESCENT; ANTIDEPRESSIVE AGENTS; ANXIETY; CHILD; COMBINED MODALITY THERAPY; DEPRESSION; HUMANS; PSYCHOTHERAPY; RANDOMIZED CONTROLLED TRIALS AS TOPIC; SUBSTANCE-RELATED DISORDERS; SUICIDAL IDEATION; DEPRESSIVE DISORDER, MAJOR;

EID: 84962571933     PISSN: 14651858     EISSN: None     Source Type: Journal    
DOI: 10.1002/14651858.CD008324.pub3     Document Type: Review

References (179)

1. Byford S, Barrett B, Roberts C, Wilkinson P, Dubicka B, Kelvin RG, et al.Cost-effectiveness of selective serotonin reuptake inhibitors and routine specialist care with and without cognitive behavioural therapy in adolescents with major depression. British Journal of Psychiatry 2007;191:521-7.
2. Goodyer I, Dubicka B, Wilkinson P, Kelvin R, Roberts C, Byford S, et al.Selective serotonin reuptake inhibitors (SSRIs) and routine specialist care with and without cognitive behaviour therapy in adolescents with major depression: randomised controlled trial. BMJ 2007;335(7611):142-5.
3. Goodyer I, Kutcher S. CBT plus an SSRI was as effective as an SSRI alone for adolescents with moderate to severe depression: Commentary. Evidence Based Medicine 2008;13(1):13.
4. Harrington R, Dubicka B, Leech A, Breen S, Roberts C, Goodyer I, et al.Randomised controlled trial of fluoxetine and cognitive-behaviour therapy versus fluoxetine alone in adolescents with major depression (ADAPT Trial) [conference abstract]. Proceedings of the 30th Annual Conference of the British Association for Behavioural and Cognitive Psychotherapies; 2002 Jul 17-20; Warwick, UK. 2002.
5. Wilkinson P, Dubicka B, Kelvin R, Roberts C, Goodyer I. Treated depression in adolescents: Predictors of outcome at 28 weeks. British Journal of Psychiatry 2009;194(4):334-41.
6. Wilkinson P, Kelvin R, Roberts C, Dubicka B, Goodyer I. Clinical and psychosocial predictors of suicide attempts and nonsuicidal self-injury in the Adolescent Depression Antidepressants and Psychotherapy Trial (ADAPT). The American Journal of Psychiatry 2011;168(5):495-501.
7. Wilkinson PO, Goodyer IM. The effects of cognitive-behavioural therapy on mood-related ruminative response style in depressed adolescents. Child and Adolescent Psychiatry and Mental Health 2008;2(1):3-13.
8. Bernstein GA, Anderson LK, Hektner JM, Realmuto GM. Imipramine compliance in adolescents. Journal of the American Academy of Child and Adolescent Psychiatry 2000;39(3):284-91.
9. Bernstein GA, Borchardt CM, Perwien AR, Crosby RD, Kushner MG, Thuras PD, et al.Imipramine plus cognitive-behavioral therapy in the treatment of school refusal. Journal of the American Academy of Child and Adolescent Psychiatry 2000;39(3):276-83.
10. Bernstein GA, Hektner JM, Borchardt CM, McMillan MH. Treatment of school refusal: One-year follow-up. Journal of the American Academy of Child and Adolescent Psychiatry 2001;40(2):206-13.
11. Bernstein GA, Warren SL, Massie ED, Thuras PD. Family dimensions in anxious-depressed school refusers. Journal of Anxiety Disorders 1999;13(5):513-28.
12. Layne AE, Bernstein GA, Egan EA, Kushner MG. Predictors of treatment response in anxious-depressed adolescents with school refusal. Journal of the American Academy of Child and Adolescent Psychiatry 2003;42(3):319-26.
13. Clarke G, DeBar L, Lynch F, Powell J, Gale J, O'Connor E, et al.A randomized effectiveness trial of brief cognitive-behavioral therapy for depressed adolescents receiving antidepressant medication. Journal of the American Academy of Child and Adolescent Psychiatry 2005;44(9):888-98.
14. Cornelius J, Douaihy A, Chung T, Kelly T, Daley D, Hayes J, et al.Four-year follow-up of double-blind fluoxetine trial in comorbid MDDAUD adolescents. Alcoholism, Clinical and Experimental Research [abstracts from the 34th Annual Scientific Meeting of the Research Society on Alcoholism, RSA. 25-29 Jun 2011; Atlanta, GA United States] 2011;35:20A.
15. Cornelius JR, Bukstein OG, Wood DS, Kirisci L, Douaihy A, Clark DB. Double-blind placebo-controlled trial of fluoxetine in adolescents with comorbid major depression and an alcohol use disorder. Addictive Behaviors 2009;34(10):905-9.
16. Cornelius JR, Douaihy A, Bukstein OG, Daley DC, Wood SD, Kelly TM, et al.Evaluation of cognitive behavioral therapy/motivational enhancement therapy (CBT/MET) in a treatment trial of comorbid MDD/AUD adolescents. Addictive Behaviors 2011;36(8):843-8.
17. Deas D, Randall CL, Roberts JS, Anton RF. A double-blind, placebo-controlled trial of sertraline in depressed adolescent alcoholics: a pilot study. Human Psychopharmacology 2000;15:461-9.
