Removing endogenous tau does not prevent tau propagation yet reduces its neurotoxicity

EMBO Journal

Volumn 34, Issue 24, 2015, Pages 3028-3041

  Wegmann, Susanne ^a   Maury, Eduardo A ^a   Kirk, Molly J ^a   Saqran, Lubna ^a   Roe, Allyson ^a   DeVos, Sarah L ^a   Nicholls, Samantha ^a   Fan, Zhanyun ^a   Takeda, Shuko ^a   Cagsal Getkin, Ozge ^a   William, Christopher M ^a   Spires Jones, Tara L ^b   Pitstick, Rose ^c   Carlson, George A ^c   Pooler, Amy M ^a,d   Hyman, Bradley T ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c MCLAUGHLIN RESEARCH INSTITUTE   (United States)

^d KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Alzheimer's disease; neurodegeneration; neurofibrillary tangles; P301L tau; prion like

Indexed keywords

MAPT PROTEIN, MOUSE; TAU PROTEIN;

ALZHEIMER DISEASE; ANIMAL; C57BL MOUSE; CELL CULTURE; CYTOLOGY; DEFICIENCY; ENTORHINAL CORTEX; GENETICS; METABOLISM; MISSENSE MUTATION; MOUSE; NERVE CELL;

ALZHEIMER DISEASE; ANIMALS; CELLS, CULTURED; ENTORHINAL CORTEX; MICE; MICE, INBRED C57BL; MUTATION, MISSENSE; NEURONS; TAU PROTEINS;

EID: 84955184686     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.15252/embj.201592748     Document Type: Article

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