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Volumn 7, Issue , 2016, Pages

Endoplasmic reticulum stress drives proteinuria-induced kidney lesions via Lipocalin 2

Author keywords

[No Author keywords available]

Indexed keywords

4 PHENYLBUTYRIC ACID; ACTIVATING TRANSCRIPTION FACTOR 4; ALBUMIN; CALCIUM; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; ACUTE PHASE PROTEIN; ALBUMINOID; LCN2 PROTEIN, MOUSE; LIPOCALIN; MEMBRANE PROTEIN; ONCOPROTEIN; PODOCIN; SIGNAL PEPTIDE; WT1 PROTEIN;

EID: 84955576959     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms10330     Document Type: Article
Times cited : (93)

References (52)
  • 1
    • 84905438186 scopus 로고    scopus 로고
    • Taming the chronic kidney disease epidemic: A global view of surveillance efforts
    • Radhakrishnan, J. et al. Taming the chronic kidney disease epidemic: a global view of surveillance efforts. Kidney Int. 86, 246-250 (2014).
    • (2014) Kidney Int. , vol.86 , pp. 246-250
    • Radhakrishnan, J.1
  • 2
    • 32444451549 scopus 로고    scopus 로고
    • Mechanisms of progression and regression of renal lesions of chronic nephropathies and diabetes
    • Remuzzi, G., Benigni, A. & Remuzzi, A. Mechanisms of progression and regression of renal lesions of chronic nephropathies and diabetes. J. Clin. Invest. 116, 288-296 (2006).
    • (2006) J. Clin. Invest. , vol.116 , pp. 288-296
    • Remuzzi, G.1    Benigni, A.2    Remuzzi, A.3
  • 3
    • 84860273272 scopus 로고    scopus 로고
    • Proteinuria should be used as a surrogate in CKD
    • Cravedi, P., Ruggenenti, P. & Remuzzi, G. Proteinuria should be used as a surrogate in CKD. Nat. Rev. Nephrol. 8, 301-306 (2012).
    • (2012) Nat. Rev. Nephrol. , vol.8 , pp. 301-306
    • Cravedi, P.1    Ruggenenti, P.2    Remuzzi, G.3
  • 4
    • 0036318363 scopus 로고    scopus 로고
    • Intraperitoneal protein injection in the axolotl: The amphibian kidney as a novel model to study tubulointerstitial activation
    • Gross, M. L. et al. Intraperitoneal protein injection in the axolotl: the amphibian kidney as a novel model to study tubulointerstitial activation. Kidney Int. 62, 51-59 (2002).
    • (2002) Kidney Int. , vol.62 , pp. 51-59
    • Gross, M.L.1
  • 5
    • 16644381023 scopus 로고    scopus 로고
    • Why is proteinuria an ominous biomarker of progressive kidney disease?
    • Zandi-Nejad, K., Eddy, A. A., Glassock, R. J. & Brenner, B. M. Why is proteinuria an ominous biomarker of progressive kidney disease? Kidney Int. Suppl. S76-S89 (2004).
    • (2004) Kidney Int , pp. S76-S89
    • Zandi-Nejad, K.1    Eddy, A.A.2    Glassock, R.J.3    Brenner, B.M.4
  • 7
    • 0014421532 scopus 로고
    • Relationship between renal function and histological changes found in renal-biopsy specimens from patients with persistent glomerular nephritis
    • Risdon, R. A., Sloper, J. C. & De Wardener, H. E. Relationship between renal function and histological changes found in renal-biopsy specimens from patients with persistent glomerular nephritis. Lancet 2, 363-366 (1968).
    • (1968) Lancet , vol.2 , pp. 363-366
    • Risdon, R.A.1    Sloper, J.C.2    De Wardener, H.E.3
  • 8
    • 33750736645 scopus 로고    scopus 로고
    • How does proteinuria cause progressive renal damage? J
    • Abbate, M., Zoja, C. & Remuzzi, G. How does proteinuria cause progressive renal damage? J. Am. Soc. Nephrol. 17, 2974-2984 (2006).