18. Kim SM, Han DH, Lee YS, Renshaw PF. Combined cognitive behavioral therapy and bupropion for the treatment of problematic on-line game play in adolescents with major depressive disorder. Computers in Human Behavior 2012;28(5):1954-9.
19. Mandoki MW, Tapia MR, Tapia MA, Sumner GS, Parker JL. Venlafaxine in the treatment of children and adolescents with major depression. Psychopharmacology Bulletin 1997;33(1):149-54.
20. Dudley AL, Melvin GA, Williams NJ, Tonge BJ, King NJ. Investigation of consumer satisfaction with cognitive-behaviour therapy and sertraline in the treatment of adolescent depression. Australian and New Zealand Journal of Psychiatry 2005;39(6):500-6.
21. Gordon MS, Tonge B, Melvin GA. Outcome of adolescent depression: 6 Months after treatment. Australian and New Zealand Journal of Psychiatry 2011;45(3):232-9.
22. Melvin GA, Tonge BJ, King NJ, Heyne D, Gordon MS, Klimkeit E. A comparison of cognitive-behavioral therapy, sertraline, and their combination for adolescent depression. Journal of the American Academy of Child and Adolescent Psychiatry 2006;45(10):1151-61.
23. Riggs PD, Mikulich-Gilbertson SK, Davies RD, Lohman M, Klein C, Stover SK. A randomized controlled trial of fluoxetine and cognitive behavioral therapy in adolescents with major depression, behavior problems, and substance use disorders. Archives of Pediatrics and Adolescent Medicine 2007;161(11):1026-34.
24. Brent DA. Glad for what TADS adds, but many TADS grads still sad. Journal of the American Academy of Child and Adolescent Psychiatry 2006;45(12):1461-4.
25. Curry J, Rohde P, Simons A, Silva S, Vitiello B, Kratochvil C, et al.Predictors and moderators of acute outcome in the Treatment for Adolescents with Depression Study (TADS). Journal of the American Academy of Child and Adolescent Psychiatry 2006;45(12):1427-39.
26. Domino ME, Burns BJ, Silva SG, Kratochvil CJ, Vitiello B, Reinecke MA, et al.Cost-effectiveness of treatments for adolescent depression: Results from TADS. The American Journal of Psychiatry 2008;165(5):588-96.
27. Domino ME, Foster E, Vitiello B, Kratochvil CJ, Burns BJ, Silva SG, et al.Relative cost-effectiveness of treatments for adolescent depression: 36-week results from the TADS randomized trial. Journal of the American Academy of Child and Adolescent Psychiatry 2009;48(7):711-20.
28. Feeny NC, Silva SG, Reinecke MA, McNulty S, Findling RL, Rohde P, et al.An exploratory analysis of the impact of family functioning on treatment for depression in adolescents. Journal of Clinical Child and Adolescent Psychology 2009;38(6):814-25.
29. Glass RM. Fluoxetine, cognitive-behavioral therapy, and their combination for adolescents with depression: Treatment for Adolescents with Depression Study (TADS) randomized controlled trial. Journal of Pediatrics 2005;146:145.
30. Goodyer I, Kutcher S. CBT plus an SSRI was as effective as an SSRI alone for adolescents with moderate to severe depression: Commentary. Evidence Based Medicine 2008;13(1):13.
31. Jacobs RH, Becker-Weidman EG, Reinecke MA, Jordan N, Silva SG, Rohde P, et al.Treating depression and oppositional behavior in adolescents. Journal of Clinical Child and Adolescent Psychology 2010;39(4):559-67.
32. Jensen PS. After TADS, can we measure up, catch up, and ante up?. Journal of the American Academy of Child and Adolescent Psychiatry 2006;45(12):1456-60.
33. Jensen PS. NIMH's TADS: More than just a tad of progress?. Cognitive and Behavioral Practice 2005;12:156-8.
34. Kratochvil C, Emslie G, Silva S, McNulty S, Walkup J, Curry J, et al.Acute time to response in the Treatment for Adolescents with Depression Study (TADS). Journal of the American Academy of Child and Adolescent Psychiatry 2006;45(12):1412-8.
35. March J, Albano AM, Rosenberg D, Casat C, Emslie G, Kratochvil, et al.Treatment for Adolescents With Depression Study (TADS). www.clinicaltrials.gov/ct/show/NCT00006286 (accessed 17 January 2012).
36. March J, Silva S, Curry J, Wells K, Fairbank J, Burns B, et al.The Treatment for Adolescents With Depression Study (TADS): outcomes over 1 year of naturalistic follow-up. American Journal of Psychiatry 2009;166(10):1141-9.
37. March J, Silva S, Petrycki S, Curry J, Wells K, Fairbank J, et al.Fluoxetine, cognitive-behavioral therapy, and their combination for adolescents with depression: Treatment for Adolescents with Depression Study (TADS) randomized controlled trial. JAMA 2004;292(7):807-820.
38. March J, Silva S, Vitiello B, Team Tads. The Treatment for Adolescents with Depression Study (TADS): methods and message at 12 weeks. Journal of the American Academy of Child and Adolescent Psychiatry 2006;45(12):1393-403.
39. March JS, Silva S, Petrycki S, Dubicka B, Ramchandani P. Fluoxetine plus cognitive behavioural therapy was most effective for adolescents with major depressive disorder. Evidence Based Medicine 2005;10:46.
