메뉴 건너뛰기




Volumn 39, Issue 11, 2015, Pages 1137-1145

Smoking as a contributing factor for development of polycythemia vera and related neoplasms

Author keywords

Atherosclerosis; Chronic myelomonocytic stimulation; Essential thrombocythemia; IL 8; JAK STAT signaling; Myeloproliferative neoplasms MPNs; NF B; Polycythemia vera; Primary myelofibrosis; Smoking; Thrombosis

Indexed keywords

CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 8; JANUS KINASE; MACROPHAGE INFLAMMATORY PROTEIN 1; MONOCYTE CHEMOTACTIC PROTEIN 1; NICOTINE; STAT PROTEIN; TRANSCRIPTION FACTOR NF E2;

EID: 84955353963     PISSN: 01452126     EISSN: 18735835     Source Type: Journal    
DOI: 10.1016/j.leukres.2015.09.002     Document Type: Review
Times cited : (37)

References (100)
  • 1
    • 33845436745 scopus 로고    scopus 로고
    • The myeloproliferative disorders
    • P.J. Campbell, A.R. Green, The myeloproliferative disorders, N. Engl. J. Med.355 (2006) 2452-2466.
    • (2006) N. Engl. J. Med , vol.355 , pp. 2452-2466
    • Campbell, P.J.1    Green, A.R.2
  • 2
    • 84872424841 scopus 로고    scopus 로고
    • Chronic inflammation as a promotor of mutagenesis inessential thrombocythemia, polycythemia vera and myelofibrosis. A humaninflammation model for cancer development?
    • H.C. Hasselbalch, Chronic inflammation as a promotor of mutagenesis inessential thrombocythemia, polycythemia vera and myelofibrosis. A humaninflammation model for cancer development? Leuk Res. 37 (2) (2013) 214-220.
    • (2013) Leuk Res , vol.37 , Issue.2 , pp. 214-220
    • Hasselbalch, H.C.1
  • 3
    • 84859584516 scopus 로고    scopus 로고
    • Perspectives on chronic inflammation in essentialthrombocythemia, polycythemia vera, and myelofibrosis: is chronicinflammation a trigger and driver of clonal evolution and development ofaccelerated atherosclerosis and second cancer?
    • H.C. Hasselbalch, Perspectives on chronic inflammation in essentialthrombocythemia, polycythemia vera, and myelofibrosis: is chronicinflammation a trigger and driver of clonal evolution and development ofaccelerated atherosclerosis and second cancer? Blood 119 (2012) 3219-3225.
    • (2012) Blood , vol.119 , pp. 3219-3225
    • Hasselbalch, H.C.1
  • 4
    • 17644424955 scopus 로고    scopus 로고
    • A gain of function mutation ofJAK2 in myeloproliferative disorders
    • R. Kralovics, F. Passamonti, A.S. Buser, et al., A gain of function mutation ofJAK2 in myeloproliferative disorders, N. Engl. J. Med. 352 (2005) 1779-1790.
    • (2005) N. Engl. J. Med , vol.352 , pp. 1779-1790
    • Kralovics, R.1    Passamonti, F.2    Buser, A.S.3
  • 5
    • 20144363192 scopus 로고    scopus 로고
    • Acquired mutation of the tyrosinekinase JAK2 in human myeloproliferative disorders
    • E.J. Baxter, L.M. Scott, P.J. Campbell, et al., Acquired mutation of the tyrosinekinase JAK2 in human myeloproliferative disorders, Lancet 365 (2005) 1054-1061.
    • (2005) Lancet , vol.365 , pp. 1054-1061
    • Baxter, E.J.1    Scott, L.M.2    Campbell, P.J.3
  • 6
    • 20244369569 scopus 로고    scopus 로고
    • Activating mutation in the tyrosinekinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloidmetaplasia with myelofibrosis
    • R.L. Levine, M. Wadleigh, J. Cools, et al., Activating mutation in the tyrosinekinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloidmetaplasia with myelofibrosis, Cancer Cell 7 (2005) 387-397.
    • (2005) Cancer Cell , vol.7 , pp. 387-397
    • Levine, R.L.1    Wadleigh, M.2    Cools, J.3
  • 7
    • 34548240698 scopus 로고    scopus 로고
    • Role of JAK2 in thepathogenesis and therapy of myeloproliferative disorders
    • R.L. Levine, A. Pardanani, A. Tefferi, D.G. Gilliland, Role of JAK2 in thepathogenesis and therapy of myeloproliferative disorders, Nat. Rev. Cancer 7 (2007) 673-683.
    • (2007) Nat. Rev. Cancer , vol.7 , pp. 673-683
    • Levine, R.L.1    Pardanani, A.2    Tefferi, A.3    Gilliland, D.G.4
  • 9
    • 84890372480 scopus 로고    scopus 로고
    • Somatic mutations ofcalreticulin in myeloproliferative neoplasms
    • T. Klampfl, H. Gisslinger, A.S. Harutyunyan, et al., Somatic mutations ofcalreticulin in myeloproliferative neoplasms, N. Engl. J. Med. 369 (25) (2013) 2379-2390.
    • (2013) N. Engl. J. Med , vol.369 , Issue.25 , pp. 2379-2390
    • Klampfl, T.1    Gisslinger, H.2    Harutyunyan, A.S.3
  • 10
    • 84890328032 scopus 로고    scopus 로고
    • Somatic CALR mutations inmyeloproliferative neoplasms with nonmutated JAK2
    • J. Nangalia, C.E. Massie, E.J. Baxter, et al., Somatic CALR mutations inmyeloproliferative neoplasms with nonmutated JAK2, N. Engl. J. Med. 369 (25) (2013) 2391-2405.
    • (2013) N. Engl. J. Med , vol.369 , Issue.25 , pp. 2391-2405
    • Nangalia, J.1    Massie, C.E.2    Baxter, E.J.3
  • 11
    • 84902589906 scopus 로고    scopus 로고
    • From Janus kinase 2 to calreticulin: the clinicallyrelevant genomic landscape of myeloproliferative neoplasms
    • M. Cazzola, R. Kralovics, From Janus kinase 2 to calreticulin: the clinicallyrelevant genomic landscape of myeloproliferative neoplasms, Blood 123 (24) (2014) 3714-3719.
    • (2014) Blood , vol.123 , Issue.24 , pp. 3714-3719
    • Cazzola, M.1    Kralovics, R.2
  • 12
    • 0032877019 scopus 로고    scopus 로고
    • The role of STATs in proliferation, differentiation, and apoptosis
    • A.L. Mui, The role of STATs in proliferation, differentiation, and apoptosis, Cell. Mol. Life Sci. 55 (1999) 1547-1558.
