Glomerular endothelial fenestrae In Vivo are not formed from caveolae

Journal of the American Society of Nephrology

Volumn 13, Issue 11, 2002, Pages 2639-2647

  Sörensson, Jenny ^a   Fierlbeck, Wolfgang ^a   Heider, Torsten ^a   Schwarz, Karin ^a   Park, David S ^a   Mundel, Peter ^a   Lisanti, Michael ^a   Ballermann, Barbara J ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CAVEOLIN 1; CD2 ASSOCIATED PROTEIN; CELL PROTEIN; NEPHRIN; PODOCIN; SYNAPTOPODIN; ULEX EUROPAEUS AGGLUTININ; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CAVEOLA; CELL MEMBRANE; CELL ULTRASTRUCTURE; CONTROLLED STUDY; ENDOTHELIUM CELL; FEMALE; GLOMERULUS; GLOMERULUS CAPILLARY; GLOMERULUS ENDOTHELIUM; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE; IMMUNOGOLD ELECTRON MICROSCOPY; IMMUNOPRECIPITATION; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PODOCYTE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; UREA NITROGEN BLOOD LEVEL; URINARY EXCRETION;

EID: 0036841868     PISSN: 10466673     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.ASN.0000033277.32822.23     Document Type: Article

References (30)

1. Farquhar MG: The primary glomerular filtration barrier - Basement membrane or epithelial slits? Kidney Int 8: 197-211, 1975
2. Deen WM, Lazzara MJ, Myers BD: Structural determinants of glomerular permeability. Am J Physiol Renal Physiol 281: F579-F596, 2001
3. Galbiati F, Razani B, Lisanti MP: Emerging themes in lipid rafts and caveolae. Cell 106: 403-411, 2001
4. Razani B, Engelman JA, Wang XB, Schubert W, Zhang XL, Marks CB, Macaluso F, Russell RG, Li M, Pestell RG, Di Vizio D, Hou H, Jr., Kneitz B, Lagaud G, Christ GJ, Edelmann W, Lisanti MP: Caveolin-1 null mice are viable but show evidence of hyperproliferative and vascular abnormalities. J Biol Chem 276: 38121-38138, 2001
5. Drab M, Verkade P, Elger M, Kasper M, Lohn M, Lauterbach B, Menne J, Lindschau C, Mende F, Luft FC, Schedl A, Haller H, Kurzchalia TV: Loss of caveolae, vascular dysfunction, and pulmonary defects in caveolin-1 gene-disrupted mice. Science 293: 2449-2452, 2001
6. Chen J, Braet F, Brodsky S, Weinstein T, Romanov V, Noiri E, Goligorsky MS: VEGF-induced mobilization of caveolae and increase in permeability of endothelial cells. Am J Physiol Cell Physiol 282: C1053-C1063, 2002
7. Feng D, Nagy JA, Pyne K, Hammel I, Dvorak HF, Dvorak AM: Pathways of macromolecular extravasation across microvascular endothelium in response to VPF/VEGF and other vasoactive mediators. Microcirculation 6: 23-44, 1999
8. Clementi F, Palade GE: Intestinal capillaries. I. Permeability to peroxidase and ferritin. J Cell Biol 41: 33-58, 1969
9. Stan RV, Kubitza M, Palade GE: PV-1 is a component of the fenestral and stomatal diaphragms in fenestrated endothelia. Proc Natl Acad Sci USA 96: 13203-13207, 1999
10. Rostgaard J, Qvortrup K: Sieve plugs in fenestrae of glomerular capillaries - Site of the filtration barrier? Cells Tissues Organs 170: 132-138, 2002
11. Simionescu N, Lupu F, Simionescu M: Rings of membrane sterols surround the openings of vesicles and fenestrae, in capillary endothelium. J Cell Biol 97: 1592-1600, 1983
12. Stan RV, Ghitescu L, Jacobson BS, Palade GE: Isolation, cloning, and localization of rat PV-1, a novel endothelial caveolar protein. J Cell Biol 145: 1189-1198, 1999