40. May DE, Kratochvil CJ, Puumala SE, Silva SG, Rezac AJ, Hallin MJ, et al.A manual-based intervention to address clinical crises and retain patients in the Treatment of Adolescents With Depression Study (TADS). Journal of the American Academy of Child and Adolescent Psychiatry 2007;46:573-81.
41. The TADS Team. The Treatment for Adolescents with Depression Study (TADS): Long Term Effectiveness and Safety Outcomes. Archives of General Psychiatry 2007;64(10):1132-44.
42. Brent DA, Greenhill LI, Compton S, Emslie G, Wells K, Walkup JT, et al.The Treatment of Adolescent Suicide Attempters Study (TASA): predictors of suicidal events in an open treatment trial. Journal of the American Academy of Child and Adolescent Psychiatry 2009;48(10):987-86.
43. Stanley B, Brown G, Brent DA, Wells K, Poling K, Curry J, et al.Cognitive-behavioral therapy for suicide prevention (CBT-SP): treatment model, feasibility, and acceptability. Journal of the American Academy of Child and Adolescent Psychiatry 2009;48(10):1005-13.
44. Vitiello B, Brent DA, Greenhill Ll, Emslie G, Wells K, Walkup JT, et al.Depressive symptoms and clinical status during the Treatment of Adolescent Suicide Attempters (TASA) Study. Journal of the American Academy of Child and Adolescent Psychiatry 2009;48(10):997-1004.
45. Cheung A, Kusumakar V, Kutcher S, Dubo E, Garland J, Weiss M, et al.Maintenance study for adolescent depression. Journal of Child and Adolescent Psychopharmacology 2008;18(4):389-94.
46. Cornelius JR, Bukstein OG, Douaihy AB, Clark DB, Chung TA, Daley DC, et al.Double-blind fluoxetine trial in comorbid MDD-CUD youth and young adults. Drug and Alcohol Dependence 2010;112(1-2):39-45.
47. Douaihy A, Cornelius J, Chung RT, Daley D, Wood D, Kirisci L, et al.One-year follow-up of double-blind fluoxetine trial in comorbid MDD-CUD youth [abstract]. Alcoholism: clinical and experimental research [abstracts from the 34th annual scientific meeting of the research society on alcoholism, RSA. 25-29 jun 2011; atlanta, GA united states] 2011;35:20A.
48. Dujovne VF. Comparison of cognitive-behavioral to pharmacological treatment of depression in prepubertal children. Dissertation Abstracts International 1994;54(10-B):5384.
49. Emslie GJ, Heiligenstein JH, Wagner KD, Hoog SL, Ernest DE, Brown E, et al.Fluoxetine for acute treatment of depression in children and adolescents: a placebo-controlled, randomized clinical trial. Journal of American Child and Adolescent Psychiatry 2002;41(10):1205-15.
50. Emslie GJ, Hughes CW, Crismon ML, Lopez M, Pliszka S, Toprac MG, et al.A feasibility study of the childhood depression medication algorithm: the Texas Children's Medication Algorithm Project (CMAP). Journal of the American Academy of Child and Adolescent Psychiatry 2004;43(5):519-27.
51. Emslie, G. Pediatric MDD: Sequential treatment with fluoxetine and relapse prevention CBT [abstract]. European child & adolescent psychiatry [abstracts of the 15th International Congress of European Society for Child and Adolescent Psychiatry, ESCAP; 2013 Jul 6-10; Dublin Ireland] 2013;22:S112--S113.
52. Findling RL, Lingler J, Rowles BM, McNamara NK, Calabrese JR. A pilot pharmacotherapy trial for depressed youths at high genetic risk for bipolarity. Journal of Child and Adolescent Psychopharmacology 2008;18(6):615-21.
53. Real-world affect and social context as predictors of treatment response in child and adolescent depression and anxiety: an ecological momentary assessment study. Journal of Child and Adolescent Psychopharmacology 2012;22(1):37-47.
54. Fristad MA, Verducci JS, Walters K, Young ME. Impact of multifamily psychoeducational psychotherapy in treating children aged 8 to 12 years with mood disorders. Archives of General Psychiatry 2009;66(9):1013-21.
55. Goodyer IM, Tsancheva S, Byford S, Dubicka B, Hill J, Kelvin R, et al.Improving mood with psychoanalytic and cognitive therapies (IMPACT): a pragmatic effectiveness superiority trial to investigate whether specialised psychological treatment reduces the risk for relapse in adolescents with moderate to severe unipolar depression: study protocol for a randomised controlled trial. Trials 2011;12:175.
56. Hagan CC, Graham JME, Widmer B, Holt RJ, Ooi C, van Nieuwenhuizen AO, et al.Magnetic resonance imaging of a randomized controlled trial investigating predictors of recovery following psychological treatment in adolescents with moderate to severe unipolar depression: Study protocol for Magnetic Resonance-Improving Mood with Psychoanalytic and Cognitive Therapies [MR-IMPACT]. BMC psychiatry 2013;13:247.
57. Midgley N, Ansaldo F, Target M. The meaningful assessment of therapy outcomes: Incorporating a qualitative study into a randomized controlled trial evaluating the treatment of adolescent depression [IMPACT-ME]. Psychotherapy 2014;51(1):128-37.