    • (2006) Am. Soc. Nephrol. , vol.17 , pp. 2974-2984
    • Abbate, M.1    Zoja, C.2    Remuzzi, G.3
  • 9
    • 55349133352 scopus 로고    scopus 로고
    • Present and future drug treatments for chronic kidney diseases: Evolving targets in renoprotection
    • Perico, N., Benigni, A. & Remuzzi, G. Present and future drug treatments for chronic kidney diseases: evolving targets in renoprotection. Nat. Rev. Drug Discov. 7, 936-953 (2008).
    • (2008) Nat. Rev. Drug Discov. , vol.7 , pp. 936-953
    • Perico, N.1    Benigni, A.2    Remuzzi, G.3
  • 10
    • 0035922441 scopus 로고    scopus 로고
    • Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy
    • Brenner, B. M. et al. Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy. N. Engl. J. Med. 345, 861-869 (2001).
    • (2001) N. Engl. J. Med. , vol.345 , pp. 861-869
    • Brenner, B.M.1
  • 11
    • 0038188560 scopus 로고    scopus 로고
    • Retarding progression of chronic renal disease: The neglected issue of residual proteinuria
    • Ruggenenti, P., Perna, A. & Remuzzi, G. Retarding progression of chronic renal disease: the neglected issue of residual proteinuria. Kidney Int. 63, 2254-2261 (2003).
    • (2003) Kidney Int. , vol.63 , pp. 2254-2261
    • Ruggenenti, P.1    Perna, A.2    Remuzzi, G.3
  • 12
    • 34248178511 scopus 로고    scopus 로고
    • Albuminuria is a target for renoprotective therapy independent from blood pressure in patients with type 2 diabetic nephropathy: Post hoc analysis from the Reduction of Endpoints in NIDDM with the Angiotensin II Antagonist Losartan (RENAAL) trial
    • Eijkelkamp, W. B. et al. Albuminuria is a target for renoprotective therapy independent from blood pressure in patients with type 2 diabetic nephropathy: post hoc analysis from the Reduction of Endpoints in NIDDM with the Angiotensin II Antagonist Losartan (RENAAL) trial. J. Am. Soc. Nephrol. 18, 1540-1546 (2007).
    • (2007) J. Am. Soc. Nephrol. , vol.18 , pp. 1540-1546
    • Eijkelkamp, W.B.1
  • 13
    • 84869492851 scopus 로고    scopus 로고
    • Cardiorenal end points in a trial of aliskiren for type 2 diabetes
    • Parving, H. H. et al. Cardiorenal end points in a trial of aliskiren for type 2 diabetes. N. Engl. J. Med. 367, 2204-2213 (2012).
    • (2012) N. Engl. J. Med. , vol.367 , pp. 2204-2213
    • Parving, H.H.1
  • 14
    • 82255173966 scopus 로고    scopus 로고
    • The unfolded protein response: From stress pathway to homeostatic regulation
    • Walter, P. & Ron, D. The unfolded protein response: from stress pathway to homeostatic regulation. Science 334, 1081-1086 (2011).
    • (2011) Science , vol.334 , pp. 1081-1086
    • Walter, P.1    Ron, D.2
  • 15
    • 84883387793 scopus 로고    scopus 로고
    • Targeting the unfolded protein response in disease
    • Hetz, C., Chevet, E. & Harding, H. P. Targeting the unfolded protein response in disease. Nat. Rev. Drug Discov. 12, 703-719 (2013).
    • (2013) Nat. Rev. Drug Discov. , vol.12 , pp. 703-719
    • Hetz, C.1    Chevet, E.2    Harding, H.P.3
  • 16
    • 33749532327 scopus 로고    scopus 로고
    • Albumin induces endoplasmic reticulum stress and apoptosis in renal proximal tubular cells
    • Ohse, T. et al. Albumin induces endoplasmic reticulum stress and apoptosis in renal proximal tubular cells. Kidney Int. 70, 1447-1455 (2006).
    • (2006) Kidney Int. , vol.70 , pp. 1447-1455
    • Ohse, T.1
  • 17
    • 55749105700 scopus 로고    scopus 로고
    • Proteinuria and hyperglycemia induce endoplasmic reticulum stress
    • Lindenmeyer, M. T. et al. Proteinuria and hyperglycemia induce endoplasmic reticulum stress. J. Am. Soc. Nephrol. 19, 2225-2236 (2008).
