Exhaled endogenous particles contain lung proteins

Clinical Chemistry

Volumn 58, Issue 2, 2012, Pages 431-440

  Bredberg, Anna ^a   Gobom, Johan ^a   Almstrand, Ann Charlotte ^a   Larsson, Per ^a   Blennow, Kaj ^a   Olin, Anna Carin ^a   Mirgorodskaya, Ekaterina ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; ALPHA 2 MACROGLOBULIN; ANTITHROMBIN III; APOLIPOPROTEIN A1; APOLIPOPROTEIN E; ARGINASE 1; BETA 2 MICROGLOBULIN; BLEOMYCIN HYDROLASE; CALMODULIN DERIVATIVE; CATHEPSIN D; CERULOPLASMIN; CLARA CELL PROTEIN; CLUSTERIN; COFILIN 1; COMPLEMENT COMPONENT C1Q; COMPLEMENT COMPONENT C2; COMPLEMENT COMPONENT C3; COMPLEMENT COMPONENT C4A; COMPLEMENT COMPONENT C4B; CORNIFIN; CYSTATIN S; DESMOGLEIN 1; GLYCEROPHOSPHOINOSITOL INOSITOLPHOSPHODIESTERASE; LIPOCORTIN 1; LIPOCORTIN 2; OROSOMUCOID; PNEUMOPROTEIN; PROTEIN; PROTEIN 14 3 3; STRATIFIN; UNCLASSIFIED DRUG;

ADULT; AIRBORNE PARTICLE; ARTICLE; EXPIRED AIR; FEMALE; HUMAN; LIQUID CHROMATOGRAPHY; LUNG FLUID; LUNG LAVAGE; MALE; MASS SPECTROMETRY; NORMAL HUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN ANALYSIS; PROTEOMICS; RESPIRATORY SYSTEM; RESPIRATORY TRACT LINING FLUID;

ADULT; BREATH TESTS; CYTOPLASM; EXHALATION; EXTRACELLULAR SPACE; FEMALE; HUMANS; LUNG; MALE; MEMBRANE PROTEINS; MIDDLE AGED; PROTEINS; PROTEOMICS;

EID: 84856368675     PISSN: 00099147     EISSN: 15308561     Source Type: Journal    
DOI: 10.1373/clinchem.2011.169235     Document Type: Article

References (40)

