Measurement of brain microglial proliferation rates in vivo in response to neuroinflammatory stimuli: Application to drug discovery

Journal of Neuroscience Research

Volumn 85, Issue 11, 2007, Pages 2374-2384

  Shankaran, Mahalakshmi ^a   Marino, Michael E ^a,d   Busch, Robert ^a,e   Keim, Carole ^a   King, Chelsea ^a   Lee, Jean ^a   Killion, Salena ^a   Awada, Mohamad ^a   Hellerstein, Marc K ^b,c  

^a KINEMED INC   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d GE GLOBAL RESEARCH   (United States)

^e UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

EAE; LPS; Microglia; Neuroinflammation; Proliferation

Indexed keywords

ACETYLSALICYLIC ACID; ATORVASTATIN; BACTERIUM LIPOPOLYSACCHARIDE; CALCITRIOL; CD11 ANTIGEN; CD45 ANTIGEN; CLOFIBRATE; ENALAPRIL MALEATE; ETIOCHOLANEDOINE; FLURBIPROFEN; IBUPROFEN; IMIPRAMINE; ISOTRETINOIN; KETOCONAZOLE; MINOCYCLINE; ROSIGLITAZONE; STEROID; TOPIRAMATE; UNCLASSIFIED DRUG;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL ACTIVATION; CELL INFILTRATION; CELL PROLIFERATION; CONTROLLED STUDY; DEGENERATIVE DISEASE; FEMALE; FLOW CYTOMETRY; GAS CHROMATOGRAPHY; IN VIVO STUDY; INFLAMMATION; MASS SPECTROMETRY; MEASUREMENT; MICROGLIA; MONOCYTE; MOUSE; NERVE STIMULATION; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BRAIN; CELL PROLIFERATION; DEUTERIUM OXIDE; DRUG EVALUATION, PRECLINICAL; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; FLOW CYTOMETRY; INFLAMMATION; LIPOPOLYSACCHARIDES; MICE; MICE, INBRED C57BL; MICROGLIA; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY;

EID: 34547646703     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.21389     Document Type: Article

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