Physiological loading of tendons induces scleraxis expression in epitenon fibroblasts

Journal of Orthopaedic Research

Volumn 30, Issue 4, 2012, Pages 606-612

  Mendias, Christopher L ^a   Gumucio, Jonathan P ^a   Bakhurin, Konstantin I ^b   Lynch, Evan B ^a   Brooks, Susan V ^a,b  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

collagen 1; epitenon; scleraxis; tendon; tenomodulin

Indexed keywords

COLLAGEN TYPE 1; GREEN FLUORESCENT PROTEIN; MUSCLE PROTEIN; SCLERAXIS; TENOMODULIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; FIBROBLAST; MALE; MOUSE; MUSCLE GROWTH; NONHUMAN; PHYSICAL ACTIVITY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REST; TENDON; TREADMILL EXERCISE;

ACHILLES TENDON; ADAPTATION, PHYSIOLOGICAL; AGING; ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL DIVISION; COLLAGEN TYPE I; FIBROBLASTS; GENE EXPRESSION; GREEN FLUORESCENT PROTEINS; MALE; MEMBRANE PROTEINS; MICE; MICE, TRANSGENIC; PHYSICAL CONDITIONING, ANIMAL; WEIGHT-BEARING;

EID: 84857034912     PISSN: 07360266     EISSN: 1554527X     Source Type: Journal    
DOI: 10.1002/jor.21550     Document Type: Article

References (36)

