Tendon development and diseases

Wiley Interdisciplinary Reviews: Developmental Biology

Volumn 5, Issue 1, 2016, Pages 5-23

  Gaut, Ludovic ^a,b,c   Duprez, Delphine ^a,b,c  

^a Sorbonne Universités   (France)

^b SORBONNE UNIVERSITÉ   (France)

^c INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; COLLAGEN FIBER; DEVELOPMENT; DROSOPHILA MELANOGASTER; ELECTRON MICROSCOPY; HEALING; HUMAN; MUSCULOSKELETAL SYSTEM; NONHUMAN; ORGANIZATIONAL STRUCTURE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TENDON DISEASE; TENDON HEALING; TENDON INJURY; VERTEBRATE; ANIMAL; BIOMECHANICS; CELL DIFFERENTIATION; EMBRYOLOGY; GROWTH, DEVELOPMENT AND AGING; PATHOLOGY; PATHOPHYSIOLOGY; SIGNAL TRANSDUCTION; TENDINITIS; TENDON; WOUND HEALING;

ANIMALS; BIOMECHANICAL PHENOMENA; CELL DIFFERENTIATION; HUMANS; SIGNAL TRANSDUCTION; TENDINOPATHY; TENDON INJURIES; TENDONS; WOUND HEALING;

EID: 84954369540     PISSN: 17597684     EISSN: 17597692     Source Type: Journal    
DOI: 10.1002/wdev.201     Document Type: Article

References (123)

1. Zhang G, Young BB, Ezura Y, Favata M, Soslowsky LJ, Chakravarti S, Birk DE. Development of tendon structure and function: regulation of collagen fibrillogenesis. J Musculoskelet Neuronal Interact 2005, 5:5-21.
2. Schiele NR, Marturano JE, Kuo CK. Mechanical factors in embryonic tendon development: potential cues for stem cell tenogenesis. Curr Opin Biotechnol 2013, 24:834-840.
3. Shukunami C, Takimoto A, Oro M, Hiraki Y. Scleraxis positively regulates the expression of tenomodulin, a differentiation marker of tenocytes. Dev Biol 2006, 298:234-247.
4. Murchison ND, Price BA, Conner DA, Keene DR, Olson EN, Tabin CJ, Schweitzer R. Regulation of tendon differentiation by scleraxis distinguishes force-transmitting tendons from muscle-anchoring tendons. Development 2007, 134:2697-2708.
5. Ito Y, Toriuchi N, Yoshitaka T, Ueno-Kudoh H, Sato T, Yokoyama S, Nishida K, Akimoto T, Takahashi M, Miyaki S, et al. The Mohawk homeobox gene is a critical regulator of tendon differentiation. Proc Natl Acad Sci USA 2010, 107:10538-10542.
6. Kimura W, Machii M, Xue X, Sultana N, Hikosaka K, Sharkar MT, Uezato T, Matsuda M, Koseki H, Miura N. Irxl1 mutant mice show reduced tendon differentiation and no patterning defects in musculoskeletal system development. Genesis 2011, 49:2-9.
7. Liu W, Watson SS, Lan Y, Keene DR, Ovitt CE, Liu H, Schweitzer R, Jiang R. The atypical homeodomain transcription factor Mohawk controls tendon morphogenesis. Mol Cell Biol 2010, 30:4797-4807.
8. Onizuka N, Ito Y, Inagawa M, Nakahara H, Takada S, Lotz M, Toyama Y, Asahara H. The Mohawk homeobox transcription factor regulates the differentiation of tendons and volar plates. J Orthop Sci 2014, 19:172-180.
9. Chuang H-N, Hsiao K-M, Chang H-Y, Wu C-C, Pan H. The homeobox transcription factor Irxl1 negatively regulates MyoD expression and myoblast differentiation. FEBS J 2014, 281:2990-3003.
10. Lejard V, Blais F, Guerquin MJ, Bonnet A, Bonnin MA, Havis E, Malbouyres M, Bidaud CB, Maro G, Gilardi-Hebenstreit P, et al. EGR1 and EGR2 involvement in vertebrate tendon differentiation. J Biol Chem 2011, 286:5855-5867.
11. Becker S, Pasca G, Strumpf D, Min L, Volk T. Reciprocal signaling between Drosophila epidermal muscle attachment cells and their corresponding muscles. Development 1997, 124:2615-2622.
