Identification of argininosuccinate lyase as a hypoxia-responsive gene in rat hepatocytes

Journal of Hepatology

Volumn 33, Issue 5, 2000, Pages 709-715

  Latasa, María Ujue ^a   Carretero, M Victoria ^a   García Trevijano, Elena R ^a   Torres, Luis ^a   Mato, José M ^a   Avila, Matías A ^a  

^a UNIVERSITY OF NAVARRA   (Spain)

Author keywords

Argininosuccinate lyase; Gene expression; Hypoxia; Liver

Indexed keywords

ARGININOSUCCINATE LYASE; CYCLIC AMP; HEMOPROTEIN; MESSENGER RNA; METHIONINE ADENOSYLTRANSFERASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CATALYSIS; CELL ISOLATION; DOWN REGULATION; ENZYME ACTIVITY; ENZYME ANALYSIS; GENE EXPRESSION; GENE EXPRESSION REGULATION; HYPOXIA; LIVER CELL; LIVER PARENCHYMA; NONHUMAN; OXYGEN CONSUMPTION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; UREA CYCLE;

EID: 0033762966     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8278(00)80300-1     Document Type: Article

References (45)

1. Functional specialization of different hepatocyte populations
2. Zonation of parenchymal and nonparencymal metabolism in liver
3. Regulation of the erythropoietin gene
4. Vascular endothelial growth factor induced by hypoxia-initiated angiogenesis
5. Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1
6. Hypoxia increases rate of transcription and stability of tyrosine hydroxylase mRNA in pheochromocytoma (PC12) cells
7. 2 in muscle cells in culture
8. Regulation by hypoxia of methionine adenosyltransferase gene expression in rat hepatocytes
9. Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction
10. Regulation of enzymes of the urea and arginine synthesis
11. The product of the cph oncogene is a truncated, nucleotide-binding protein that enhances cellular survival to stress
12. Induction of TIMP-1 expression in rat hepatic stellate cells and hepatocytes: A new role for homocysteine in liver fibrosis
13. The EMBL data library
14. The GeneBank data bank
15. Improved tools for biological sequence comparison
16. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
17. Argininosuccinic aciduria. Argininosuccinase and arginase in human blood cells
18. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein dye binding
19. Molecular cloning and nucleotide sequence of the rat brain argininosuccinate lyase cDNA with an extremely long 5'-untranslated sequence: Evidence for the identity of the brain and liver enzymes
20. Expression of argininosuccinate lyase mRNA in foetal hepatocytes
21. Induction of albumin gene transcription in hepatocytes by extracellular matrix proteins
22. ATP concentration gradients in cytosol of liver cells during hypoxia
23. Dual control of glut1 glucose transporter gene expression by hypoxia and by inhibition of oxidative phosphorylation
24. Oxygen sensing and molecular adaptation to hypoxia
25. Modulation of the glucagon-dependent activation of phosphoenolpyruvate carboxykinase gene by oxygen in rat hepatocyte cultures
26. Cytochromes and oxygen radicals as putative members of the oxygen sensing pathway
27. Cellular respiration during hypoxia
28. The molecular mechanisms of the metabolism and transport in normal and neoplastic cells
29. 2+ homeostasis on hepatocyte canalicular function in vitro
30. Role of peroxide in hypoxia-induced erythropoietin production
31. Mammalian urea cycle enzymes
32. Development of the ornithine cycle in rat liver: Zonation of a metabolic pathway
33. Hypoxia and mitochondrial inhibitors regulate expression of glucose transporter-1 via distinct cis-acting sequences
34. Intracellular degradation of mitochondrial enzymes
35. The urea cycle: Enzymes and defects
36. Regulation of messenger ribonucleic acid levels for five urea cycle enzymes in cultured rat hepatocytes. Requirement for cyclic adenosine monophosphate, glucocorticoids, and ongoing protein synthesis
37. Hypoxic effects on the expression of mineralocorticoid and glucocorticoid receptors in human renal cortex epithelial cells
38. 2+/calmodulin signaling systems in PC12 cells
39. Regulation of erythropoietin gene: Evidence that the oxygen sensor is a heme protein
40. Oxygen sensing and signaling: Impact on the regulation of physiologically important genes
41. EPAS1 trans-activation during hypoxia requires p42/p44 MAPK
42. Mitogen-activated protein kinase phosphatase-1 (MKP-1) expression is induced by low oxygen conditions found in solid tumor microenvironments. A candidate MKP for the inactivation of hypoxia-inducible stress-activated protein kinase/c-Jun N-terminal protein kinase activity
43. Modulation by oxygen of zonal gene expression in liver studied in primary rat hepatocyte cultures
44. Changes in levels of argininosuccinate lyase mRNA during induction by glucagon and cyclic AMP in cultured foetal-rat hepatocytes
45. Identification of an oxygen-responsive element in the 5'-flanking sequence of the rat cytosolic phosphoenolpyruvate carboxykinase-1 gene, modulating its glucagon-dependent activation