A single aspiration of rod-like carbon nanotubes induces asbestos-like pulmonary inflammation mediated in part by the IL-1 receptor

Toxicological Sciences

Volumn 147, Issue 1, 2015, Pages 140-155

  Rydman, Elina M ^a   Ilves, Marit ^a   Vanhala, Esa ^a   Vippola, Minnamari ^b   Lehto, Maili ^a   Kinaret, Pia A S ^a   Pylkkänen, Lea ^a   Happo, Mikko ^c   Hirvonen, Maija Riitta ^c   Greco, Dario ^a   Savolainen, Kai ^a   Wolff, Henrik ^a   Alenius, Harri ^a  

^a FINNISH INSTITUTE OF OCCUPATIONAL HEALTH   (Finland)

^b TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^c UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

Asbestos; Charcot Leyden like crystals; IL 1 ; Multiwalled carbon nanotubes; Th2

Indexed keywords

ASBESTOS; CARBON NANOTUBE; CHEMOKINE; CROCIDOLITE; ETANERCEPT; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 13; INTERLEUKIN 1BETA; MESSENGER RNA; RECOMBINANT INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; CYTOKINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CRYSTAL; FEMALE; GOBLET CELL; HYPERPLASIA; LOEFFLER PNEUMONIA; LUNG GRANULOMA; LUNG PARENCHYMA; MACROPHAGE; MOUSE; NEUTROPHILIA; NONHUMAN; PNEUMONIA; PROTEIN EXPRESSION; TH2 CELL; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CD4+ T LYMPHOCYTE; CHEMICALLY INDUCED; DRUG EFFECTS; GENETICS; KNOCKOUT MOUSE; METABOLISM; MUCUS; NEUTROPHIL; PATHOLOGY; SECRETION (PROCESS);

ANIMALS; ASBESTOS; ASBESTOS, CROCIDOLITE; CD4-POSITIVE T-LYMPHOCYTES; CHEMOKINES; CYTOKINES; MACROPHAGES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MUCUS; NANOTUBES, CARBON; NEUTROPHILS; PNEUMONIA; RECEPTORS, INTERLEUKIN-1; RNA, MESSENGER;

EID: 84940658114     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfv112     Document Type: Article

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