12. Frommer G, Vorbrüggen G, Pasca G, Jäckle H, Volk T. Epidermal egr-like zinc finger protein of Drosophila participates in myotube guidance. EMBO J 1996, 15:1642-1649.
13. Guerquin MJ, Charvet B, Nourissat G, Havis E, Ronsin O, Bonnin MA, Ruggiu M, Olivera-Martinez I, Robert N, Lu Y, et al. Transcription factor EGR1 directs tendon differentiation and promotes tendon repair. J Clin Invest 2013, 123:3564-3576.
14. Volohonsky G, Edenfeld G, Klämbt C, Volk T. Muscle-dependent maturation of tendon cells is induced by post-transcriptional regulation of stripeA. Development 2007, 134:347-356.
15. Lorda-Diez CI, Montero JA, Martinez-Cue C, Garcia-Porrero JA, Hurle JM. Transforming growth factors β coordinate cartilage and tendon differentiation in the developing limb mesenchyme. J Biol Chem 2009, 284:29988-29996.
16. Pryce BA, Watson SS, Murchison ND, Staverosky JA, Dunker N, Schweitzer R. Recruitment and maintenance of tendon progenitors by TGFβ signaling are essential for tendon formation. Development 2009, 136:1351-1361.
17. Mendias CL, Bakhurin KI, Faulkner JA. Tendons of myostatin-deficient mice are small, brittle, and hypocellular. Proc Natl Acad Sci USA 2008, 105:388-393.
18. Chen JW, Galloway JL. The development of zebrafish tendon and ligament progenitors. Development 2014, 141:2035-2045.
19. Berthet E, Chen C, Butcher K, Schneider RA, Alliston T, Amirtharajah M. Smad3 binds Scleraxis and Mohawk and regulates tendon matrix organization. J Orthop Res 2013, 31:1475-1483.
20. Schweitzer R, Chyung JH, Murtaugh LC, Brent AE, Rosen V, Olson EN, Lassar A, Tabin CJ. Analysis of the tendon cell fate using scleraxis, a specific marker for tendons and ligaments. Development 2001, 128:3855-3866.
21. Blitz E, Viukov S, Sharir A, Shwartz Y, Galloway JL, Pryce BA, Johnson RL, Tabin CJ, Schweitzer R, Zelzer E. Bone ridge patterning during musculoskeletal assembly is mediated through SCX regulation of Bmp4 at the tendon-skeleton junction. Dev Cell 2009, 17:861-873.
22. Brent AE, Braun T, Tabin CJ. Genetic analysis of interactions between the somitic muscle, cartilage and tendon cell lineages during mouse development. Development 2005, 132:515-528.
23. Brent AE, Schweitzer R, Tabin CJ. A somitic compartment of tendon progenitors. Cell 2003, 113:235-248.
24. Edom-Vovard F, Schuler B, Bonnin M-A, Teillet M-A, Duprez D. Fgf4 positively regulates scleraxis and tenascin expression in chick limb tendons. Dev Biol 2002, 247:351-366.
25. Eloy-Trinquet S, Wang H, Edom-Vovard F, Duprez D. Fgf signaling components are associated with muscles and tendons during limb development. Dev Dyn 2009, 238:1195-1206.
26. Smith TG, Sweetman D, Patterson M, Keyse SM, Münsterberg A. Feedback interactions between MKP3 and ERK MAP kinase control scleraxis expression and the specification of rib progenitors in the developing chick somite. Development 2005, 132:1305-1314.
27. Havis E, Bonnin MA, Olivera-Martinez I, Nazaret N, Ruggiu M, Weibel J, Durand C, Guerquin MJ, Bonod-Bidaud C, Ruggiero F, et al. Transcriptomic analysis of mouse limb tendon cells during development. Development 2014, 141:3683-3696.
28. Docheva D, Hunziker EB, Fa R, Brandau O. Tenomodulin is necessary for tenocyte proliferation and tendon maturation. Mol Cell Biol 2005, 25:699-705.
29. Alberton P, Dex S, Popov C, Shukunami C, Schieker M, Docheva D. Loss of tenomodulin results in reduced self-renewal and augmented senescence of tendon stem/progenitor cells. Stem Cells Dev 2015, 24:597-609.
