Dietary component isorhamnetin is a PPARγ antagonist and ameliorates metabolic disorders induced by diet or leptin deficiency

Scientific Reports

Volumn 6, Issue , 2016, Pages

  Zhang, Yu ^a   Gu, Ming ^a   Cai, Wujie ^a   Yu, Lijing ^a   Feng, Li ^a   Zhang, Lu ^a   Zang, Qingqing ^a   Wang, Yahui ^a   Wang, Dongshan ^a   Chen, Hui ^a   Tong, Qingchun ^b   Ji, Guang ^a   Huang, Cheng ^a  

^a SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3-METHYLQUERCETIN; LEPTIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN BINDING; QUERCETIN;

3T3-L1 CELL LINE; ADIPOCYTE; ADIPOGENESIS; ADVERSE EFFECTS; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL DIFFERENTIATION; CHEMISTRY; CONFORMATION; CYTOLOGY; DEFICIENCY; DIETARY SUPPLEMENT; DISEASE MODEL; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; HUMAN; LIPID DIET; METABOLIC DISEASES; METABOLISM; MOLECULAR MODEL; MOUSE; NON-ALCOHOLIC FATTY LIVER DISEASE; OBESITY; TRANSCRIPTION INITIATION;

3T3-L1 CELLS; ADIPOCYTES; ADIPOGENESIS; ANIMALS; CELL DIFFERENTIATION; DIET, HIGH-FAT; DIETARY SUPPLEMENTS; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; HUMANS; LEPTIN; METABOLIC DISEASES; MICE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NON-ALCOHOLIC FATTY LIVER DISEASE; OBESITY; PPAR GAMMA; PROTEIN BINDING; QUERCETIN; TRANSCRIPTIONAL ACTIVATION;

EID: 84955120922     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep19288     Document Type: Article

References (46)

