AMPK activation by isorhamnetin protects hepatocytes against oxidative stress and mitochondrial dysfunction

European Journal of Pharmacology

Volumn 740, Issue , 2014, Pages 634-640

  Dong, Guang Zhi ^a   Lee, Ju Hee ^a   Ki, Sung Hwan ^b   Yang, Ji Hye ^b   Cho, Il Je ^a   Kang, Seung Ho ^a,c   Zhao, Rong Jie ^a,d   Kim, Sang Chan ^a   Kim, Young Woo ^a,e  

^a Daegu Haany University   (South Korea)

^b Chosun University   (South Korea)

^c Sunlin University   (South Korea)

^d MUDANJIANG MEDICAL UNIVERSITY   (China)

^e Dongguk University   (South Korea)

Author keywords

AMPK; Isorhamnetin; Mitochondria; Oxidative stress

Indexed keywords

ARACHIDONIC ACID; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE KINASE; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE KINASE 2; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE KINASE 2 INHIBITOR; COMPOUND C; ENZYME INHIBITOR; GLUTATHIONE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE INHIBITOR; IRON; ISORHAMNETIN; LIVER KINASE B1; PHOSPHOTRANSFERASE; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; STO 609; THREONINE; UNCLASSIFIED DRUG; 3-METHYLQUERCETIN; CAMKK2 PROTEIN, HUMAN; HYDROGEN PEROXIDE; PROTECTIVE AGENT; QUERCETIN;

ANIMAL CELL; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVATION; HEPG2 CELL LINE; HUMAN; HUMAN CELL; IN VITRO STUDY; LIVER CELL; LIVER TOXICITY; MITOCHONDRIAL DYSFUNCTION; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; NONHUMAN; OXIDATIVE STRESS; ANALOGS AND DERIVATIVES; ANIMAL; CELL LINE; CELL SURVIVAL; DRUG EFFECTS; GENETICS; METABOLISM; MOUSE; RAT;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE KINASE; CELL LINE; CELL SURVIVAL; GLUTATHIONE; HEP G2 CELLS; HEPATOCYTES; HUMANS; HYDROGEN PEROXIDE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; OXIDATIVE STRESS; PROTECTIVE AGENTS; QUERCETIN; RATS; RNA, SMALL INTERFERING;

EID: 84919443362     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2014.06.017     Document Type: Article

References (52)