30. Chen F, Guo R, Itoh S, Moreno L, Rosenthal E, Zappitelli T, Zirngibl RA, Flenniken A, Cole W, Grynpas M, et al. First mouse model for combined osteogenesis imperfecta and Ehlers-Danlos syndrome. J Bone Miner Res 2014, 29:1412-1423.
31. Liu X, Wu H, Byrne M, Krane S, Jaenisch R. Type III collagen is crucial for collagen I fibrillogenesis and for normal cardiovascular development. Proc Natl Acad Sci USA 1997, 94:1852-1856.
32. Wenstrup RJ, Smith SM, Florer JB, Zhang G, Beason DP, Seegmiller RE, Soslowsky LJ, Birk DE. Regulation of collagen fibril nucleation and initial fibril assembly involves coordinate interactions with collagens V and XI in developing tendon. J Biol Chem 2011, 286:20455-20465.
33. Izu Y, Sun M, Zwolanek D, Veit G, Williams V, Cha B, Jepsen KJ, Koch M, Birk DE. Type XII collagen regulates osteoblast polarity and communication during bone formation. J Cell Biol 2011, 193:1115-1130.
34. Ansorge HL, Meng X, Zhang G, Veit G, Sun M, Klement JF, Beason DP, Soslowsky LJ, Koch M, Birk DE. Type IV collagen regulates fibrillogenesis: premature collagen fibril growth and tissue dysfunction in null mice. J Biol Chem 2009, 284:8427-8438.
35. Zwolanek D, Veit G, Eble JA, Gullberg D, Ruggiero F, Heino J, Meier M, Stetefeld J, Koch M. Collagen XXII binds to collagen-binding integrins via the novel motifs GLQGER and GFKGER. Biochem J 2014, 459:217-227.
36. Charvet B, Guiraud A, Malbouyres M, Zwolanek D, Guillon E, Bretaud S, Monnot C, Schulze J, Bader HL, Allard B, et al. Knockdown of col22a1 gene in zebrafish induces a muscular dystrophy by disruption of the myotendinous junction. Development 2013, 140:4602-4613.
37. Subramanian A, Schilling TF. Thrombospondin-4 controls matrix assembly during development and repair of myotendinous junctions. Elife 2014, 3:1-21.
38. Subramanian A, Wayburn B, Bunch T, Volk T. Thrombospondin-mediated adhesion is essential for the formation of the myotendinous junction in Drosophila. Development 2007, 134:1269-1278.
39. Frolova EG, Drazba J, Krukovets I, Kostenko V, Blech L, Harry C, Vasanji A, Drumm C, Sul P, Jenniskens GJ, et al. Control of organization and function of muscle and tendon by thrombospondin-4. Matrix Biol 2014, 37:35-48.
40. Jepsen KJ, Wu F, Peragallo JH, Paul J, Roberts L, Ezura Y, Oldberg A, Birk DE, Chakravarti S. A syndrome of joint laxity and impaired tendon integrity in lumican- and fibromodulin-deficient mice. J Biol Chem 2002, 277:35532-35540.
41. Zhang G, Ezura Y, Chervoneva I, Robinson PS, Beason DP, Carine ET, Soslowsky LJ, Iozzo RV, Birk DE. Decorin regulates assembly of collagen fibrils and acquisition of biomechanical properties during tendon development. J Cell Biochem 2006, 98:1436-1449.
42. Corsi A, Xu T, Chen XD, Boyde A, Liang J, Mankani M, Sommer B, Iozzo RV, Eichstetter I, Robey PG, et al. Phenotypic effects of biglycan deficiency are linked to collagen fibril abnormalities, are synergized by decorin deficiency, and mimic Ehlers-Danlos-like changes in bone and other connective tissues. J Bone Miner Res 2002, 17:1180-1189.
43. Ameye L, Aria D, Jepsen K, Oldberg A, Xu T, Young MF. Abnormal collagen fibrils in tendons of biglycan/fibromodulin-deficient mice lead to gait impairment, ectopic ossification, and osteoarthritis. FASEB J 2002, 16:673-680.
44. Bi Y, Ehirchiou D, Kilts TM, Inkson CA, Embree MC, Sonoyama W, Li L, Leet AI, Seo BM, Zhang L, et al. Identification of tendon stem/progenitor cells and the role of the extracellular matrix in their niche. Nat Med 2007, 13:1219-1227.