1. Wang, Y. X., et al. Peroxisome-proliferator-Activated receptor delta activates fat metabolism to prevent obesity. Cell 113, 159-170 (2003
2. Nolte, R. T., et al. Ligand binding and co-Activator assembly of the peroxisome proliferator-Activated receptor-gamma. Nature 395, 137-143 (1998
3. Gavrilova, O., et al. Liver peroxisome proliferator-Activated receptor gamma contributes to hepatic steatosis, triglyceride clearance, and regulation of body fat mass. J Biol Chem 278, 34268-34276 (2003
4. Yu, S., et al. Adipocyte-specific gene expression and adipogenic steatosis in the mouse liver due to peroxisome proliferator-Activated receptor gamma1 (PPARgamma1) overexpression. J Biol Chem 278, 498-505 (2003
5. Garcia-Ruiz, I., et al. Effects of rosiglitazone on the liver histology and mitochondrial function in ob/ob mice. Hepatology 46, 414-423 (2007
6. Kubota, N., et al. PPAR gamma mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance. Mol Cell 4, 597-609 (1999
7. Miles, P. D., Barak, Y., He, W., Evans, R. M., & Olefsky, J. M. Improved insulin-sensitivity in mice heterozygous for PPAR-gamma deficiency. J Clin Invest 105, 287-292 (2000
8. Deeb, S. S., et al. A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity. Nat Genet 20, 284-287 (1998
9. Altshuler, D., et al. The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes. Nat Genet 26, 76-80 (2000
10. Gong, Z., et al. The role of tanshinone IIA in the treatment of obesity through peroxisome proliferator-Activated receptor gamma antagonism. Endocrinology 150, 104-113 (2009
11. Rieusset, J., et al. A new selective peroxisome proliferator-Activated receptor gamma antagonist with antiobesity and antidiabetic activity. Mol Endocrinol 16, 2628-2644 (2002
12. Goto, T., Kim, Y. I., Takahashi, N., & Kawada, T. Natural compounds regulate energy metabolism by the modulating the activity of lipid-sensing nuclear receptors. Mol Nutr Food Res 57, 20-33 (2013
13. Zhang, Y., et al. Protopanaxatriol, a novel PPARgamma antagonist from Panax ginseng, alleviates steatosis in mice. Sci Rep 4, 7375 (2014
14. Steinberg, D., Parthasarathy, S., Carew, T. E., Khoo, J. C., & Witztum, J. L. Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity. N Engl J Med 320, 915-924 (1989
15. Katan, M. B. Flavonoids and heart disease. Am J Clin Nutr 65, 1542-1543 (1997
16. Saleh, N. A., Mansour, R. M., & Markham, K. R. An acylated isorhamnetin glycoside from Aerva javanica. Phytochemistry 29, 1344-1345 (1990
17. Park, J. C., Young, H. S., Yu, Y. B., & Lee, J. H. Isorhamnetin sulphate from the leaves and stems of Oenanthe javanica in Korea. Planta Med 61, 377-378 (1995
18. Sikorska, M., & Matlawska, I. Kaempferol, isorhamnetin and their glycosides in the flowers of Asclepias syriaca L. Acta Pol Pharm 58, 269-272 (2001
19. Schieber, A., Keller, P., Streker, P., Klaiber, I., & Carle, R. Detection of isorhamnetin glycosides in extracts of apples (Malus domestica cv. Brettacher) by HPLC-PDA and HPLC-APCI-MS/MS. Phytochem Anal 13, 87-94 (2002
20. Boesch-Saadatmandi, C., et al. Effect of quercetin and its metabolites isorhamnetin and quercetin-3-glucuronide on inflammatory gene expression: role of miR-155. J Nutr Biochem 22, 293-299 (2011
21. Kobori, M., Masumoto, S., Akimoto, Y., & Oike, H. Chronic dietary intake of quercetin alleviates hepatic fat accumulation associated with consumption of a Western-style diet in C57/BL6J mice. Mol Nutr Food Res 55, 530-540 (2011
22. Igarashi, K., & Ohmuma, M. Effects of isorhamnetin, rhamnetin, and quercetin on the concentrations of cholesterol and lipoperoxide in the serum and liver and on the blood and liver antioxidative enzyme activities of rats. Biosci Biotechnol Biochem 59, 595-601 (1995
23. Saud, S. M., et al. Chemopreventive activity of plant flavonoid isorhamnetin in colorectal cancer is mediated by oncogenic Src and beta-catenin. Cancer Res 73, 5473-5484 (2013
24. Hamalainen, M., Nieminen, R., Vuorela, P., Heinonen, M., & Moilanen, E. Anti-inflammatory effects of flavonoids: genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 and NF-kappaB activations, whereas flavone, isorhamnetin, naringenin, and pelargonidin inhibit only NF-kappaB activation along with their inhibitory effect on iNOS expression and NO production in activated macrophages. Mediators Inflamm 2007, 45673 (2007
25. Dou, W., et al. Plant flavonol isorhamnetin attenuates chemically induced inflammatory bowel disease via a PXR-dependent pathway. J Nutr Biochem 25, 923-933 (2014
26. Dong, G. Z., et al. AMPK activation by isorhamnetin protects hepatocytes against oxidative stress and mitochondrial dysfunction. Eur J Pharmacol 740, 634-640 (2014
27. Ramachandran, L., et al. Isorhamnetin inhibits proliferation and invasion and induces apoptosis through the modulation of peroxisome proliferator-Activated receptor gamma activation pathway in gastric cancer. J Biol Chem 287, 38028-38040 (2012
28. Lee, J., Jung, E., Hwang, W., Kim, Y. S., & Park, D. Isorhamnetin-induced anti-Adipogenesis is mediated by stabilization of betacatenin protein. Life Sci 86, 416-423 (2010
29. Lee, J., et al. Isorhamnetin represses adipogenesis in 3T3-L1 cells. Obesity (Silver Spring) 17, 226-232 (2009
30. Rodriguez-Rodriguez, C., et al. The effect of isorhamnetin glycosides extracted from Opuntia ficus-indica in a mouse model of diet induced obesity. Food Funct 6, 805-815 (2015
31. Mahmoud, M. F., Hassan, N. A., El Bassossy, H. M., & Fahmy, A. Quercetin protects against diabetes-induced exaggerated vasoconstriction in rats: effect on low grade inflammation. PLoS One 8, e63784 (2013
32. Wang, W., et al. Quercetin and allopurinol reduce liver thioredoxin-interacting protein to alleviate inflammation and lipid accumulation in diabetic rats. Br J Pharmacol 169, 1352-1371 (2013
33. Yamauchi, T., et al. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med 7, 941-946 (2001
34. Frederich, R. C., et al. Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action. Nat Med 1, 1311-1314 (1995
35. Yamauchi, T., et al. The mechanisms by which both heterozygous peroxisome proliferator-Activated receptor gamma (PPARgamma) deficiency and PPARgamma agonist improve insulin resistance. J Biol Chem 276, 41245-41254 (2001
36. Cikim, A. S., et al. Epicardial adipose tissue, hepatic steatosis and obesity. J Endocrinol Invest 30, 459-464 (2007
37. Haber, M. M., West, A. B., Haber, A. D., & Reuben, A. Relationship of aminotransferases to liver histological status in chronic hepatitis C. Am J Gastroenterol 90, 1250-1257 (1995
38. Begriche, K., Igoudjil, A., Pessayre, D., & Fromenty, B. Mitochondrial dysfunction in NASH: causes, consequences and possible means to prevent it. Mitochondrion 6, 1-28 (2006
39. Garcia-Ruiz, I., Solis-Munoz, P., Fernandez-Moreira, D., Munoz-Yague, T., & Solis-Herruzo, J. A. Pioglitazone leads to an inactivation and disassembly of complex I of the mitochondrial respiratory chain. BMC Biol 11, 88 (2013
40. Forman, B. M., et al. 15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma. Cell 83, 803-812 (1995
41. Tontonoz, P., Hu, E., & Spiegelman, B. M. Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-Activated transcription factor. Cell 79, 1147-1156 (1994
42. Liu, C., et al. Identification of a novel selective agonist of PPARgamma with no promotion of adipogenesis and less inhibition of osteoblastogenesis. Sci Rep 5, 9530 (2015
43. Zhang, N., et al. Isorhamnetin protects rat ventricular myocytes from ischemia and reperfusion injury. Exp Toxicol Pathol 63, 33-38 (2011
44. Pisonero-Vaquero, S., et al. Quercetin ameliorates dysregulation of lipid metabolism genes via the PI3K/AKT pathway in a dietinduced mouse model of nonalcoholic fatty liver disease. Mol Nutr Food Res 59, 879-893 (2015
45. Marcolin, E., et al. Quercetin decreases liver damage in mice with non-Alcoholic steatohepatitis. Basic Clin Pharmacol Toxicol 112, 385-391 (2013
46. Ying, H. Z., et al. Dietary quercetin ameliorates nonalcoholic steatohepatitis induced by a high-fat diet in gerbils. Food Chem Toxicol 52, 53-60 (2013