Deficiency of telomerase activity aggravates the blood-brain barrier disruption and neuroinflammatory responses in a model of experimental stroke

Journal of Neuroscience Research

Volumn 88, Issue 13, 2010, Pages 2859-2868

  Zhang, Bei ^a,b   Chen, Lei ^b   Swartz, Karin R ^b   Bruemmer, Dennis ^a,b   Eum, Sung Yong ^b   Huang, Wen ^b   Seelbach, Melissa ^b   Choi, Yean Jung ^b   Hennig, Bernhard ^a,c   Toborek, Michal ^a,b  

^a UNIVERSITY OF KENTUCKY   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

^c UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Blood brain barrier; Cerebral microvessels; Stroke; Telomerase reverse transcriptase; Tight junction proteins

Indexed keywords

GLUTATHIONE; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1BETA; PROTEIN ZO1; SUPEROXIDE; TELOMERASE; TELOMERASE REVERSE TRANSCRIPTASE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD BRAIN BARRIER; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; BRAIN SIZE; CONTROLLED STUDY; ENZYME ACTIVITY; HEMISPHERE; MALE; MEMBRANE PERMEABILITY; MICROVASCULATURE; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCORING SYSTEM; STROKE; TIGHT JUNCTION;

ANIMALS; BLOOD-BRAIN BARRIER; BRAIN; BRAIN INFARCTION; CYTOKINES; DISEASE MODELS, ANIMAL; ENCEPHALITIS; GENE EXPRESSION REGULATION; GLUTATHIONE; INFARCTION, MIDDLE CEREBRAL ARTERY; MICE; MICE, KNOCKOUT; MICROVESSELS; NERVOUS SYSTEM DISEASES; OXIDATIVE STRESS; PROTO-ONCOGENE PROTEINS; RNA, MESSENGER; STATISTICS, NONPARAMETRIC; SUPEROXIDES; TELOMERASE;

EID: 77957224445     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.22450     Document Type: Article

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