The effects of exogenous basic fibroblast growth factor on intrasynovial flexor tendon healing in a canine model

Journal of Bone and Joint Surgery

Volumn 92, Issue 13, 2010, Pages 2285-2293

  Thomopoulos, Stavros ^a   Kim, H Mike ^a   Das, Rosalina ^a   Silva, Matthew J ^a   Sakiyama Elbert, Shelly ^b   Amiel, David ^c   Gelberman, Richard H ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WASHINGTON UNIVERSITY IN ST LOUIS   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; COLLAGEN TYPE 1; COLLAGEN TYPE 3;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOMECHANICS; BLOOD FLOW; CELL PROLIFERATION; COLLAGEN SYNTHESIS; CONTROLLED STUDY; DNA CONTENT; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG MEGADOSE; EXPERIMENTAL DOG; FLEXOR TENDON INJURY; INFLAMMATION; INTERMETHOD COMPARISON; LOW DRUG DOSE; NONHUMAN; PRIORITY JOURNAL; RANGE OF MOTION; SCAR FORMATION; TENDON RECONSTRUCTION; TISSUE ADHESION; WOUND HEALING;

EID: 77957927172     PISSN: 00219355     EISSN: 15351386     Source Type: Journal    
DOI: 10.2106/JBJS.I.01601     Document Type: Article

References (32)

