Isorhamnetin inhibits proliferation and invasion and induces apoptosis through the modulation of peroxisome proliferator-activated receptor γ activation pathway in gastric cancer

Journal of Biological Chemistry

Volumn 287, Issue 45, 2012, Pages 38028-38040

  Ramachandran, Lalitha ^a   Manu, Kanjoormana Aryan ^a   Shanmugam, Muthu K ^a   Li, Feng ^a   Siveen, Kodappully Sivaraman ^a   Vali, Shireen ^b,c   Kapoor, Shweta ^b,c   Abbasi, Taher ^b,c   Surana, Rohit ^a,d   Smoot, Duane T ^e   Ashktorab, Hassan ^e   Tan, Patrick ^d,f,g   Ahn, Kwang Seok ^h   Yap, Chun Wei ^g   Kumar, Alan Prem ^a,d,i,j   Sethi, Gautam ^a,d  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b CELLWORKS GROUP INC   (United States)

^c Lam Research India Pvt Ltd   (India)

^d NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^e HOWARD UNIVERSITY CANCER CENTER   (United States)

^f GENOME INSTITUTE OF SINGAPORE   (Singapore)

^g NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^h Kyung Hee University   (South Korea)

ⁱ CURTIN UNIVERSITY   (Australia)

^j UNIVERSITY OF NORTH TEXAS   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL ACTIVATION; DISEASES; TRANSCRIPTION;

ACTIVATION PATHWAY; GASTRIC CANCERS; NUCLEAR TRANSCRIPTION FACTORS; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR; PPAR GAMMAS;

CELL DEATH;

EID: 84868314521     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.388702     Document Type: Article

References (47)

