Demonstration that methadone is being present in the exhaled breath aerosol fraction

Journal of Pharmaceutical and Biomedical Analysis

Volumn 56, Issue 5, 2011, Pages 1024-1028

  Beck, Olof ^a   Sandqvist, Sören ^a   Franck, Johan ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Abused drug testing; Bioaerosol; Exhaled breath; Liquid chromatography mass spectrometry; Methadone

Indexed keywords

2 PROPANOL; GLASS FIBER; METHADONE; METHANOL; POLYMER; SILICON DIOXIDE;

ADULT; AEROSOL; ARTICLE; DRUG ISOLATION; EXHALATION; FEMALE; HUMAN; LIMIT OF QUANTITATION; LIQUID CHROMATOGRAPHY; MAINTENANCE THERAPY; MALE; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY;

AEROSOLS; BREATH TESTS; CHROMATOGRAPHY, LIQUID; HUMANS; METHADONE; NARCOTICS; TANDEM MASS SPECTROMETRY;

EID: 80052784674     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2011.08.004     Document Type: Article

References (21)

1. Beck O., Leine K., Palmskog G., Franck J. Amphetamines detected in exhaled breath from drug addicts: a new possible method for drugs-of-abuse testing. J. Anal. Toxicol. 2010, 34:233-237.
2. Beck O., Sandqvist S., Eriksen P., Franck J., Palmskog G. Method for determination of methadone in exhaled breath collected from subjects undergoing methadone maintenance treatment. J. Chromatogr. B 2010, 878:2255-2259.
3. Beck O., Sandqvist S., Eriksen P., Franck J., Palmskog G. Determination of methadone in exhaled breath condensate by liquid chromatography-tandem mass spectrometry. J. Anal. Toxicol. 2011, 35:129-133.
4. Beck O., Sandqvist S., Böttcher M., Eriksen P., Franck J., Palmskog G. Study on the sampling of methadone from exhaled breath. J. Anal. Toxicol. 2011, 35:257-263.
5. O. Beck, S. Sandqvist, I. Dubbelboer, J. Franck, Detection of THC in exhaled breath collected from cannabis users, J. Anal. Toxicol., in press.
6. Almstrand A.C., Ljungström E., Lausmaa J., Bake B., Sjövall P., Olin A.C. Airway monitoring by collection and mass spectrometric analysis of exhaled particles. Anal Chem. 2009, 81:662-668.
7. Almstrand A.C., Bake B., Ljungström E., Larsson P., Bredberg A., Mirgorodskaya E., Olin A.C. Effect of airway opening on productoin of exhaled particles. J. Appl. Physiol. 2010, 108:584-588.
8. Miekisch W., Schubert J.K. From highly sophisticated analytical techniques to life-saving diagnostics: technical developments in breath analysis. Trends Anal. Chem. 2005, 25:665-673.
9. Montuschi P. Analysis of exhaled breath condensate in respiratory medicine: methodological aspects and potential clinical applications. Ther. Adv. Respir. Dis. 2007, 1:5-23.
10. Buszewski B., Kesy M., Ligor T., Amann A. Human exhaled air analytics: biomarkers of disease. Biomed. Chromatogr. 2007, 21:553-566.
11. Montuschi P., Ragazzoni E., Valente S., Corbo G., Mondino C., Ciappi G., Ciabattoni G. Validation of 8-isoprostane and prostaglandin E2 measurements in exhaled breath condensate. Inflamm. Res. 2003, 52:502-507.
12. Montuschi P., Ragazzoni E., Valente S., Corbo G., Mondino C., Ciappi G., Barnes P.J., Ciabattoni G. Validation of leukotriene B4 measurements in exhaled breath condensate. Inflamm. Res. 2003, 52:69-73.
13. Montuschi P., Martello S., Felli M., Mondino C., Barnes P.J., Chiarotti M. Liquid chromatography/mass spectrometry analysis of exhaled leukotriene B4 in asthmatic children. Respir. Res. 2005, 6:119.
14. Montuschi P., Martello S., Felli M., Mondino C., Chiarotti M. Ion trap liquid chromatography/tandem mass spectrometry analysis of leukotriene B4 in exhaled breath condensate. Rapid Commun. Mass Spectrom. 2004, 18:2723-2729.
15. Montuschi P. LC/MS/MS analysis of leukotriene B4 and other eicosanoids in exhaled breath condensate for assessing lung inflammation. J. Chromatogr. B 2009, 877:1272-1280.
16. Carpenter C.T., Price P.V., Christman B.W. Exhaled breath condensate isoprostanes are elevated in patients with acute lung injury or ARDS. Chest 1998, 114:1653-1659.
17. Papineni R.S., Rosenthal F.S. The size and distribution of droplets in the exhaled breath of healthy subjects. J. Aerosol Med. 1997, 10:105-116.
18. Srikanth P., Sudharsanam S., Steinberg R. Bio-aerosols in indoor environment: composition, health effects and analysis. Indian J. Med. Microbiol. 2008, 26:302-312.
19. Efflein L., Berger-Preiss E., Levsen K., Wunsch G. Development of a gas chromatography-mass spectrometry method for the determination of household insecticides in indoor air. J. Chromatogr. A 2003, 985:147-157.
20. Yoshida T., Matsunaga I., Oda H. Simultaneous determination of semivolatile organic compounds in indoor air by gas chromatography-mass spectrometry after solid-phase extraction. J. Chromatogr. A 2004, 1032:255-269.
21. Barrett L.W., Rousseau A.D. Aerosol loading performance of electret filter media. Am. Ind. Hyg. Assoc. 1998, 59:532-539.