Urinary Neutrophil Gelatinase-Associated Lipocalin (NGAL) is associated with severity of renal disease in proteinuric patients

Nephrology Dialysis Transplantation

Volumn 23, Issue 1, 2008, Pages 414-416

  Bolignano, Davide ^a   Coppolino, Giuseppe ^a   Campo, Susanna ^a   Aloisi, Carmela ^a   Nicocia, Giacomo ^a   Frisina, Nicola ^a   Buemi, Michele ^a  

^a UNIVERSITY OF MESSINA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CREATININE; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; ACUTE PHASE PROTEIN; LCN2 PROTEIN, HUMAN; LIPOCALIN; ONCOPROTEIN;

ADULT; CHRONIC KIDNEY FAILURE; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE ASSOCIATION; DISEASE COURSE; DISEASE SEVERITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FIBROSING ALVEOLITIS; HUMAN; KIDNEY DISEASE; KIDNEY FUNCTION; LETTER; MALE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN URINE LEVEL; PROTEINURIA; URINALYSIS; GLOMERULONEPHRITIS; HOSPITALIZATION; MIDDLE AGED; URINE;

ACUTE-PHASE PROTEINS; FEMALE; GLOMERULONEPHRITIS; HUMANS; LIPOCALINS; MALE; MIDDLE AGED; PROTEINURIA; PROTO-ONCOGENE PROTEINS; SEVERITY OF ILLNESS INDEX;

EID: 44449154830     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfm541     Document Type: Letter

References (17)

1. Tryggvason K, Pettersson E. Causes and consequences of proteinuria: the kidney filtration barrier and progressive renal failure. J Intern Med. 2003; 254: 216-224
2. Thomas ME, Schreiner GF. Contribution of proteinuria to progressive renal injury: consequences of tubular uptake of fatty acid bearing albumin. Am J Nephrol 1993; 13: 385-398
3. Abbate M, Zoja C, Rottoli D et al. Antiproteinuric therapy while preventing the abnormal protein traffic in proximal tubule abrogates protein- and complement-dependent interstitial inflammation in experimental renal disease. J Am Soc Nephrol 1999; 10: 804-813
4. Abbate M, Zoja C, Remuzzi G. How does proteinuria cause progressive renal damage? J Am Soc Nephrol 2006; 17: 2974-2984
5. Yang J, Mori K, Li JY, Barasch J. Iron, lipocalin, and kidney epithelia. Am J Physiol Renal Physiol 2003; 285: F9-F18
6. Hraba-Renevey S, Turler H, Kress M, Salomon C, Weil R. SV40-induced expression of mouse gene 24p3 involves a post-transcriptional mechanism. Oncogene 1989; 4: 601-608
7. Mishra J, Ma Q, Prada A et al. Identification of neutrophil gelatinase-associated lipocalin as a novel early urinary biomarker for ischemic renal injury. J Am Soc Nephrol 2003; 14: 2534-2543
8. Mishra J, Mori K, Ma Q, Kelly C, Barasch J, Devarajan P. Neutrophil gelatinase-associated lipocalin: a novel early urinary biomarker for cisplatin nephrotoxicity. Am J Nephrol 2004; 24: 307-315
9. Thomas ME, Brunskill NJ, Harris KP et al. Proteinuria induces tubular cell turnover: a potential mechanism for tubular atrophy. Kidney Int 1999; 55: 890-898
10. Kamijo A, Sugaya T, Hikawa A et al. Urinary excretion of fatty acid-binding protein reflects stress overload on the proximal tubules. Am J Pathol 2004; 165: 1243-1255
11. Kikuchi H, Kawachi H, Ito Y et al. Severe proteinuria, sustained for 6 months, induces tubular epithelial cell injury and cell infiltration in rats but not progressive interstitial fibrosis. Nephrol Dial Transplant 2000; 15: 799-810
12. Camussi G, Stratta P, Mazzucco G et al. In vivo localization of C3 on the brush border of proximal tubules of kidneys from nephrotic patients. Clin Nephrol 1985; 23: 134-141
13. Branten AJ, Kock-Jansen M, Klasen IS, Wetzels JF. Urinary excretion of complement C3d in patients with renal diseases. Eur J Clin Invest 2003; 33: 449-456
14. Morita Y, Ikeguchi H, Nakamura J, Hotta N, Yuzawa Y, Matsuo S. Complement activation products in the urine from proteinuric patients. J Am Soc Nephrol 2000; 11: 700-707
15. van Timmeren MM, Bakker SJ, Vaidya VS et al. Tubular kidney injury molecule-1 in protein-overload nephropathy. Am J Physiol Renal Physiol 2006; 291: F456-F464
16. Brunner HI, Mueller M, Rutherford C et al. Urinary neutrophil gelatinase-associated lipocalin as a biomarker of nephritis in childhood-onset systemic lupus erythematosus. Arthritis Rheum 2006; 54: 2577-2584
17. Mitsnefes MM, Kathman TS, Mishra J et al. Serum neutrophil gelatinase-associated lipocalin as a marker of renal function in children with chronic kidney disease. Pediatr Nephrol 2007; 22: 101-108