Potential of mass spectrometry in developing clinical laboratory biomarkers of nonvolatiles in exhaled breath

Clinical Chemistry

Volumn 62, Issue 1, 2016, Pages 84-91

  Beck, Olof ^a   Olin, Anna Carin ^b   Mirgorodskaya, Ekaterina ^b  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHETAMINE; BIOLOGICAL MARKER; CYTOKERATIN; LEUKOTRIENE B4; METHADONE; PEPTIDOLEUKOTRIENE; SURFACTANT; SURFACTANT PROTEIN A; TETRAHYDROCANNABINOL;

AEROSOL; BREATHING; BRONCHOALVEOLAR LAVAGE FLUID; CLINICAL LABORATORY; EXHALATION; HUMAN; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MOLECULAR WEIGHT; PH; RESPIRATORY SYSTEM; REVIEW; BREATH ANALYSIS; LABORATORY TEST; PARTICLE SIZE; PROCEDURES;

BIOMARKERS; BREATH TESTS; CLINICAL LABORATORY TECHNIQUES; EXHALATION; HUMANS; MASS SPECTROMETRY; PARTICLE SIZE;

EID: 84954515543     PISSN: 00099147     EISSN: 15308561     Source Type: Journal    
DOI: 10.1373/clinchem.2015.239285     Document Type: Review

References (41)