1. K.A. Anderson, T.J. Ribar, F. Lin, P.K. Noeldner, M.F. Green, M.J. Muehlbauer, L.A. Witters, B.E. Kemp, and A.R. Means Hypothalamic CaMKK2 contributes to the regulation of energy balance Cell Metab. 7 2008 377 388
2. K. Apel, and H. Hirt Reactive oxygen species: metabolism, oxidative stress, and signal transduction Annu. Rev. Plant Biol. 55 2004 373 399
3. M.A. Balboa, and J. Balsinde Oxidative stress and arachidonic acid mobilization Biochim. Biophys. Acta 1761 2006 385 391
4. C.M. Bergamini, S. Gambetti, A. Dondi, and C. Cervellati Oxygen, reactive oxygen species and tissue damage Curr. Pharm. Des. 10 2004 1611 1626
5. X. Cao, Y. Wei, and Y. Ito Preparative isolation of isorhamnetin from stigma maydis using high-speed countercurrent chromatography J. Liq. Chromatogr.Relat. Technol, 32 2009 273 280
6. A.A. Caro, and A.I. Cederbaum Synergistic toxicity of iron and arachidonic acid in HepG2 cells overexpressing CYP2E1 Mol. Pharmacol. 60 2001 742 752
7. S.H. Choi, Y.W. Kim, and S.G. Kim AMPK-mediated GSK3beta inhibition by isoliquiritigenin contributes to protecting mitochondria against iron-catalyzed oxidative stress Biochem. Pharmacol. 79 2010 1352 1362
8. Q.F. Collins, H.Y. Liu, J. Pi, Z. Liu, M.J. Quon, and W. Cao Epigallocatechin-3-gallate (EGCG), a green tea polyphenol, suppresses hepatic gluconeogenesis through 5'-AMP-activated protein kinase J. Biol. Chem. 282 2007 30143 30149
9. D. Detaille, B. Guigas, C. Chauvin, C. Batandier, E. Fontaine, N. Wiernsperger, and X. Leverve Metformin prevents high-glucose-induced endothelial cell death through a mitochondrial permeability transition-dependent process Diabetes 54 2005 2179 2187
10. G.Z. Dong, E.J. Jang, S.H. Kang, I.J. Cho, S.D. Park, S.C. Kim, and Y.W. Kim Red ginseng abrogates oxidative stress via mitochondria protection mediated by LKB1-AMPK pathway BMC complement. Altern. Med. 13 2013 64
11. R.E. Fleming, and B.R. Bacon Orchestration of iron homeostasis N. Engl. J. Med. 352 2005 1741 1744
12. D. Galaris, and K. Pantopoulos Oxidative stress and iron homeostasis: mechanistic and health aspects Crit. Rev. Clin. Lab. Sci. 45 2008 1 23
13. M.A. Gijon, and C.C. Leslie Regulation of arachidonic acid release and cytosolic phospholipase A2 activation J. Leukoc. Biol. 65 1999 330 336
14. M.F. Green, K.A. Anderson, and A.R. Means Characterization of the CaMKKbeta-AMPK signaling complex Cell. Signal. 23 2011 2005 2012
15. J.W. Halliday, and J. Searle Hepatic iron deposition in human disease and animal models Biometals 9 1996 205 209
16. D.G. Hardie, and D. Carling The AMP-activated protein kinase - fuel gauge of the mammalian cell? Eur. J. Biochem. 246 1997 259 273
17. S.A. Hawley, D.A. Pan, K.J. Mustard, L. Ross, J. Bain, A.M. Edelman, B.G. Frenguelli, and D.G. Hardie Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase Cell Metab. 2 2005 9 19
18. T. Hayashi, M.F. Hirshman, N. Fujii, S.A. Habinowski, L.A. Witters, and L.J. Goodyear Metabolic stress and altered glucose transport: activation of AMP-activated protein kinase as a unifying coupling mechanism Diabetes 49 2000 527 531
19. K. Hino, S. Nishina, and Y. Hara Iron metabolic disorder in chronic hepatitis C: mechanisms and relevance to hepatocarcinogenesis J. Gastroenterol. Hepatol. Suppl 4 2013 S93 S98
20. R.L. Hurley, K.A. Anderson, J.M. Franzone, B.E. Kemp, A.R. Means, and L.A. Witters The Ca2+/calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinases J. Biol. Chem. 280 2005 29060 29066
21. Y. Ido, D. Carling, and N. Ruderman Hyperglycemia-induced apoptosis in human umbilical vein endothelial cells: inhibition by the AMP-activated protein kinase activation Diabetes 51 2002 159 167
22. J.E. Kim, D.E. Lee, K.W. Lee, J.E. Son, S.K. Seo, J. Li, S.K. Jung, Y.S. Heo, M. Mottamal, A.M. Bode, Z. Dong, and H.J. Lee Isorhamnetin suppresses skin cancer through direct inhibition of MEK1 and PI3-K Cancer Prev. Res. 4 2011 582 591
23. Y.W. Kim, H.E. Kang, M.G. Lee, S.J. Hwang, S.C. Kim, C.H. Lee, and S.G. Kim Liquiritigenin, a flavonoid aglycone from licorice, has a choleretic effect and the ability to induce hepatic transporters and phase-II enzymes Am. J. Physiol. Gastrointest. Liver Physiol. 296 2009 G372 381
24. Y.W. Kim, S.M. Lee, S.M. Shin, S.J. Hwang, J.S. Brooks, H.E. Kang, M.G. Lee, S.C. Kim, and S.G. Kim Efficacy of sauchinone as a novel AMPK-activating lignan for preventing iron-induced oxidative stress and liver injury Free Radic. Biol. Med. 47 2009 1082 1092
25. C.S. Kong, J.A. Kim, Z.J. Qian, Y.A. Kim, J.I. Lee, S.K. Kim, T.J. Nam, and Y. Seo Protective effect of isorhamnetin 3-O-beta-D-glucopyranoside from Salicornia herbacea against oxidation-induced cell damage Food Chem. Toxicol. 47 2009 1914 1920
26. R. Mattera, G.P. Stone, N. Bahhur, and Y.A. Kuryshev Increased release of arachidonic acid and eicosanoids in iron-overloaded cardiomyocytes Circulation 103 2001 2395 2401
