Characterization of blood donors with high haemoglobin concentration

Vox Sanguinis

Volumn 104, Issue 2, 2013, Pages 110-114

  Magnussen, K ^a   Hasselbalch, H C ^b   Ullum, H ^a   Bjerrum, O W ^c  

^a HVIDOVRE HOSPITAL   (Denmark)

^b Mental Health Center Glostrup   (Denmark)

^c University of Copenhagen   (Denmark)

Author keywords

Donor vigilance; Donors; Haemoglobin; Polycythaemia; Red cell components; Transfusion medicine (in general)

Indexed keywords

ERYTHROPOIETIN; FERRITIN; HEMOGLOBIN;

ADULT; ALGORITHM; ARTICLE; BLOOD DONOR; CELL VOLUME; DIABETES MELLITUS; DISEASE SEVERITY; ERYTHROCYTE; EXON; FEMALE; HEMATOCRIT; HEMOGLOBIN BLOOD LEVEL; HUMAN; HYPERTENSION; KIDNEY ARTERY STENOSIS; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MORBIDITY; POLYCYTHEMIA VERA; PRIORITY JOURNAL; THROMBOCYTE COUNT;

AGED; BLOOD DONORS; FEMALE; HEMATOCRIT; HEMOGLOBINS; HUMANS; MALE; MIDDLE AGED; POLYCYTHEMIA VERA;

EID: 84872603489     PISSN: 00429007     EISSN: 14230410     Source Type: Journal    
DOI: 10.1111/j.1423-0410.2012.01644.x     Document Type: Article

References (21)

1. McMullin MF: The classification and diagnosis of erythrocytosis. Int J Lab Hematol 2008; 30:447-459
2. Merk K, Mattsson B, Mattsson A, et al. : The incidence of cancer among blood donors. Int J Epidemiol 1990; 19:505-509
3. Najean Y, Rain JD, Billotey C: Epidemiological data in polycythaemia vera: a study of 842 cases. Hematol Cell Ther 1998; 40:159
4. Randi ML, Rossi C, Barbone E, et al. : Myeloproliferative disease in patients with a history of multiple blood donations: a report of 8 cases. Haematologica 1994; 79:137-140
5. Zanella A, Silvani C, Banfi P, et al. : Screening and evaluation of blood donors with upper-limit hematocrit levels. Transfusion 1987; 27:485-487
6. Tagariello G, Di Gaetano R, Sartori R, et al. : The JAK2V617F tyrosine kinase mutation in blood donors with upper-limit haematocrit levels. Blood Transfus 2009; 7:111
7. Swerdlow SH, Campo E, Harris N: WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. Lyon, International Agency for Research on Cancer, 2008. International Agency for Research on Cancer and World Health Organization 2009
8. Larsen TS, Pallisgaard N, Moeller MB, et al. : Quantitative assessment of the JAK2 V617F allele burden: equivalent levels in peripheral blood and bone marrow. Leukemia 2007; 22:194-195
9. Scott LM, Tong W, Levine RL, et al. : JAK2 exon 12 mutations in polycythemia vera and idiopathic erythrocytosis. N Engl J Med 2007; 356:459-468
10. Guide to the Preparation, Use and Quality Assurance of Blood Components: 16th edn. Council of Europe and European Directorate for the Quality of Medicines & HealthCare (EDQM). ISBN 978-92-871-7022-4. 2010.
11. Pearson TC: Apparent polycythaemia. Blood Rev 1991; 5:205-213
12. Johansson PL, Safai-Kutti S, Kutti J: An elevated venous haemoglobin concentration cannot be used as a surrogate marker for absolute erythrocytosis: a study of patients with polycythaemia vera and apparent polycythaemia. Br J Haematol 2005; 129:701-705
13. Spivak JL, Silver RT: The revised World Health Organization diagnostic criteria for polycythemia vera, essential thrombocytosis, and primary myelofibrosis: an alternative proposal. Blood 2008; 112:231-239
14. Pearson TC, Grimes AJ, Slater NGP, et al. : Viscosity and iron deficiency in treated polycythaemia. Br J Haematol 1981; 49:123-127
15. Kutti J, Ridell B: Epidemiology of the myeloproliferative disorders: essential thrombocythaemia, polycythaemia vera and idiopathic myelofibrosis. Pathol Biol (Paris) 2001; 49:164-166
16. Nielsen C, Birgens HS, Nordestgaard BG, et al. : The JAK2 V617F somatic mutation, mortality and cancer risk in the general population. Haematologica 2011; 96:450-453
17. Weinberg I, Borochowitz A, Krichevski S, et al. : Janus Kinase V617F mutation in cigarette smokers. Am J Hematol 2012; 87:5-8
18. Magnussen K, Bork N, Asmussen L: The effect of a standardized protocol for iron supplementation to blood donors low in hemoglobin concentration. Transfusion 2008; 48:749-754
19. Messinezy M, Pearson TC: Apparent polycythaemia: diagnosis, pathogenesis and management. Eur J Haematol 1993; 51:125-131
20. Percy MJ, Butt NN, Crotty GM, et al. : Identification of high oxygen affinity hemoglobin variants in the investigation of patients with erythrocytosis. Haematologica 2009; 94:1321-1322
21. Albiero E, Ruggeri M, Fortuna S, et al. : Isolated erythrocytosis: study of 67 patients and identification of three novel germ-line mutations in the prolyl hydroxylase domain protein 2 (PHD2) gene. Haematologica 2012; 97:123-127