    • (1999) Cell. Mol. Life Sci , vol.55 , pp. 1547-1558
    • Mui, A.L.1
  • 13
    • 33847351136 scopus 로고    scopus 로고
    • The JAK-STAT signaling pathway: input and output integration
    • P.J. Murray, The JAK-STAT signaling pathway: input and output integration, J. Immunol. 178 (2007) 2623-2629.
    • (2007) J. Immunol , vol.178 , pp. 2623-2629
    • Murray, P.J.1
  • 14
    • 84858078774 scopus 로고    scopus 로고
    • The many faces of Janus kinase
    • M.M. Seavey, P. Dobrzanski, The many faces of Janus kinase, Biochem.Pharmacol. 83 (2011) 1136-1145.
    • (2011) Biochem.Pharmacol , vol.83 , pp. 1136-1145
    • Seavey, M.M.1    Dobrzanski, P.2
  • 15
    • 84878232331 scopus 로고    scopus 로고
    • JAK/STAT signaling in hematologicalmalignancies
    • W. Vainchenker, S.N. Constantinescu, JAK/STAT signaling in hematologicalmalignancies, Oncogene 32 (21) (2013) 2601-2613.
    • (2013) Oncogene , vol.32 , Issue.21 , pp. 2601-2613
    • Vainchenker, W.1    Constantinescu, S.N.2
  • 16
    • 70350500225 scopus 로고    scopus 로고
    • STATs in cancer inflammation and immunity: aleading role for STAT3
    • H. Yu, D. Pardoll, R. Jove, STATs in cancer inflammation and immunity: aleading role for STAT3, Nat. Rev. Cancer 9 (2009) 798-809.
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 798-809
    • Yu, H.1    Pardoll, D.2    Jove, R.3
  • 17
    • 84875279909 scopus 로고    scopus 로고
    • The role of cytokines in the initiation and progression ofmyelofibrosis
    • H.C. Hasselbalch, The role of cytokines in the initiation and progression ofmyelofibrosis, Cytokine Growth Factor Rev. 24 (2) (2013) 133-145.
    • (2013) Cytokine Growth Factor Rev , vol.24 , Issue.2 , pp. 133-145
    • Hasselbalch, H.C.1
  • 18
    • 9144220309 scopus 로고    scopus 로고
    • Nicotine induces human neutrophils toproduce IL-8 through the generation of peroxynitrite and subsequentactivation of NF-kappaB
    • S. Iho, Y. Tanaka, R. Takauji, et al., Nicotine induces human neutrophils toproduce IL-8 through the generation of peroxynitrite and subsequentactivation of NF-kappaB, J. Leukoc. Biol. 74 (2003) 942-951.
    • (2003) J. Leukoc. Biol , vol.74 , pp. 942-951
    • Iho, S.1    Tanaka, Y.2    Takauji, R.3
  • 19
    • 0022360331 scopus 로고
    • The relationship ofwhite cell count, platelet count, and hematocrit to cigarette smoking inadolescents: the Oslo Youth Study
    • G.S. Tell, R.H.J. Grimm, V. r, O.D. Ellar, L. Theodorsen, The relationship ofwhite cell count, platelet count, and hematocrit to cigarette smoking inadolescents: the Oslo Youth Study, Circulation 72 (5) (1985) 971-974.
    • (1985) Circulation , vol.72 , Issue.5 , pp. 971-974
    • Tell, G.S.1    Grimm, R.H.J.2    Ellar, O.D.V.3    Theodorsen, L.4
  • 20
    • 0034702485 scopus 로고    scopus 로고
    • Low grade inflammation andcoronary heart disease: prospective study and updated meta-analyses
    • J. Danesh, P. Whincup, M. Walker, et al., Low grade inflammation andcoronary heart disease: prospective study and updated meta-analyses, BMJ321 (2000) 199-204.
    • (2000) BMJ , vol.321 , pp. 199-204
    • Danesh, J.1    Whincup, P.2    Walker, M.3
  • 21
    • 0032501991 scopus 로고    scopus 로고
    • Plasmaconcentration of C-reactive protein and risk of developing peripheralvascular disease
    • P.M. Ridker, M. Cushman, M.J. Stampfer, R.P. Tracy, C.H. Hennekens, Plasmaconcentration of C-reactive protein and risk of developing peripheralvascular disease, Circulation 97 (5) (1998) 425-428.
    • (1998) Circulation , vol.97 , Issue.5 , pp. 425-428
    • Ridker, P.M.1    Cushman, M.2    Stampfer, M.J.3    Tracy, R.P.4    Hennekens, C.H.5
  • 23
    • 84896690603 scopus 로고    scopus 로고
    • Meta-analysis of the association betweensmoking and peripheral arterial disease
    • L. Lu, D.F. Mackay, J.P. Pell, Meta-analysis of the association betweensmoking and peripheral arterial disease, Heart 100 (2014) 414-423.
    • (2014) Heart , vol.100 , pp. 414-423
    • Lu, L.1    Mackay, D.F.2    Pell, J.P.3
  • 24
    • 84919603678 scopus 로고    scopus 로고
    • Smoking and atherosclerosis:mechanisms of disease and new therapeutic approaches
    • G. Siasos, V. Tsigkou, E. Kokkou, et al., Smoking and atherosclerosis:mechanisms of disease and new therapeutic approaches, Curr. Med. Chem.21 (34) (2014) 3936-3948.
    • (2014) Curr. Med. Chem , vol.21 , Issue.34 , pp. 3936-3948
    • Siasos, G.1    Tsigkou, V.2    Kokkou, E.3
  • 25
    • 0037152628 scopus 로고    scopus 로고
    • Tobacco smoke carcinogens, DNA damage and p53 mutations in smoking-associated cancers
    • G.P. Pfeifer, M.F. Denissenko, M. Olivier, et al., Tobacco smoke carcinogens, DNA damage and p53 mutations in smoking-associated cancers, Oncogene21 (2002) 7435-7451.
    • (2002) Oncogene , vol.21 , pp. 7435-7451
    • Pfeifer, G.P.1    Denissenko, M.F.2    Olivier, M.3
  • 27
    • 0015373706 scopus 로고
    • Hemoglobin and the risk of cerebralinfarction: the Framingham study
    • W.B. Kannel, T. Gordon, P.A. Wolf, et al., Hemoglobin and the risk of cerebralinfarction: the Framingham study, Stroke 3 (1972) 409-420.
    • (1972) Stroke , vol.3 , pp. 409-420
    • Kannel, W.B.1    Gordon, T.2    Wolf, P.A.3
  • 28
    • 0027537177 scopus 로고
    • Vascular complications of essential thrombocythaemia:a link to cardiovascular risk factors
    • K.V. Watson, N. Key, Vascular complications of essential thrombocythaemia:a link to cardiovascular risk factors, Br. J. Haematol. 83 (2) (1993) 198-203.
