Human exhaled breath analysis

Annals of Allergy, Asthma and Immunology

Volumn 106, Issue 6, 2011, Pages 451-456

  Popov, Todor A ^a  

^a MEDICAL UNIVERSITY OF SOFIA   (Bulgaria)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE; ARACHIDONIC ACID; BIOLOGICAL MARKER; CARBON MONOXIDE; CYTOKINE; NITRIC OXIDE; VOLATILE ORGANIC COMPOUND;

ASTHMA; BODY TEMPERATURE; BREATH ANALYSIS; EXHALATION; EXHALED BREATH ANALYSIS; GAS ANALYSIS; HUMAN; METABOLOMICS; NANOSENSOR; NONHUMAN; OXIDATIVE STRESS; PHENOTYPE; PRIORITY JOURNAL; RESPIRATORY TRACT INFLAMMATION; REVIEW; SMOKING; STANDARDIZATION; TEMPERATURE MEASUREMENT;

BIOLOGICAL MARKERS; BREATH TESTS; EXHALATION; HUMANS; INFLAMMATION; LUNG; LUNG DISEASES; RESPIRATORY SYSTEM;

EID: 79957882314     PISSN: 10811206     EISSN: 15344436     Source Type: Journal    
DOI: 10.1016/j.anai.2011.02.016     Document Type: Review

References (64)

