-
1
-
-
76349095132
-
Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics
-
G.L. Semenza Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics Oncogene 29 2010 625 634
-
(2010)
Oncogene
, vol.29
, pp. 625-634
-
-
Semenza, G.L.1
-
2
-
-
2342661143
-
Intratumoral hypoxia, radiation resistance and HIF-1
-
G.L. Semenza Intratumoral hypoxia, radiation resistance and HIF-1 Cancer Cell 5 2004 405 406
-
(2004)
Cancer Cell
, vol.5
, pp. 405-406
-
-
Semenza, G.L.1
-
3
-
-
34547098129
-
Targeting hypoxia cell signaling for cancer therapy
-
G. Melino Targeting hypoxia cell signaling for cancer therapy Cancer Metastasis Rev. 26 2007 341 352
-
(2007)
Cancer Metastasis Rev.
, vol.26
, pp. 341-352
-
-
Melino, G.1
-
4
-
-
0029051439
-
Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
-
G.L. Wang, B.H. Jiang, E.A. Rue, and G.L. Semenza Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension Proc. Natl. Acad. Sci. U. S. A. 92 1995 5510 5514
-
(1995)
Proc. Natl. Acad. Sci. U. S. A.
, vol.92
, pp. 5510-5514
-
-
Wang, G.L.1
Jiang, B.H.2
Rue, E.A.3
Semenza, G.L.4
-
5
-
-
84897042356
-
Hypoxia-inducible factor 3 is an oxygen-dependent transcription activator and regulates a distinct transcriptional response to hypoxia
-
P. Zhang, Q. Yao, L. Lu, Y. Li, P.J. Chen, and C. Duan Hypoxia-inducible factor 3 is an oxygen-dependent transcription activator and regulates a distinct transcriptional response to hypoxia Cell Rep. 6 2014 1110 1121
-
(2014)
Cell Rep.
, vol.6
, pp. 1110-1121
-
-
Zhang, P.1
Yao, Q.2
Lu, L.3
Li, Y.4
Chen, P.J.5
Duan, C.6
-
6
-
-
27544477748
-
The von Hippel-Lindau protein, HIF hydroxylation, and oxygen sensing
-
W.G. Kaelin The von Hippel-Lindau protein, HIF hydroxylation, and oxygen sensing Biochem. Biophys. Res. Commun. 338 2005 627 638
-
(2005)
Biochem. Biophys. Res. Commun.
, vol.338
, pp. 627-638
-
-
Kaelin, W.G.1
-
7
-
-
10044276783
-
Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex
-
J. Brugarolas, K. Lei, R.L. Hurley, B.D. Manning, J.H. Reiling, E. Hafen, L.A. Witters, L.W. Ellisen, and W.G. Kaelin Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex Genes Dev. 18 2004 2893 2904
-
(2004)
Genes Dev.
, vol.18
, pp. 2893-2904
-
-
Brugarolas, J.1
Lei, K.2
Hurley, R.L.3
Manning, B.D.4
Reiling, J.H.5
Hafen, E.6
Witters, L.A.7
Ellisen, L.W.8
Kaelin, W.G.9
-
8
-
-
0036789574
-
Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin
-
C.C. Hudson, M. Liu, G.G. Chiang, D.M. Otterness, D.C. Loomis, F. Kaper, A.J. Giaccia, and R.T. Abraham Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin Mol. Cell. Biol. 22 2002 7004 7014
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 7004-7014
-
-
Hudson, C.C.1
Liu, M.2
Chiang, G.G.3
Otterness, D.M.4
Loomis, D.C.5
Kaper, F.6
Giaccia, A.J.7
Abraham, R.T.8
-
9
-
-
0034050050
-
Loss of PTEN facilitates HIF-1-mediated gene expression
-
W. Zundel, C. Schindler, D. Haas-Kogan, A. Koong, F. Kaper, E. Chen, A.R. Gottschalk, H.E. Ryan, R.S. Johnson, A.B. Jefferson, D. Stokoe, and A.J. Giaccia Loss of PTEN facilitates HIF-1-mediated gene expression Genes Dev. 14 2000 391 396
-
(2000)
Genes Dev.