45. Juneja SC, Veillette C. Defects in tendon, ligament, and enthesis in response to genetic alterations in key proteoglycans and glycoproteins: a review. Arthritis 2013, 2013:1-30, 154812.
46. Halper J. Advances in the use of growth factors for treatment of disorders of soft tissues. Adv Exp Med Biol 2014, 802:59-76.
47. Kassar-Duchossoy L, Gayraud-Morel B, Gomes D, Rocancourt D, Buckingham M, Shinin V, Tajbakhsh S. Mrf4 determines skeletal muscle identity in Myf5: myod double-mutant mice. Nature 2004, 431:466-471.
48. Weintraub H. The MyoD family and myogenesis: redundancy, networks, and thresholds. Cell 1993, 75:1241-1244.
49. Delfini M-C, Duprez D. Ectopic Myf5 or MyoD prevents the neuronal differentiation program in addition to inducing skeletal muscle differentiation, in the chick neural tube. Development 2004, 131:713-723.
50. Akiyama H, Chaboissier MC, Martin JF, Schedl A, De Crombrugghe B. The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6. Genes Dev 2002, 16:2813-2828.
51. Takimoto A, Oro M, Hiraki Y, Shukunami C. Direct conversion of tenocytes into chondrocytes by Sox9. Exp Cell Res 2012, 318:1492-1507.
52. Doane J, Birk DE. Fibroblasts retain their tissue phenotype when grown in three-dimensional collagen gels. Exp Cell Res 1991, 442:432-442.
53. Benjamin M, Ralphs JR. The cell and developmental tendons and ligaments. Int Rev Cytol 2000, 196:85-130.
54. Screen HR, Berk DE, Kadler KE, Ramirez F, Young MF. Tendon functional extracellular matrix. J Orthop Res 2015, 33:793-799.
55. Zhang J, Wang JH-C. Mechanobiological response of tendon stem cells: implications of tendon homeostasis and pathogenesis of tendinopathy. J Orthop Res 2010, 28:639-643.
56. Tidball JG, Lin C. Structural changes at the myogenic cell surface during the formation of myotendinous junctions. Cell Tissue Res 1989, 257:77-84.
57. Bökel C, Brown NH. Integrins in development: moving on, responding to, and sticking to the extracellular matrix. Dev Cell 2002, 3:311-321.
58. Charvet B, Ruggiero F, Le Guellec D. The development of the myotendinous junction. A review. Muscles Ligaments Tendons J 2012, 2:53-63.
59. Schejter ED, Baylies MK. Born to run: creating the muscle fiber. Curr Opin Cell Biol 2010, 22:566-574.
60. Benjamin M, Kumai T, Milz S, Boszczyk BM, Boszczyk AA, Ralphs JR. The skeletal attachment of tendons - tendon 'entheses'. Comp Biochem Physiol A Mol Integr Physiol 2002, 133:931-945.
61. Zelzer E, Blitz E, Killian ML, Thomopoulos S. Tendon-to-bone attachment: from development to maturity. Birth Defects Res Part C 2014, 102:101-112.
62. Schwartz AG, Pasteris JD, Genin GM, Daulton TL, Thomopoulos S. Mineral distributions at the developing tendon enthesis. PLoS One 2012, 7:1-11, e48630.
63. Huang AH, Lu HH, Schweitzer R. Molecular regulation of tendon cell fate during development. J Orthop Res 2015, 33:800-812.
64. Lejard V, Brideau G, Blais F, Salingcarnboriboon R, Wagner G, Roehrl MH, Noda M, Duprez D, Houillier P, Rossert J. Scleraxis and NFATc regulate the expression of the pro-α1(I) collagen gene in tendon fibroblasts. J Biol Chem 2007, 282:17665-17675.
65. Pryce BA, Brent AE, Murchison ND, Tabin CJ, Schweitzer R. Generation of transgenic tendon reporters, ScxGFP and ScxAP, using regulatory elements of the scleraxis gene. Dev Dyn 2007, 236:1677-1682.
66. Mendias CL, Gumucio JP, Bakhurin KI, Lynch EB, Brooks SV. Physiological loading of tendons induces scleraxis expression in epitenon fibroblasts. J Orthop Res 2012, 30:606-612.