    • (1993) Br. J. Haematol , vol.83 , Issue.2 , pp. 198-203
    • Watson, K.V.1    Key, N.2
  • 29
    • 0031750207 scopus 로고    scopus 로고
    • Cerebral vascularaccidents in young patients with essential thrombocythemia: relation withother known cardiovascular risk factors
    • M.L. Randi, F. Fabris, G. Cella, C. Rossi, A. Girolami, Cerebral vascularaccidents in young patients with essential thrombocythemia: relation withother known cardiovascular risk factors, Angiology 49 (6) (1998) 477-481.
    • (1998) Angiology , vol.49 , Issue.6 , pp. 477-481
    • Randi, M.L.1    Fabris, F.2    Cella, G.3    Rossi, C.4    Girolami, A.5
  • 30
    • 0035112570 scopus 로고    scopus 로고
    • Thepredictive value of vascular risk factors and gender for the development ofthrombotic complications in essential thrombocythemia
    • R. Jantunen, E. Juvonen, E. Ikkala, K. Oksanen, P. Anttila, T. Ruutu, Thepredictive value of vascular risk factors and gender for the development ofthrombotic complications in essential thrombocythemia, Ann. Hematol. 80 (2) (2001) 74-78.
    • (2001) Ann. Hematol , vol.80 , Issue.2 , pp. 74-78
    • Jantunen, R.1    Juvonen, E.2    Ikkala, E.3    Oksanen, K.4    Anttila, P.5    Ruutu, T.6
  • 31
    • 84871746842 scopus 로고    scopus 로고
    • Cardiovascular events andintensity of treatment in polycythemia vera
    • R. Marchioli, G. Finazzi, G. Specchia, et al., Cardiovascular events andintensity of treatment in polycythemia vera, N. Engl. J. Med. 368 (2013) 22-33.
    • (2013) N. Engl. J. Med , vol.368 , pp. 22-33
    • Marchioli, R.1    Finazzi, G.2    Specchia, G.3
  • 32
    • 20244389579 scopus 로고    scopus 로고
    • Vascular and neoplastic risk in alarge cohort of patients with polycythemia vera
    • R. Marchioli, G. Finazzi, R. Landolfi, et al., Vascular and neoplastic risk in alarge cohort of patients with polycythemia vera, J. Clin. Oncol. 23 (2005) 2224-2232.
    • (2005) J. Clin. Oncol , vol.23 , pp. 2224-2232
    • Marchioli, R.1    Finazzi, G.2    Landolfi, R.3
  • 33
    • 0346727336 scopus 로고    scopus 로고
    • Efficacy and safety of low-dose aspirinin polycythemia vera
    • R. Landolfi, R. Marchioli, J. Kutti, et al., Efficacy and safety of low-dose aspirinin polycythemia vera, N. Engl. J. Med. 350 (2004) 114-124.
    • (2004) N. Engl. J. Med , vol.350 , pp. 114-124
    • Landolfi, R.1    Marchioli, R.2    Kutti, J.3
  • 34
    • 21444434751 scopus 로고    scopus 로고
    • United Kingdom medicalresearch council primary thrombocythemia 1 study. Hydroxyurea comparedwith anagrelide in high-risk essential thrombocythemia
    • C.N. Harrison, P.J. Campbell, G. Buck, et al., United Kingdom medicalresearch council primary thrombocythemia 1 study. Hydroxyurea comparedwith anagrelide in high-risk essential thrombocythemia, N. Engl. J. Med. 353 (1) (2005) 33-45.
    • (2005) N. Engl. J. Med , vol.353 , Issue.1 , pp. 33-45
    • Harrison, C.N.1    Campbell, P.J.2    Buck, G.3
  • 35
    • 33947208087 scopus 로고    scopus 로고
    • European collaboration onlow-dose aspirin in polycythemia vera (ECLAP). Leukocytosis as a majorthrombotic risk factor in patients with polycythemia vera
    • R. Landolfi, L. Di Gennaro, T. Barbui, et al., European collaboration onlow-dose aspirin in polycythemia vera (ECLAP). Leukocytosis as a majorthrombotic risk factor in patients with polycythemia vera, Blood 109 (6) (2007) 2446-2452.
    • (2007) Blood , vol.109 , Issue.6 , pp. 2446-2452
    • Landolfi, R.1    Di Gennaro, L.2    Barbui, T.3
  • 36
    • 84860835694 scopus 로고    scopus 로고
    • Gender and vascularcomplications in the JAK2 V617F-positive myeloproliferative neoplasms
    • B.L. Stein, A. Rademaker, J.L. Spivak, A.R. Moliterno, Gender and vascularcomplications in the JAK2 V617F-positive myeloproliferative neoplasms, Thrombosis (2011) 874146.
    • (2011) Thrombosis
    • Stein, B.L.1    Rademaker, A.2    Spivak, J.L.3    Moliterno, A.R.4
  • 37
    • 79551491928 scopus 로고    scopus 로고
    • European LeukemiaNet.Philadelphia-negative classical myeloproliferative neoplasms: criticalconcepts and management recommendations from European LeukemiaNet
    • T. Barbui, G. Barosi, G. Birgegard, et al., European LeukemiaNet.Philadelphia-negative classical myeloproliferative neoplasms: criticalconcepts and management recommendations from European LeukemiaNet, J. Clin. Oncol. 29 (6) (2011) 761-770.
    • (2011) J. Clin. Oncol , vol.29 , Issue.6 , pp. 761-770
    • Barbui, T.1    Barosi, G.2    Birgegard, G.3
  • 38
    • 84921409486 scopus 로고    scopus 로고
    • Polycythemia vera and essential thrombocythemia:2015 update on diagnosis, risk-stratification and management
    • A. Tefferi, T. Barbui, Polycythemia vera and essential thrombocythemia:2015 update on diagnosis, risk-stratification and management, Am. J.Hematol. 90 (2) (2015) 162-173.
    • (2015) Am. J.Hematol , vol.90 , Issue.2 , pp. 162-173
    • Tefferi, A.1    Barbui, T.2
  • 39
    • 84904342753 scopus 로고    scopus 로고
    • The relation between cigarettesmoking and risk of acute myeloid leukemia: an updated meta-analysis ofepidemiological studies
    • S. Fircanis, P. Merriam, N. Khan, J.J. Castillo, The relation between cigarettesmoking and risk of acute myeloid leukemia: an updated meta-analysis ofepidemiological studies, Am. J. Hematol. 89 (8) (2014) E125-E132.
