The homeobox gene Mohawk represses transcription by recruiting the Sin3A/HDAC co-repressor complex

Developmental Dynamics

Volumn 238, Issue 3, 2009, Pages 572-580

  Anderson, Douglas M ^a,b   Beres, Brian J ^a,b   Wilson Rawls, Jeanne ^a,b   Rawls, Alan ^a,b  

^a ARIZONA STATE UNIVERSITY   (United States)

^b ARIZONA STATE UNIVERSITY   (United States)

Author keywords

HDAC; Iroquois; Irx; Mkx; Mohawk; MRD; Myogenesis; Repressor; Sap18; Sin3a; Tbp

Indexed keywords

AMINO ACID; HISTONE DEACETYLASE 1; HOMEODOMAIN PROTEIN; MOHAWK PROTEIN; TRANSCRIPTION FACTOR SIN3A; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL DIFFERENTIATION; CELL LINEAGE; FIBROBLAST; GENE MUTATION; IMMUNOPRECIPITATION; MUSCLE DEVELOPMENT; MYOBLAST; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN FUNCTION; TRANSCRIPTION REGULATION;

AMINO ACID SEQUENCE; ANIMALS; CELL DIFFERENTIATION; CELL LINE; DOWN-REGULATION; HISTONE DEACETYLASES; HOMEODOMAIN PROTEINS; MICE; MODELS, MOLECULAR; MYOBLASTS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; REPRESSOR PROTEINS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 61649108768     PISSN: 10588388     EISSN: 10970177     Source Type: Journal    
DOI: 10.1002/dvdy.21873     Document Type: Article

References (51)

