Curcumin protects against fructose-induced podocyte insulin signaling impairment through upregulation of miR-206

Molecular Nutrition and Food Research

Volumn 59, Issue 12, 2015, Pages 2355-2370

  Ding, Xiao Qin ^a   Gu, Ting Ting ^a   Wang, Wei ^a   Song, Lin ^a   Chen, Tian Yu ^a   Xue, Qiao Chu ^a   Zhou, Fan ^a   Li, Jian Mei ^a   Kong, Ling Dong ^a  

^a NANJING UNIVERSITY   (China)

Author keywords

Curcumin; Fructose intake; Insulin resistance; MiRNA 206; Podocyte injury

Indexed keywords

CURCUMIN; FRUCTOSE; INSULIN; MICRORNA; MIRN206 MICRORNA, RAT; PROTECTIVE AGENT; PROTEIN TYROSINE PHOSPHATASE 1B; PTPN1 PROTEIN, RAT;

ANIMAL; CHEMICALLY INDUCED; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; INSULIN RESISTANCE; MALE; METABOLIC SYNDROME X; METABOLISM; PATHOLOGY; PODOCYTE; PROTEINURIA; SPRAGUE DAWLEY RAT; UPREGULATION;

ANIMALS; CURCUMIN; FRUCTOSE; GENE EXPRESSION REGULATION; INSULIN; INSULIN RESISTANCE; MALE; METABOLIC SYNDROME X; MICRORNAS; PODOCYTES; PROTECTIVE AGENTS; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1; PROTEINURIA; RATS, SPRAGUE-DAWLEY; UP-REGULATION;

EID: 84954368754     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.201500370     Document Type: Article

References (50)