    • (2008) J. Am. Soc. Nephrol. , vol.19 , pp. 2225-2236
    • Lindenmeyer, M.T.1
  • 18
    • 77049098363 scopus 로고    scopus 로고
    • Albumin overload induces apoptosis in renal tubular epithelial cells through a CHOP-dependent pathway
    • Wu, X., He, Y., Jing, Y., Li, K. & Zhang, J. Albumin overload induces apoptosis in renal tubular epithelial cells through a CHOP-dependent pathway. OMICS 14, 61-73 (2010).
    • (2010) OMICS , vol.14 , pp. 61-73
    • Wu, X.1    He, Y.2    Jing, Y.3    Li, K.4    Zhang, J.5
  • 19
    • 77649321533 scopus 로고    scopus 로고
    • A murine model of Denys-Drash syndrome reveals novel transcriptional targets of WT1 in podocytes
    • Ratelade, J. et al. A murine model of Denys-Drash syndrome reveals novel transcriptional targets of WT1 in podocytes. Hum. Mol. Genet. 19, 1-15 (2010).
    • (2010) Hum. Mol. Genet. , vol.19 , pp. 1-15
    • Ratelade, J.1
  • 20
    • 70349897728 scopus 로고    scopus 로고
    • Podocin inactivation in mature kidneys causes focal segmental glomerulosclerosis and nephrotic syndrome
    • Mollet, G. et al. Podocin inactivation in mature kidneys causes focal segmental glomerulosclerosis and nephrotic syndrome. J. Am. Soc. Nephrol. 20, 2181-2189 (2009).
    • (2009) J. Am. Soc. Nephrol. , vol.20 , pp. 2181-2189
    • Mollet, G.1
  • 21
    • 60549083305 scopus 로고    scopus 로고
    • Inducible rodent models of acquired podocyte diseases
    • Pippin, J. W. et al. Inducible rodent models of acquired podocyte diseases. Am. J. Physiol. Renal Physiol. 296, F213-F229 (2009).
    • (2009) Am. J. Physiol. Renal Physiol. , vol.296 , pp. F213-F229
    • Pippin, J.W.1
  • 22
    • 0037324549 scopus 로고    scopus 로고
    • Albumin stimulates interleukin-8 expression in proximal tubular epithelial cells in vitro and in vivo
    • Tang, S. et al. Albumin stimulates interleukin-8 expression in proximal tubular epithelial cells in vitro and in vivo. J. Clin. Invest. 111, 515-527 2003
    • (2003) J. Clin. Invest. , vol.111 , pp. 515-527
    • Tang, S.1
  • 23
    • 41149115545 scopus 로고    scopus 로고
    • Albumin-stimulated DNA synthesis is mediated by Ca2/PKC as well as EGF receptor-dependent p44/42 MAPK and NF-kappaB signal pathways in renal proximal tubule cells
    • Lee, Y. J. & Han, H. J. Albumin-stimulated DNA synthesis is mediated by Ca2/PKC as well as EGF receptor-dependent p44/42 MAPK and NF-kappaB signal pathways in renal proximal tubule cells. Am. J. Physiol. Renal Physiol. 294, F534-F541 (2008).
    • (2008) Am. J. Physiol. Renal Physiol. , vol.294 , pp. F534-F541
    • Lee, Y.J.1    Han, H.J.2
  • 24
    • 67651114108 scopus 로고    scopus 로고
    • Small-molecule inhibitors of store-operated calcium entry
    • Sweeney, Z. K., Minatti, A., Button, D. C. & Patrick, S. Small-molecule inhibitors of store-operated calcium entry. ChemMedChem 4, 706-718 2009
    • (2009) ChemMedChem , vol.4 , pp. 706-718
    • Sweeney, Z.K.1    Minatti, A.2    Button, D.C.3    Patrick, S.4
  • 25
    • 79957967093 scopus 로고    scopus 로고
    • ER stress drives Lipocalin 2 upregulation in prostate cancer cells in an NF-kappaB-dependent manner
    • Mahadevan, N. R. et al. ER stress drives Lipocalin 2 upregulation in prostate cancer cells in an NF-kappaB-dependent manner. BMC Cancer 11, 229 (2011).