1. Amthor H, Christ B, Patel K. 1999. A molecular mechanism enabling continuous embryonic muscle growth - a balance between proliferation and differentiation. Development 126:1041-1053.
2. Anderson DM, Arredondo J, Hahn K, Valente G, Martin JF, Wilson-Rawls J, Rawls A. 2006. Mohawk is a novel homeobox gene expressed in the developing mouse embryo. Dev Dyn 235:792-801.
3. Arkin MR, Wells JA. 2004. Small-molecule inhibitors of protein-protein interactions: progressing towards the dream. Nat Rev Drug Discov 3:301-317.
4. Asahara H, Dutta S, Kao HY, Evans RM, Montminy M. 1999. Pbx-Hox heterodimers recruit coactivator-corepressor complexes in an isoform-specific manner. Mol Cell Biol 19:8219-8225.
5. Ayer DE. 1999. Histone deacetylases: transcriptional repression with SINers and NuRDs. Trends Cell Biol 9:193-198.
6. Bao ZZ, Bruneau BG, Seidman JG, Seidman CE, Cepko CL. 1999. Regulation of chamber-specific gene expression in the developing heart by Irx4. Science 283:1161-1164.
7. Bilioni A, Craig G, Hill C, McNeill H. 2005. Iroquois transcription factors recognize a unique motif to mediate transcriptional repression in vivo. Proc Natl Acad Sci U S A 102:14671-14676.
8. Brendolan A, Ferretti E, Salsi V, Moses K, Quaggin S, Blasi F, Cleary ML, Selleri L. 2005. A Pbx1-dependent genetic and transcriptional network regulates spleen ontogeny. Development 132:3113-3126.
9. Bruneau BG, Bao ZZ, Fatkin D, Xavier-Neto J, Georgakopoulos D, Maguire CT, Berul CI, Kass DA, Kuroski-de Bold ML, de Bold AJ, Conner DA, Rosenthal N, Cepko CL, Seidman CE, Seidman JG. 2001. Cardiomyopathy in Irx4-deficient mice is preceded by abnormal ventricular gene expression. Mol Cell Biol 21:1730-1736.
10. Burglin TR. 1997. Analysis of TALE superclass homeobox genes (MEIS, PBC, KNOX, Iroquois, TGIF) reveals a novel domain conserved between plants and animals. Nucleic Acid Res 25:4173-4180.
11. Burke LJ, Baniahmad A. 2000. Co-repressors 2000. FASEB J 14:1876-1888.
12. Cahill MA, Ernst WH, Janknecht R, Nordheim A. 1994. Regulatory squelching. FEBS Lett 344:105-108.
13. Christ B, Ordahl CP. 1995. Early stages of chick somite development. Anat Embryol (Berl) 191:381-396.
14. Cossu G, Tajbakhsh S, Buckingham M. 1996. How is myogenesis initiated in the embryo? Trends Genet 12:218-223.
15. Davis RL, Weintraub H, Lassar AB. 1987. Expression of a single transfected cDNA converts fibroblasts to myoblasts. Cell 51:987-1000.
16. Denetclaw WF Jr, Christ B, Ordahl CP. 1997. Location and growth of epaxial myotome precursor cells. Development 124:1601-1610.
17. diIorio P, Alexa K, Choe SK, Etheridge L, Sagerström CG. 2007. TALE-family homeodomain proteins regulate endodermal sonic hedgehog expression and pattern the anterior endoderm. Dev Biol 304:221-231.
18. Eilers AL, Billin AN, Liu J, Ayer DE. 1999. A 13-amino acid amphipathic alpha-helix is required for the functional interaction between the transcriptional repressor Mad1 and mSin3A. J Biol Chem 274:32750-32756.
19. Gomez-Skarmeta JL, Modolell J. 2002. Iroquois genes: genomic organization and function in vertebrate neural development. Curr Opin Genet Dev 12:403-408.
20. Han K, Manley JL. 1993a. Functional domains of the Drosophila Engrailed protein. EMBO J 12:2723-2733.
21. Han K, Manley JL. 1993b. Transcriptional repression by the Drosophila even-skipped protein: definition of a minimal repression domain. Genes Dev 7:491-503.
22. Heinzel T, Lavinsky RM, Mullen TM, Soderstrom M, Laherty CD, Torchia J, Yang WM, Brard G, Ngo SD, Davie JR, Seto E, Eisenman RN, Rose DW, Glass CK, Rosenfeld M. G. 1997. A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression. Nature 387:43-48.
23. Jaynes JB, O'Farrell PH. 1991. Active repression of transcription by the engrailed homeodomain protein. EMBO J 10:1427-1433.
24. Kudoh T, Dawid IB. 2001. Role of the iroquois3 homeobox gene in organizer formation. Proc Natl Acad Sci U S A 98:7852-7857.
25. Laherty CD, Yang WM, Sun JM, Davie JR, Seto E, Eisenman RN. 1997. Histone deacetylases associated with the mSin3 co-repressor mediate mad transcriptional repression. Cell 89:349-356.
26. Lecaudey V, Anselme I, Dildrop R, Ruther U, Schneider-Maunoury S. 2005. Expression of the zebrafish Iroquois genes during early nervous system formation and patterning. J Comp Neurol 492:289-302.