58. King CA, Klaus N, Kramer A, Venkataraman S, Quinlan P, Gillespie B. The Youth-Nominated Support Team-Version II for suicidal adolescents: A randomized controlled intervention trial. Journal of Consulting and Clinical Psychology 2009;77(5):880-93.
59. Hides L, Lubman D, Wong L, Carroll S, Kay-Lambkin F, Allen N, et al.Treating coexisting depression and alcohol/other drug misuse in young people. 29th Australian Association for Cognitive and Behaviour Therapy Annual Conference; 2006 October 18 -23; Manly 2006 2005:50.
60. Lubman D. n Integrated Pharmacological and Psychological Approach to Young People With Comorbid Depression and Substance Abuse [Treatment of Comorbid Depression and Substance Abuse in Young People]. https://clinicaltrials.gov/ct2/show/NCT00232284 2005 (accessed 20 June 2014).
61. Pallavi, P. A randomized, single-blind, trial of yoga therapy as an adjunct to SSRI treatment for adolescent depression patients: Variations in serum cytokine and neurotrophin levels abstract. Biological psychiatry [abstracts of the 69th Annual Scientific Convention and Meeting of the Society of Biological Psychiatry, SOBP; 2014 May 5-10; New York, NY United States] 2014;75(9 Suppl 1):118S.
62. Siddique J, Chung JY, Brown C, Hendricks MJ. Comparative effectiveness of medication versus cognitive-behavioral therapy in a randomized controlled trial of low-income young minority women with depression. Journal of Consulting and Clinical Psychology 2012;80(6):995-1006.
63. Tang TC, Jou SH, Ko CH, Huang SY, Yen CF. Randomized study of school-based intensive interpersonal psychotherapy for depressed adolescents with suicidal risk and parasuicide behaviors. Psychiatry and Clinical Neurosciences 2009;63(4):463-70.
64. Asarnow JR, Emslie G, Clarke G, Wagner KD, Spirito A, Vitiello B, et al.Treatment of selective serotonin reuptake inhibitor-resistant depression in adolescents: predictors and moderators of treatment response. Journal of the American Academy of Child and Adolescent Psychiatry 2009;48(3):330-9.
65. Brent D, Emslie G, Clarke G, Wagner KD, Asarnow JR, Keller M, et al.Switching to another SSRI or to venlafaxine with or without cognitive behavioral therapy for adolescents with SSRI-resistant depression: the TORDIA randomized controlled trial. JAMA 2008;299(8):901-13.
66. Brent DA. The treatment of SSRI-resistant depression in adolescents (TORDIA): In search of the best next step. Depression and Anxiety 2009;26(10):871-4.
67. Brent DA, Emslie GJ, Clarke GN, Asarnow J, Spirito A, Ritz L, et al.Predictors of spontaneous and systematically assessed suicidal adverse events in the treatment of SSRI-resistant depression in adolescents (TORDIA) study. The American Journal of Psychiatry 2009;166(4):418-26.
68. Emslie GJ, Mayes T, Porta G, Vitiello B, Clarke G, Wagner KD, et al.Treatment of Resistant Depression in Adolescents (TORDIA): Week 24 outcomes. American Journal of Psychiatry 2010;167(7):782-91.
69. Kennard BD, Clarke GN, Weersing V, Asarnow JR, Shamseddeen W, Porta G, et al.Effective components of TORDIA cognitive-behavioral therapy for adolescent depression: Preliminary findings. Journal of Consulting and Clinical Psychology 2009;77(6):1033-41.
70. Kennard BD, Emslie GJ, Mayes TL, Nightingale-Teresi J, Nakonezny PA, Hughes JL, et al.Cognitive-behavioral therapy to prevent relapse in pediatric responders to pharmacotherapy for major depressive disorder. Journal of the American Academy of Child and Adolescent Psychiatry 2008;47(12):1395-404.
71. Wagner KD, Ambrosini P, Rynn M, Wohlberg C, Yang R, Greenbaum MS, et al.Efficacy of sertraline in the treatment of children and adolescents with major depressive disorder: two randomized controlled trials. JAMA 2003;290(8):1033-41.
72. Warden D, Riggs PD, Min SJ, Mikulich-Gilbertson SK, Tamm L, Trello-Rishel K, et al.Major depression and treatment response in adolescents with ADHD and substance use disorder. Drug and Alcohol Dependence 2012;120(1-3):214-9.
73. Wu X, Liu F, Cai H, Huang L, Li Y, Mo Z, et al.Cognitive behaviour therapy combined fluoxetine treatment superior to cognitive behaviour therapy alone for school refusal. International Journal of Pharmacology 2013;9(3):197-203.
74. Craighead E. Randomized Trial of Behavioral Activation and Antidepressant Medication in the Treatment of Adolescents With Major Depression [Comparison of Behavioral Activation and Antidepressant Medication in the Treatment of Adolescents With Depression]. https://clinicaltrials.gov/ct2/show/study/NCT01740726 2012 (accessed 20 June 2014).
75. Davey C. Youth Depression Alleviation: A Randomised Controlled Trial of Cognitive Behavioural Therapy with Fluoxetine or Placebo (YoDA-C). http://www.anzctr.org.au/ACTRN12612001281886.aspx 2012 (accessed 4 September 2014).