    • (2011) BMC Cancer , vol.11 , pp. 229
    • Mahadevan, N.R.1
  • 26
    • 78049434336 scopus 로고    scopus 로고
    • Lipocalin 2 is essential for chronic kidney disease progression in mice and humans
    • Viau, A. et al. Lipocalin 2 is essential for chronic kidney disease progression in mice and humans. J. Clin. Invest. 120, 4065-4076 (2010).
    • (2010) J. Clin. Invest. , vol.120 , pp. 4065-4076
    • Viau, A.1
  • 27
  • 28
    • 79952264011 scopus 로고    scopus 로고
    • Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress
    • Tabas, I. & Ron, D. Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress. Nat. Cell Biol. 13, 184-190 (2011).
    • (2011) Nat. Cell Biol. , vol.13 , pp. 184-190
    • Tabas, I.1    Ron, D.2
  • 29
    • 84860222365 scopus 로고    scopus 로고
    • The multifaceted roles of neutrophil gelatinase associated lipocalin (NGAL) in inflammation and cancer
    • Chakraborty, S., Kaur, S., Guha, S. & Batra, S. K. The multifaceted roles of neutrophil gelatinase associated lipocalin (NGAL) in inflammation and cancer. Biochim. Biophys. Acta 1826, 129-169 (2012).
    • (2012) Biochim. Biophys. Acta , vol.1826 , pp. 129-169
    • Chakraborty, S.1    Kaur, S.2    Guha, S.3    Batra, S.K.4
  • 30
    • 20544433886 scopus 로고    scopus 로고
    • Induction of renal tubular cell apoptosis in focal segmental glomerulosclerosis: Roles of proteinuria and Fas-dependent pathways
    • Erkan, E. et al. Induction of renal tubular cell apoptosis in focal segmental glomerulosclerosis: roles of proteinuria and Fas-dependent pathways. J. Am. Soc. Nephrol. 16, 398-407 (2005).
    • (2005) J. Am. Soc. Nephrol. , vol.16 , pp. 398-407
    • Erkan, E.1
  • 31
    • 84877578475 scopus 로고    scopus 로고
    • ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death
    • Han, J. et al. ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death. Nat. Cell Biol. 15, 481-490 (2013).
    • (2013) Nat. Cell Biol. , vol.15 , pp. 481-490
    • Han, J.1
  • 32
    • 0029786498 scopus 로고    scopus 로고
    • Long-term treatment of girls with ornithine transcarbamylase deficiency
    • Maestri, N. E., Brusilow, S. W., Clissold, D. B. & Bassett, S. S. Long-term treatment of girls with ornithine transcarbamylase deficiency. N. Engl. J. Med. 335, 855-859 (1996).
    • (1996) N. Engl. J. Med. , vol.335 , pp. 855-859
    • Maestri, N.E.1    Brusilow, S.W.2    Clissold, D.B.3    Bassett, S.S.4
  • 33
    • 82855161328 scopus 로고    scopus 로고
    • Calcium entry via TRPC6 mediates albumin overload-induced endoplasmic reticulum stress and apoptosis in podocytes
    • Chen, S. et al. Calcium entry via TRPC6 mediates albumin overload-induced endoplasmic reticulum stress and apoptosis in podocytes. Cell Calcium 50, 523-529 (2011).
    • (2011) Cell Calcium , vol.50 , pp. 523-529
    • Chen, S.1
  • 34
    • 41449095253 scopus 로고    scopus 로고
    • KCNA1 and TRPC6 ion channels and NHE1 exchanger operate the biological outcome of HGF/scatter factor in renal tubular cells
    • Rampino, T. et al. KCNA1 and TRPC6 ion channels and NHE1 exchanger operate the biological outcome of HGF/scatter factor in renal tubular cells. Growth Factors 25, 382-391 (2007).
    • (2007) Growth Factors , vol.25 , pp. 382-391
    • Rampino, T.1
  • 35
    • 0036155055 scopus 로고    scopus 로고
    • Megalin and cubilin are endocytic receptors involved in renal clearance of hemoglobin
    • Gburek, J. et al. Megalin and cubilin are endocytic receptors involved in renal clearance of hemoglobin. J. Am. Soc. Nephrol. 13, 423-430 (2002).