27. Liu H, Liu W, Maltby KM, Lan Y, Jiang R. 2006. Identification and developmental expression analysis of a novel homeobox gene closely linked to the mouse Twirler mutation. Gene Expr Patterns 6:632-636.
28. Matsumoto K, Nishihara S, Kamimura M, Shiraishi T, Otoguro T, Uehara M, Maeda Y, Ogura K, Lumsden A, Ogura T. 2004. The prepattern transcription factor Irx2, a target of the FGF8/MAP kinase cascade, is involved in cerebellum formation. Nat Neurosci 7:605-612.
29. Moens CB, Selleri L. 2006. Hox cofactors in vertebrate development. Dev Biol 291:193-206.
30. Mukherjee K, Burglin TR. 2007. Comprehensive analysis of animal TALE homeobox genes: new conserved motifs and cases of accelerated evolution. J Mol Evol 65:137-153.
31. Nagy L, Kao HY, Chakravarti D, Lin RJ, Hassig CA, Ayer DE, Schreiber SL, Evans RM. 1997. Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase. Cell 89:373-380.
32. Reggiani L, Raciti D, Airik R, Kispert A, Brandli AW. 2007. The prepattern transcription factor Irx3 directs nephron segment identity. Genes Dev 21:2358-2370.
33. Rupp RAW, Snider L, Weintraub H. 1994. Xenopus embryos regulate the nuclear localization of XMyoD. Genes Dev 8:1311-1323.
34. Sadowski I, Ma J, Triezenberg S, Ptashne M. 1988. GAL4-VP16 is an unusually potent transcriptional activator. Nature 335:563-564.
35. Selleri L, Depew MJ, Jacobs Y, Chanda SK, Tsang KY, Cheah KS, Rubenstein JL, O'Gorman S, Cleary ML. 2001. Requirement for Pbx1 in skeletal patterning and programming chondrocyte proliferation and differentiation. Development 128:3543-3557.
36. Sharma M, Sun Z. 2001. 5'TG3' interacting factor interacts with Sin3A and represses AR-mediated transcription. Mol Endocrinol 15:1918-1928.
37. Sheeba CJ, Palmeirim I, Andrade RP. 2007. Chick Hairy1 protein interacts with Sap18, a component of the Sin3/HDAC transcriptional repressor complex. BMC Dev Biol 7:1-8.
38. Silverstein RA, Ekwall K. 2005. Sin3: a flexible regulator of global gene expression and genome stability. Curr Genet 47:1-17.
39. Tapscott SJ, Davis RL, Thayer MJ, Cheng PF, Weintraub H, Lassar AB. 1988. MyoD1: a nuclear phosphoprotein requiring a Myc homology region to convert fibroblasts to myoblasts. Science 242:405-411.
40. Takeuchi JK, Bruneau BG. 2007. Irxl1, a divergent Iroquois homeobox family transcription factor gene. Gene Expr Patterns 7:51-56.
41. van Tuyl M, Liu J, Groenman F, Ridsdale R, Han RN, Venkatesh V, Tibboel D, Post M. 2006. Iroquois genes influence proximo-distal morphogenesis during rat lung development. Am J Physiol Lung Cell Mol Physiol 290:L777-L789.
42. Venters SJ, Ordahl CP. 2002. Persistent myogenic capacity of the dermomyotome dorsomedial lip and restriction of myogenic competence. Development 129:3873-3885.
43. Wilson-Rawls J, Molkentin JD, Black BL, Olson EN. 1999. Activated notch inhibits myogenic activity of the MADS-Box transcription factor myocyte enhancer factor 2C. Mol Cell Biol 19:2853-2862.
44. Wilson-Rawls J, Rhee JM, Rawls A. 2004. Paraxis is a basic helix-loop-helix protein that positively regulates transcription through binding to specific E-box elements. J Biol Chem 279:37685-37692.
45. Wotton D, Knoepfler PS, Laherty CD, Eisenman RN, Massagué J. 2001. The Smad transcriptional corepressor TGIF recruits mSin3. Cell Growth Differ 12:457-463.
46. Wu S, Skolnick J, Zhang Y. 2007. Ab initio modeling of small proteins by iterative TASSER simulations. BMC Biol 5:17.
47. Yang X, Zhang F, Kudlow JE. 2002. Recruitment of O-GlcNAc transferase to promoters by corepressor mSin3A: coupling protein O-GlcNAcylation to transcriptional repression. Cell 110:69-80.
48. Yang L, Mei Q, Zielinska-Kwiatkowska A, Matsui Y, Blackburn ML, Benedetti D, Krumm AA, Taborsky GJ Jr, Chansky HA. 2003. An ERG (ets-related gene)-associated histone methyltransferase interacts with histone deacetylases 1/2 and transcription co-repressors mSin3A/B. Biochem J 369:651-657.
49. Zhang Y. 2007. Template-based modeling and free modeling by I-TASSER in CASP7. Proteins 8:108-117.
50. Zhang Y. 2008. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics 9:40.
51. Zhang Y, Iratni R, Erdjument-Bromage H, Tempst P, Reinberg D. 1997. Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex. Cell 89:357-364.