1. Davis CE, Frank M, Mizaikoff B, Oser H. The future of sensors and instrumentation for human breath analysis. IEEE Sensors J. 2010;10: 3-6.
2. Pauling L, Robinson AB, Teranishi R, Cary P. Quantitative analysis of urine vapor and breath by gas-liquid partition chromatography. Proc Natl Acad Sci U S A. 1971;68:2374-2376.
3. Davis CE, Bogan MJ, Sankaran S, et al. Analysis of volatile and non-volatile biomarkers in human breath using differential mobility spectrometry (DMS). IEEE Sensors J. 2010;10:114-123.
4. WHO/NHLBI Workshop Report. Global Strategy for Asthma Management and Prevention. Bethesda, MD: National Institutes of Health, National Heart, Lung, and Blood Institute; 1995. Publication 95-3659.
5. Davies DE, Wicks J, Powell RM, Puddicombe SM, Holgate ST. Airway remodeling in asthma: new insights. J Allergy Clin Immunol. 2003;111: 215-225.
6. Popov TA, Gottschalk R, Kolendowicz R, Dolovich J, Powers P, Hargreave FE. The evaluation of a cell dispersion method of sputum examination. Clin Exp Allergy. 1994; 24: 778-783. (Pubitemid 24265178)
7. Popov TA, Pizzichini MMM, Pizzichini E, et al. Some technical factors influencing the induction of sputum for cell analysis. Eur Respir J. 1995;8:559-565.
8. Hök B, Pettersson H, Andersson AK, Haasl S, Åkerlund P. Breath analyzer for alcolocks and screening devices. IEEE Sensors J. 2010;10: 10-15.
9. Gouma P, Kalyanasundaram K, Yun X, Stanacevic M, Wang L. Nanosensor and breath analyzer for ammonia detection in exhaled human breath. IEEE Sensors J. 2010;10:49-53.
10. Saraoglu HM, Koçan M. Determination of blood glucose level-based breath analysis by a quartz crystal microbalance sensor array. IEEE Sensors J. 2010;10:104-109.
11. Gustafsson LE, Leone AM, Persson MG, Wiklund NP, Moncada S. Endogenous nitric oxide is present in the exhaled air of rabbits, Guiney pigs, and humans. Biochem Biophys Res Commun. 1991;181:852-857.
12. Alving K, Weitzberg E, Lundberg JM. Increased amount of nitric oxide in exhaled air of asthmatics. Eur Respir J. 1993;9:1368-1370. (Pubitemid 23329557)
13. Eiserich JP, Patel RP, O'Donnell VB. Pathophysiology of nitric oxide and related species: free radical reactions and modification of biomolecules. Mol Aspects Med. 1998;19:221-357. (Pubitemid 29184931)
14. Alving K, Malinovschi A. Basic aspects of exhaled nitric oxide: exhaled biomarkers. Eur Respir Monograph. 2010;49:1-31.
15. Covar RA, Szefler SJ, Martin RJ, et al. Relations between exhaled nitric oxide and measures of disease activity among children with mild-to-moderate asthma. J Pediatr. 2003;142:469-475. (Pubitemid 36623553)
16. Kovesi T, Kulka R, Dales R. Exhaled nitric oxide concentration is affected by age, height, and race in healthy 9-to 12-year-old children. Chest. 2008;133:169-175.
17. Dressel H, de la Motte D, Reichert J, et al. Exhaled nitric oxide: independent effects of atopy, smoking, respiratory tract infection, gender and height. Respir Med. 2008;102:962-969.
18. Komakula S, Khatri S, Mermis J, et al. Body mass index is associated with reduced exhaled nitric oxide and higher exhaled 8-isoprostanes in asthmatics. Respir Res. 2007;8:32-41.
19. Kharitonov S, Alving K, Barnes PJ; The European Respiratory Society Task Force. Exhaled and nasal nitric oxide measurements: recommendations. Eur Respir J. 1997;10:1683-1693. (Pubitemid 27311092)
20. ATS/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide, 2005. Am J Respir Crit Care Med. 2005;171:912-930.
21. Kharitonov SA, Barnes PJ. Exhaled biomarkers. Chest. 2006;130: 1541-1546. (Pubitemid 44786751)
22. Murugan A, Prys-Picard C, Calhoun WJ. Biomarkers in asthma. Curr Opinion Pulm Med. 2009;15:12-18.
23. Smith AD, Cowan JO, Filsell S, et al. Diagnosing asthma: comparisons between exhaled nitric oxide measurements and conventional tests. Am J Respir Crit Care Med. 2004;169:473-478. (Pubitemid 38187119)
24. Pijnenburg MW, Hofhuis W, Hop WC, De Jongste JC. Exhaled nitric oxide predicts asthma relapse in children with clinical asthma remission. Thorax. 2005;60:215-218. (Pubitemid 40380280)
25. Harkins MS, Fiato KL, Iwamoto GK. Exhaled nitric oxide predicts asthma exacerbation. J Asthma. 2004;41:471-476. (Pubitemid 38955405)
26. Pijnenburg MW, Bakker EM, Hop WC, De Jongste JC. Titrating steroids on exhaled nitric oxide in children with asthma: a randomized controlled trial. Am J Respir Crit Care Med. 2005;172:831-836. (Pubitemid 41369065)
27. Taylor DR. Nitric oxide as a clinical guide for asthma management. J Allergy Clin Immunol. 2006;117:259-262. (Pubitemid 43190136)
28. Szefler SJ, Mitchell H, Sorkness CA, , et al. Management of asthma based on exhaled nitric oxide in addition to guideline-based treatment for inner-city adolescents and young adults: a randomised controlled trial. Lancet. 2008;372:1065-1072.
29. Baraldi E, Carraro S. Exhaled NO and breath condensate. Paediatr Respir Rev. 2006;7(suppl 1):S20-S22.
30. Gogate S, Katial R. Pediatric biomarkers in asthma: eosinophils and leukotriene. Curr Opin Allergy Clin Immunol. 2008;8:154-157.
31. Oetsky HL, Cates CJ, Li A, et al. Tailored interventions based on exhaled nitric oxide versus clinical symptoms for asthma in children and adults. Cochrane Database Syst Rev. 2009;4:CD006340.