, vol.14
, pp. 391-396
-
-
Zundel, W.1
Schindler, C.2
Haas-Kogan, D.3
Koong, A.4
Kaper, F.5
Chen, E.6
Gottschalk, A.R.7
Ryan, H.E.8
Johnson, R.S.9
Jefferson, A.B.10
Stokoe, D.11
Giaccia, A.J.12
-
10
-
-
18844444774
-
HIF-1alpha, STAT3, CBP/p300 and Ref-1/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas
-
M.J. Gray, J. Zhang, L.M. Ellis, G.L. Semenza, D.B. Evans, S.S. Watowich, and G.E. Gallick HIF-1alpha, STAT3, CBP/p300 and Ref-1/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas Oncogene 24 2005 3110 3120
-
(2005)
Oncogene
, vol.24
, pp. 3110-3120
-
-
Gray, M.J.1
Zhang, J.2
Ellis, L.M.3
Semenza, G.L.4
Evans, D.B.5
Watowich, S.S.6
Gallick, G.E.7
-
11
-
-
0037119415
-
Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway
-
J.S. Isaacs, Y.J. Jung, E.G. Mimnaugh, A. Martinez, F. Cuttitta, and L.M. Neckers Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway J. Biol. Chem. 277 2002 29936 29944
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 29936-29944
-
-
Isaacs, J.S.1
Jung, Y.J.2
Mimnaugh, E.G.3
Martinez, A.4
Cuttitta, F.5
Neckers, L.M.6
-
12
-
-
34247583794
-
Glycogen synthase kinase-3 phosphorylates hypoxia-inducible factor-1 alpha and mediates its destabilization in a VHL-independent manner
-
D. Flugel, A. Gorlach, C. Michiels, and T. Kietzmann Glycogen synthase kinase-3 phosphorylates hypoxia-inducible factor-1 alpha and mediates its destabilization in a VHL-independent manner Mol. Cell. Biol. 27 2007 3253 3265
-
(2007)
Mol. Cell. Biol.
, vol.27
, pp. 3253-3265
-
-
Flugel, D.1
Gorlach, A.2
Michiels, C.3
Kietzmann, T.4
-
13
-
-
0042029755
-
The forkhead transcription factor FOXO4 induces the down-regulation of hypoxia-inducible factor 1 alpha by a von Hippel-Lindau protein-independent mechanism
-
T.T. Tang, and L.A. Lasky The forkhead transcription factor FOXO4 induces the down-regulation of hypoxia-inducible factor 1 alpha by a von Hippel-Lindau protein-independent mechanism J. Biol. Chem. 278 2003 30125 30135
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 30125-30135
-
-
Tang, T.T.1
Lasky, L.A.2
-
14
-
-
33644780111
-
Histone deacetylase inhibitors induce VHL and ubiquitin-independent proteasomal degradation of hypoxia-inducible factor 1alpha
-
X. Kong, Z. Lin, D. Liang, D. Fath, N. Sang, and J. Caro Histone deacetylase inhibitors induce VHL and ubiquitin-independent proteasomal degradation of hypoxia-inducible factor 1alpha Mol. Cell. Biol. 26 2006 2019 2028
-
(2006)
Mol. Cell. Biol.
, vol.26
, pp. 2019-2028
-
-
Kong, X.1
Lin, Z.2
Liang, D.3
Fath, D.4
Sang, N.5
Caro, J.6
-
15
-
-
84875500244
-
Trichostatin A destabilizes HIF-2α through a VHL-independent but proteasome-dependent pathway in cancer cell lines and tumor xenografts
-
Q. Yang, Y. Du, D. Cheng, Z. Zhang, and X. Du Trichostatin A destabilizes HIF-2α through a VHL-independent but proteasome-dependent pathway in cancer cell lines and tumor xenografts Bangladesh J. Pharmacol. 8 2013 142 148
-
(2013)
Bangladesh J. Pharmacol.
, vol.8
, pp. 142-148
-
-
Yang, Q.1
Du, Y.2
Cheng, D.3
Zhang, Z.4
Du, X.5
-
16
-
-
57349136768
-
Hypoxia-associated factor, a novel E3-ubiquitin ligase, binds and ubiquitinates hypoxia-inducible factor 1alpha, leading to its oxygen-independent degradation
-
M.Y. Koh, B.G. Darnay, and G. Powis Hypoxia-associated factor, a novel E3-ubiquitin ligase, binds and ubiquitinates hypoxia-inducible factor 1alpha, leading to its oxygen-independent degradation Mol. Cell. Biol. 28 2008 7081 7095
-
(2008)
Mol. Cell. Biol.