1. Ford, A. C. (2011) Chemoprevention for gastric cancer. Best Pract. Res. Clin. Gastroenterol. 25, 581-5922
2. Yeoh, K. G. (2007) How do we improve outcomes for gastric cancer? J. Gastroenterol. Hepatol. 22, 970-9722
3. Lochhead, P., and El-Omar, E. M. (2008)Gastric cancer. Br. Med. Bull. 85, 87-1000
4. Roukos, D. H., and Kappas, A. M. (2005) Perspectives in the treatment of gastric cancer. Nat. Clin. Pract. Oncol. 2, 98-1077
5. Ohtsu, A. (2008)Chemotherapy for metastatic gastric cancer. Past, present, and future. Journal of gastroenterology 43, 256-2644
6. Selgrad, M., Bornschein, J., Rokkas, T., and Malfertheiner, P. (2010) Clinical aspects of gastric cancer and Helicobacter pylori. Screening, prevention, and treatment. Helicobacter 15, 40-455
7. Koeffler, H. P. (2003) Peroxisome proliferator-activated receptorand cancers. Clin. Cancer Res. 9, 1-99
8. Bishop-Bailey, D. (2011) PPARs and angiogenesis. Biochem. Soc. Trans. 39, 1601-16055
9. Peters, J. M., Shah, Y. M., and Gonzalez, F. J. (2012) The role of peroxisome proliferator-activated receptors in carcinogenesis and chemoprevention. Nat. Rev. Cancer 12, 181-1955
10. Wang, T., Xu, J., Yu, X., Yang, R., and Han, Z. C. (2006) Peroxisome proliferator-activated receptorin malignant diseases. Crit. Rev. Oncol. Hematol. 58, 1-144
11. Schmidt, M. V., Brune, B., and von Knethen, A. (2010) The nuclear hormone receptor PPAR-as a therapeutic target in major diseases. Sci. World J. 10, 2181-21977
12. Mannelli, M., Cantini, G., Poli, G., Mangoni, M., Nesi, G., Canu, L., Rapizzi, E., Borgogni, E., Ercolino, T., Piccini, V., and Luconi, M. (2010) Role of the PPAR-system in normal and tumoral pituitary corticotropic cells and adrenal cells. Neuroendocrinology 92, 23-277
13. Wan, Z., Shi, W., Shao, B., Shi, J., Shen, A., Ma, Y., Chen, J., and Lan, Q. (2011) Peroxisome proliferator-activated receptoragonist pioglitazone inhibits-catenin-mediated glioma cell growth and invasion. Mol. Cell. Biochem. 349, 1-100
14. Kumar, A. P., Quake, A. L., Chang, M. K., Zhou, T., Lim, K. S., Singh, R., Hewitt, R. E., Salto-Tellez, M., Pervaiz, S., and Clément, M. V. (2009)Repression of NHE1 expression by PPAR-activation is a potential new approach for specific inhibition of the growth of tumor cells in vitro and in vivo. Cancer Res. 69, 8636-86444
15. Yokoyama, Y., Xin, B., Shigeto, T., and Mizunuma, H. (2011) Combination of ciglitazone, a peroxisome proliferator-activated receptorligand, and cisplatin enhances the inhibition of growth of human ovarian cancers. J. Cancer Res. Clin. Oncol. 137, 1219-12288
16. Yao, L., Liu, F., Sun, L., Wu, H., Guo, C., Liang, S., Liu, L., Liu, N., Han, Z., Zhang, H., Wu, K., and Fan, D. (2010) Upregulation of PPAR-in tissue with gastric carcinoma. Hybridoma 29, 341-3433
17. Lu, J., Imamura, K., Nomura, S., Mafune, K., Nakajima, A., Kadowaki, T., Kubota, N., Terauchi, Y., Ishii, G., Ochiai, A., Esumi, H., and Kaminishi, M. (2005) Chemopreventive effect of peroxisome proliferator-activated receptoron gastric carcinogenesis in mice. Cancer Res. 65, 4769-47744
18. Reka, A. K., Goswami, M. T., Krishnapuram, R., Standiford, T. J., and Keshamouni, V. G. (2011) Molecular cross-regulation between PPAR-and other signaling pathways. Implications for lung cancer therapy. Lung Cancer 72, 154-1599
19. Nickkho-Amiry, M., McVey, R., and Holland, C. (2012) Peroxisome proliferator-activated receptors modulate proliferation and angiogenesis in human endometrial carcinoma. Mol. Cancer Res. 10, 441-4533
20. Papi, A., Rocchi, P., Ferreri, A. M., and Orlandi, M. (2010) RXR-and PPAR-ligands in combination to inhibit proliferation and invasiveness in colon cancer cells. Cancer Lett. 297, 65-744
21. Oyekan, A. (2011) PPARs and their effects on the cardiovascular system. Clin. Exp. Hypertension 33, 287-2933
22. Wilding, J. P. (2012) PPAR agonists for the treatment of cardiovascular disease in patients with diabetes. Diabetes Obes. Metab., in presss
23. Chen, Y. C., Wu, J. S., Tsai, H. D., Huang, C. Y., Chen, J. J., Sun, G. Y., and Lin, T. N. (2012) Peroxisome proliferator-activated receptor gamma (PPAR-) and neurodegenerative disorders. Mol. Neurobiol. 46, 114-1244
24. Yao, H., Xu, W., Shi, X., and Zhang, Z. (2011) Dietary flavonoids as cancer prevention agents. J. Environ. Sci. Health C Environ. Carcinog. Ecotoxicol. Rev. 29, 1-311
25. Asensi, M., Ortega, A., Mena, S., Feddi, F., and Estrela, J. M. (2011) Natural polyphenols in cancer therapy. Crit. Rev. Clin. Lab. Sci. 48, 197-2166
26. Cushnie, T. P., and Lamb, A. J. (2011) Recent advances in understanding the antibacterial properties of flavonoids. Int. J. Antimicrob. Agents 38, 99-1077