1. Fiegel J, Clarke R, Edwards DA. Airborne infectious disease and the suppression of pulmonary bioaerosols. Drug Discov Today 2006;11:51-7. (Pubitemid 43227852)
2. Jarjour NN, Enhorning G. Antigen-induced airway inflammation in atopic subjects generates dysfunction of pulmonary surfactant. Am J Respir Crit Care Med 1999;160:336-41. (Pubitemid 29326109)
3. Goerke J. Lung surfactant. Biochim Biophys Acta 1974;344:241- 61.
4. Nishioka T, Uchida K, Meno K, Ishii T, Aoki T, Imada Y, et al. Alpha-1-antitrypsin and complement component C7 are involved in asthma exacerbation. Proteomics Clin Appl 2008;2:46 -54.
5. Plymoth A, Yang Z, Lofdahl CG, Ekberg-Jansson A, Dahlback M, Fehniger TE, et al. Rapid proteome analysis of bronchoalveolar lavage samples of lifelong smokers and never-smokers by micro-scale liquid chromatography and mass spectrometry. Clin Chem 2006;52:671-9.
6. Wu J, Kobayashi M, Sousa EA, Liu W, Cai J, Goldman SJ, et al. Differential proteomic analysis of bronchoalveolar lavage fluid in asthmatics following segmental antigen challenge. Mol Cell Proteomics 2005;4:1251- 64.
7. Jackson AS, Sandrini A, Campbell C, Chow S, Thomas PS, Yates DH. Comparison of biomarkers in exhaled breath condensate and bronchoalveolar lavage. Am J Respir Crit Care Med 2007;175: 222-7. (Pubitemid 46203124)
8. Horvath I, Hunt J, Barnes PJ, Alving K, Antczak A, Baraldi E, et al. Exhaled breath condensate: methodological recommendations and unresolved questions. Eur Respir J 2005;26:523- 48.
9. Rosias PP, Dompeling E, Hendriks HJ, Heijnens JW, Donckerwolcke RA, Jöbsis Q. Exhaled breath condensate in children: pearls and pitfalls. Pediatr Allergy Immunol 2004;15:4 -19.
10. Almstrand AC, Ljungstrom E, Lausmaa J, Bake B, Sjovall P, Olin AC. Airway monitoring by collection and mass spectrometric analysis of exhaled particles. Anal Chem 2009;81:662- 8.
11. Almstrand AC, Bake B, Ljungstrom E, Larsson P, Bredberg A, Mirgorodskaya E, et al. Effect of airway opening on production of exhaled particles. J Appl Physiol 2010;108:584-8.
12. Ishihama Y, Rappsilber J, Andersen JS, Mann M. Microcolumns with self-assembled particle frits for proteomics. J Chromatogr A 2002;979:233-9. (Pubitemid 35341547)
13. Miller I, Eberini I, Gianazza E. Proteomics of lung physiopathology. Proteomics 2008;8:5053-73.
14. Ishihama Y, Oda Y, Tabata T, Sato T, Nagasu T, Rappsilber J, et al. Exponentially modified protein abundance index (emPAI) for estimation of absolute protein amount in proteomics by the number of sequenced peptides per protein. Mol Cell Proteomics 2005;4:1265-72. (Pubitemid 41448714)
15. Conrad D, Goyette J, Thomas P. Proteomics as a method for early detection of cancer: a review of proteomics, exhaled breath condensate, and lung cancer screening. J Gen Intern Med 2008;23:78- 84.
16. Hunt J. Exhaled breath condensate: an overview. Immunol Allergy Clin North Am 2007;27:587-96. (Pubitemid 350051335)
17. Effros RM, Peterson B, Casaburi R, Su J, Dunning M, Torday J, et al. Epithelial lining fluid solute concentrations in chronic obstructive lung disease patients and normal subjects. J Appl Physiol 2005;99:1286 -92.
18. Vitorino R, Lobo MJC, Ferrer-Correira AJ, Dubin JR, Tomer KB, Domingues PM, et al. Identification of human whole saliva protein components using proteomics. Proteomics 2004;4:1109 -15.
19. Rifai N, Gillette MA, Carr SA. Protein biomarker discovery and validation: the long and uncertain path to clinical utility. Nat Biotechnol 2006;24: 971-83. (Pubitemid 44215392)
20. Larsson P, Mirgorodskaya E, Samuelsson L, Bake B, Almstrand A-C, Bredberg A, et al. Surfactant protein A and albumin in particles in exhaled air. Respir Med 2012;106:197-204.
21. 2- macroglobulin and increases its innate immune potential. J Biol Chem 2010;285:13461-70.