1. Boyer MI, Goldfarb CA, Gelberman RH. Recent progress in flexor tendon healing. The modulation of tendon healing with rehabilitation variables. J Hand Ther. 2005;18:80-5.
2. Khanna A, Friel M, Gougoulias N, Longo UG, Maffulli N. Prevention of adhesions in surgery of the flexor tendons of the hand: what is the evidence? Br Med Bull. 2009;90:85-109.
3. Gelberman RH, Thomopoulos S, Sakiyama-Elbert SE, Das R, Silva MJ. The early effects of sustained platelet-derived growth factor administration on the functional and structural properties of repaired intrasynovial flexor tendons: an in vivo biomechanic study at 3 weeks in canines. J Hand Surg Am. 2007;32:373-9.
4. Thomopoulos S, Zaegel M, Das R, Harwood FL, Silva MJ, Amiel D, Sakiyama-Elbert S, Gelberman RH. PDGF-BB released in tendon repair using a novel delivery system promotes cell proliferation and collagen remodeling. J Orthop Res. 2007;25:1358-68. (Pubitemid 47523366)
5. Thomopoulos S, Das R, Silva MJ, Sakiyama-Elbert S, Harwood FL, Zampiakis E, Kim HM, Amiel D, Gelberman RH. Enhanced flexor tendon healing through controlled delivery of PDGF-BB. J Orthop Res. 2009;27:1209-15.
6. Gelberman RH, Amiel D, Harwood F. Genetic expression for type I procollagen in the early stages of flexor tendon healing. J Hand Surg Am. 1992;17:551-8.
7. Hamada Y, Katoh S, Hibino N, Kosaka H, Hamada D, Yasui N. Effects of mono- filament nylon coated with basic fibroblast growth factor on endogenous intrasynovial flexor tendon healing. J Hand Surg Am. 2006;31:530-40.
8. Letson AK, Dahners LE. The effect of combinations of growth factors on ligament healing. Clin Orthop Relat Res. 1994;308:207-12.
9. Tang JB, Cao Y, Zhu B, Xin KQ, Wang XT, Liu PY. Adeno-associated virus-2- mediated bFGF gene transfer to digital flexor tendons significantly increases healing strength. An in vivo study. J Bone Joint Surg Am. 2008;90:1078-89. (Pubitemid 351632653)
10. Molloy T, Wang Y, Murrell G. The roles of growth factors in tendon and ligament healing. Sports Med. 2003;33:381-94. (Pubitemid 36560710)
11. Sakiyama-Elbert SE, Hubbell JA. Development of fibrin derivatives for controlled release of heparin-binding growth factors. J Control Release. 2000;65:389-402.
12. Thomopoulos S, Das R, Sakiyama-Elbert S, Silva MJ, Charlton N, Gelberman RH. bFGF and PDGF-BB for tendon repair: controlled release and biologic activity by tendon fibroblasts in vitro. Ann Biomed Eng. 2010;38:225-34.
13. Winters SC, Gelberman RH, Woo SL, Chan SS, Grewal R, Seiler JG 3rd. The effects of multiple-strand suture methods on the strength and excursion of repaired intrasynovial flexor tendons: a biomechanical study in dogs. J Hand Surg Am. 1998;23:97-104. (Pubitemid 29097747)
14. Silva MJ, Boyer MI, Ditsios K, Burns ME, Harwood FL, Amiel D, Gelberman RH. The insertion site of the canine flexor digitorum profundus tendon heals slowly following injury and suture repair. J Orthop Res. 2002;20:447-53.
15. Boyer MI, Gelberman RH, Burns ME, Dinopoulos H, Hofem R, Silva MJ. Intrasynovial flexor tendon repair. An experimental study comparing low and high levels of in vivo force during rehabilitation in canines. J Bone Joint Surg Am. 2001;83:891-9.
16. Gelberman RH, Boyer MI, Brodt MD, Winters SC, Silva MJ. The effect of gap formation at the repair site on the strength and excursion of intrasynovial flexor tendons. An experimental study on the early stages of tendon-healing in dogs. J Bone Joint Surg Am. 1999;81:975-82.
17. May EJ, Silfverskiöld KL. Rate of recovery after flexor tendon repair in zone II. A prospective longitudinal study of 145 digits. Scand J Plast Reconstr Surg Hand Surg. 1993;27:89-94.
18. Silfverskiöld KL, May EJ. Gap formation after flexor tendon repair in zone II. Results with a new controlled motion programme. Scand J Plast Reconstr Surg Hand Surg. 1993;27:263-8.
19. Gelberman RH, Khabie V, Cahill CJ. The revascularization of healing flexor tendons in the digital sheath. A vascular injection study in dogs. J Bone Joint Surg Am. 1991;73:868-81.
20. Lundborg G, Myrhage R, Rydevik B. The vascularization of human flexor tendons within the digital synovial sheath region-structural and functional aspects. J Hand Surg Am. 1997;2:417-27.
21. Chan BP, Fu S, Qin L, Lee K, Rolf CG, Chan K. Effects of basic fibroblast growth factor (bFGF) on early stages of tendon healing: a rat patellar tendon model. Acta Orthop Scand. 2000;71:513-8.
22. Kobayashi D, Kurosaka M, Yoshiya S, Mizuno K. Effect of basic fibroblast growth factor on the healing of defects in the canine anterior cruciate ligament. Knee Surg Sports Traumatol Arthrosc. 1997;5:189-94.
23. Potenza AD. Tendon healing within the flexor digital sheath in the dog. J Bone Joint Surg Am. 1962;44:49-64.
24. Friesel RE, Maciag T. Molecular mechanisms of angiogenesis: fibroblast growth factor signal transduction. FASEB J. 1995;9:919-25.
25. Poole TJ, Finkelstein EB, Cox CM. The role of FGF and VEGF in angioblast induction and migration during vascular development. Dev Dyn. 2001;220:1-17.
26. Gualandris A, Urbinati C, Rusnati M, Ziche M, Presta M. Interaction of highmolecular- weight basic fibroblast growth factor with endothelium: biological activity and intracellular fate of human recombinant M(r) 24,000 bFGF. J Cell Physiol. 1994;161:149-59.
27. Montesano R, Vassalli JD, Baird A, Guillemin R, Orci L. Basic fibroblast growth factor induces angiogenesis in vitro. Proc Natl Acad Sci USA. 1986;83:7297-301. (Pubitemid 16000508)
28. Takayama S, Murakami S, Miki Y, Ikezawa K, Tasaka S, Terashima A, Asano T, Okada H. Effects of basic fibroblast growth factor on human periodontal ligament cells. J Periodontal Res. 1997;32:667-75. (Pubitemid 127524313)
29. Thomopoulos S, Harwood FL, Silva MJ, Amiel D, Gelberman RH. Effect of several growth factors on canine flexor tendon fibroblast proliferation and collagen synthesis in vitro. J Hand Surg Am. 2005;30:441-7.
30. Fukui N, Katsuragawa Y, Sakai H, Oda H, Nakamura K. Effect of local application of basic fibroblast growth factor on ligament healing in rabbits. Rhum Engl Rev Ed. 1998;65:406-14.
31. Palmon A, Roos H, Edel J, Zax B, Savion N, Grosskop A, Pitaru S. Inverse doseand time-dependent effect of basic fibroblast growth factor on the gene expression of collagen type I and matrix metalloproteinase-1 by periodontal ligament cells in culture. J Periodontol. 2000;71:974-80.
32. Silverio-Ruiz KG, Martinez AE, Garlet GP, Barbosa CF, Silva JS, Cicarelli RM, Valentini SR, Abi-Rached RS, Junior CR. Opposite effects of bFGF and TGF-beta on collagen metabolism by human periodontal ligament fibroblasts. Cytokine. 2007;39:130-7.