Uric acid regulates hepatic steatosis and insulin resistance through the NLRP3 inflammasome-dependent mechanism

Journal of Hepatology

Volumn 64, Issue 4, 2016, Pages 925-932

  Wan, Xingyong ^a   Xu, Chengfu ^a   Lin, Yiming ^a   Lu, Chao ^a   Li, Dejian ^a   Sang, Jianzhong ^a   He, Haijian ^a   Liu, Xiao ^a   Li, Youming ^a   Yu, Chaohui ^a  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Fatty liver; Hyperuricemia; Insulin resistance; NLRP3 inflammasome; Uric acid

Indexed keywords

ALLOPURINOL; CRYOPYRIN; INFLAMMASOME; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR; URIC ACID; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; REACTIVE OXYGEN METABOLITE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; INSULIN RESISTANCE; LIPID STORAGE; LIVER CELL; MOUSE; NONALCOHOLIC FATTY LIVER; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; ANIMAL; C57BL MOUSE; CHEMICALLY INDUCED; DRUG EFFECTS; FATTY LIVER; HEP-G2 CELL LINE; HUMAN; METABOLISM; PHYSIOLOGY;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; FATTY LIVER; HEP G2 CELLS; HEPATOCYTES; HUMANS; INFLAMMASOMES; INSULIN RESISTANCE; MICE; MICE, INBRED C57BL; NLR FAMILY, PYRIN DOMAIN-CONTAINING 3 PROTEIN; REACTIVE OXYGEN SPECIES; URIC ACID;

EID: 84955482082     PISSN: 01688278     EISSN: 16000641     Source Type: Journal    
DOI: 10.1016/j.jhep.2015.11.022     Document Type: Article

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