76. Gunlicks-Stoessel M. An Adaptive Treatment Strategy for Adolescent Depression (PTAD). http://clinicaltrials.gov/ct2/show/NCT01802437 2013 (Accessed 20 June 2014).
77. Gunlicks-Stoessel M. A Personalized Approach to Achieving a Sustained Response to Treatment for Adolescent Depression [An Adaptive Treatment Strategy for Adolescent Depression-Continuation (PTAD GIA)]. http://clinicaltrials.gov/ct2/show/NCT02017535 2013 (Accessed 20 June 2014).
78. AACAP. Practice parameter for the assessment and treatment of children and adolescents with depressive disorders. Journal of the American Academy of Child and Adolescent Psychiatry 2007;46(11):1503-26.
79. Achenbach TM, Edelbrock CS. The classification of child psychopathology: A review and analysis of empirical efforts. Psychological Bulletin 1978;85(6):1275-1301.
80. Achenbach TM. Integrative Guide for the 1991 CBCL/4-18, YSR, and TRF profiles. Burlington, VT: University of Vermont, Department of Psychiatry, 1991.
81. Achenbach TM. Manual for the Child Behaviour Checklist 4-18. Burlington, VT: Associates in Psychiatry, 1993.
82. Ackerson J, Scogin F, McKendree-Smith N, Lyman RD. Cognitive bibliotherapy for mild and moderate adolescent depressive symptomatology. Journal of Consulting and Clinical Psychology 1998;66(4):685-90.
83. Angold A, Messer SC, Stangl D, Farmer EM, Costello EJ, Burns BJ. Perceived parental burden and service use for child and adolescent psychiatric disorders. American Journal of Public Health 1998;88(1):75-80.
84. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, (DSM-IV). 4th Edition. Washington, DC: American Psychiatric Association, 1994.
85. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR). 4th Edition. Washington, DC: American Psychiatric Association, 2000.
86. Baker R W, Siryk B. Measuring adjustment to college. Journal ofCounseling Psychology 1984;31(2):179-189.
87. Baker K. Treatment and management of depression in children. Current Paediatrics 2006; Vol. 16, issue 7:478-83.
88. Beck A T, Ward C H, Mendelson M, Mock J, Erbaugh J. An inventoryfor measuring depression. Archives of General Psychiatry 1961;4:561-571.
89. Beck AT, Rush AJ, Shaw FB, Emery G. The Cognitive Therapy of Depression. New York: Guilford Press, 1979.
90. Beck AT, Kovacs M, Weissman A. Assessment of suicidal ideation: The Scale for Suicidal Ideation. Journal of Consulting and Clinical Psychology 1979;47(2):343-52.
91. Beck AT, Steer RA, Carbin MG. Psychometric properties of the Beck Depression Inventory: Twenty-five years of evaluation. Clinical Psychology Review 1988;8(1):77-100.
92. Bernstein GA, Crosby RD, Perwein AR, Borchardt CM. Anxiety rating for children-revised: reliability and validity. Journal of Anxiety Disorders 1996;10(2):97-114.
93. Birmaher BMD, Ryan NDMD, Williamson DEBA, Brent DAMD, Kaufman JP, Dahl REMD, et al.Childhood and adolescent depression: a review of the past 10 years. Part I. Journal of the American Academy of Child and Adolescent Psychiatry 1996;35(11):1427-39.
94. Bortolotti B, Menchetti M, Bellini F, Montaguti MB, Berardi D. Psychological interventions for major depression in primary care: a meta-analytic review of randomized controlled trials. General Hospital Psychiatry 2008;30(4):293-302.
95. Brent D, Holder D, Kolko D, Birmaher B, Baugher M, Roth C, et al.A clinical psychotherapy trial for adolescent depression comparing cognitive, family, and supportive therapy. Archives of General Psychiatry 1997;54(9):877-85.
96. Brent DA, Emslie GJ, Clarke GN, Asarnow J, Spirito A, Ritz L, et al.Predictors of spontaneous and systematically assessed suicidal adverse events in the treatment of SSRI-resistant depression in adolescents (TORDIA) study. American Journal of Psychiatry 2009; Vol. 166, issue 4:418-26.
97. Brooks SJ, Kutcher S. Diagnosis and measurement of adolescent depression: A review of commonly utilized instruments. Journal of Child and Adolescent Psychopharmacology 2001;11(4):341-76.
98. Chambers WJ, Puig-Antich J, Hirsch M, Paez P, Ambrosini PJ, Tabrizi MA, et al.The assessment of affective disorders in children and adolescents by semistructured interview. Test-retest reliability of the schedule for affective disorders and schizophrenia for school age children, present episode version. Archives of General Psychology 1985;42(7):696-702.
99. Cheung AH, Zuckerbrot RA, Jensen PS, Ghalib K, Laraque D, Stein REK. Guidelines for adolescent depression in primary care (GLAD-PC): II treatment and ongoing management. Pediatrics 2008;121(1):227.
100. Clarke GN, Lewinsohn PM, Hops H. Adolescent Coping with Depression Course: Leaders Manual for Adolescent Groups. Eugene, OR: Castalia Publishing, 1990.
101. Clarke GN, Lewisohn PM, Hops H, Seeley J. A self-and parent-report measure of adolescent depression: the Child Behaviour Checklist Depression Scale (CBCL-D). Behavioural Assessment 1992;14:443-63.