    • (2014) Am. J. Hematol , vol.89 , Issue.8 , pp. E125-E132
    • Fircanis, S.1    Merriam, P.2    Khan, N.3    Castillo, J.J.4
  • 40
    • 84879274650 scopus 로고    scopus 로고
    • Meta-analysis of therelationship between cigarette smoking and incidence of myelodysplasticsyndromes
    • 21
    • H. Tong, C. Hu, X. Yin, M. Yu, J. Yang, J.A. Jin, Meta-analysis of therelationship between cigarette smoking and incidence of myelodysplasticsyndromes, PLoS One 8 (6) (2013 21) e67537.
    • (2013) PLoS One , vol.8 , Issue.6
    • Tong, H.1    Hu, C.2    Yin, X.3    Yu, M.4    Yang, J.5    Jin, J.A.6
  • 41
    • 84870775655 scopus 로고    scopus 로고
    • Diagnostic value ofJAK2 V617F somatic mutation for myeloproliferative cancer in 49 488individuals from the general population
    • C. Nielsen, H.S. Birgens, B.G. Nordestgaard, S.E. Bojesen, Diagnostic value ofJAK2 V617F somatic mutation for myeloproliferative cancer in 49 488individuals from the general population, Br. J. Haematol. 160 (1) (2013) 70-79.
    • (2013) Br. J. Haematol , vol.160 , Issue.1 , pp. 70-79
    • Nielsen, C.1    Birgens, H.S.2    Nordestgaard, B.G.3    Bojesen, S.E.4
  • 43
    • 84865405480 scopus 로고    scopus 로고
    • Alcohol drinking, tobacco smoking andsubtypes of haematological malignancy in the UK Million Women Study
    • M.E. Kroll, F. Murphy, K. Pirie, et al., Alcohol drinking, tobacco smoking andsubtypes of haematological malignancy in the UK Million Women Study, Br.J. Cancer 107 (2012) 879-887.
    • (2012) Br.J. Cancer , vol.107 , pp. 879-887
    • Kroll, M.E.1    Murphy, F.2    Pirie, K.3
  • 44
    • 84892612635 scopus 로고    scopus 로고
    • Anthropometric, medical historyand lifestyle risk factors for myeloproliferative neoplasms in the Iowawomen's health study cohort
    • A.D. Leal, C.A. Thompson, A.H. Wang, et al., Anthropometric, medical historyand lifestyle risk factors for myeloproliferative neoplasms in the Iowawomen's health study cohort, Int. J. Cancer 134 (7) (2014) 1741-1750.
    • (2014) Int. J. Cancer , vol.134 , Issue.7 , pp. 1741-1750
    • Leal, A.D.1    Thompson, C.A.2    Wang, A.H.3
  • 46
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • D. Hanahan, R.A. Weinberg, The hallmarks of cancer, Cell 100 (1) (2000) 57-70.
    • (2000) Cell , vol.100 , Issue.1 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 47
    • 4644324186 scopus 로고    scopus 로고
    • NF-kappaB functions as a tumourpromoter in inflammation associated cancer
    • E. Pikarsky, R.M. Porat, I. Stein, et al., NF-kappaB functions as a tumourpromoter in inflammation associated cancer, Nature 431 (7007) (2004) 461-466.
    • (2004) Nature , vol.431 , Issue.7007 , pp. 461-466
    • Pikarsky, E.1    Porat, R.M.2    Stein, I.3
  • 48
    • 25844459154 scopus 로고    scopus 로고
    • NF-kappaB linking inflammation and immunity tocancer development and progression
    • M. Karin, F.R. Greten, NF-kappaB linking inflammation and immunity tocancer development and progression, Nat. Rev. Immunol. 5 (10) (2005) 749-759.
    • (2005) Nat. Rev. Immunol , vol.5 , Issue.10 , pp. 749-759
    • Karin, M.1    Greten, F.R.2
  • 49
    • 77950825019 scopus 로고    scopus 로고
    • Molecular pathways and targets incancer-related inflammation
    • A. Mantovani, C. Garlanda, P. Allavena, Molecular pathways and targets incancer-related inflammation, Ann. Med. 42 (3) (2010) 161-170.
    • (2010) Ann. Med , vol.42 , Issue.3 , pp. 161-170
    • Mantovani, A.1    Garlanda, C.2    Allavena, P.3
  • 50
    • 80052164831 scopus 로고    scopus 로고
    • Monocytes link atherosclerosis and cancer
    • M.J. Pittet, F.K. Swirski, Monocytes link atherosclerosis and cancer, Eur. J.Immunol. 41 (9) (2011) 2519-2522.
    • (2011) Eur. J.Immunol , vol.41 , Issue.9 , pp. 2519-2522
    • Pittet, M.J.1    Swirski, F.K.2
  • 51
    • 20244377844 scopus 로고    scopus 로고
    • Role for the nuclear factorkappaB pathway in transforming growth factor-beta1 production inidiopathic myelofibrosis: possible relationship with FK506 binding protein51 overexpression
    • E. Komura, C. Tonetti, V. Penard-Lacronique, et al., Role for the nuclear factorkappaB pathway in transforming growth factor-beta1 production inidiopathic myelofibrosis: possible relationship with FK506 binding protein51 overexpression, Cancer Res. 65 (8) (2005) 3281-3289.
    • (2005) Cancer Res , vol.65 , Issue.8 , pp. 3281-3289
    • Komura, E.1    Tonetti, C.2    Penard-Lacronique, V.3
  • 52
    • 84905052881 scopus 로고    scopus 로고
    • Nicotine upregulates microRNA-21 andpromotes TGF-β-dependent epithelial-mesenchymal transition ofesophageal cancer cells
    • Y. Zhang, T. Pan, X. Zhong, C. Cheng, Nicotine upregulates microRNA-21 andpromotes TGF-β-dependent epithelial-mesenchymal transition ofesophageal cancer cells, Tumour Biol. 35 (7) (2014) 7063-7072.
    • (2014) Tumour Biol , vol.35 , Issue.7 , pp. 7063-7072
    • Zhang, Y.1    Pan, T.2    Zhong, X.3    Cheng, C.4
  • 53
    • 84055218968 scopus 로고    scopus 로고
    • Chronic myeloproliferative neoplasms and subsequent cancer risk: a Danishpopulation-based cohort study
    • H. Frederiksen, D.K. Farkas, C.F. Christiansen, H.C. Hasselbalch, H.T. Sørensen, Chronic myeloproliferative neoplasms and subsequent cancer risk: a Danishpopulation-based cohort study, Blood 118 (25) (2011) 6515-6520.
    • (2011) Blood , vol.118 , Issue.25 , pp. 6515-6520
    • Frederiksen, H.1    Farkas, D.K.2    Christiansen, C.F.3    Hasselbalch, H.C.4    Sørensen, H.T.5
  • 54
    • 84908017917 scopus 로고    scopus 로고
    • The platelet-cancer loop in myeloproliferative cancer. Isthrombocythemia an enhancer of invasiveness and metastasis in essentialthrombocythemia, polycythemia vera and myelofibrosis?