    • (2002) J. Am. Soc. Nephrol. , vol.13 , pp. 423-430
    • Gburek, J.1
  • 36
    • 0029908225 scopus 로고    scopus 로고
    • Megalin/gp330 mediates uptake of albumin in renal proximal tubule
    • Cui, S., Verroust, P. J., Moestrup, S. K. & Christensen, E. I. Megalin/gp330 mediates uptake of albumin in renal proximal tubule. Am. J. Physiol. 271, F900-F907 (1996).
    • (1996) Am. J. Physiol. , vol.271 , pp. F900-F907
    • Cui, S.1    Verroust, P.J.2    Moestrup, S.K.3    Christensen, E.I.4
  • 37
    • 84865415167 scopus 로고    scopus 로고
    • Lipocalin 2, a new GADD153 target gene, as an apoptosis inducer of endoplasmic reticulum stress in lung cancer cells
    • Hsin, I. L. et al. Lipocalin 2, a new GADD153 target gene, as an apoptosis inducer of endoplasmic reticulum stress in lung cancer cells. Toxicol. Appl. Pharmacol. 263, 330-337 (2012).
    • (2012) Toxicol. Appl. Pharmacol. , vol.263 , pp. 330-337
    • Hsin, I.L.1
  • 38
    • 29244492306 scopus 로고    scopus 로고
    • A cell-surface receptor for lipocalin 24p3 selectively mediates apoptosis and iron uptake
    • Devireddy, L. R., Gazin, C., Zhu, X. & Green, M. R. A cell-surface receptor for lipocalin 24p3 selectively mediates apoptosis and iron uptake. Cell 123, 1293-1305 (2005).
    • (2005) Cell , vol.123 , pp. 1293-1305
    • Devireddy, L.R.1    Gazin, C.2    Zhu, X.3    Green, M.R.4
  • 39
    • 79958013241 scopus 로고    scopus 로고
    • Multiple apoptotic defects in hematopoietic cells from mice lacking lipocalin 24p3
    • Liu, Z. et al. Multiple apoptotic defects in hematopoietic cells from mice lacking lipocalin 24p3. J. Biol. Chem. 286, 20606-20614 (2011).
    • (2011) J. Biol. Chem. , vol.286 , pp. 20606-20614
    • Liu, Z.1
  • 40
    • 84909594302 scopus 로고    scopus 로고
    • JAK2V617F myeloproliferative neoplasm clones evoke paracrine DNA damage to adjacent normal cells through secretion of lipocalin-2
    • Kagoya, Y. et al. JAK2V617F myeloproliferative neoplasm clones evoke paracrine DNA damage to adjacent normal cells through secretion of lipocalin-2. Blood 124, 2996-3006 (2014).
    • (2014) Blood , vol.124 , pp. 2996-3006
    • Kagoya, Y.1
  • 41
    • 77955886660 scopus 로고    scopus 로고
    • Iron traffics in circulation bound to a siderocalin (Ngal)-catechol complex
    • Bao, G. et al. Iron traffics in circulation bound to a siderocalin (Ngal)-catechol complex. Nat. Chem. Biol. 6, 602-609 (2010).
    • (2010) Nat. Chem. Biol. , vol.6 , pp. 602-609
    • Bao, G.1
  • 42
    • 38449111059 scopus 로고    scopus 로고
    • Carnosic acid, a catechol-type electrophilic compound, protects neurons both in vitro and in vivo through activation of the Keap1/Nrf2 pathway via S-alkylation of targeted cysteines on Keap1
    • Satoh, T. et al. Carnosic acid, a catechol-type electrophilic compound, protects neurons both in vitro and in vivo through activation of the Keap1/Nrf2 pathway via S-alkylation of targeted cysteines on Keap1. J. Neurochem. 104, 1116-1131 (2008).
    • (2008) J. Neurochem. , vol.104 , pp. 1116-1131
    • Satoh, T.1
  • 43
    • 4644221457 scopus 로고    scopus 로고
    • Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization
    • Go, A. S., Chertow, G. M., Fan, D., McCulloch, C. E. & Hsu, C. Y. Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. N. Engl. J. Med. 351, 1296-1305 (2004).