67. Grenier J, Teillet M-A, Grifone R, Kelly RG, Duprez D. Relationship between neural crest cells and cranial mesoderm during head muscle development. PLoS One 2009, 4:e4381.
68. Sugimoto Y, Takimoto A, Akiyama H, Kist R, Scherer G, Nakamura T, Hiraki Y, Shukunami C. Scx+/Sox9+ progenitors contribute to the establishment of the junction between cartilage and tendon/ligament. Development 2013, 140:2280-2288.
69. Blitz E, Sharir A, Akiyama H, Zelzer E. Tendon-bone attachment unit is formed modularly by a distinct pool of Scx- and Sox9-positive progenitors. Development 2013, 140:2680-2690.
70. Jelinsky SA, Archambault J, Li L, Seeherman H. Tendon-selective genes identified from rat and human musculoskeletal tissues. J Orthop Res 2010, 28:289-297.
71. Dupin E, Le Douarin NM. The neural crest, a multifaceted structure of the vertebrates. Birth Defects Res C Embryo Today 2014, 102:187-209.
72. Crane JF, Trainor PA. Neural crest stem and progenitor cells. Annu Rev Cell Dev Biol 2006, 22:267-286.
73. Kieny M, Chevallier A. Autonomy of tendon development in the embryonic chick wing. J Embryol Exp Morph 1979, 49:153-165.
74. Couly GF, Coltey PM, Le Douarin NM. The developmental fate of the cephalic mesoderm in quail-chick chimeras. Development 1992, 15:1-15.
75. Chevallier BA, Kieny M, Mauger A. Limb-somite relationship : origin of the limb musculature. J Embryol Exp Morph 1977, 41:245-258.
76. Christ B, Ordahl CP. Early stages of chick somite development. Anat Embryol (Berl) 1995, 191:381-396.
77. Volk T. Singling out Drosophila tendon cells: a dialogue between two distinct cell types. Trends Genet 1999, 15:448-453.
78. Volk T, VijayRaghavan K. A central role for epidermal segment border cells in the induction of muscle patterning in the Drosophila embryo. Development 1994, 120:59-70.
79. Bonnin MA, Laclef C, Blaise R, Eloy-Trinquet S, Relaix F, Maire P, Duprez D, et al. Six1 is not involved in limb tendon development, but is expressed in limb connective tissue under Shh regulation. Mech Dev 2005, 122:573-585.
80. Schweitzer R, Zelzer E, Volk T. Connecting muscles to tendons: tendons and musculoskeletal development in flies and vertebrates. Development 2010, 137:3347.
81. Lorda-Diez CI, Montero JA, Garcia-porrero JA, Hurle JM. Divergent differentiation of skeletal progenitors into cartilage and tendon: lessons from the embryonic limb. ACS Chem Biol 2014, 9:72-79.
82. Alberton P, Popov C, Pragert M, Kohler J, Shukunami C, Schieker M, Docheva D. Conversion of human bone marrow-derived mesenchymal stem cells into tendon progenitor cells by ectopic expression of scleraxis. Stem Cells Dev 2012, 21:846-858.
83. Otabe K, Nakahara H, Hasegawa A, Matsukawa T, Ayabe F, Onizuka N, Inui M, Takada S, Ito Y, Sekiya I, et al. Transcription factor mohawk controls tenogenic differentiation of bone marrow mesenchymal stem cells in vitro and in vivo. J Orthop Res 2015, 33:1-8. doi:10.1002/jor.22750.
84. Liu, H, Zhang C, Zhu S, Lu P, Zhu T, Gong X, Zhang Z, Hu J, Yin Z, Heng BC, et al. Mohawk promotes the tenogenesis of mesenchymal stem cells through activation of the TGFβ signaling pathway. Stem Cells 2015, 33:443-455.
85. Anderson DM, Arredondo J, Hahn K, Valente G, Martin JF, Wilson-Rawls J, Rawls A. Mohawk is a novel homeobox gene expressed in the developing mouse embryo. Dev Dyn 2006, 235:792-801.
86. Liu H, Liu W, Maltby KM, Lan Y, Jiang R. Identification and developmental expression analysis of a novel homeobox gene closely linked to the mouse Twirler mutation. Gene Expr Patterns 2006, 6:632-636.