1. Wei, C., Moller, C. C., Altintas, M. M., Li, J. et al., Modification of kidney barrier function by the urokinase receptor. Nat. Med. 2008, 14, 55-63.
2. Palanisamy, N., Kannappan, S., Anuradha, C. V., Genistein modulates NF-kappaB-associated renal inflammation, fibrosis and podocyte abnormalities in fructose-fed rats. Eur. J. Pharmacol. 2011, 667, 355-364.
3. Wang, W., Ding, X. Q., Gu, T. T., Song, L. et al., Pterostilbene and allopurinol reduce fructose-induced podocyte oxidative stress and inflammation via microRNA-377. Free Radic. Biol. Med. 2015, 83, 214-226.
4. Egawa, K., Maegawa, H., Shimizu, S., Morino, K. et al., Protein-tyrosine phosphatase-1B negatively regulates insulin signaling in l6 myocytes and Fao hepatoma cells. J. Biol. Chem. 2001, 276, 10207-10211.
5. Goldstein, B. J., Regulation of insulin receptor signaling by protein-tyrosine dephosphorylation. Receptor 1993, 3, 1-15.
6. Nezvitsky, L., Tremblay, M. L., Takano, T., Papillon, J. et al., Complement-mediated glomerular injury is reduced by inhibition of protein-tyrosine phosphatase 1B. Am. J. Physiol. Renal Physiol. 2014, 307, F634-647.
7. Sorensson, J., Fierlbeck, W., Heider, T., Schwarz, K. et al., Glomerular endothelial fenestrae in vivo are not formed from caveolae. J. Am. Soc. Nephrol. 2002, 13, 2639-2647.
8. Lee, H., Xie, L., Luo, Y., Lee, S. Y. et al., Identification of phosphocaveolin-1 as a novel protein tyrosine phosphatase 1B substrate. Biochemistry 2006, 45, 234-240.
9. Harvey, S. J., Jarad, G., Cunningham, J., Goldberg, S. et al., Podocyte-specific deletion of dicer alters cytoskeletal dynamics and causes glomerular disease. J. Am. Soc. Nephrol. 2008, 19, 2150-2158.
10. Zhdanova, O., Srivastava, S., Di, L., Li, Z. et al., The inducible deletion of Drosha and microRNAs in mature podocytes results in a collapsing glomerulopathy. Kidney Int. 2011, 80, 719-730.
11. Ho, J., Ng, K. H., Rosen, S., Dostal, A. et al., Podocyte-specific loss of functional microRNAs leads to rapid glomerular and tubular injury. J. Am. Soc. Nephrol. 2008, 19, 2069-2075.
12. Shi, S., Yu, L., Chiu, C., Sun, Y. et al., Podocyte-selective deletion of dicer induces proteinuria and glomerulosclerosis. J. Am. Soc. Nephrol. 2008, 19, 2159-2169.
13. Gallagher, I. J., Scheele, C., Keller, P., Nielsen, A. R. et al., Integration of microRNA changes in vivo identifies novel molecular features of muscle insulin resistance in type 2 diabetes. Genome Med. 2010, 2, 9.
14. Hu, Q. H., Zhang, X., Pan, Y., Li, Y. C. et al., Allopurinol, quercetin and rutin ameliorate renal NLRP3 inflammasome activation and lipid accumulation in fructose-fed rats. Biochem. Pharmacol. 2012, 84, 113-125.
15. Li, J. M., Li, Y. C., Kong, L. D., Hu, Q. H., Curcumin inhibits hepatic protein-tyrosine phosphatase 1B and prevents hypertriglyceridemia and hepatic steatosis in fructose-fed rats. Hepatology 2010, 51, 1555-1566.
16. Yang, H., Xu, W., Zhou, Z., Liu, J. et al., Curcumin attenuates urinary excretion of albumin in type II diabetic patients with enhancing nuclear factor erythroid-derived 2-like 2 (Nrf2) system and repressing inflammatory signaling efficacies. Exp. Clin. Endocrinol. Diabetes 2015, 123, 360-367.
17. Yang, Y. S., Su, Y. F., Yang, H. W., Lee, Y. H. et al., Lipid-lowering effects of curcumin in patients with metabolic syndrome: a randomized, double-blind, placebo-controlled trial. Phytother. Res. 2014, 28, 1770-1777.
18. Maradana, M. R., Thomas, R., O'Sullivan, B. J., Targeted delivery of curcumin for treating type 2 diabetes. Mol. Nutr. Food Res. 2013, 57, 1550-1556.
19. Li, D., Lu, Z., Jia, J., Zheng, Z. et al., Curcumin ameliorates podocytic adhesive capacity damage under mechanical stress by inhibiting miR-124 expression. Kidney Blood Press. Res. 2013, 38, 61-71.
20. Tikoo, K., Meena, R. L., Kabra, D. G., Gaikwad, A. B., Change in post-translational modifications of histone H3, heat-shock protein-27 and MAP kinase p38 expression by curcumin in streptozotocin-induced type I diabetic nephropathy. Br. J. Pharmacol. 2008, 153, 1225-1231.
21. Sun, L. N., Chen, Z. X., Liu, X. C., Liu, H. Y. et al., Curcumin ameliorates epithelial-to-mesenchymal transition of podocytes in vivo and in vitro via regulating caveolin-1. Biomed. Pharmacother. 2014, 68, 1079-1088.
22. Sun, L. N., Yang, Z. Y., Lv, S. S., Liu, X. C. et al., Curcumin prevents diabetic nephropathy against inflammatory response via reversing caveolin-1 Tyr14 phosphorylation influenced TLR4 activation. Int. Immunopharmacol. 2014, 23, 236-246.
23. Sarafidis, P. A., Stafylas, P. C., Georgianos, P. I., Saratzis, A. N. et al., Effect of thiazolidinediones on albuminuria and proteinuria in diabetes: a meta-analysis. Am. J. Kidney Dis. 2010, 55, 835-847.
24. Miglio, G., Rosa, A. C., Rattazzi, L., Grange, C. et al., Protective effects of peroxisome proliferator-activated receptor agonists on human podocytes: proposed mechanisms of action. Br. J. Pharmacol. 2012, 167, 641-653.
25. Guthmann, F., Schachtrup, C., Tolle, A., Wissel, H. et al., Phenotype of palmitic acid transport and of signalling in alveolar type II cells from E/H-FABP double-knockout mice: contribution of caveolin-1 and PPARgamma. Biochim. Biophys. Acta 2004, 1636, 196-204.