1. Kjaer M,. 2004. Role of extracellular matrix in adaptation of tendon and skeletal muscle to mechanical loading. Physiol Rev 84: 649-698. (Pubitemid 38365495)
2. Wang JH-C,. 2006. Mechanobiology of tendon. J Biomech 39: 1563-1582.
3. Fontana K, Almeida FM, Tomiosso TC, et al. 2010. Effect of high intensity aerobic exercise and mesterolone on remodeling of Achilles tendon of C57BL/6 transgenic mice. Cell Tissue Res 339: 411-420.
4. Michna H, Hartmann G,. 1989. Adaptation of tendon collagen to exercise. Int Orthop 13: 161-165. (Pubitemid 19250554)
5. Suominen H, Kiiskinen A, Heikkinen E,. 1980. Effects of physical training on metabolism of connective tissues in young mice. Acta Physiol Scand 108: 17-22. (Pubitemid 10166627)
6. Sharma P, Maffulli N,. 2006. Biology of tendon injury: healing, modeling and remodeling. J Musculoskelet Neuronal Interact 6: 181-190. (Pubitemid 44193219)
7. Gayraud-Morel B, Chretien F, Tajbakhsh S,. 2009. Skeletal muscle as a paradigm for regenerative biology and medicine. Regen Med 4: 293-319.
8. Murchison ND, Price BA, Conner DA, et al. 2007. Regulation of tendon differentiation by scleraxis distinguishes force-transmitting tendons from muscle-anchoring tendons. Development 134: 2697-2708. (Pubitemid 47225965)
9. Pryce BA, Brent AE, Murchison ND, et al. 2007. Generation of transgenic tendon reporters, ScxGFP and ScxAP, using regulatory elements of the scleraxis gene. Dev Dyn 236: 1677-1682. (Pubitemid 46932370)
10. Gulotta LV, Kovacevic D, Packer JD, et al. 2011. Bone marrow-derived mesenchymal stem cells transduced with scleraxis improve rotator cuff healing in a rat model. Am J Sports Med 39: 1282-1289.
11. Mendias CL, Bakhurin KI, Faulkner JA,. 2008. Tendons of myostatin-deficient mice are small, brittle, and hypocellular. Proc Natl Acad Sci USA 105: 388-393.
12. Loiselle AE, Bragdon GA, Jacobson JA, et al. 2009. Remodeling of murine intrasynovial tendon adhesions following injury: MMP and neotendon gene expression. J Orthop Res 27: 833-840.
13. Scott A, Sampaio A, Abraham T, et al. 2011. Scleraxis expression is coordinately regulated in a murine model of patellar tendon injury. J Orthop Res 29: 289-296.
14. Eliasson P, Andersson T, Aspenberg P,. 2009. Rat Achilles tendon healing: mechanical loading and gene expression. J Appl Physiol 107: 399-407.
15. Maeda T, Sakabe T, Sunaga A, et al. 2011. Conversion of mechanical force into TGF-β-mediated biochemical signals. Curr Biol 21: 933-941.
16. Docheva D, Hunziker EB, Fässler R, et al. 2005. Tenomodulin is necessary for tenocyte proliferation and tendon maturation. Mol Cell Biol 25: 699-705. (Pubitemid 40096590)
17. Jelinsky S, Archambault J, Li L, et al. 2010. Tendon-selective genes identified from rat and human musculoskeletal tissues. J Orthop Res 28: 289-297.
18. Shukunami C, Oshima Y, Hiraki Y,. 2005. Chondromodulin-I and tenomodulin: a new class of tissue-specific angiogenesis inhibitors found in hypovascular connective tissues. Biochem Biophys Res Commun 333: 299-307. (Pubitemid 40848292)
19. Shukunami C, Takimoto A, Oro M, et al. 2006. Scleraxis positively regulates the expression of tenomodulin, a differentiation marker of tenocytes. Dev Biol 298: 234-247. (Pubitemid 44414808)
20. Michna H,. 1984. Morphometric analysis of loading-induced changes in collagen-fibril populations in young tendons. Cell Tissue Res 236: 465-470. (Pubitemid 14143347)
21. Livak KJ, Schmittgen TD,. 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25: 402-408. (Pubitemid 34164012)
22. Schmittgen TD, Livak KJ,. 2008. Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc 3: 1101-1108. (Pubitemid 351818697)
23. Léjard V, Brideau G, Blais F, et al. 2007. Scleraxis and NFATc regulate the expression of the pro-alpha 1(I) collagen gene in tendon fibroblasts. J Biol Chem 282: 17665-17675. (Pubitemid 47100274)
24. Pryce BA, Watson SS, Murchison ND, et al. et al. 2009. Recruitment and maintenance of tendon progenitors by TGF{beta} signaling are essential for tendon formation. Development 136: 1351-1361.
25. Lorda-Diez CI, Montero JA, Martinez-Cue C, et al. 2009. Transforming growth factors beta coordinate cartilage and tendon differentiation in the developing limb mesenchyme. J Biol Chem 284: 29988-29996.
26. Heinemeier K, Langberg H, Olesen JL, et al. 2003. Role of TGF-beta1 in relation to exercise-induced type I collagen synthesis in human tendinous tissue. J Appl Physiol 95: 2390-2397. (Pubitemid 37444984)
27. Eliasson P, Andersson T, Kulas J, et al. 2009. Myostatin in tendon maintenance and repair. Growth Factors 27: 247-254.
28. Taylor SH, Al-Youha S, Van Agtmael T, et al. 2011. Tendon is covered by a basement membrane epithelium that is required for cell retention and the prevention of adhesion formation. PLoS ONE 6: e16337.
29. Manske PR, Lesker PA,. 1984. Histologic evidence of intrinsic flexor tendon repair in various experimental animals. An in vitro study. Clin Orthop Relat Res 182: 297-304. (Pubitemid 14182875)
30. Gelberman RH, Steinberg D, Amiel D, et al. 1991. Fibroblast chemotaxis after tendon repair. J Hand Surg Am 16: 686-693.
31. Jones ME, Mudera V, Brown RA, et al. 2003. The early surface cell response to flexor tendon injury. J Hand Surg 28: 221-230. (Pubitemid 36373317)
32. Bi Y, Ehirchiou D, Kilts TM, et al. 2007. Identification of tendon stem/progenitor cells and the role of the extracellular matrix in their niche. Nat Med 13: 1219-1227. (Pubitemid 47530625)
33. Zhang J, Pan T, Liu Y, et al. 2010. Mouse treadmill running enhances tendons by expanding the pool of tendon stem cells (TSCs) and TSC-related cellular production of collagen. J Orthop Res 28: 1178-1183.
34. Zhang J, Wang JH-C,. 2010. Production of PGE(2) increases in tendons subjected to repetitive mechanical loading and induces differentiation of tendon stem cells into non-tenocytes. J Orthop Res 28: 198-203.
35. Maffulli N, Wong J, Almekinders LC,. 2003. Types and epidemiology of tendinopathy. Clin Sports Med 22: 675-692. (Pubitemid 37175570)
36. Khan K, Cook J,. 2003. The painful nonruptured tendon: clinical aspects. Clin Sports Med 22: 711-725. (Pubitemid 37175573)