27. A.R. Ndhlala, M. Moyo, and J. Van Staden Natural antioxidants: fascinating or mythical biomolecules? Molecules 15 2010 6905 6930
28. E.J. Neufeld Oral chelators deferasirox and deferiprone for transfusional iron overload in thalassemia major: new data, new questions Blood 107 2006 3436 3441
29. H. Nohl, A.V. Kozlov, L. Gille, and K. Staniek Cell respiration and formation of reactive oxygen species: facts and artefacts Biochem. Soc. Trans. 31 2003 1308 1311
30. L. Price, and K.V. Kowdley The role of iron in the pathophysiology and treatment of chronic hepatitis C Can. J. Gastroenterol. 23 2009 822 828
31. M.B. Reddy, and L. Clark Iron, oxidative stress, and disease risk Nutr. Rev. 62 2004 120 124
32. N. Sambandam, and G.D. Lopaschuk AMP-activated protein kinase (AMPK) control of fatty acid and glucose metabolism in the ischemic heart Prog. Lipid Res. 42 2003 238 256
33. J.G. Scandalios The rise of ROS Trends Biochem. Sci. 27 2002 483 486
34. L. Scorrano, S.A. Oakes, J.T. Opferman, E.H. Cheng, M.D. Sorcinelli, T. Pozzan, and S.J. Korsmeyer BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis Science 300 2003 135 139
35. K. Seo, J.H. Yang, S.C. Kim, S.K. Ku, S.H. Ki, and S.M. Shin The antioxidant effects of isorhamnetin contribute to inhibit COX-2 expression in response to inflammation: a potential role of HO-1 Inflammation 37 2014 712 722
36. A.M. Shah, and K.M. Channon Free radicals and redox signalling in cardiovascular disease Heart 90 2004 486 487
37. S.M. Shin, I.J. Cho, and S.G. Kim Resveratrol protects mitochondria against oxidative stress through AMP-activated protein kinase-mediated glycogen synthase kinase-3beta inhibition downstream of poly(ADP-ribose)polymerase-LKB1 pathway Mol. Pharmacol. 76 2009 884 895
38. S.M. Shin, and S.G. Kim Inhibition of arachidonic acid and iron-induced mitochondrial dysfunction and apoptosis by oltipraz and novel 1,2-dithiole-3-thione congeners Mol. Pharmacol. 75 2009 242 253
39. B. Sid, J. Verrax, and P.B. Calderon Role of AMPK activation in oxidative cell damage: Implications for alcohol-induced liver disease Biochem. Pharmacol. 86 2013 200 209
40. B. Sun, G.B. Sun, J. Xiao, R.C. Chen, X. Wang, Y. Wu, L. Cao, Z.H. Yang, and X.B. Sun Isorhamnetin inhibits H(2)O(2)-induced activation of the intrinsic apoptotic pathway in H9c2 cardiomyocytes through scavenging reactive oxygen species and ERK inactivation J. Cell. Biochem. 113 2012 473 485
41. J. Sun, G. Sun, X. Meng, H. Wang, Y. Luo, M. Qin, B. Ma, M. Wang, D. Cai, P. Guo, and X. Sun Isorhamnetin protects against doxorubicin-induced cardiotoxicity in vivo and in vitro PLoS One 8 2013 e64526
42. B. Tadolini, and G. Hakim The mechanism of iron (III) stimulation of lipid peroxidation Free Radic. Res. 25 1996 221 227
43. K. Terai, Y. Hiramoto, M. Masaki, S. Sugiyama, T. Kuroda, M. Hori, I. Kawase, and H. Hirota AMP-activated protein kinase protects cardiomyocytes against hypoxic injury through attenuation of endoplasmic reticulum stress Mol. Cell. Biol. 25 2005 9554 9575
44. M. Thursz Iron, haemochromatosis and thalassaemia as risk factors for fibrosis in hepatitis C virus infection Gut 56 2007 613 614
45. R. Tian, N. Musi, J. D'Agostino, M.F. Hirshman, and L.J. Goodyear Increased adenosine monophosphate-activated protein kinase activity in rat hearts with pressure-overload hypertrophy Circulation 104 2001 1664 1669
46. N.K. Upadhyay, M.S. Kumar, and A. Gupta Antioxidant, cytoprotective and antibacterial effects of Sea buckthorn (Hippophae rhamnoides L.) leaves Food Chem. Toxicol. 48 2010 3443 3448
47. M. Valko, C.J. Rhodes, J. Moncol, M. Izakovic, and M. Mazur Free radicals, metals and antioxidants in oxidative stress-induced cancer Chem. Biol. Interact. 160 2006 1 40
48. B. Viollet, B. Guigas, J. Leclerc, S. Hébrard, L. Lantier, R. Mounier, F. Andreelli, and M. Foretz AMP-activated protein kinase in the regulation of hepatic energy metabolism: from physiology to therapeutic perspectives Acta Physiol. 196 2009 81 98
49. C. Willner An overview of the pathophysiology of neurodegenerative disorders Altern. Ther. Health Med. 10 2004 26 34 (quiz 35, 96)
50. Y. Xing, N. Musi, N. Fujii, L. Zou, I. Luptak, M.F. Hirshman, L.J. Goodyear, and R. Tian Glucose metabolism and energy homeostasis in mouse hearts overexpressing dominant negative alpha2 subunit of AMP-activated protein kinase J. Biol. Chem. 278 2003 28372 28377
51. J.H. Yang, S.C. Kim, B.Y. Shin, S.H. Jin, M.J. Jo, K.H. Jegal, Y.W. Kim, J.R. Lee, S.K. Ku, I.J. Cho, and S.H. Ki O-methylated flavonol isorhamnetin prevents acute inflammation through blocking of NF-kappaB activation Food Chem. Toxicol. 59 2013 362 372
52. N. Zhang, F. Pei, H. Wei, T. Zhang, C. Yang, G. Ma, and C. Yang Isorhamnetin protects rat ventricular myocytes from ischemia and reperfusion injury Exp. Toxicol. Pathol. 63 2011 33 38