22. Wang P, Chintagari NR, Narayanaperumal J, Ayalew S, Hartson S, Liu L. Proteomic analysis of lamellar bodies isolated from rat lungs. BMC Cell Biol 2008;9:34.
23. Singh TK, Abonyo B, Narasaraju TA, Liu L. Reorganization of cytoskeleton during surfactant secretion in lung type II cells: a role of annexin II. Cell Signal 2004;16:63-70. (Pubitemid 37357192)
24. Kim TH, Lee YH, Kim KH, Lee SH, Cha JY, Shin EK, et al. Role of lung apolipoprotein A-I in idiopathic pulmonary fibrosis: antiinflammatory and antifibrotic effect on experimental lung injury and fibrosis. Am J Respir Crit Care Med 2010;182: 633-42.
25. Yao X, Fredriksson K, Yu ZX, Xu X, Raghavachari N, Keeran KJ, et al. Apolipoprotein E negatively regulates house dust mite-induced asthma via a low-density lipoprotein receptor-mediated pathway. Am J Respir Crit Care Med 2010;182:1228- 38.
26. Carnevali S, Luppi F, D'Arca D, Caporali A, Ruggieri MP, Vettori MV, et al. Clusterin decreases oxidative stress in lung fibroblasts exposed to cigarette smoke. Am J Respir Crit Care Med 2006; 174:393-9. (Pubitemid 44223119)
27. Vasavda N, Eichholtz T, Takahashi A, Affleck K, Matthews JG, Barnes PJ, et al. Expression of nonmuscle cofilin-1 and steroid responsiveness in severe asthma. J Allergy Clin Immunol 2006;118: 1090-6. (Pubitemid 44666984)
28. Bolger MS, Ross DS, Jiang H, Frank MM, Ghio AJ, Schwartz DA, et al. Complement levels and activity in the normal and LPS-injured lung. Am J Physiol Lung Cell Mol Physiol 2007;292:L748 -59.
29. Shum BO, Mackay CR, Gorgun CZ, Frost MJ, Kumar RK, Hotamisligil GS, et al. The adipocyte fatty acid-binding protein aP2 is required in allergic airway inflammation. J Clin Invest 2006; 116:2183-92. (Pubitemid 44162327)
30. Tokunaga K, Nakamura Y, Sakata K, Fujimori K, Ohkubo M, Sawada K, et al. Enhanced expression of a glyceraldehyde-3-phosphate dehydrogenase gene in human lung cancers. Cancer Res 1987; 47:5616 -9.
31. Rottoli P, Magi B, Cianti R, Bargagli E, Vagaggini C, Nikiforakis N, et al. Carbonylated proteins in bronchoalveolar lavage of patients with sarcoidosis, pulmonary fibrosis associated with systemic sclerosis and idiopathic pulmonary fibrosis. Proteomics 2005;5:2612- 8.
32. Beck-Schimmer B, Madjdpour C, Kneller S, Ziegler U, Pasch T, Wuthrich RP, et al. Role of alveolar epithelial ICAM-1 in lipopolysaccharide-induced lung inflammation. Eur Respir J 2002;19:1142- 50.
33. Adair JE, Stober V, Sobhany M, Zhuo L, Roberts JD, Negishi M, et al. Inter-alpha-trypsin inhibitor promotes bronchial epithelial repair after injury through vitronectin binding. J Biol Chem 2009; 284:16922-30.
34. 1- antichymotrypsin allele associated with familial obstructive lung disease. Genomics 1993;17:740 -3.
35. Maniatis NA, Harokopos V, Thanassopoulou A, Oikonomou N, Mersinias V, Witke W, et al. A critical role for gelsolin in ventilator-induced lung injury. Am J Respir Cell Mol Biol 2009;41:426- 32.
36. Chishimba L, Thickett DR, Stockley RA, Wood AM. The vitamin D axis in the lung: a key role for vitamin D-binding protein. Thorax 2010;65:456- 62.
37. Rogan MP, Geraghty P, Greene CM, O'Neill SJ, Taggart CC, McElvaney NG. Antimicrobial proteins and polypeptides in pulmonary innate defence. Respir Res 2006;7:29.
38. Beharka AA, Gaynor CD, Kang BK, Voelker DR, McCormack FX, Schlesinger LS. Pulmonary surfactant protein A up-regulates activity of the mannose receptor, a pattern recognition receptor expressed on human macrophages. J Immunol 2002;169:3565-73.
39. Eagan TM, Damas JK, Ueland T, Voll-Aanerud M, Mollnes TE, Hardie JA, et al. Neutrophil gelatinase-associated lipocalin: a biomarker in COPD. Chest 2010;138:888 -95.
40. Chen Y, Chang L, Li W, Rong Z, Liu W, Shan R, et al. Thioredoxin protects fetal type II epithelial cells from hyperoxia-induced injury. Pediatr Pulmonol 2010;45:1192-200.