Lipocalin 2, a new GADD153 target gene, as an apoptosis inducer of endoplasmic reticulum stress in lung cancer cells

Toxicology and Applied Pharmacology

Volumn 263, Issue 3, 2012, Pages 330-337

  Hsin, I Lun ^a   Hsiao, Yueh Chieh ^a   Wu, Ming Fang ^a,b   Jan, Ming Shiou ^a   Tang, Sheau Chung ^a   Lin, Yu Wen ^a   Hsu, Chung Ping ^c,d   Ko, Jiunn Liang ^a,b  

^a CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^b CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^c TAICHUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^d NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

Apoptosis; ER stress; GADD153 CHOP; Lipocalin 2 NGAL; Thapsigargin; Unfolded protein response

Indexed keywords

GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; THAPSIGARGIN;

APOPTOSIS; ARTICLE; CANCER CELL; CHROMATIN IMMUNOPRECIPITATION; CYTOTOXICITY; DNA BINDING; ENDOPLASMIC RETICULUM STRESS; HUMAN; HUMAN CELL; LUNG CANCER; PROTEIN EXPRESSION;

ACUTE-PHASE PROTEINS; APOPTOSIS; CELL LINE, TUMOR; CHROMATIN IMMUNOPRECIPITATION; ENDOPLASMIC RETICULUM STRESS; GENE SILENCING; HUMANS; LIPOCALINS; LUNG NEOPLASMS; PROTO-ONCOGENE PROTEINS; THAPSIGARGIN; TRANSCRIPTION FACTOR CHOP;

EID: 84865415167     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2012.07.005     Document Type: Article

References (36)