, vol.28
, pp. 7081-7095
-
-
Koh, M.Y.1
Darnay, B.G.2
Powis, G.3
-
17
-
-
33846254999
-
RACK1 competes with HSP90 for binding to HIF-1alpha and is required for O(2)-independent and HSP90 inhibitor-induced degradation of HIF-1alpha
-
Y.V. Liu, J.H. Baek, H. Zhang, R. Diez, R.N. Cole, and G.L. Semenza RACK1 competes with HSP90 for binding to HIF-1alpha and is required for O(2)-independent and HSP90 inhibitor-induced degradation of HIF-1alpha Mol. Cell 25 2007 207 217
-
(2007)
Mol. Cell
, vol.25
, pp. 207-217
-
-
Liu, Y.V.1
Baek, J.H.2
Zhang, H.3
Diez, R.4
Cole, R.N.5
Semenza, G.L.6
-
18
-
-
34447522124
-
Constitutive/hypoxic degradation of HIF-alpha proteins by the proteasome is independent of von Hippel Lindau protein ubiquitylation and the transactivation activity of the protein
-
X. Kong, B. Alvarez-Castelao, Z. Lin, J.G. Castano, and J. Caro Constitutive/hypoxic degradation of HIF-alpha proteins by the proteasome is independent of von Hippel Lindau protein ubiquitylation and the transactivation activity of the protein J. Biol. Chem. 282 2007 15498 15505
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 15498-15505
-
-
Kong, X.1
Alvarez-Castelao, B.2
Lin, Z.3
Castano, J.G.4
Caro, J.5
-
19
-
-
0033937208
-
Molecular characterization of the thermosensitive E1 ubiquitin- activating enzyme cell mutant A31N-ts20: Requirements upon different levels of E1 for the ubiquitination/degradation of the various protein substrates in vivo
-
C. Salvat, C. Acquaviva, M. Scheffner, I. Robbins, M. Piechaczyk, and I. Jariel-Encontre Molecular characterization of the thermosensitive E1 ubiquitin- activating enzyme cell mutant A31N-ts20: Requirements upon different levels of E1 for the ubiquitination/degradation of the various protein substrates in vivo Eur. J. Biochem. 267 2000 3712 3722
-
(2000)
Eur. J. Biochem.
, vol.267
, pp. 3712-3722
-
-
Salvat, C.1
Acquaviva, C.2
Scheffner, M.3
Robbins, I.4
Piechaczyk, M.5
Jariel-Encontre, I.6
-
20
-
-
35148886143
-
Inhibitors of ubiquitin-activating enzyme (E1), a new class of potential cancer therapeutics
-
Y. Yang, J. Kitagaki, R.M. Dai, Y.C. Tsai, K.L. Lorick, R.L. Ludwig, S.A. Pierre, J.P. Jensen, I.V. Davydov, P. Oberoi, C.C. Li, J.H. Kenten, J.A. Beutler, K.H. Vousden, and A.M. Weissman Inhibitors of ubiquitin-activating enzyme (E1), a new class of potential cancer therapeutics Cancer Res. 67 2007 9472 9481
-
(2007)
Cancer Res.
, vol.67
, pp. 9472-9481
-
-
Yang, Y.1
Kitagaki, J.2
Dai, R.M.3
Tsai, Y.C.4
Lorick, K.L.5
Ludwig, R.L.6
Pierre, S.A.7
Jensen, J.P.8
Davydov, I.V.9
Oberoi, P.10
Li, C.C.11
Kenten, J.H.12
Beutler, J.A.13
Vousden, K.H.14
Weissman, A.M.15
-
21
-
-
35548935098
-
SUMO-specific protease is essential for stabilization of HIF1 during hypoxia
-
J. Cheng, X. Kang, S. Zhang, and E.T. Yeh SUMO-specific protease is essential for stabilization of HIF1 during hypoxia Cell 131 2007 584 595
-
(2007)
Cell
, vol.131
, pp. 584-595
-
-
Cheng, J.1
Kang, X.2
Zhang, S.3
Yeh, E.T.4
-
22
-
-
4744353220
-
Sumoylation increases HIF-1alpha stability and its transcriptional activity
-
S.H. Bae, J.W. Jeong, J.A. Park, S.H. Kim, M.K. Bae, S.J. Choi, and K.W. Kim Sumoylation increases HIF-1alpha stability and its transcriptional activity Biochem. Biophys. Res. Commun. 324 2004 394 400
-
(2004)
Biochem. Biophys. Res. Commun.
