Inhibition of CYP3A4 and CYP1A2 by Aegle marmelos and its constituents

Xenobiotica

Volumn 46, Issue 2, 2016, Pages 117-125

  Manda, Vamshi K ^a   Avula, Bharathi ^a   Chittiboyina, Amar G ^a,b   Khan, Ikhlas A ^a,b   Walker, Larry A ^a,b   Khan, Shabana I ^a,b,c  

^a UNIVERSITY OF MISSISSIPPI   (United States)

^b UNIVERSITY OF MISSISSIPPI   (United States)

^c KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

aegeline; Aegle marmelos; CYP450 enzymes; liver microsomes; marmelosin; Myrsinaceae

Indexed keywords

6BETA HYDROXYTESTOSTERONE; 8 HYDROXYPSORALEN; AEGELINE; AEGLE MARMELOS EXTRACT; ALKALOID DERIVATIVE; CYTOCHROME P450 1A2; CYTOCHROME P450 2C19; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; FURAFYLLINE; FUROCOUMARIN DERIVATIVE; GLUTATHIONE; KETOCONAZOLE; MARMELOSIN; MARMESININ; PARACETAMOL; PHENACETIN; TESTOSTERONE DERIVATIVE; TROLEANDOMYCIN; UNCLASSIFIED DRUG; AMIDE; COUMARIN DERIVATIVE; CYP1A2 PROTEIN, HUMAN; CYP3A4 PROTEIN, HUMAN; CYTOCHROME P450 1A2 INHIBITOR; CYTOCHROME P450 3A; CYTOCHROME P450 3A INHIBITOR; FURAN DERIVATIVE; PLANT EXTRACT; XANTHOTOXOL;

AEGLE MARMELOS; ARTICLE; CHEMICAL COMPOSITION; COMPETITIVE INHIBITION; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; ENZYME INHIBITION; ENZYME KINETICS; HUMAN; HUMAN CELL; IC50; LIVER MICROSOME; NONHUMAN; PHYTOCHEMISTRY; QUANTITATIVE ANALYSIS; SHIFT TO THE LEFT; TESTOSTERONE METABOLISM; TIME-DEPENDENT INHIBITION; AEGLE; CHEMISTRY; DRUG EFFECTS; FRUIT; METABOLISM;

AEGLE; AMIDES; COUMARINS; CYTOCHROME P-450 CYP1A2; CYTOCHROME P-450 CYP1A2 INHIBITORS; CYTOCHROME P-450 CYP3A; CYTOCHROME P-450 CYP3A INHIBITORS; FRUIT; FURANS; FUROCOUMARINS; HUMANS; MICROSOMES, LIVER; PLANT EXTRACTS;

EID: 84955696759     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.3109/00498254.2015.1053006     Document Type: Article

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