    • (2004) N. Engl. J. Med. , vol.351 , pp. 1296-1305
    • Go, A.S.1    Chertow, G.M.2    Fan, D.3    McCulloch, C.E.4    Hsu, C.Y.5
  • 44
    • 77749298787 scopus 로고    scopus 로고
    • Study strategies for neurobiology mechanism of 'kidney storing will and responding to fear'
    • Liu, S. K., Yan, C., Wu, L. L. & Pan, Y. [Study strategies for neurobiology mechanism of 'kidney storing will and responding to fear']. Zhong. Xi. Yi. Jie. He. Xue. Bao. 8, 106-110 (2010).
    • (2010) Zhong. Xi. Yi. Jie. He. Xue. Bao. , vol.8 , pp. 106-110
    • Liu, S.K.1    Yan, C.2    Wu, L.L.3    Pan, Y.4
  • 45
    • 84877031005 scopus 로고    scopus 로고
    • Urine neutrophil gelatinase-associated lipocalin levels do not improve risk prediction of progressive chronic kidney disease
    • Liu, K. D. et al. Urine neutrophil gelatinase-associated lipocalin levels do not improve risk prediction of progressive chronic kidney disease. Kidney Int. 83, 909-914 (2013).
    • (2013) Kidney Int. , vol.83 , pp. 909-914
    • Liu, K.D.1
  • 46
    • 44449154830 scopus 로고    scopus 로고
    • Urinary neutrophil gelatinase-associated lipocalin (NGAL) is associated with severity of renal disease in proteinuric patients
    • Bolignano, D. et al. Urinary neutrophil gelatinase-associated lipocalin (NGAL) is associated with severity of renal disease in proteinuric patients. Nephrol. Dial. Transplant. 23, 414-416 (2008).
    • (2008) Nephrol. Dial. Transplant. , vol.23 , pp. 414-416
    • Bolignano, D.1
  • 48
    • 33748069813 scopus 로고    scopus 로고
    • Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes
    • Ozcan, U. et al. Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science 313, 1137-1140 (2006).
    • (2006) Science , vol.313 , pp. 1137-1140
    • Ozcan, U.1
  • 49
    • 0037084401 scopus 로고    scopus 로고
    • Vimentin affects localization and activity of sodium-glucose cotransporter SGLT1 in membrane rafts
    • Runembert, I. et al. Vimentin affects localization and activity of sodium-glucose cotransporter SGLT1 in membrane rafts. J. Cell. Sci. 115, 713-724 (2002).
    • (2002) J. Cell. Sci. , vol.115 , pp. 713-724
    • Runembert, I.1
  • 50
    • 77957861954 scopus 로고    scopus 로고
    • Glomerular structure and function require paracrine, not autocrine, VEGF-VEGFR-2 signaling
    • Sison, K. et al. Glomerular structure and function require paracrine, not autocrine, VEGF-VEGFR-2 signaling. J. Am. Soc. Nephrol. 21, 1691-1701 (2010).
    • (2010) J. Am. Soc. Nephrol. , vol.21 , pp. 1691-1701
    • Sison, K.1
  • 51
    • 0032080835 scopus 로고    scopus 로고
    • Hepatocyte growth factor prevents renal fibrosis and dysfunction in a mouse model of chronic renal disease
    • Mizuno, S. et al. Hepatocyte growth factor prevents renal fibrosis and dysfunction in a mouse model of chronic renal disease. J. Clin. Invest. 101, 1827-1834 (1998).
    • (1998) J. Clin. Invest. , vol.101 , pp. 1827-1834
    • Mizuno, S.1
  • 52
    • 0037129827 scopus 로고    scopus 로고
    • Accurate normalization of real-time quantitative RTPCR data by geometric averaging of multiple internal control genes
    • RESEARCH0034
    • Vandesompele, J. et al. Accurate normalization of real-time quantitative RTPCR data by geometric averaging of multiple internal control genes. Genome Biol. 3, RESEARCH0034 (2002).
    • (2002) Genome Biol. , vol.3
    • Vandesompele, J.1


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