102. Costello E, Erkanli A, Angold A. Is there an epidemic of child or adolescent depression?. Journal of Child Psychology and Psychiatry 2006; Vol. 47, issue 12:1263-71.
103. Cox GR, Fisher CA, De Silva S, Phelan M, Akinwale OP, Simmons MB, et al.Interventions for preventing relapse and recurrence of a depressive disorder in children and adolescents. Cochrane Database of Systematic Reviews 2012, (11):CD007504. [DOI: 10.1002/14651858.CD007504.pub2]
104. Committee for Safety in Medicines (CSM) (Chairman: Ian Weller). Report of the CSM Expert Working Group on the Safety of Selective Serotonin Reuptake Inhibitor Antidepressants (available online: http://www.mhra.gov.uk/home/groups/pl-p/documents/drugsafetymessage/con019472.pdf; accessed November 2009). London: MHRA, 2004 (December).
105. de Maat SM, Dekker J, Schoevers RA, de Jonghe F. Relative efficacy of psychotherapy and combined therapy in the treatment of depression: A meta-analysis. European Psychiatry 2007;22(1):1-8.
106. Der Simonian R, Laird N. Meta-analysis in clinical trials. Controlled Clinical Trials 1986;7(3):177-88.
107. Dubicka B, Hadley S, Roberts C. Suicidal behaviour in youths with depression treated with new-generation antidepressants: meta-analysis. British Journal of Psychiatry 2006;189:393-8.
108. Dubrika B, Elvins R, Roberts C, Chick G, Wilkinson P, Goodyer P. Combined treatment with cognitive behavioural therapy in adolescent depression: a meta-analysis. British Journal of Psychiatry 2010;197:433-40.
109. Emslie GJ, Mayes TL, Ruberu M. Continuation and maintenance therapy of early-onset major depressive disorder. Paediatric Drugs 2005;7(4):203-17.
110. Epstein NB, Baldwin LM, Bishop DS. The McMaster family assessment device. Journal of Marital Family Therapy 1983;9(2):171-80.
111. Food, Drug Administration. Food and Drug Administration Label change to antidepressants. www.fda.gov/cder/drug/antidepressants/SSRIlabelChange.htm (accessed 10 March 2008).
112. Goodyer I, Dubicka B, Wilkinson P, Kelvin R, Roberts C, Byford S, et al.Selective serotonin reuptake inhibitors (SSRIs) and routine specialist care with and without cognitive behaviour therapy in adolescents with major depression: randomised controlled trial. BMJ 2007;335(7611):142.
113. Goodyer IM, Wilkinson P, Dubicka B, Kelvin R. Forum: The use of selective serotonin reuptake inhibitors in depressed children and adolescents: commentary on the meta-analysis of Hetrick et al. Current Opinion in Psychiatry 2010;23(1):58-61.
114. Gould MS, King R, Greenwald S, Fisher P, Schwab-Stone M, Kramer R, et al.Psychopathology associated with suicidal ideation and attempts among children and adolescents. Journal of the American Academy of Child and Adolescent Psychiatry 1998;37(9):915-23.
115. Gowers SG, Harrington RC, Whitton A, Lelliott P, Beevor A, Wing J, et al.A brief scale for measuring the outcomes of emotional and behavioural disorders in children: Health of the Nation Outcome Scales for Children and Adolescents (HoNOSCA). British Journal of Psychiatry 1999;174:413-6.
116. Guy W. Clinical Global Impressions. ECDEU Assessment Manual for Psychopharmacology-Revised. Rockville, M: National Institute for Mental Health, 1976:218-22.
117. Hamilton M. A rating scale for depression. Journal of Neurology, Neurosurgery & Psychiatry 1960;23:56-62.
118. Hammad TA, Laughren T, Racoosin J. Suicidality in pediatric patients treated with antidepressant drugs. Archives of General Psychiatry 2006;63(3):332-9.
119. Harrington R, Dubicka B, Leech A, et al.Randomised controlled trial of fluoxetine and cognitive-behaviour therapy versus fluoxetine alone in adolescents with major depression (ADAPT Trial). Proceedings of the 30th Annual Conference of the British Association for Behavioural and Cognitive Psychotherapies; 2002 July 17-20, Warwick, UK. 2002.
120. Hatcher-Kay C, King CA. Depression and suicide. Pediatrics in Review 2003;24(11):363-71.
121. Hazell P, O'Connell D, Heathcote D, Henry D. Tricyclic drugs for depression in children and adolescents. Cochrane Database of Systematic Reviews 2002, Issue 2. [DOI: 10.1002/14651858.CD002317]
122. Hetrick SE, McKenzie JE, Merry SN. The use of SSRIs in children and adolescents. Current Opinion in Psychiatry 2010;23:53-7.
123. Hetrick SE, Cox GR, Merry SN. Treatment-resistant depression in adolescents: is the addition of cognitive behavioural therapy of benefit?. Psychology Research and Behaviour Management 2011;4:97-112.
124. Hetrick SE, McKenzie JE, Cox GR, Simmons MB, Merry SN. Newer generation antidepressants for depressivedisorders in children and adolescents. Cochrane Database of Systematic Reviews 2012, Issue 11. [DOI: 10.1002/14651858.CD004851.pub3]
125. Hetrick SE, Cox GR, Fisher CA, Bhar SS, Rice SM, Davey CG, Parker AG. Back to basics: could behavioural therapy be a good treatment option for youth depression? A critical review. Early Intervention in Psychiatry 2014;Epub 4 April: DOI 10.1111/eip.12142.