    • H.C. Hasselbalch, The platelet-cancer loop in myeloproliferative cancer. Isthrombocythemia an enhancer of invasiveness and metastasis in essentialthrombocythemia, polycythemia vera and myelofibrosis? Leuk. Res. 38 (10) (2014) 1230-1236.
    • (2014) Leuk. Res , vol.38 , Issue.10 , pp. 1230-1236
    • Hasselbalch, H.C.1
  • 55
    • 77953023274 scopus 로고    scopus 로고
    • TGF-beta and immune cells: an importantregulatory axis in the tumor microenvironment and progression
    • L. Yang, Y. Pang, H.L. Moses, TGF-beta and immune cells: an importantregulatory axis in the tumor microenvironment and progression, TrendsImmunol. 31 (6) (2010) 220-227.
    • (2010) TrendsImmunol , vol.31 , Issue.6 , pp. 220-227
    • Yang, L.1    Pang, Y.2    Moses, H.L.3
  • 56
    • 66349136312 scopus 로고    scopus 로고
    • The JAK2 (V617F) tyrosinekinase mutation in blood donors with upper-limit haematocrit levels
    • G. Tagariello, R. Di Gaetano, R. Sartori, et al., The JAK2 (V617F) tyrosinekinase mutation in blood donors with upper-limit haematocrit levels, BloodTransfus. 7 (2009) 111-116.
    • (2009) BloodTransfus , vol.7 , pp. 111-116
    • Tagariello, G.1    Di Gaetano, R.2    Sartori, R.3
  • 58
    • 84896384320 scopus 로고    scopus 로고
    • Perspectives on the impact of JAK-inhibitor therapy uponinflammation-mediated comorbidities in myelofibrosis and relatedneoplasms
    • H.C. Hasselbalch, Perspectives on the impact of JAK-inhibitor therapy uponinflammation-mediated comorbidities in myelofibrosis and relatedneoplasms, Expert. Rev. Hematol. 7 (2) (2014) 203-216.
    • (2014) Expert. Rev. Hematol , vol.7 , Issue.2 , pp. 203-216
    • Hasselbalch, H.C.1
  • 59
    • 0042490546 scopus 로고    scopus 로고
    • Abnormal production of interleukin (IL)-11 and IL-8 in polycythaemia vera
    • S. Hermouet, A. Godard, D. Pineau, et al., Abnormal production of interleukin (IL)-11 and IL-8 in polycythaemia vera, Cytokine 20 (4) (2002) 178-183.
    • (2002) Cytokine , vol.20 , Issue.4 , pp. 178-183
    • Hermouet, S.1    Godard, A.2    Pineau, D.3
  • 60
    • 11244283159 scopus 로고    scopus 로고
    • IL-8 and its CXCR1 and CXCR2 receptorsparticipate in the control of megakaryocytic proliferation, differentiation, and ploidy in myeloid metaplasia with myelofibrosis
    • S. Emadi, D. Clay, C. Desterke, et al., IL-8 and its CXCR1 and CXCR2 receptorsparticipate in the control of megakaryocytic proliferation, differentiation, and ploidy in myeloid metaplasia with myelofibrosis, Blood 105 (2) (2005) 464-473.
    • (2005) Blood , vol.105 , Issue.2 , pp. 464-473
    • Emadi, S.1    Clay, D.2    Desterke, C.3
  • 61
    • 79954433836 scopus 로고    scopus 로고
    • Circulating interleukin (IL)-8, IL-2R, IL-12, and IL-15 levels areindependently prognostic in primary myelofibrosis: a comprehensivecytokine profiling study
    • A. Tefferi, R. Vaidya, D. Caramazza, C. Finke, T. Lasho, A. Pardanani, Circulating interleukin (IL)-8, IL-2R, IL-12, and IL-15 levels areindependently prognostic in primary myelofibrosis: a comprehensivecytokine profiling study, J. Clin. Oncol. 29 (10) (2011) 1356-1363.
    • (2011) J. Clin. Oncol , vol.29 , Issue.10 , pp. 1356-1363
    • Tefferi, A.1    Vaidya, R.2    Caramazza, D.3    Finke, C.4    Lasho, T.5    Pardanani, A.6
  • 62
    • 84867918380 scopus 로고    scopus 로고
    • Plasma cytokines in polycythemia vera:phenotypic correlates, prognostic relevance, and comparison withmyelofibrosis
    • R. Vaidya, N. Gangat, T. Jimma, et al., Plasma cytokines in polycythemia vera:phenotypic correlates, prognostic relevance, and comparison withmyelofibrosis, Am. J. Hematol. 87 (11) (2012) 1003-1005.
    • (2012) Am. J. Hematol , vol.87 , Issue.11 , pp. 1003-1005
    • Vaidya, R.1    Gangat, N.2    Jimma, T.3
  • 63
    • 84879562933 scopus 로고    scopus 로고
    • Transcription factor nuclear factor erythroid-2 mediates expression of thecytokine interleukin 8, a known predictor of inferior outcome in patientswith myeloproliferative neoplasms
    • J. Wehrle, T.S. Seeger, S. Schwemmers, D. Pfeifer, A. Bulashevska, H.L. Pahl, Transcription factor nuclear factor erythroid-2 mediates expression of thecytokine interleukin 8, a known predictor of inferior outcome in patientswith myeloproliferative neoplasms, Haematologica 98 (7) (2013) 1073-1080.
    • (2013) Haematologica , vol.98 , Issue.7 , pp. 1073-1080
    • Wehrle, J.1    Seeger, T.S.2    Schwemmers, S.3    Pfeifer, D.4    Bulashevska, A.5    Pahl, H.L.6
  • 64
    • 84856911269 scopus 로고    scopus 로고
    • A novel murine model ofmyeloproliferative disorders generated by overexpression of thetranscription factor NF-E2
    • K. Kaufmann, A. Gründer, T. Hadlich, et al., A novel murine model ofmyeloproliferative disorders generated by overexpression of thetranscription factor NF-E2, J. Exp. Med. 209 (1) (2012) 35-50.
    • (2012) J. Exp. Med , vol.209 , Issue.1 , pp. 35-50
    • Kaufmann, K.1    Gründer, A.2    Hadlich, T.3
  • 65
    • 84897019549 scopus 로고    scopus 로고
    • RUNX1 and NF-E2 upregulation is not specific for MPNs, but is seenin polycythemic disorders with augmented HIF signaling
    • K. Kapralova, L. Lanikova, F. Lorenzo, J. Song, M. Horvathova, V. Divoky, J.T. Prchal, RUNX1 and NF-E2 upregulation is not specific for MPNs, but is seenin polycythemic disorders with augmented HIF signaling, Blood 123 (3) (2014) 391-394.