27. Wang, P., Heber, D., and Henning, S. M. (2012) Quercetin increased the antiproliferative activity of green tea polyphenol (-)-epigallocatechin gallate in prostate cancer cells. Nutr. Cancer 64, 580-5877
28. Wang, P., Zhang, K., Zhang, Q., Mei, J., Chen, C. J., Feng, Z. Z., and Yu, D. H. (2012) Effects of quercetin on the apoptosis of the human gastric carcinoma cells. Toxicol. In Vitro 26, 221-2288
29. Jaramillo, S., Lopez, S., Varela, L. M., Rodriguez-Arcos, R., Jimenez, A., Abia, R., Guillen, R., and Muriana, F. J. (2010) The flavonol isorhamnetin exhibits cytotoxic effects on human colon cancer cells. J. Agric. Food Chem. 58, 10869-108755
30. Kim, J. E., Lee, D. E., Lee, K. W., Son, J. E., Seo, S. K., Li, J., Jung, S. K., Heo, Y. S., Mottamal, M., Bode, A. M., Dong, Z., and Lee, H. J. (2011) Isorhamnetin suppresses skin cancer through direct inhibition of MEK1 and PI3-K. Cancer Prev. Res. 4, 582-5911
31. Lee, H. J., Lee, H. J., Lee, E. O., Ko, S. G., Bae, H. S., Kim, C. H., Ahn, K. S., Lu, J., and Kim, S. H. (2008)Mitochondria-cytochrome C-caspase-9 cascade mediates isorhamnetin-induced apoptosis. Cancer Lett. 270, 342-3533
32. Choi, K. C., Chung, W. T., Kwon, J. K., Yu, J. Y., Jang, Y. S., Park, S. M., Lee, S. Y., and Lee, J. C. (2010) Inhibitory effects of quercetin on aflatoxin B1-induced hepatic damage in mice. Food Chem. Toxicol. 48, 2747-27533
33. Woo, C. C., Loo, S. Y., Gee, V., Yap, C. W., Sethi, G., Kumar, A. P., and Tan, K. H. (2011) Anticancer activity of thymoquinone in breast cancer cells. Possible involvement of PPAR-pathway. Biochem. Pharmacol. 82, 464-4755
34. Kannaiyan, R., Hay, H. S., Rajendran, P., Li, F., Shanmugam, M. K., Vali, S., Abbasi, T., Kapoor, S., Sharma, A., Kumar, A. P., Chng, W. J., and Sethi, G. (2011) Celastrol inhibits proliferation and induces chemosensitization through down-regulation of NF-B and STAT3 regulated gene products in multiple myeloma cells. Br. J. Pharmacol. 164, 1506-15211
35. Manu, K. A., Shanmugam, M. K., Rajendran, P., Li, F., Ramachandran, L., Hay, H. S., Kannaiyan, R., Swamy, S. N., Vali, S., Kapoor, S., Ramesh, B., Bist, P., Koay, E. S., Lim, L. H., Ahn, K. S., Kumar, A. P., and Sethi, G. (2011) Plumbagin inhibits invasion and migration of breast and gastric cancer cells by downregulating the expression of chemokine receptor CXCR4. Mol. Cancer 10, 1077
36. Shanmugam, M. K., Rajendran, P., Li, F., Nema, T., Vali, S., Abbasi, T., Kapoor, S., Sharma, A., Kumar, A. P., Ho, P. C., Hui, K. M., and Sethi, G. (2011) Ursolic acid inhibits multiple cell survival pathways leading to suppression of growth of prostate cancer xenograft in nude mice. J. Mol. Med. 89, 713-7277
37. Kelly, P. N., and Strasser, A. (2011) The role of Bcl-2 and its pro-survival relatives in tumourigenesis and cancer therapy. Cell Death Differ. 18, 1414-14244
38. Evan, G. I., and Vousden, K. H. (2001) Proliferation, cell cycle and apoptosis in cancer. Nature 411, 342-3488
39. Hanahan, D., and Weinberg, R. A. (2011) Hallmarks of cancer. The next generation. Cell 144, 646-6744
40. Carmeliet, P., and Jain, R. K. (2011) Molecular mechanisms and clinical applications of angiogenesis. Nature 473, 298-3077
41. Patel, L. R., Camacho, D. F., Shiozawa, Y., Pienta, K. J., and Taichman, R. S. (2011) Mechanisms of cancer cell metastasis to the bone. A multistep process. Future Oncol. 7, 1285-12977
42. Hannelien, V., Karel, G., Jo, V. D., and Sofie, S. (2012) The role of CXC chemokines in the transition of chronic inflammation to esophageal and gastric cancer. Biochim. Biophys. Acta 1825, 117-1299
43. Burris, T. P., Busby, S. A., and Griffin, P. R. (2012) Targeting orphan nuclear receptors for treatment of metabolic diseases and autoimmunity. Chem. Biol. 19, 51-599
44. Nolte, R. T., Wisely, G. B., Westin, S., Cobb, J. E., Lambert, M. H., Kurokawa, R., Rosenfeld, M. G., Willson, T. M., Glass, C. K., and Milburn, M. V. (1998) Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor. Nature 395, 137-1433
45. Takahashi, N., Okumura, T., Motomura, W., Fujimoto, Y., Kawabata, I., and Kohgo, Y. (1999)Activation of PPAR-inhibits cell growth and induces apoptosis in human gastric cancer cells. FEBS Lett. 455, 135-1399
46. Boik, J. C., and Newman, R. A. (2008)A classification model to predict synergism/antagonism of cytotoxic mixtures using protein-drug docking scores. BMC Pharmacol. 8, 133
47. Salam, N. K., Huang, T. H., Kota, B. P., Kim, M. S., Li, Y., and Hibbs, D. E. (2008)Novel PPAR-agonists identified from a natural product library. A virtual screening, induced-fit docking and biological assay study. Chem. Biol. Drug Des. 71, 57-700