Uric acid-dependent inhibition of AMP kinase induces hepatic glucose production in diabetes and starvation: Evolutionary implications of the uricase loss in hominids

FASEB Journal

Volumn 28, Issue 8, 2014, Pages 3339-3350

  Cicerchi, Christina ^a   Li, Nanxing ^a   Kratzer, James ^b   Garcia, Gabriela ^a   Roncal Jimenez, Carlos A ^a   Tanabe, Katsuyuki ^a   Hunter, Brandi ^a   Rivard, Christopher J ^a   Sautin, Yuri Y ^c   Gaucher, Eric A ^b   Johnson, Richard J ^a   Lanaspa, Miguel A ^a  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^b GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

^c UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

Gluconeogenesis; Insulin; Phosphate; Urate

Indexed keywords

ADENOSINE MONOPHOSPHATE DEAMINASE; ADENYLATE KINASE; GLUCOSE; GLUCOSE 6 PHOSPHATASE; INOSINE; PHOSPHATE; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR TORC2; UNCLASSIFIED DRUG; URATE OXIDASE; URIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; GENE MUTATION; GENE OVEREXPRESSION; GLUCONEOGENESIS; HEPG2 CELL LINE; HOMINID; HUMAN; HUMAN CELL; HUNGER; INSULIN RESISTANCE; LIVER; MALE; MAMMAL; METABOLITE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; STARVATION; UPREGULATION;

GLUCONEOGENESIS; INSULIN; PHOSPHATE; URATE;

AMP DEAMINASE; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; EUROPE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUCONEOGENESIS; GLUCOSE-6-PHOSPHATASE; HEP G2 CELLS; HISTORY, ANCIENT; HOMINIDAE; HUMANS; INSULIN; INSULIN RESISTANCE; LIVER; MALE; MICE; MICE, INBRED C57BL; MODELS, BIOLOGICAL; MULTIPROTEIN COMPLEXES; PHOSPHATES; PHOSPHOENOLPYRUVATE CARBOXYKINASE (ATP); RECOMBINANT FUSION PROTEINS; SELECTION, GENETIC; SPECIFIC PATHOGEN-FREE ORGANISMS; STARVATION; TOR SERINE-THREONINE KINASES; TRANSDUCTION, GENETIC; URATE OXIDASE; URIC ACID;

EID: 84905233774     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.13-243634     Document Type: Article

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