Mechanism-based inhibition of cytochrome P450 (CYP)2A6 by chalepensin in recombinant systems, in human liver microsomes and in mice in vivo

British Journal of Pharmacology

Volumn 163, Issue 6, 2011, Pages 1250-1262

  Ueng, Yune Fang ^a,b,c   Chen, Chien Chih ^a,d   Chung, Yu Ting ^e   Liu, Tsung Yun ^c,e,f   Chang, Yu Ping ^a   Lo, Wei Sheng ^a   Murayama, Norie ^g   Yamazaki, Hiroshi ^g   Souček, Pavel ^h   Chau, Gar Yang ^e   Chi, Chin Wen ^c,e   Chen, Ruei Ming ^b   Li, Ding Tzai ⁱ  

^a NATIONAL RESEARCH INSTITUTE OF CHINESE MEDICINE   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^c NATIONAL YANG MING UNIVERSITY   (Taiwan)

^d HUNGKUANG UNIVERSITY   (Taiwan)

^e TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^f Institute of Environmental Health   (United States)

^g SHOWA PHARMACEUTICAL UNIVERSITY   (Japan)

^h NATIONAL INSTITUTE OF PUBLIC HEALTH   (Czech Republic)

ⁱ Mass Solutions Technology Co Ltd   (Taiwan)

Author keywords

chalepensin; CYP2A6; genotype; inhibition; mechanism based

Indexed keywords

CHALEPENSIN; COUMARIN; CYTOCHROME P450 2A6; CYTOCHROME P450 2A6.1; CYTOCHROME P450 2A6.10; CYTOCHROME P450 2A6.7; FUROCOUMARIN DERIVATIVE; GLUTATHIONE; PILOCARPINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TRANYLCYPROMINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BACTERIAL MEMBRANE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG STRUCTURE; ENZYME INHIBITION; EX VIVO STUDY; GENETIC VARIABILITY; GLUTATHIONE METABOLISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HYDROXYLATION; IC 50; IN VITRO STUDY; IN VIVO STUDY; LIQUID CHROMATOGRAPHY; LIVER MICROSOME; MALE; MASS SPECTROMETRY; MOUSE; NONHUMAN; PRIORITY JOURNAL;

AGED; AGED, 80 AND OVER; ANIMALS; ARYL HYDROCARBON HYDROXYLASES; CELL MEMBRANE; CELLS, CULTURED; GLUTATHIONE; HUMANS; MALE; MICE; MICROSOMES, LIVER; MOLECULAR STRUCTURE; MUTAGENESIS, SITE-DIRECTED; PILOCARPINE; POINT MUTATION; PSORALENS; TRANYLCYPROMINE;

EID: 79959743932     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2011.01341.x     Document Type: Article

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