87. Anderson DM, Beres BJ, Wilson-Rawls J, Rawls A. The homeobox gene Mohawk represses transcription by recruiting the Sin3A/HDAC co-repressor complex. Dev Dyn 2009, 238:572-580.
88. Anderson DM, George R, Noyes MB, Rowton M, Liu W, Jiang R, Wolfe SA, Wilson-Rawls J, Rawls A. Characterization of the DNA-binding properties of the Mohawk homeobox transcription factor. J Biol Chem 2012, 287:35351-35359.
89. Yamamoto-Shiraishi YI, Kuroiwa A. Wnt and BMP signaling cooperate with Hox in the control of Six2 expression in limb tendon precursor. Dev Biol 2013, 377:363-374.
90. Liu H, Xu J, Liu CF, Lan Y, Wylie C, Jiang R. Whole transcriptome expression profiling of mouse limb tendon development by using RNA-seq. J Orthop Res 2015, 33:840-848.
91. Brent AE, Tabin CJ. FGF acts directly on the somitic tendon progenitors through the Ets transcription factors Pea3 and Erm to regulate scleraxis expression. Development 2004, 131:3885-3896.
92. Lorda-Diez CI, Montero JA, Garcia-Porrero JA, Hurle JM. Tgfβ2 and 3 are coexpressed with their extracellular regulator Ltbp1 in the early limb bud and modulate mesodermal outgrowth and BMP signaling in chicken embryos. BMC Dev Biol 2010, 10:69.
93. Maeda T, Sakabe T, Sunaga A, Sakai K, Rivera AL, Keene DR, Sasaki T, Stavnezer E, Iannotti J, Schweitzer R, et al. Conversion of mechanical force into TGF-β-mediated biochemical signals. Curr Biol 2011, 21:933-941.
94. Manceau M, Gros J, Savage K, Thome V, McPherron A, Paterson B, Marcelle C. Myostatin promotes the terminal differentiation of embryonic muscle progenitors. Genes Dev 2008, 22:668-681.
95. Wang H, Noulet F, Edom-Vovard F, Le Grand F, Duprez D. Bmp signaling at the tips of skeletal muscles regulates the number of fetal muscle progenitors and satellite cells during development. Dev Cell 2010, 18:643-654.
96. Brown JP, Finley VG, Kuo CK. Embryonic mechanical and soluble cues regulate tendon progenitor cell gene expression as a function of developmental stage and anatomical origin. J Biomech 2014, 47:214-222.
97. Edom-Vovard F, Bonnin MA, Duprez D. Fgf8 transcripts are located in tendons during embryonic chick limb development. Mech Dev 2001, 108:203-206.
98. Yarnitzky T, Min L, Volk T. The Drosophila neuregulin homolog Vein mediates inductive interactions between myotubes and their epidermal attachment cells. Genes Dev 1997, 11:2691-2700.
99. Schnorrer F, Kalchhauser I, Dickson BJ. The transmembrane protein kon-tiki couples to Dgrip to mediate myotube targeting in Drosophila. Dev Cell 2007, 12:751-766.
100. Martin-Bermudo MD. Integrins modulate the Egfr signaling pathway to regulate tendon cell differentiation in the Drosophila embryo. Development 2000, 127:2607-2615.
101. Mammoto T, Mammoto A, Ingber DE. Mechanobiology and developmental control. Annu Rev Cell Dev Biol 2013, 29:27-61.
102. Ward KA, Caulton JM, Adams JE, Mughal MZ. Perspective: cerebral palsy as a model of bone development in the absence of postnatal mechanical factors. J Musculoskelet Neuronal Interact 2006, 6:154-159.
103. Shwartz Y, Blitz E, Zelzer E. One load to rule them all: mechanical control of the musculoskeletal system in development and aging. Differentiation 2013, 86:104-111.
104. Kook S-H, Jang Y-S, Lee J-C. Involvement of JNK-AP-1 and ERK-NF-B signaling in tension-stimulated expression of Type I collagen and MMP-1 in human periodontal ligament fibroblasts. J Appl Physiol 2011, 111:1575-1583.
105. Nguyen J, Tang SY, Nguyen D, Alliston T. Load regulates bone formation and sclerostin expression through a TGFβ-dependent mechanism. PLoS One 2013, 8:1-9, e53813.