    • (2014) Blood , vol.123 , Issue.3 , pp. 391-394
    • Kapralova, K.1    Lanikova, L.2    Lorenzo, F.3    Song, J.4    Horvathova, M.5    Divoky, V.6    Prchal, J.T.7
  • 66
    • 84892530527 scopus 로고    scopus 로고
    • A role of NF-E2 in chronic inflammation and clonalevolution in essential thrombocythemia, polycythemia vera andmyelofibrosis?
    • H.C. Hasselbalch, A role of NF-E2 in chronic inflammation and clonalevolution in essential thrombocythemia, polycythemia vera andmyelofibrosis? Leuk. Res. 38 (2) (2014) 263-266.
    • (2014) Leuk. Res , vol.38 , Issue.2 , pp. 263-266
    • Hasselbalch, H.C.1
  • 67
    • 34548102391 scopus 로고    scopus 로고
    • Nicotine induceshypoxia-inducible factor-1alpha expression in human lung cancer cells vianicotinic acetylcholine receptor-mediated signaling pathway
    • Q. Zhang, X. Tang, Z.F. Zhang, R. Velikina, S. Shi, A.D. Le, Nicotine induceshypoxia-inducible factor-1alpha expression in human lung cancer cells vianicotinic acetylcholine receptor-mediated signaling pathways, Clin. CancerRes. 15;13 (16) (2007) 4686-4694.
    • (2007) Clin. CancerRes. 15 , vol.13 , Issue.16 , pp. 4686-4694
    • Zhang, Q.1    Tang, X.2    Zhang, Z.F.3    Velikina, R.4    Shi, S.5    Le, A.D.6
  • 68
    • 84861845402 scopus 로고    scopus 로고
    • The updated biology ofhypoxia-inducible factor
    • S.N. Greer, J.L. Metcalf, Y. Wang, M. Ohh, The updated biology ofhypoxia-inducible factor, EMBO J. 31 (11) (2012) 2448-2460.
    • (2012) EMBO J , vol.31 , Issue.11 , pp. 2448-2460
    • Greer, S.N.1    Metcalf, J.L.2    Wang, Y.3    Ohh, M.4
  • 69
    • 59349084923 scopus 로고    scopus 로고
    • Formaldehydeexposure and leukemia: a new meta-analysis and potential mechanisms
    • L. Zhang, C. Steinmaus, D.A. Eastmond, X.K. Xin, M.T. Smith, Formaldehydeexposure and leukemia: a new meta-analysis and potential mechanisms, Mutat. Res. 681 (2009) 150-168.
    • (2009) Mutat. Res , vol.681 , pp. 150-168
    • Zhang, L.1    Steinmaus, C.2    Eastmond, D.A.3    Xin, X.K.4    Smith, M.T.5
  • 70
    • 84871732208 scopus 로고    scopus 로고
    • AReview of Human Carcinogens: Chemical Agents and Related Occupations
    • IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. AReview of Human Carcinogens: Chemical Agents and Related Occupations.WHO International Agency for Research on Cancer 2012; 100F:401-435.
    • (2012) WHO International Agency for Research on Cancer , vol.100F , pp. 401-435
  • 71
    • 84955333414 scopus 로고    scopus 로고
    • Report on Carcinogens, TwelfthEdition. Research Triangle Park
    • NTP. (National Toxicology Program). Report on Carcinogens, TwelfthEdition. Research Triangle Park. 2012; 195-205.
    • (2012) , pp. 195-205
  • 72
    • 79960790215 scopus 로고    scopus 로고
    • Isexposure to formaldehyde in air causally associated with leukemia?-Ahypothesis-based weight-of-evidence analysis
    • L.R. Rhomberg, L.A. Bailey, J.E. Goodman, A.K. Hamade, D. Mayfield, Isexposure to formaldehyde in air causally associated with leukemia?-Ahypothesis-based weight-of-evidence analysis, Crit. Rev. Toxicol. 41 (2011) 555-621.
    • (2011) Crit. Rev. Toxicol , vol.41 , pp. 555-621
    • Rhomberg, L.R.1    Bailey, L.A.2    Goodman, J.E.3    Hamade, A.K.4    Mayfield, D.5
  • 73
    • 74549222229 scopus 로고    scopus 로고
    • Occupationalexposure to formaldehyde, hematotoxicity, and leukemia-specificchromosome changes in cultured myeloid progenitor cells, CancerEpidemiol
    • L. Zhang, X. Tang, N. Rothman, R. Vermeulen, Z. Ji, et al., Occupationalexposure to formaldehyde, hematotoxicity, and leukemia-specificchromosome changes in cultured myeloid progenitor cells, CancerEpidemiol. Biomarkers Prev. 19 (2010) 80-88.
    • (2010) Biomarkers Prev , vol.19 , pp. 80-88
    • Zhang, L.1    Tang, X.2    Rothman, N.3    Vermeulen, R.4    Ji, Z.5
  • 74
    • 84887163019 scopus 로고    scopus 로고
    • Bonemarrow injury induced via oxidative stress in mice by inhalation exposureto formaldehyd
    • Y. Zhang, X. Liu, C. McHale, R. Li, L. Zhang, Y. Wu, X. Ye, X. Yang, S. Ding, Bonemarrow injury induced via oxidative stress in mice by inhalation exposureto formaldehyde, PLoS One 11;8 (9) (2013) e74974.
    • (2013) PLoS One 11 , vol.8 , Issue.9
    • Zhang, Y.1    Liu, X.2    McHale, C.3    Li, R.4    Zhang, L.5    Wu, Y.6    Ye, X.7    Yang, X.8    Ding, S.9
  • 75
    • 80052930073 scopus 로고    scopus 로고
    • Accumulation of oxidative DNA damage restricts the self-renewal capacityof human hematopoietic stem cells
    • T. Yahata, T. Takanashi, Y. Muguruma, A.A. Ibrahim, H. Matsuzawa, et al., Accumulation of oxidative DNA damage restricts the self-renewal capacityof human hematopoietic stem cells, Blood 118 (2011) 2941-2950.
    • (2011) Blood , vol.118 , pp. 2941-2950
    • Yahata, T.1    Takanashi, T.2    Muguruma, Y.3    Ibrahim, A.A.4    Matsuzawa, H.5
  • 76
    • 79959496299 scopus 로고    scopus 로고
    • Whole blood transcriptionalprofiling of interferon inducible genes identifies highly upregulated IFI27 inprimary myelofibrosis
    • V. Skov, T.S. Larsen, M. Thomassen, et al., Whole blood transcriptionalprofiling of interferon inducible genes identifies highly upregulated IFI27 inprimary myelofibrosis, Eur. J. Haematol. 87 (1) (2011) 54-60.
