Characterization of in vitro ADME properties of diosgenin and dioscin from dioscorea villosa

Planta Medica

Volumn 79, Issue 15, 2013, Pages 1421-1428

  Manda, Vamshi K ^a   Avula, Bharathi ^a   Ali, Zulfiqar ^a   Wong, Yan Hong ^a   Smillie, Troy J ^a   Khan, Ikhlas A ^a,b   Khan, Shabana I ^a,b  

^a UNIVERSITY OF MISSISSIPPI   (United States)

^b UNIVERSITY OF MISSISSIPPI   (United States)

Author keywords

Caco 2; CYP inhibition; dioscin; Dioscorea villosa; Dioscoreaceae; diosgenin; intestinal transport; metabolic stability

Indexed keywords

CYTOCHROME P450 1A2; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; DIOSCIN; DIOSGENIN; FURAFYLLINE; KETOCONAZOLE; MULTIDRUG RESISTANCE PROTEIN; PLANT MEDICINAL PRODUCT; QUINIDINE; TRANYLCYPROMINE; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL FRACTIONATION; CELL LINE; CELL STRAIN CACO 2; CONTROLLED STUDY; DIOSCOREA VILLOSA; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DETERMINATION; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG METABOLISM; DRUG PENETRATION; DRUG STABILITY; DRUG TRANSPORT; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; INTESTINE ABSORPTION; INTESTINE FLUID; LIVER MICROSOME; MASS SPECTROMETRY; MEDICINAL PLANT; QUANTITATIVE ANALYSIS; SIMULATED GASTRIC FLUID; STOMACH JUICE; STOMACH PH; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; YAM;

DIOSCOREA VILLOSA; DIOSCOREACEAE;

ANTI-INFLAMMATORY AGENTS; CACO-2 CELLS; CYTOCHROME P-450 CYP3A; DIOSCOREA; DIOSGENIN; HALF-LIFE; HUMANS; INHIBITORY CONCENTRATION 50; INTESTINAL ABSORPTION; METABOLIC DETOXICATION, PHASE II; P-GLYCOPROTEIN; PARASYMPATHOLYTICS; PERMEABILITY; PLANT EXTRACTS;

EID: 84886098000     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0033-1350699     Document Type: Article

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