32. Horvath I, Donnelly LE, Kiss A, Paredi P, Kharitonov SA, Barnes PJ. Raised levels of exhaled carbon monoxide are associated with an increased expression of heme oxygenase-1 in airway macrophages in asthma: a new marker of oxidative stress. Thorax. 1998;53:668-672. (Pubitemid 28378481)
33. Ryter SW, Choi AM. Heme oxygenase-1/carbonmonoxide: from metabolism to molecular therapy. Am J Respir Cell Mol Biol. 2009;41: 251-260.
34. Dolinay T, Choi AM, Ryter SW. Exhaled carbon monoxide: mechanisms and clinical applications. Exhaled Biomarkers. Eur Respir Monograph. 2010;49:82-93.
35. Zhang J, Yao X, Yu R, et al. Exhaled carbon monoxide in asthmatics: a meta-analysis. Respir Res. 2010;11:50.
36. Pearson P, Lewis S, Britton J, Fogarty A. Exhaled carbon monoxide levels in atopic asthma: a longitudinal study. Respir Med. 2005;99: 1292-1296.
37. Hunt J. Exhaled breath condensate: an evolving tool for noninvasive evaluation of lung disease. J Allergy Clin Immunol. 2002;110:28-34. (Pubitemid 36132721)
38. Effros RM. Exhaled breath condensate: delusion or dilution? Chest. 2010;138:471-472.
39. Baraldi E, Ghiro L, Piovan V, Carraro S, Zacchello F, Zanconato S. Safety and success of exhaled breath condensate collection in asthma. Arch Dis Child. 2003;88:358-360. (Pubitemid 36398984)
40. Moeller A, Franklin P, Hall G, Horak F Jr, Wildhaber J, Stick S. Measuring exhaled breath condensates in infants. Pediatr Pulmonol. 2006;41:184-187. (Pubitemid 43165449)
41. Kullmann T, Barta I, Antus B, Valyon M, Horváth I. Environmental temperature and relative humidity influence exhaled breath condensate pH. Eur Respir J. 2008;31:474-475.
42. Czebe K, Barta I, Antus B, Valyon M, Horváth I, Kullmann T. Influence of condensing equipment and temperature on exhaled breath condensate pH, total protein and leukotriene concentrations. Respir Med. 2008;102: 720-725.
43. Nording ML, Yang J, Hegedus CM, et al. Endogenous levels of five fatty acid metabolites in exhaled breath condensate to monitor asthma by high-performance liquid chromatography: electrospray tandem mass spectrometry. IEEE Sensors J. 2010;10:123-130.
44. ATS/ERS Task Force on Exhaled Breath Condensate. Exhaled breath condensate: methodological recommendations and unresolved questions. Eur Respir J. 2005;26:523-548.
45. Horvath I, de Jongste JC. Exhaled biomarkers. Eur Respir Monograph. 2010;49:152-230.
46. Lázár Z, Cervenak L, Orosz M, et al. Adenosine triphosphate concentration of exhaled breath condensate in asthma. Chest. 2010;138: 536-542.
47. Paredi P, Kharitonov SA, Barnes PJ. Faster rise of EBT in asthma: a novel marker of airway inflammation? Am J Respir Crit Care Med. 2002;165:181-184. (Pubitemid 34084454)
48. Piacentini GL, Bodini A, Zerman L, et al. Relationship between exhaled air temperature and exhaled nitric oxide in childhood asthma. Eur Respir J. 2002;20:108-111. (Pubitemid 34822930)
49. Popov TA, Kralimarkova TZ, Tzachev CT, Dunev S, Dimitrov VD, Gill J. Development of an individual device for exhaled breath temperature measurement. IEEE Sensors J. 2010;10:110-113.
50. Paredi P, Kharitonov SA, Barnes PJ. Correlation of exhaled breath temperature with bronchial blood flow in asthma. Respir Res. 2005;6: 1-10.
51. Piacentini G, Peroni D, Crestani E, et al. Exhaled air temperature in asthma: methods and relationship with markers of disease. Clin Exp Allergy. 2007;37:415-419. (Pubitemid 46393242)
52. Popov TA, Dunev SS, Kralimarkova TK, Kraeva S, DuBuske LM. Evaluation of a simple, potentially individual device for exhaled breath temperature measurement. Respir Med. 2007;101:2044-2050. (Pubitemid 47324258)
53. Popov TA, Kralimarkova TZ, Lazarova C, Tzachev CT, Dimitrov VD. Daily monitoring of asthmatics by means of individual devices for exhaled breath. IEEE Sensors J. 2010;10:44-48.
54. Popov TA, Kralimarkova TZ, Tzachev CT, Dimitrov VD, Mun KK, Gill J. Exhaled breath temperature measurement made easy. Pediatr Allergy Immunol. 2009;20:200-201.
55. Lewis NS. Comparison of mammalian and artificial olfaction based on arrays of carbon black-polymer composite vapor detectors. Acc Chem Res. 2004;37:663-672.
56. Thaler ER, Hanson CW. Medical applications of electronic nose technology. Expert Rev Med Devices. 2005;2:559-566. (Pubitemid 41447653)
57. Dragonieri S, Schot R, Mertens BJ, et al. An electronic nose in the discrimination of patients with asthma and controls. J Allergy Clin Immunol. 2007;120:856-862. (Pubitemid 47542280)
58. Fens N, Zwinderman AH, van der Schee MP, et al. Exhaled breath profiling enables discrimination of chronic obstructive pulmonary disease and asthma. Am J Respir Crit Care Med. 2009;180:1076-1082.
59. Johnson ATC, Khamis SM, Preti G, Kwak J, Gelperin A. DNA-coated nanosensors for breath analysis. IEEE Sensors J. 2010;10:159-166.
60. Nicholson JK, Lindon JC, Holmes E. "Metabonomics": understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data. Xenobiotica. 1999;11:1181-1189.
61. Carraro S, Rezzi S, Reniero F, et al. Metabolomics applied to exhaled breath condensate in childhood asthma. Am J Respir Crit Care Med. 2007;175:986-990. (Pubitemid 46741749)
62. Laenzel SE. Asthma: defining of the persistent adult phenotypes. Lancet. 2006;368:804-811.
63. Global Initiative for Asthma. GINA report: global strategy for asthma. www.ginasthma.com. Accessed March 17, 2011.
64. Bossuit PM, Reitsma JB, Bruns DE, et al. The STARD statement for reporting studies of diagnostic accuracy: explanation and elaboration. Ann Intern Med. 2003;138:W1-W12.