1. Popov TA. Human exhaled breath analysis. Ann Allergy Asthma Immunol 2011;106:451-6.
2. Amann A, Miekisch W, Schubert J, Buszewski B, Ligor T, Jezierski T, et al. Analysis of exhaled breath for disease detection. Ann Rev Anal Chem 2014;7:455-82.
3. Papineni RS, Rosenthal FS. The size distribution of droplets in the exhaled breath of healthy human subjects. J Aerosol Med 1997;10:105-16.
4. Schwartz K, Biller H, Windt H, Koch W, Hohlfeld JM. Characterization of exhaled particles from the healthy human lung-a systematic analysis in relation to pulmonary function variables. J Aerosol Med Pulm Drug Deliv 2010;23:371-9.
5. Kuban P, Foret F. Exhaled breath condensate: determination of non-volatile compounds and their potential for clinical diagnosis and monitoring. Anal Chim Acta 2013;805:1-18.
6. Sofia M, Maniscalco M, de Laurentiis G, Paris D, Melck D, Motta A. Exploring ayrway diseases by NMR-based metabolomics: a review of applications to exhaled breath condensate. J Biomed Biotechnol 2011;2011:403260.
7. Almstrand AC, Bake B, Ljungström E, Larsson P, Bredberg A, Mirgorodskaya E, Olin AC. Effect of airway opening on production of exhaled particles. J Appl Physiol 2010;108:584-8.
8. Holmgren H, Gerth E, Ljungström E, Larsson P, Almstrand AC, Bake B, et al. Effects of breath holding at low and high lung volumes on amount of exhaled particles. Respir Physiol Neurobiol 2013;185:228-34.
9. Holmgren H, Ljungström E, Almstrand A-C, Bake B, Olin A-C. Size distribution of exhaled particles in the range from 0.01 to 2.0 μm. J Aerosol Science 2010;41:439-46.
10. Almstrand AC, Ljungstrom E, Lausmaa J, Bake B, Sjovall, Olin AC. Airway monitoring by collection and mass spectrometric analysis of exhaled particles. Anal Chem 2009;81:662-8.
11. Bredberg A, Gobom J, Almstrand A-C, Larsson P, Blennow K, Olin A-C, et al. Exhaled endogenous particles contain lung proteins. Clin Chem 2012;58:431-40.
12. Beck O, Leine K, Palmskog G, Franck J. Amphetamines detected in exhaled breath from drug addicts: a new possible method for drugs-of-abuse testing, J Anal Toxicol 2010;34:233-7.
13. Beck O, Stephanson N, Sandqvist S, Franck J. Detection of drugs of abuse in exhaled breath using a device for rapid collection: comparison with plasma, urine and self-reporting in 47 drug users. J Breath Res 2013;7:026006.
14. Griese M. Pulmonary surfactant in health and human lung diseases: state of the art. Eur Respir J 1999;13:1455-76.
15. van den Berge M, ten Hacken NH, van der Wiel E, Postma DS. Treatment of the bronchial tree from beginning to end: targeting small airway inflammation in asthma. Allergy 2013;68:16-26.
16. Manolis A, McBurney L. J, Bobbie BA. The detection of delta 9-tetrahydrocannabinol in the breath of human subjects. Clin Biochem 1983;16:229-33.
17. Beck O, Sandqvist S, Eriksen P, Franck J, Palmskog G. Method for determination of methadone in exhaled breath collected from subjects undergoing methadone maintenance treatment. J Chromatog B 2010;878:2255-9.
18. Beck O, Sandqvist S, Dubbelboer I, Franck J. Detection of Δ9-tetrahydrocannabinol in exhaled breath collected from cannabis users. J Anal Toxicol 2011;35:541-4.
19. Beck O, Sandqvist S, Franck J. Demonstration that methadone is being present in the exhaled breath aerosol fraction. J Pharm Biomed Anal 2011;56:1024-8.
20. Yang S, Lee WMG, Huang HL, Huang YC, Luo CH, Wu CC, et al. Aerosol penetration properties of an electret filter with submicron aerosols with various operating factors. J Environ Sci Health 2007;42:51-7.
21. Himes SK, Scheidweiler KB, Beck O, Gorelick DA, Desrosiers NA, Huestis MA. Cannabinoids in exhaled breath following controlled administration of smoked cannabis. Clin Chem 2013;59:1780-9.
22. Skoglund C, Hermansson U, Beck O. Clinical trial of a new technique for drugs of abuse testing: a new possible sampling technique. J Subst Abuse Treat 2015;48:132-6.
23. Helander A, Ullah S, Beck O. Phosphatidylethanols in breath: a possible noninvasive screening test for heavy alcohol consumption. Clin Chem 2015;61:991-3.
24. Berchtold C, Bosilkovska M, Daali Y, Walder B, Zenobi R. Real-time monitoring of exhaled drugs by mass spectrometry. Mass Spectrom Rev 2014;33:394-413.
25. Esther CR Jr. Boucher RC, Johnson MR, Ansede JH, Donn KH, O'Riordan TG, et al. Airway drug pharmacokinetics via analysis of exhaled breath condensate. Pulm Pharmacol Ther 2014;27:76-82.
26. Munoz X, Bustamante V, Lopez-Campos J. L, Cruz MJ, Barreiro E. Usefulness of noninvasive methods for the study of bronchial inflammation in the control of patients with asthma. Int Arch Allergy Immunol 2015;166:1-12.
27. Larsson P, Mirgorodskaya E, Samuelsson L, Bake B, Almstrand AC, Bredberg A, Olin AC. Surfactant protein A and albumin in particles in exhaled air. Respir Med 2012;106:197-204.
28. Eriksson P, Almstrand AC, Mirgorodskaya E, Lärstad M, Viklund E, Riise GC, et al. Surfactant protein A in exhaled particles is decreased in lung transplant patients with chronic rejection. Am J Respir Crit Care Med 2015;191:A6138.
29. Larstad M, Larsson S, Bake B, Olin AC. Exhaled particles from small airways in COPD patients-a pilot study. Eur Respir J 2014;44:P397.
30. Bloemen K, van den Heuvel R, Govarts E, Hooyberghs J, Nelen V, Witters E, et al. A new approach to study exhaled proteins as potential biomarkers for asthma. Clin Exp Allergy 2011;41:346-56.
31. Kurova VS, Anaev EC, Kononikhin AS, Fedorchenko KY, Popov IA, Kalupov TL, et al. Proteomics of exhaled breath: methodological nuances and pitfalls. Clin Chem Lab Med 2009;47:706-12.
32. Fumagalli M, Ferrari F, Luisetti M, Stolk J, Hiemstra PS, Capuano D, et al. Profiling the proteome of exhaled breath condensate in healthy smokers and COPD patients by LC-MS/MS. Int J Mol Sci 2012;13:13894-910.
33. Muccilli V, Saletti R, Cunsolo V, Ho J, Gili E, Conte E, et al. Protein profile of exhaled breath condensate determined by high resolution mass spectrometry. J Pharm Biomed Anal 2015;105:134-49.
34. Rosa MJ, Yan B, Chillrud SN, Acosta LM, Divjan A, Jacobson JS, et al. Domestic airborne black carbon levels and 8-isoprostane in exhaled breath condensate among children in New York City. Environ Res 2014;135:105-10.
35. Agassandian M, Mallampalli RK. Surfactant phosholipid metabolism. Biochim Biophys Acta 2013;1831:612-25.
36. Almstrand AC, Josefson M, Bredberg A, Lausmaa J, Sjövall P, Larsson P, et al. TOF-SIMS analysis of exhaled particles from patients with asthma and healthy controls. Europ Resp J 2012;39:59-66.
37. Ross PL, Huang YN, Marchese JN, Williamson B, Parker K, Hattan S, et al. Multiplexed protein quantitation in Saccharomyces cerevisiae using amine-reactive isobaric tagging reagents. Mol Cell Proteomics 2004;3:1154-69.
38. Thompson A, Schäfer J, Kuhn K, Kienle S, Schwarz J, Schmidt G, et al. Tandem mass tags: a novel quantification strategy for comparative analysis of complex protein mixtures by MS/MS. Anal Chem 2003;75:1895-904.
39. Kiyonami R, Domon B. Selected reaction monitoring applied to quantitative proteomics. Methods Mol Biol 2010;658:155-66.
40. Picotti P, Aebersold R. Selected reaction monitoringbased proteomics: workflows, potential, pitfalls and future directions. Nature methods 2012;9:555-66.
41. Ng KM, Tang HW, Man SH, Mak PY, Choi YC, Wong MYM. Direct analysis of large living organism by megavolt electrostatic ionization mass spectrometry. J Am Soc Mass Spectrom 2014;25:1515-20.