1. Christensen S.B., Skytte D.M., Denmeade S.R., Dionne C., Moller J.V., Nissen P., Isaacs J.T. A Trojan horse in drug development: targeting of thapsigargins towards prostate cancer cells. Anticancer Agents Med. Chem. 2009, 9:276-294.
2. Cowland J.B., Sorensen O.E., Sehested M., Borregaard N. Neutrophil gelatinase-associated lipocalin is up-regulated in human epithelial cells by IL-1 beta, but not by TNF-alpha. J. Immunol. 2003, 171:6630-6639.
3. Cowland J.B., Muta T., Borregaard N. IL-1beta-specific up-regulation of neutrophil gelatinase-associated lipocalin is controlled by IkappaB-zeta. J. Immunol. 2006, 176:5559-5566.
4. Decuypere J.P., Bultynck G., Parys J.B. A dual role for Ca(2+) in autophagy regulation. Cell Calcium 2011, 50:242-250.
5. Denmeade S.R., Isaacs J.T. The SERCA pump as a therapeutic target: making a "smart bomb" for prostate cancer. Cancer Biol. Ther. 2005, 4:14-22.
6. Denmeade S.R., Jakobsen C.M., Janssen S., Khan S.R., Garrett E.S., Lilja H., Christensen S.B., Isaacs J.T. Prostate-specific antigen-activated thapsigargin prodrug as targeted therapy for prostate cancer. J. Natl. Cancer Inst. 2003, 95:990-1000.
7. Fougere M., Gaudineau B., Barbier J., Guaddachi F., Feugeas J.P., Auboeuf D., Jauliac S. NFAT3 transcription factor inhibits breast cancer cell motility by targeting the lipocalin 2 gene. Oncogene 2010, 29:2292-2301.
8. Heath-Engel H.M., Chang N.C., Shore G.C. The endoplasmic reticulum in apoptosis and autophagy: role of the BCL-2 protein family. Oncogene 2008, 27:6419-6433.
9. Hoyer-Hansen M., Jaattela M. Connecting endoplasmic reticulum stress to autophagy by unfolded protein response and calcium. Cell Death Differ. 2007, 14:1576-1582.
10. Hsin I.L., Ou C.C., Wu T.C., Jan M.S., Wu M.F., Chiu L.Y., Lue K.H., Ko J.L. GMI, an immunomodulatory protein from Ganoderma microsporum, induces autophagy in non-small cell lung cancer cells. Autophagy 2011, 7:873-882.
11. Kehrer J.P. Lipocalin-2: pro- or anti-apoptotic?. Cell Biol. Toxicol. 2010, 26:83-89.
12. Lee S., Lee J., Kim S., Park J.Y., Lee W.H., Mori K., Kim S.H., Kim I.K., Suk K. A dual role of lipocalin 2 in the apoptosis and deramification of activated microglia. J. Immunol. 2007, 179:3231-3241.
13. Lee J.H., Kye K.C., Seo E.Y., Lee K., Lee S.K., Lim J.S., Seo Y.J., Kim C.D., Park J.K. Expression of neutrophil gelatinase-associated lipocalin in calcium-induced keratinocyte differentiation. J. Korean Med. Sci. 2008, 23:302-306.
14. Leng X., Lin H., Ding T., Wang Y., Wu Y., Klumpp S., Sun T., Zhou Y., Monaco P., Belmont J., Aderem A., Akira S., Strong R., Arlinghaus R. Lipocalin 2 is required for BCR-ABL-induced tumorigenesis. Oncogene 2008, 27:6110-6119.
15. Leng X., Ding T., Lin H., Wang Y., Hu L., Hu J., Feig B., Zhang W., Pusztai L., Symmans W.F., Wu Y., Arlinghaus R.B. Inhibition of lipocalin 2 impairs breast tumorigenesis and metastasis. Cancer Res. 2009, 69:8579-8584.
16. Lin C.H., Hsiao Y.M., Ou C.C., Lin Y.W., Chiu Y.L., Lue K.H., Chang J.G., Ko J.L. GMI, a Ganoderma immunomodulatory protein, down-regulates tumor necrosis factor alpha-induced expression of matrix metalloproteinase 9 via NF-kappaB pathway in human alveolar epithelial A549 cells. J. Agric. Food Chem. 2010, 58:12014-12021.
17. Mahadevan N.R., Rodvold J., Almanza G., Perez A.F., Wheeler M.C., Zanetti M. ER stress drives lipocalin 2 upregulation in prostate cancer cells in an NF-kappaB-dependent manner. BMC Cancer 2011, 11:229.
18. Mandic A., Hansson J., Linder S., Shoshan M.C. Cisplatin induces endoplasmic reticulum stress and nucleus-independent apoptotic signaling. J. Biol. Chem. 2003, 278:9100-9106.
19. Manthey K.C., Rodriguez-Melendez R., Hoi J.T., Zempleni J. Riboflavin deficiency causes protein and DNA damage in HepG2 cells, triggering arrest in G1 phase of the cell cycle. J. Nutr. Biochem. 2006, 17:250-256.
20. Nilsen-Hamilton M., Liu Q., Ryon J., Bendickson L., Lepont P., Chang Q. Tissue involution and the acute phase response. Ann. N. Y. Acad. Sci. 2003, 995:94-108.
21. Nuntagowat C., Leelawat K., Tohtong R. NGAL knockdown by siRNA in human cholangiocarcinoma cells suppressed invasion by reducing NGAL/MMP-9 complex formation. Clin. Exp. Metastasis 2010, 27:295-305.
22. Ogata M., Hino S., Saito A., Morikawa K., Kondo S., Kanemoto S., Murakami T., Taniguchi M., Tanii I., Yoshinaga K., Shiosaka S., Hammarback J.A., Urano F., Imaizumi K. Autophagy is activated for cell survival after endoplasmic reticulum stress. Mol. Cell. Biol. 2006, 26:9220-9231.
23. Oyadomari S., Mori M. Roles of CHOP/GADD153 in endoplasmic reticulum stress. Cell Death Differ. 2004, 11:381-389.
24. Qin L., Wang Z., Tao L., Wang Y. ER stress negatively regulates AKT/TSC/mTOR pathway to enhance autophagy. Autophagy 2010, 6:239-247.
25. Roudkenar M.H., Halabian R., Ghasemipour Z., Roushandeh A.M., Rouhbakhsh M., Nekogoftar M., Kuwahara Y., Fukumoto M., Shokrgozar M.A. Neutrophil gelatinase-associated lipocalin acts as a protective factor against H(2)O(2) toxicity. Arch. Med. Res. 2008, 39:560-566.
26. Rzymski T., Milani M., Pike L., Buffa F., Mellor H.R., Winchester L., Pires I., Hammond E., Ragoussis I., Harris A.L. Regulation of autophagy by ATF4 in response to severe hypoxia. Oncogene 2010, 29:4424-4435.
27. Shemin D., Dworkin L.D. Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for early acute kidney injury. Crit. Care Clin. 2011, 27:379-389.
28. Su L., Liu G., Hao X., Zhong N., Zhong D., Liu X., Singhal S. Death receptor 5 and cellular FLICE-inhibitory protein regulate pemetrexed-induced apoptosis in human lung cancer cells. Eur. J. Cancer 2011, 47:2471-2478.
29. Tang S.C., Wu M.F., Wong R.H., Liu Y.F., Tang L.C., Lai C.H., Hsu C.P., Ko J.L. Epigenetic mechanisms for silencing glutathione S-transferase m2 expression by hypermethylated specificity protein 1 binding in lung cancer. Cancer 2011, 117:3209-3221.
30. Tong Z., Wu X., Ovcharenko D., Zhu J., Chen C.S., Kehrer J.P. Neutrophil gelatinase-associated lipocalin as a survival factor. Biochem. J. 2005, 391:441-448.
31. Tong Z., Kunnumakkara A.B., Wang H., Matsuo Y., Diagaradjane P., Harikumar K.B., Ramachandran V., Sung B., Chakraborty A., Bresalier R.S., Logsdon C., Aggarwal B.B., Krishnan S., Guha S. Neutrophil gelatinase-associated lipocalin: a novel suppressor of invasion and angiogenesis in pancreatic cancer. Cancer Res. 2008, 68:6100-6108.
32. Verfaillie T., Garg A.D., Agostinis P. Targeting ER stress induced apoptosis and inflammation in cancer. Cancer Lett. 2010, 10.1016/j.canlet.2010.07.016.
33. Wang P.H., Ko J.L., Yang S.F., Lin L.Y. Implication of human nonmetastatic clone 23 type 1 and its downstream gene lipocalin 2 in metastasis and patient's survival of cancer of uterine cervix. Int. J. Cancer 2011, 129:2380-2389.
34. Wu M.F., Hsiao Y.M., Huang C.F., Huang Y.H., Yang W.J., Chan H.W., Chang J.T., Ko J.L. Genetic determinants of pemetrexed responsiveness and nonresponsiveness in non-small cell lung cancer cells. J. Thorac. Oncol. 2010, 5:1143-1151.
35. Zhang K., Kaufman R.J. From endoplasmic-reticulum stress to the inflammatory response. Nature 2008, 454:455-462.
36. Zinszner H., Kuroda M., Wang X., Batchvarova N., Lightfoot R.T., Remotti H., Stevens J.L., Ron D. CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum. Genes Dev. 1998, 12:982-995.