Evaluation of in vitro absorption, distribution, metabolism, and excretion (ADME) properties of mitragynine, 7-hydroxymitragynine, and mitraphylline

Planta Medica

Volumn 80, Issue 7, 2014, Pages 568-576

  Manda, Vamshi K ^a   Avula, Bharathi ^a   Ali, Zulfiqar ^a   Khan, Ikhlas A ^a,b   Walker, Larry A ^a,b   Khan, Shabana I ^a,b  

^a UNIVERSITY OF MISSISSIPPI   (United States)

^b UNIVERSITY OF MISSISSIPPI   (United States)

Author keywords

blood brain barrier; intestinal transport; Mitragyna speciosa; P gp; Rubiaceae; Uncaria tomentosa

Indexed keywords

7 HYDROXYMITRAGYNINE; ATENOLOL; CAFFEINE; CENTRAL NERVOUS SYSTEM AGENTS; MITRAGYNINE; MITRAPHYLLINE; MULTIDRUG RESISTANCE PROTEIN; PROPRANOLOL; TESTOSTERONE; UMBELLIFERONE; UNCLASSIFIED DRUG; VERAPAMIL; 7-HYDROXYMITRAGYNINE; INDOLE ALKALOID; OPIATE RECEPTOR; PLANT EXTRACT; RAUWOLFIA ALKALOID;

ANIMAL CELL; ARTICLE; BLOOD BRAIN BARRIER; CALCEIN-AM ASSAY; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BINDING; DRUG BIOAVAILABILITY; DRUG DEGRADATION; DRUG DIFFUSION; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG HALF LIFE; DRUG INHIBITION; DRUG PENETRATION; DRUG SCREENING; EQUILIBRIUM DIALYSIS; HUMAN; HUMAN CELL; IN VITRO STUDY; INTESTINE FLUID; LIPOPHILICITY; LIVER MICROSOME; MASS SPECTROMETRY; NONHUMAN; PLASMA PROTEIN BINDING; QUANTITATIVE ANALYSIS; STOMACH JUICE; TIME OF FLIGHT MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; UNCARIA TOMENTOSA; BARK; CACO 2 CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; MEDICINAL PLANT; METABOLISM; MITRAGYNA; ORIENTAL MEDICINE; TRANSPORT AT THE CELLULAR LEVEL; UNCARIA;

BIOLOGICAL TRANSPORT; CACO-2 CELLS; HUMANS; INDOLE ALKALOIDS; MEDICINE, EAST ASIAN TRADITIONAL; MICROSOMES, LIVER; MITRAGYNA; MOLECULAR STRUCTURE; P-GLYCOPROTEINS; PLANT BARK; PLANT EXTRACTS; PLANTS, MEDICINAL; RECEPTORS, OPIOID; SECOLOGANIN TRYPTAMINE ALKALOIDS; UNCARIA;

EID: 84901044881     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0034-1368444     Document Type: Article

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