, vol.324
, pp. 394-400
-
-
Bae, S.H.1
Jeong, J.W.2
Park, J.A.3
Kim, S.H.4
Bae, M.K.5
Choi, S.J.6
Kim, K.W.7
-
23
-
-
35348904953
-
RSUME, a small RWD-containing protein, enhances SUMO conjugation and stabilizes HIF-1alpha during hypoxia
-
A. Carbia-Nagashima, J. Gerez, C. Perez-Castro, M. Paez-Pereda, S. Silberstein, G.K. Stalla, F. Holsboer, and E. Arzt RSUME, a small RWD-containing protein, enhances SUMO conjugation and stabilizes HIF-1alpha during hypoxia Cell 131 2007 309 323
-
(2007)
Cell
, vol.131
, pp. 309-323
-
-
Carbia-Nagashima, A.1
Gerez, J.2
Perez-Castro, C.3
Paez-Pereda, M.4
Silberstein, S.5
Stalla, G.K.6
Holsboer, F.7
Arzt, E.8
-
24
-
-
55549107180
-
Atypical CRM1-dependent nuclear export signal mediates regulation of hypoxia-inducible factor-1alpha by MAPK
-
I. Mylonis, G. Chachami, E. Paraskeva, and G. Simos Atypical CRM1-dependent nuclear export signal mediates regulation of hypoxia-inducible factor-1alpha by MAPK J. Biol. Chem. 283 2008 27620 27627
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 27620-27627
-
-
Mylonis, I.1
Chachami, G.2
Paraskeva, E.3
Simos, G.4
-
25
-
-
0021099710
-
Components of ubiquitin-protein ligase system. Resolution, affinity purification, and role in protein breakdown
-
A. Hershko, H. Heller, S. Elias, and A. Ciechanover Components of ubiquitin-protein ligase system. Resolution, affinity purification, and role in protein breakdown J. Biol. Chem. 258 1983 8206 8214
-
(1983)
J. Biol. Chem.
, vol.258
, pp. 8206-8214
-
-
Hershko, A.1
Heller, H.2
Elias, S.3
Ciechanover, A.4
-
26
-
-
34347329214
-
Dual E1 activation systems for ubiquitin differentially regulate E2 enzyme charging
-
J. Jin, X. Li, S.P. Gygi, and J.W. Harper Dual E1 activation systems for ubiquitin differentially regulate E2 enzyme charging Nature 447 2007 1135 1138
-
(2007)
Nature
, vol.447
, pp. 1135-1138
-
-
Jin, J.1
Li, X.2
Gygi, S.P.3
Harper, J.W.4
-
27
-
-
0020479562
-
The mechanism of ubiquitin activating enzyme. A kinetic and equilibrium analysis
-
A.L. Haas, and I.A. Rose The mechanism of ubiquitin activating enzyme. A kinetic and equilibrium analysis J. Biol. Chem. 257 1982 10329 10337
-
(1982)
J. Biol. Chem.
, vol.257
, pp. 10329-10337
-
-
Haas, A.L.1
Rose, I.A.2
-
28
-
-
0028205667
-
Accumulation of p53 in a mutant cell line defective in the ubiquitin pathway
-
D.R. Chowdary, J.J. Dermody, K.K. Jha, and H.L. Ozer Accumulation of p53 in a mutant cell line defective in the ubiquitin pathway Mol. Cell. Biol. 14 1994 1997 2003
-
(1994)
Mol. Cell. Biol.
, vol.14
, pp. 1997-2003
-
-
Chowdary, D.R.1
Dermody, J.J.2
Jha, K.K.3
Ozer, H.L.4
-
29
-
-
84862909299
-
Two Mutations Impair the Stability and Function of Ubiquitin-Activating Enzyme (E1)
-
T. Lao, S. Chen, and N. Sang Two Mutations Impair the Stability and Function of Ubiquitin-Activating Enzyme (E1) J. Cell Physiol. 227 2012 1561 1568
-
(2012)
J. Cell Physiol.
, vol.227
, pp. 1561-1568
-
-
Lao, T.1
Chen, S.2
Sang, N.3
-
30
-
-
0033553390
-
Down-regulation of p27(Kip1) by two mechanisms, ubiquitin-mediated degradation and proteolytic processing
-
M. Shirane, Y. Harumiya, N. Ishida, A. Hirai, C. Miyamoto, S. Hatakeyama, K. Nakayama, and M. Kitagawa Down-regulation of p27(Kip1) by two mechanisms, ubiquitin-mediated degradation and proteolytic processing J. Biol. Chem. 274 1999 13886 13893
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 13886-13893
-
-
Shirane, M.1
Harumiya, Y.2
Ishida, N.3
Hirai, A.4
Miyamoto, C.5
Hatakeyama, S.6
Nakayama, K.7
Kitagawa, M.8
-
31
-
-
84892442493
-
GSK3β negatively regulates HIF1α mRNA stability via nucleolin in the MG63 osteosarcoma cell line
-
D.D. Cheng, H.G. Zhao, Y.S. Yang, T. Hu, and Q.C. Yang GSK3β negatively regulates HIF1α mRNA stability via nucleolin in the MG63 osteosarcoma cell line Biochem. Biophys. Res. Commun. 443 2014 598 603
-
(2014)
Biochem. Biophys. Res. Commun.
, vol.443
, pp. 598-603
-
-
Cheng, D.D.1
Zhao, H.G.2
Yang, Y.S.3
Hu, T.4
Yang, Q.C.5
|