In vitro determination of the CYP 3A4 activity in rat hepatic microsomes by liquid-phase extraction and HPLC-photodiode array detection

Journal of Pharmacological and Toxicological Methods

Volumn 66, Issue 1, 2012, Pages 29-34

  Baati, Tarek ^a   Horcajada, Patricia ^a   Gref, Ruxandra ^b   Couvreur, Patrick ^b   Serre, Christian ^a  

^a UNIVERSITÉ DE VERSAILLES SAINT QUENTIN EN YVELINES   (France)

^b UNIV PARIS SUD   (France)

Author keywords

CYP3A4; HPLC; MIL 100; NanoMOFs; Salicylamid acid; Testosterone

Indexed keywords

CYTOCHROME P450 3A4; NANOCARRIER; NANOPARTICLE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SALICYLAMIDE; TESTOSTERONE; TESTOSTERONE 6BETA OL; UNCLASSIFIED DRUG;

ACCURACY; ANIMAL CELL; ARTICLE; CALIBRATION; CONTROLLED STUDY; DIODE; DRUG STRUCTURE; ENZYME ACTIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROXYLATION; IN VITRO STUDY; INCUBATION TIME; LIMIT OF DETECTION; LIQUID PHASE MICROEXTRACTION; LIVER MICROSOME; NONHUMAN; PHOTODIODE; POROSITY; PROTEIN CONTENT; QUALITY CONTROL; RAT;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; FEMALE; HIGH-THROUGHPUT SCREENING ASSAYS; HYDROXYTESTOSTERONES; LIMIT OF DETECTION; LIQUID-LIQUID EXTRACTION; MICROSOMES, LIVER; RATS; RATS, WISTAR; REPRODUCIBILITY OF RESULTS; SPECTROPHOTOMETRY, ULTRAVIOLET;

RATTUS;

EID: 84864106532     PISSN: 10568719     EISSN: 1873488X     Source Type: Journal    
DOI: 10.1016/j.vascn.2012.05.006     Document Type: Article

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