    • (2011) Eur. J. Haematol , vol.87 , Issue.1 , pp. 54-60
    • Skov, V.1    Larsen, T.S.2    Thomassen, M.3
  • 77
    • 84865037440 scopus 로고    scopus 로고
    • Gene expression profiling withprincipal component analysis depicts the biological continuum fromessential thrombocythemia over polycythemia vera to myelofibrosis
    • V. Skov, M. Thomassen, C.H. Riley, et al., Gene expression profiling withprincipal component analysis depicts the biological continuum fromessential thrombocythemia over polycythemia vera to myelofibrosis, Exp.Hematol. 40 (9) (2012) 771-780.
    • (2012) Exp.Hematol , vol.40 , Issue.9 , pp. 771-780
    • Skov, V.1    Thomassen, M.2    Riley, C.H.3
  • 78
    • 84866332049 scopus 로고    scopus 로고
    • Molecular profiling of peripheralblood cells from patients with polycythemia vera and related neoplasms:identification of deregulated genes of significance for inflammation andimmune surveillance
    • V. Skov, T.S. Larsen, M. Thomassen, et al., Molecular profiling of peripheralblood cells from patients with polycythemia vera and related neoplasms:identification of deregulated genes of significance for inflammation andimmune surveillance, Leuk. Res. 36 (11) (2012) 1387-1392.
    • (2012) Leuk. Res , vol.36 , Issue.11 , pp. 1387-1392
    • Skov, V.1    Larsen, T.S.2    Thomassen, M.3
  • 79
    • 84911497964 scopus 로고    scopus 로고
    • Whole bloodtranscriptional profiling reveals deregulation of oxidative and antioxidativedefence genes in myelofibrosis and related neoplasms. Potentialimplications of downregulation of Nrf2 for genomic instability and diseaseprogression
    • H.C. Hasselbalch, M. Thomassen, C. Hasselbalch Riley, et al., Whole bloodtranscriptional profiling reveals deregulation of oxidative and antioxidativedefence genes in myelofibrosis and related neoplasms. Potentialimplications of downregulation of Nrf2 for genomic instability and diseaseprogression, PLoS One 9 (11) (2014) e112786.
    • (2014) PLoS One , vol.9 , Issue.11
    • Hasselbalch, H.C.1    Thomassen, M.2    Hasselbalch Riley, C.3
  • 80
    • 80355126571 scopus 로고    scopus 로고
    • The JAK2 46/1 haplotype: a marker of inappropriatemyelomonocytic response to cytokine stimulation, leading to increased riskof inflammation, myeloid neoplasm, and impaired defense againstinfection?
    • S. Hermouet, M. Vilaine, The JAK2 46/1 haplotype: a marker of inappropriatemyelomonocytic response to cytokine stimulation, leading to increased riskof inflammation, myeloid neoplasm, and impaired defense againstinfection? Haematologica 96 (11) (2011) 1575-1579.
    • (2011) Haematologica , vol.96 , Issue.11 , pp. 1575-1579
    • Hermouet, S.1    Vilaine, M.2
  • 81
    • 84887345428 scopus 로고    scopus 로고
    • Myeloproliferative neoplasms andthrombosis
    • T. Barbui, G. Finazzi, A. Falanga, Myeloproliferative neoplasms andthrombosis, Blood 122 (13) (2013) 2176-2184.
    • (2013) Blood , vol.122 , Issue.13 , pp. 2176-2184
    • Barbui, T.1    Finazzi, G.2    Falanga, A.3
  • 82
    • 2142811498 scopus 로고    scopus 로고
    • Upregulation of the CD40/CD40ligand dyad and platelet-monocyte aggregation in cigarette smokers
    • S.A. Harding, J. Sarma, D.H. Josephs, et al., Upregulation of the CD40/CD40ligand dyad and platelet-monocyte aggregation in cigarette smokers, Circulation 109 (2004) 1926-1929.
    • (2004) Circulation , vol.109 , pp. 1926-1929
    • Harding, S.A.1    Sarma, J.2    Josephs, D.H.3
  • 83
    • 33845370433 scopus 로고    scopus 로고
    • Incidence ofpulmonary hypertension in patients with chronic myeloproliferativedisorders
    • R. Gupta, S. Perumandla, Y. Patsiornik, S. Niranjan, A. Ohri, Incidence ofpulmonary hypertension in patients with chronic myeloproliferativedisorders, J. Natl. Med. Assoc. 98 (11) (2006) 1779-1782.
    • (2006) J. Natl. Med. Assoc , vol.98 , Issue.11 , pp. 1779-1782
    • Gupta, R.1    Perumandla, S.2    Patsiornik, Y.3    Niranjan, S.4    Ohri, A.5
  • 84
    • 0033869985 scopus 로고    scopus 로고
    • Platelet production in the pulmonarycapillary bed: new ultrastructural evidence for an old concept
    • D. Zucker-Franklin, C.S. Philipp, Platelet production in the pulmonarycapillary bed: new ultrastructural evidence for an old concept, Am. J. Pathol.157 (2000) 69-74.
    • (2000) Am. J. Pathol , vol.157 , pp. 69-74
    • Zucker-Franklin, D.1    Philipp, C.S.2
  • 85
    • 0020680268 scopus 로고
    • Megakaryocytes in cubital venous bloodin patients with chronic myeloproliferative diseases
    • N. Tinggaard Pedersen, B. Laursen, Megakaryocytes in cubital venous bloodin patients with chronic myeloproliferative diseases, Scand. J. Haematol. 30 (1) (1983) 50-58.
    • (1983) Scand. J. Haematol , vol.30 , Issue.1 , pp. 50-58
    • Tinggaard Pedersen, N.1    Laursen, B.2
  • 86
    • 84897999475 scopus 로고    scopus 로고
    • Transcriptional profilingof whole blood identifies a unique 5-gene signature for myelofibrosis andimminent myelofibrosis transformation
    • H.C. Hasselbalch, V. Skov, L. Stauffer, T. arsen, et al., Transcriptional profilingof whole blood identifies a unique 5-gene signature for myelofibrosis andimminent myelofibrosis transformation, PLoS One 9 (1) (2014) e85567.
    • (2014) PLoS One , vol.9 , Issue.1
    • Hasselbalch, H.C.1    Skov, V.2    Stauffer, L.3    Larsen, T.4
  • 87
    • 84904070596 scopus 로고    scopus 로고
    • Ruxolitinib leads toimprovement of pulmonary hypertension in patients with myelofibrosis
    • A. Tabarroki, D.J. Lindner, V. Visconte, et al., Ruxolitinib leads toimprovement of pulmonary hypertension in patients with myelofibrosis, Leukemia 28 (7) (2014) 1486-1493.