126. Higgins JPT, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ 2003;327(7414):557-60.
127. Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
128. Hilsenroth MJ, Ackerman SJ, Blagys MD, Baumann BD, Baity MR, Smith SR, et al.Reliability and validity of DSM-IV Axis V. American Journal of Psychiatry 2000;157(11):1858-63.
129. Huebner E S. Initial development of the student's life satisfaction scale. School Psychology International 1991;12(3):231-240.
130. Jain S, Carmody TJ, Trivedi MH, Hughes C, Bernstein IH, Morris DW, et al.A psychometric evaluation of the CDRS and MADRS in assessing depressive symptoms in children. Journal of the American Academy of Child and Adolescent Psychiatry 2007;46(9):1204-12.
131. Kahn JS, Kehle TJ. Comparison of cognitive-behavioral, relaxation, and self-modeling interventions for depression. School Psychology Review 1990;19(2):196.
132. Kaufman JPD, Birmaher BMD, Brent DMD, Rao UMD, Flynn CMA, Moreci PMSW, et al.Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version (K-SADS-PL): initial reliability and validity data. Journal of the American Academy of Child and Adolescent Psychiatry 1997;36(7):980-8.
133. Keller MB, Shapiro RW, Lavori PW, Wolfe N. Recovery in major depressive disorder: analysis with the life table and regression models. Archives of General Psychiatry 1982;39(8):905-10.
134. Kovacs, M. Children's Depression Inventory, Manual. New York: Multi-Health System, INC, 1992.
135. Last CG, Hansen C, Franco N. Cognitive-behavioral treatment of school phobia. Journal of American Child and Adolescent Psychiatry 1998;37(4):404-11.
136. Lebo D. A theoretical framework for nondirective play therapy: Concepts from psychoanalysis and learning theory. Journal of Consulting Psychology 1958;22(4):275-9.
137. Lewinsohn PM, Clarke GN, Hops H, Andrews J. Cognitive-behavioral treatment for depressed adolescents. Behavior Therapy 1990;21(4):385-401.
138. Lewinsohn PM, Rohde P, Seeley JR. Major depressive disorder in older adolescents: Prevalence, risk factors, and clinical implications. Clinical Psychology Review 1998;18(7):765-94.
139. March JS, Parker JD, Sullivan K, Stallings P, Conners CK. The multidimensional Anxiety Scale for Children (MASC): factor structure, reliability and validity. Journal of the American Academy of Child and Adolescent Psychiatry 1997;36(4):554-65.
140. March J, Silva S, Petrycki S, Curry J, Wells K, Fairbank J, et al.Fluoxetine, cognitive-behavioral therapy, and their combination for adolescents with depression: Treatment for Adolescents With Depression Study (TADS) randomized controlled trial. JAMA 2004;292(7):807-20.
141. McDermott B, Baigent M, Chanen A, Fraser L, Graetz B, Hayman N, Beyondblue Expert Working Committee. Clinical practice guidelines: Depression in adolescents and young adults. www.beyondblue.org.au 2010.
142. Miller WR, Zweben A, DiClemente DD, Rychtarik RG. Motivational Enhancement Therapy Manual Project MATCH Monoseries. Vol. 2, National Institute of Alcohol Abuse and Alcoholism, 1992.
143. Montgomery SA, Åsberg M. A new depression scale designed to be sensitive to change. British Journal of Psychiatry 1979;134:382-9.
144. Mufson L, Weissman MM, Moreau D, Garfinkel R. Efficacy of interpersonal psychotherapy for depressed adolescents. Archives of General Psychiatry 1999;56(6):573-9.
145. Mufson L, Dorta KP, Wickramaratne P, Nomura Y, Olfson M, Weissman MM. A randomized effectiveness trial of interpersonal psychotherapy for depressed adolescents. Archives of General Psychiatry 2004;61(6):577-84.
146. Myers K, Winters NC. Ten-year review of rating scales: II: scales for internalizing disorders. Journal of the American Academy of Child and Adolescent Psychiatry 2002;1(6):634-59.
147. NICE. Depression in children and young people: Full guideline. www.nice.org.uk/nicemedia/pdf/cg028fullguideline.pdf (accessed 23 March 2008).
148. Pampallona S, Bollini P, Tibaldi G, Kupelnick B, Munizza C. Combined pharmacotherapy and psychological treatment for depression: A systematic review. Archives of General Psychiatry 2004;61(7):714-9.
149. Papanikolaou K, Richardson C, Pehlivanidis A, Papadopoulou-Daifoti Z. Efficacy of antidepressants in child and adolescent depression: a meta-analytic study. Journal of Neural Transmission 2006;113(3):399.
150. Poznanski EO, Cook SC, Carroll BJ. Depression rating scale for children. Paediatrics 1979;64(4):442-50.
151. Poznanski EO, Freeman LN, Mokros HB. Children's depression rating scale-revised. Psychpharmacology Bulletin 1985;4:979-89.
152. Poznanski EO, Mokros HB. Children's Depression Rating Scale, Revised (CDRS-R) Manual. Los Angeles: Western Psychological Services, 1996.
