Tau pathology spread in PS19 tau transgenic mice following locus coeruleus (LC) injections of synthetic tau fibrils is determined by the LC’s afferent and efferent connections

Acta Neuropathologica

Volumn 130, Issue 3, 2015, Pages 349-362

  Iba, Michiyo ^a   McBride, Jennifer D ^a   Guo, Jing L ^a   Zhang, Bin ^a   Trojanowski, John Q ^a   Lee, Virginia M Y ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Alzheimer s disease; Locus coeruleus; Mouse models of tauopathies; Transmission of misfolded tau

Indexed keywords

MUTANT PROTEIN; SYNTHETIC PEPTIDE; TAU PROTEIN; MAPT PROTEIN, HUMAN; TYROSINE 3 MONOOXYGENASE;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN REGION; BRAIN STEM; CONNECTOME; CONTROLLED STUDY; EFFERENT NERVE; ENTORHINAL CORTEX; FEMALE; HIPPOCAMPUS; LOCUS CERULEUS; MALE; MOUSE; NERVE DEGENERATION; NERVE ENDING; NERVE PROJECTION; NEUROPATHOLOGY; NEUROTRANSMISSION; NONHUMAN; PERIKARYON; PRIORITY JOURNAL; SENSORY NERVE; TRANSGENIC MOUSE; ANIMAL; DISEASE COURSE; DISEASE MODEL; ESCHERICHIA COLI; GENETICS; HUMAN; HYPOTHALAMUS; IMMUNOHISTOCHEMISTRY; METABOLISM; MUTATION; NERVE CELL; PATHOLOGY; TAUOPATHY; THALAMUS;

AFFERENT PATHWAYS; ANIMALS; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; EFFERENT PATHWAYS; ESCHERICHIA COLI; FEMALE; HUMANS; HYPOTHALAMUS; IMMUNOHISTOCHEMISTRY; LOCUS COERULEUS; MALE; MICE, TRANSGENIC; MUTATION; NEURONS; TAU PROTEINS; TAUOPATHIES; THALAMUS; TYROSINE 3-MONOOXYGENASE;

EID: 84939569230     PISSN: 00016322     EISSN: 14320533     Source Type: Journal    
DOI: 10.1007/s00401-015-1458-4     Document Type: Article

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