    • (2014) Leukemia , vol.28 , Issue.7 , pp. 1486-1493
    • Tabarroki, A.1    Lindner, D.J.2    Visconte, V.3
  • 88
    • 57349151482 scopus 로고    scopus 로고
    • Down-regulated NF-E2-related factor 2in pulmonary macrophages of aged smokers and patients with chronicobstructive pulmonary disease
    • M. Suzuki, T. Betsuyaku, Y. Ito, et al., Down-regulated NF-E2-related factor 2in pulmonary macrophages of aged smokers and patients with chronicobstructive pulmonary disease, Am. J. Respir. Cell Mol. Biol. 39 (6) (2008) 673-682.
    • (2008) Am. J. Respir. Cell Mol. Biol , vol.39 , Issue.6 , pp. 673-682
    • Suzuki, M.1    Betsuyaku, T.2    Ito, Y.3
  • 89
    • 84896721964 scopus 로고    scopus 로고
    • Evaluation of the prevalence andprospective clinical impact of the JAK2 V617F mutation in coronary patients
    • A. Muendlein, K. Gasser, E. Kinz, et al., Evaluation of the prevalence andprospective clinical impact of the JAK2 V617F mutation in coronary patients, Am. J. Hematol. 89 (3) (2014) 295-301.
    • (2014) Am. J. Hematol , vol.89 , Issue.3 , pp. 295-301
    • Muendlein, A.1    Gasser, K.2    Kinz, E.3
  • 90
    • 84919663556 scopus 로고    scopus 로고
    • Occurrence of the JAK2 V617Fmutation in patients with peripheral arterial disease
    • A. Muendlein, E. Kinz, K. Gasser, et al., Occurrence of the JAK2 V617Fmutation in patients with peripheral arterial disease, Am. J. Hematol. 90 (1) (2015) E17-21.
    • (2015) Am. J. Hematol , vol.90 , Issue.1 , pp. E17-E21
    • Muendlein, A.1    Kinz, E.2    Gasser, K.3
  • 92
    • 77954415692 scopus 로고    scopus 로고
    • Genetic factors in chronicinflammation: single nucleotide polymorphisms in the STAT-JAK pathway, susceptibility to DNA damage and Crohn's disease in a New Zealandpopulation
    • L.R. Ferguson, D.Y. Han, A.G. Fraser, et al., Genetic factors in chronicinflammation: single nucleotide polymorphisms in the STAT-JAK pathway, susceptibility to DNA damage and Crohn's disease in a New Zealandpopulation, Mutat. Res. 690 (1-2) (2010) 108-115.
    • (2010) Mutat. Res , vol.690 , Issue.1-2 , pp. 108-115
    • Ferguson, L.R.1    Han, D.Y.2    Fraser, A.G.3
  • 93
    • 48349136889 scopus 로고    scopus 로고
    • Genome-wide association definesmore than 30 distinct susceptibility loci for Crohn's disease
    • J.C. Barrett, S. Hansoul, D.L. Nicolae, et al., Genome-wide association definesmore than 30 distinct susceptibility loci for Crohn's disease, Nat. Genet. 40 (8) (2008) 955-962.
    • (2008) Nat. Genet , vol.40 , Issue.8 , pp. 955-962
    • Barrett, J.C.1    Hansoul, S.2    Nicolae, D.L.3
  • 94
    • 41949128334 scopus 로고    scopus 로고
    • Host genetic variation contributesto phenotypic diversity in myeloproliferative disorders
    • A. Pardanani, B.L. Fridley, T.L. Lasho, et al., Host genetic variation contributesto phenotypic diversity in myeloproliferative disorders, Blood 111 (2008) 2785-2789.
    • (2008) Blood , vol.111 , pp. 2785-2789
    • Pardanani, A.1    Fridley, B.L.2    Lasho, T.L.3
  • 95
    • 84872603489 scopus 로고    scopus 로고
    • Characterization ofblood donors with high haemoglobin concentration
    • K. Magnussen, H.C. Hasselbalch, H. Ullum, O.W. Bjerrum, Characterization ofblood donors with high haemoglobin concentration, Vox Sang. 104 (2) (2013) 110-114.
    • (2013) Vox Sang , vol.104 , Issue.2 , pp. 110-114
    • Magnussen, K.1    Hasselbalch, H.C.2    Ullum, H.3    Bjerrum, O.W.4
  • 96
    • 33645121427 scopus 로고    scopus 로고
    • Earlymenopause, low body mass index, and smoking are independent risk factorsfor developing giant cell arteritis
    • K. Larsson, D. Mellström, E. Nordborg, A. Odén, E. Nordborg, Earlymenopause, low body mass index, and smoking are independent risk factorsfor developing giant cell arteritis, Ann. Rheum. Dis. 65 (4) (2006) 529-532.
    • (2006) Ann. Rheum. Dis , vol.65 , Issue.4 , pp. 529-532
    • Larsson, K.1    Mellström, D.2    Nordborg, E.3    Odén, A.4    Nordborg, E.5
  • 97
    • 84880790074 scopus 로고    scopus 로고
    • A clinical review of recent findings in the epidemiologyof inflammatory bowel disease
    • A. Ponder, M.D. Long, A clinical review of recent findings in the epidemiologyof inflammatory bowel disease, Clin. Epidemiol. 5 (2013) 237-247.
    • (2013) Clin. Epidemiol , vol.5 , pp. 237-247
    • Ponder, A.1    Long, M.D.2
  • 98
    • 33745580391 scopus 로고    scopus 로고
    • Oxidative stress inhibitsIFN-alpha-induced antiviral gene expression by blocking the JAK-STATpathway
    • D. Di Bona, M. Cippitelli, C. Fionda, et al., Oxidative stress inhibitsIFN-alpha-induced antiviral gene expression by blocking the JAK-STATpathway, J. Hepatol. 45 (2) (2006) 271-279.
    • (2006) J. Hepatol , vol.45 , Issue.2 , pp. 271-279
    • Di Bona, D.1    Cippitelli, M.2    Fionda, C.3
  • 99
    • 84925060829 scopus 로고    scopus 로고
    • Fibrosis-a common pathway to organ injuryand failure
    • D.C. Rockey, P.D. Bell, J.A. Hill, Fibrosis-a common pathway to organ injuryand failure, N. Engl. J. Med. 372 (12) (2015) 1138-1149.
    • (2015) N. Engl. J. Med , vol.372 , Issue.12 , pp. 1138-1149
    • Rockey, D.C.1    Bell, P.D.2    Hill, J.A.3
  • 100
    • 0033552883 scopus 로고    scopus 로고
    • Atherosclerosis-an inflammatory disease
    • R. Ross, Atherosclerosis-an inflammatory disease, N. Engl. J. Med. 340 (1999) 115-126.
    • (1999) N. Engl. J. Med , vol.340 , pp. 115-126
    • Ross, R.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.