106. Schwachtgen JL, Houston P, Campbell C, Sukhatme V, Braddock M. Fluid shear stress activation of egr-1 transcription in cultured human endothelial and epithelial cells is mediated via the extracellular signal-related kinase 1/2 mitogen-activated protein kinase pathway. J Clin Invest 1998, 101:2540-2549.
107. Eliasson P, Andersson T, Hammerman M, Aspenberg P. Primary gene response to mechanical loading in healing rat Achilles tendons. J Appl Physiol 2013, 114:1519-1526.
108. Tomasetti C, Vogelstein B. Variation in cancer risk among tissues can be explained by the number of stem cell divisions. Science 2015, 80:78-81.
109. Walsh EF, Mechrefe A, Akelman E, Schiller AL. Giant cell tumor of tendon sheath. Am J Orthop (Belle Mead NJ) 2005, 34:116-121.
110. Nakashima M, Uchida T, Tsukazaki T, Hamanaka Y, Fukuda E, Ito M, Sekine I. Expression of tyrosine kinase receptors Tie-1 and Tie-2 in giant cell tumor of the tendon sheath: a possible role in synovial proliferation. Pathol Res Pract 2001, 197:101-107.
111. Tozer S, Duprez D. Tendon and ligament: development, repair and disease. Birth Defects Res C Embryo Today 2005, 75:226-236.
112. Kaux JF, Forthomme B, le Goff C, Crielaard JM, Croisier JL. Current opinions on tendinopathy. J Sport Sci Med 2011, 10:238-253.
113. Magnusson SP, Langberg H, Kjaer M. The pathogenesis of tendinopathy: balancing the response to loading. Nat Rev Rheumatol 2010, 6:262-268.
114. Docheva D, Müller SA, Majewski M, Evans CH. Biologics for tendon repair. Adv Drug Deliv Rev 2014, 84:222-239.
115. Halper J. Advances in the use of growth factors for treatment of disorders of soft tissues. Adv Exp Med Biol 2014, 802:59-76.
116. Katzel EB, Wolenski M, Loiselle AE, Basile P, Flick LM, Langstein HN, Hilton MJ, Awad HA, Hammert WC, O'Keefe RJ. Impact of Smad3 loss of function on scarring and adhesion formation during tendon healing. J Orthop Res 2011, 29:684-693.
117. Chan BP, Fu S, Qin L, Lee K, Rolf CG, Chan K. Effects of basic fibroblast growth factor (bFGF) on early stages of tendon healing: a rat patellar tendon model. Acta Orthop Scand 2000, 71:513-518.
118. Thomopoulos S, Kim HM, Das R, Silva MJ, Sakiyama-Elbert S, Amiel D, Gelberman RH. The effects of exogenous basic fibroblast growth factor on intrasynovial flexor tendon healing in a canine model. J Bone Joint Surg Am 2010, 92:2285-2293.
119. Chen CH, Cao Y, Wu YF, Bais AJ, Gao JS, Tang JB. Tendon healing in vivo: gene expression and production of multiple growth factors in early tendon healing period. J Hand Surg Am 2008, 33:1834-1842.
120. Tang JB, Cao Y, Zhu B, Xin KQ, Wang XT, Liu PY. Adeno-associated virus-2-mediated bFGF gene transfer to digital flexor tendons significantly increases healing strength: an in vivo study. J Bone Joint Surg Am 2008, 90:1078-1089.
121. Tang JB, Chen CH, Zhou YL, McKeever C, Liu PY. Regulatory effects of introduction of an exogenous FGF2 gene on other growth factor genes in a healing tendon. Wound Repair Regen 2014, 22:111-118.
122. Kim JG, Kim HJ, Kim SE, Bae JH, Ko YJ, Park JH. Enhancement of tendon-bone healing with the use of bone morphogenetic protein-2 inserted into the suture anchor hole in a rabbit patellar tendon model. Cytotherapy 2014, 16:857-867.
123. Chen CH, Chang CH, Wang KC, Su CI, Liu HT, Yu CM, Wong CB, Wang IC, Whu SW, Liu HW. Enhancement of rotator cuff tendon-bone healing with injectable periosteum progenitor cells-BMP-2 hydrogel in vivo. Knee Surg Sport Traumatol Arthrosc 2011, 19:1597-1607.