26. Zhang, D. M., Li, Y. C., Xu, D., Ding, X. Q. et al., Protection of curcumin against fructose-induced hyperuricaemia and renal endothelial dysfunction involves NO-mediated JAK-STAT signalling in rats. Food Chem. 2012, 134, 2184-2193.
27. Sharma, S., Kulkarni, S. K., Chopra, K., Curcumin, the active principle of turmeric (Curcuma longa), ameliorates diabetic nephropathy in rats. Clin. Exp. Pharmacol. Physiol. 2006, 33, 940-945.
28. Wang, X., Zhang, D. M., Gu, T. T., Ding, X. Q. et al., Morin reduces hepatic inflammation-associated lipid accumulation in high fructose-fed rats via inhibiting sphingosine kinase 1/sphingosine 1-phosphate signaling pathway. Biochem. Pharmacol. 2013, 86, 1791-1804.
29. Marsh, S. A., Dell'italia, L. J., Chatham, J. C., Interaction of diet and diabetes on cardiovascular function in rats. Am. J. Physiol. Heart Circ. Physiol. 2009, 296, H282-H292.
30. Li, X., Wang, X., Liu, R., Ma, Y. et al., Chronic leucine supplementation increases body weight and insulin sensitivity in rats on high-fat diet likely by promoting insulin signaling in insulin-target tissues. Mol. Nutr. Food Res. 2013, 57, 1067-1079.
31. Mundel, P., Reiser, J., Zuniga Mejia Borja, A., Pavenstadt, H. et al., Rearrangements of the cytoskeleton and cell contacts induce process formation during differentiation of conditionally immortalized mouse podocyte cell lines. Exp. Cell Res. 1997, 236, 248-258.
32. Li, J. M., Ge, C. X., Xu, M. X., Wang, W. et al., Betaine recovers hypothalamic neural injury by inhibiting astrogliosis and inflammation in fructose-fed rats. Mol. Nutr. Food Res. 2015, 59, 189-202.
33. Cirillo, P., Gersch, M. S., Mu, W., Scherer, P. M. et al., Ketohexokinase-dependent metabolism of fructose induces proinflammatory mediators in proximal tubular cells. J. Am. Soc. Nephrol. 2009, 20, 545-553.
34. Carroll, J. J., Coburn, H., Douglass, R., Babson, A. L., A simplified alkaline phosphotungstate assay for uric acid in serum. Clin. Chem. 1971, 17, 158-160.
35. Koop, K., Eikmans, M., Baelde, H. J., Kawachi, H. et al., Expression of podocyte-associated molecules in acquired human kidney diseases. J. Am. Soc. Nephrol. 2003, 14, 2063-2071.
36. van den Berg, J. G., van den Bergh Weerman, M. A., Assmann, K. J., Weening, J. J. et al., Podocyte foot process effacement is not correlated with the level of proteinuria in human glomerulopathies. Kidney Int. 2004, 66, 1901-1906.
37. Welsh, G. I., Hale, L. J., Eremina, V., Jeansson, M. et al., Insulin signaling to the glomerular podocyte is critical for normal kidney function. Cell Metab. 2010, 12, 329-340.
38. Coward, R. J., Welsh, G. I., Yang, J., Tasman, C. et al., The human glomerular podocyte is a novel target for insulin action. Diabetes 2005, 54, 3095-3102.
39. Lanaspa, M. A., Ishimoto, T., Cicerchi, C., Tamura, Y. et al., Endogenous fructose production and fructokinase activation mediate renal injury in diabetic nephropathy. J. Am. Soc. Nephrol. 2014, 25, 2526-2538.
40. Liu, Z. Q., Liu, T., Chen, C., Li, M. Y. et al., Fumosorinone, a novel PTP1B inhibitor, activates insulin signaling in insulin-resistance HepG2 cells and shows anti-diabetic effect in diabetic KKAy mice. Toxicol. Appl. Pharmacol. 2015, 285, 61-70.
41. Koren, S., Fantus, I. G., Inhibition of the protein tyrosine phosphatase PTP1B: potential therapy for obesity, insulin resistance and type-2 diabetes mellitus. Best Pract. Res. Clin. Endocrinol. Metab. 2007, 21, 621-640.
42. Ormazabal, P., Romero, C., Gabler, F., Quest, A. F. et al., Decreased phosphorylation of Y(1)(4)caveolin-1 in endometrial tissue of polycystic ovary syndrome patients may be related with an insulin resistant state in this tissue. Horm. Metab. Res. 2013, 45, 291-296.
43. Kumagai, T., Baldwin, C., Aoudjit, L., Nezvitsky, L. et al., Protein tyrosine phosphatase 1B inhibition protects against podocyte injury and proteinuria. Am. J. Pathol. 2014, 184, 2211-2224.
44. Jacob, A., Chaves, L., Eadon, M. T., Chang, A. et al., Curcumin alleviates immune-complex-mediated glomerulonephritis in factor-H-deficient mice. Immunology 2013, 139, 328-337.
45. Soetikno, V., Sari, F. R., Veeraveedu, P. T., Thandavarayan, R. A. et al., Curcumin ameliorates macrophage infiltration by inhibiting NF-kappaB activation and proinflammatory cytokines in streptozotocin induced-diabetic nephropathy. Nutr. Metab. 2011, 8, 35.
46. Lee, H., Kim, H., Lee, G., Chung, H. S. et al., Curcumin attenuates lupus nephritis upon interaction with regulatory T cells in New Zealand Black/White mice. Br. J. Nutr. 2013, 110, 69-76.
47. Gaedeke, J., Noble, N. A., Border, W. A., Curcumin blocks fibrosis in anti-Thy 1 glomerulonephritis through up-regulation of heme oxygenase 1. Kidney Int. 2005, 68, 2042-2049.
48. Wang, R., Li, Y. H., Xu, Y., Li, Y. B. et al., Curcumin produces neuroprotective effects via activating brain-derived neurotrophic factor/TrkB-dependent MAPK and PI-3K cascades in rodent cortical neurons. Prog. Neuropsychopharmacol. Biol. Psychiatry 2010, 34, 147-153.
49. Kobayashi, N., Gao, S. Y., Chen, J., Saito, K. et al., Process formation of the renal glomerular podocyte: is there common molecular machinery for processes of podocytes and neurons? Anat. Sci. Int. 2004, 79, 1-10.
50. Sahebkar, A., Why it is necessary to translate curcumin into clinical practice for the prevention and treatment of metabolic syndrome? Biofactors 2013, 39, 197-208.