153. Radloff LS. The CES-D scale: A self report depression scale for research in the general population. Applied Psychological Measurement 1977;1:385-401.
154. Reich W, Welner Z. Diagnostic Interview for Children and Adolescents-revised-child version and Diagnostic Interview for Children and Adolescents-revised-parent version. St. Louis, MO: Washington University Division of Child Psychiatry, 1990.
155. The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). 5.1. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2011.
156. Reynolds CR, Richmond BO. What I Think and Feel: a revised measure of children's manifest anxiety. Journal of Abnormal Child Psychology 1978;6:271-80.
157. Reynolds WM. Reynolds Adolescent Depression Scale-Professional Manual. Odessa, FL: Psycyhological Assessment Resources, 1986.
158. Reynolds WM. Suicidal Ideation Questionnaire-Junior. Odessa, FL: Psychological Assessment Resources, 1987.
159. Rhode P, Clarke GN, Mace DE, Jorgensen JS, Seeley JR. An efficacy/effectiveness study of cognitive-behavioral treatment for adolescents with comorbid major depression and conduct disorder. Journal of the American Academy of Child and Adolescent Psychiatry 2004;43(6):660-8.
160. Richardson T, Stallard P, Velleman S. Computerised cognitive behavioural therapy for the prevention and treatment of depression and anxiety in children and adolescents: A systematic review. Clinical Child and Family Psychology Review 2010;13:275-90.
161. Richmond TK, Rosen DS. The treatment of adolescent depression in the era of the black box warning. Current Opinion in Pediatrics 2005;17(4):466-72.
162. Shaffer D, Gould MS, Brasic J, Ambrosini P, Fisher P, Bird H, et al.A children's global assessment scale (CGAS). Archives of General Psychiatry 1983;40(11):1228-31.
163. Sobell LC, Sobell MB, Leo GI, Cancilla A. Reliability of a timeline method: assessing normal drinkers' reports of recent drinking and a comparative evaluation across several populations. British Journal of Addiction 1988;83(4):393-402.
164. Stark KD, Reynolds WM, Kaslow NJ. A comparison of the relative efficacy of self-control therapy and a behavioral problem-solving therapy for depression in children. Journal of Abnormal Child Psychology 1987;15(1):91-113.
165. Tonge B, King N, Klimkeit E, Melvin G, Heyne D, Gordon M. The Self-Efficacy Questionnaire for Depression in Adolescents (SEQ-DA). European Child & Adolescent Psychiatry 2005;14(7):357-63.
166. Tsapakis EM, Soldani F, Tondo L, Baldessarini RJ. Efficacy of antidepressants in juvenile depression: meta-analysis. British Journal of Psychiatry 2008;193:10-7.
167. Vallis TM, Shaw BF, Dobson KS. The cognitive therapy scale: psychometric properties. Journal of Consulting and Clinical Psychology 1986;54(3):381-5.
168. Ware JE Jr, Kosimski M, Keller SD. SF-12: how to score the SF-12 Physical and Mental health Summary Scales. Lincoln, RI: Quality Metric Incorporated, 1998.
169. Watanabe N, Churchill R, Hunot V, Furukawa TA. Psychotherapy for depression in children and adolescents. Cochrane Database of Systematic Reviews 2004, Issue 4. [DOI: 10.1002/14651858.CD005334]
170. Watanabe N, Hunot V, Omori IM, Churchill R, Furukawa TA. Psychotherapy for depression among children and adolescents: A systematic review. Acta Psychiatrica Scandinavica 2007;116(2):84-95.
171. Weissman MM, Orvaschel H, Padian N. Children's symptom and social functioning self-report scales. Comparison of mothers' and children's reports. Journal of Nervous and Mental Disorders 1980;168:736-40.
172. Weisz JR, Thurber CA, Proffitt VD, Sweeney L, LeGagnoux GL. Brief treatment of mild-to-moderate child depression using Primary and Secondary Control Enhancement Training. Journal of Consulting and Clinical Psychology 1997;65(4):703-7.
173. Weller EB, Weller RA. Treatment options in the management of adolescent depression. Journal of Affective Disorders 2000;61(Suppl):23-8.
174. Whittington CJ, Kendall T, Fonagy P, Cottrell D, Cotgrove A, Boddington E. Selective serotonin reuptake inhibitors in childhood depression: systematic review of published versus unpublished data. Lancet 2004;363(9418):1341-5.
175. World Health Organization. International Classification of Diseases and Related Health Problems 10th Revision (ICD-10) (accessible online: http://apps.who.int/classifications/apps/icd/icd10online/). Geneva: WHO, 2007.
176. World Health Organization. Depression. Available from: http://www.who.int/mental_health/management/depression/definition/en/ (accessed 18 August 2008).
177. Wood A, Kroll L, Moore A, Harrington RC. Properties of the mood and feelings questionnaire: a research note. Journal of Child and Adolescent Psychology and Psychiatry 1995;36:298-302.
178. Young K S. Psychology of computer use: XL. Addictive use of the Internet: A case that breaks the stereotype. Psychological Reports 1996;79(3 Pt1):899-902.
179. Zuckerbrot RA, Cheung AH, Jensen PS, Stein REK, Laraque D, Ghalib K, et al.Guidelines for adolescent depression in primary care (GLAD-PC): I. Identification, assessment, and initial management. Pediatrics 2007;120(5):e1299-e1312.