Sirtuins as possible targets in neurodegenerative diseases

Current Drug Targets

Volumn 14, Issue 6, 2013, Pages 644-647

  Donmez, Gizem ^a  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Aging; Alzheimer's disease; Neurodegeneration; Parkinson's disease; Sirtuins; Therapeutic targets

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; EX 527; EX527; HYDROLASE INHIBITOR; SIRTUIN; SIRTUIN 1; SIRTUIN 2; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; AMYOTROPHIC LATERAL SCLEROSIS; BRAIN ISCHEMIA; DEGENERATIVE DISEASE; DISEASE ASSOCIATION; GENETIC RISK; HUNTINGTON CHOREA; IMMUNOELECTRON MICROSCOPY; MULTIPLE SCLEROSIS; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; PARKINSON DISEASE; PHASE 1 CLINICAL TRIAL (TOPIC); PROTEIN AGGREGATION; PROTEIN EXPRESSION; REVIEW; WALLERIAN DEGENERATION;

AGE FACTORS; ANIMALS; HISTONE DEACETYLASE INHIBITORS; HUMANS; MOLECULAR TARGETED THERAPY; NEURODEGENERATIVE DISEASES; SIRTUINS;

EID: 84878617717     PISSN: 13894501     EISSN: 18735592     Source Type: Journal    
DOI: 10.2174/1389450111314060004     Document Type: Review

References (30)

1. Donmez G. and Guarente L. Aging and disease: connections to sirtuins. Aging Cell 2010; 9: 285-290.
2. Imai SI, Guarente L. Ten years of NAD-dependent SIR2 family deacetylases-implications for metabolic diseases. TIPS 2010; 31: 212-220.
3. Du J, Zhou Y, Su X, et al. Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase. Science 2011; 334: 806-819.
4. Burnett C, Valentini S, Cabreiro F, et al. Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila. Nature 2011; 477: 482-485.
5. Donmez G. The neurobiology of sirtuins and their role in neurodegeneration. TIPS. 2012; 33(9): 494-501.
6. Zhang F, Wang S, Gan L, et al. Protective effects and mechanisms of sirtuins in the nervous system. Progress in Neurobiology 2011; 95: 373-395.
7. Donmez G, Wang D, Cohen D, Guarente L. SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10. Cell 2010; 142: 320-332.
8. Min SW, Cho SH, Zhou Y, et al. Acetylation of tau inhibits its degradation and contributes to tauopathy. Neuron 2010; 67: 953-966.
9. Qin W, Chachich M, Lane M, et al. Calorie restriction attenuates Alzheimer's disease type brain amyloidosis in Squirrel monkeys (Saimiri sciureus). J Alzheimers Dis 2006; 10: 417-422.
10. Albani D, Polito L, Batelli S, et al. The SIRT1 activator resveratrol protects SK-N-BE cells from oxidative stress and against toxicity caused by a-synuclein or amyloid-b (1-42) peptide. J Neurochem 2009; 110: 1445-1456.
11. Alvira D, Yeste-Velasco M, Folch J, et al. Comparative analysis of the effects of resveratrol in two apoptotic models: inhibition of complex I and potassium deprivation in cerebellar neurons. Neuroscience 2007; 147: 746-756.
12. Chao J, Yu MS, Ho YS, Wang M, Chang RC. Dietary oxyresveratrol prevents parkinsonian mimetic 6-hydroxydopamine neurotoxicity. Free Radic Biol Med 2008; 45: 1019-1026.
13. Okawara M, Katsuki H, Kurimoto E, Shibata H, Kume T, Akaike A. Resveratrol protects dopaminergic neurons in midbrain slice culture from multiple insults. Biochem Pharmacol 2007; 73: 550-560.
14. Donmez G, Arun A, Chung CY, McLean PJ, Lindquist S, Guarente L. SIRT1 protects against _-synuclein aggregation by activating molecular chaperones. J Neurosci 2012; 32: 124-132.
15. Westerheide SD, Anckar J, Stevens SM Jr, Sistonen L, Morimoto RI. Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1. Science 2009; 323:1063-1066.
16. Kakefuda K, Fujita Y, Oyagi A, et al. Sirtuin 1 overexpression mice show a reference memory deficit, but not neuroprotection. Biochem. Biophys Res Commun 2009; 387: 784-788.
17. Parker JA, Arango M, Abderrahmane S, et al. Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons. Nat Genet 2005; 37: 349-350.
18. Sorolla MA, Nierga C, Rodriguez-Colman MJ, et al. Sir2 is induced by oxidative stress in a yeast model of Huntington disease and its activation reduces protein aggregation. Arch. Biochem. Biophys 2011; 510: 27-34.
19. Ho DJ, Calingasan NY, Wille E, Dumont M, Beal MF. Resveratrol protects against peripheral deficits in a mouse model of Huntington's disease. Exp Neurol 2010; 225: 74-84.
20. Jeong H, Cohen DE, Cui L, et al. Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway. Nat Med 2011; 18: 159-165.
21. Li W, Zhang B, Tang J, et al. Sirtuin 2, a mammalian homolog of yeast silent information regulator-2 longevity regulator, is an oligodendroglial protein that decelerates cell differentiation through deacetylating alpha-tubulin. J Neurosci 2007; 27: 2606-2016.
22. Bobrowska A, Donmez G, Weiss A, Guarente L, Bates G. SIRT2 ablation has no effect in tubulin acetylation in brain, cholesterol biosynthesis or the progression of Huntington's disease phenotypes in vivo. PLoS One 2012; 7(4): e34805.
23. Werner HB, Kuhlmann K, Shen S, et al. Proteolipid protein is required for transport of sirtuin 2 into CNS myelin. J Neurosci 2007; 27: 7717-7730.
24. Outeiro TF, Kontopoulos E, Altmann SM, et al. Sirtuin 2 inhibitors rescue a-synuclein-mediated toxicity in models of Parkinson's disease. Science 2007; 317: 516-519.
25. Liu L, Arun A, Ellis L, Peritore C, Donmez G. Sirtuin 2 (SIRT2) Enhances 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)- induced Nigrostriatal Damage via Deacetylating Forkhead Box O3a (Foxo3a) and Activating Bim Protein. J Biol Chem 2012; 287(39): 32307-32311.
26. Luthi-Carter R, Taylor DM, Pallos J, et al. SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis. PNAS 2010; 107: 7927-7232.
27. Taylor DM, Balabadra U, Xiang Z, et al. A brain-permeable small molecule reduces neuronal cholesterol by inhibiting activity of sirtuin 2 deacetylase. ACS Chem Biol 2011; 6: 540-546.
28. Pallos J, Bodai L, Lukacsovich T, et al. Inhibition of specific HDACs and sirtuins suppresses pathogenesis in a Drosophila model of Huntington's disease. Hum Mol Genet 2008; 17: 3767-3775.
29. Kim SH, Lu HF, Alano CC. Neuronal Sirt3 protects against excitotoxic injury in mouse cortical neuron culture. PLoS One 2011; 6: e14731.
30. Polito L, Kehoe PG, Davin A, et al. The SIRT2 polymorphism rs10410544 and risk of Alzheimer's disease in two Caucasian casecontrol cohorts. Alzheimers Dement 2012 May 30.[Epub ahead of print].