13. Vasile E, Qu H, Dvorak HF, Dvorak AM: Caveolae and vesiculo-vacuolar organelles in bovine capillary endothelial cells cultured with VPF/VEGF on floating Matrigel-collagen gels. J Histochem Cytochem 47: 159-167, 1999
14. Breier G, Albrecht U, Sterrer S, Risau W: Expression of vascular endothelial growth factor during embryonic angiogenesis and endothelial cell differentiation. Development 114: 521-532, 1992
15. Roberts WG, Palade GE: Increased microvascular permeability and endothelial fenestration induced by vascular endothelial growth factor. J Cell Sci 108: 2369-2379, 1995
16. Esser S, Wolburg K, Wolburg H, Breier G, Kurzchalia T, Risau W: Vascular endothelial growth factor induces endothelial fenestrations in vitro. J Cell Biol 140: 947-959, 1998
17. Mundel P, Heid HW, Mundel TM, Kruger M, Reiser J, Kriz W: Synaptopodin: An actin-associated protein in telencephalic dendrites and renal podocytes. J Cell Biol 139: 193-204, 1997
18. Schwarz K, Simons M, Reiser J, Saleem MA, Faul C, Kriz W, Shaw AS, Holzman LB, Mundel P: Podocin, a raft-associated component of the glomerular slit diaphragm, interacts with CD2AP and nephrin. J Clin Invest 108: 1621-1629, 2001
19. Holzman LB, St John PL, Kovari IA, Verma R, Holthofer H, Abrahamson DR: Nephrin localizes to the slit pore of the glomerular epithelial cell. Kidney Int 56: 1481-1491, 1999
20. Shih NY, Li J, Karpitskii V, Nguyen A, Dustin ML, Kanagawa O, Miner JH, Shaw AS: Congenital nephrotic syndrome in mice lacking CD2-associated protein. Science 286: 312-315, 1999
21. Laemmli UK: Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680-685, 1970
22. Breton S, Lisanti MP, Tyszkowski R, McLaughlin M, Brown D: Basolateral distribution of caveolin-1 in the kidney. Absence from H+- atpase-coated endocytic vesicles in intercalated cells. J Histochem Cytochem 46: 205-214, 1998
23. Simons M, Schwarz K, Kriz W, Miettinen A, Reiser J, Mundel P, Holthofer H: Involvement of lipid rafts in nephrin phosphorylation and organization of the glomerular slit diaphragm. Am J Pathol 159: 1069-1077, 2001
24. Roberts WG, Palade GE: Neovasculature induced by vascular endothelial growth factor is fenestrated. Cancer Res 57: 765-772, 1997
25. Bankston PW, Milici AJ: A survey of the binding of polycationic ferritin in several fenestrated capillary beds: Indication of heterogeneity in the luminal glycocalyx of fenestral diaphragms. Microvasc Res 26: 36-48, 1983
26. Tamai O, Oka N, Kikuchi T, Koda Y, Soejima M, Wada Y, Fujisawa M, Tamaki K, Kawachi H, Shimizu F, Kimura H, Imaizumi T, Okuda S: Caveolae in mesangial cells and caveolin expression in mesangial proliferative glomerulonephritis. Kidney Int 59: 471-480, 2001
27. Shih NY, Li J, Cotran R, Mundel P, Miner JH, Shaw AS: CD2AP localizes to the slit diaphragm and binds to nephrin via a novel C-terminal domain. Am J Pathol 159: 2303-2308, 2001
28. Kestila M, Lenkkeri U, Mannikko M, Lamerdin J, McCready P, Putaala H, Ruotsalainen V, Morita T, Nissinen M, Herva R, Kashtan CE, Peltonen L, Holmberg C, Olsen A, Tryggvason K: Positionally cloned gene for a novel glomerular protein-nephrin-is mutated in congenital nephrotic syndrome. Mol Cell 1: 575-582, 1998
29. Boute N, Gribouval O, Roselli S, Benessy F, Lee H, Fuchshuber A, Dahan K, Gubler MC, Niaudet P, Antignac C: NPHS2, encoding the glomerular protein podocin, is mutated in autosomal recessive steroid-resistant nephrotic syndrome. Nat Genet 24: 349-354, 2000
30. Feron O, Belhassen L, Kobzik L, Smith TW, Kelly RA, Michel T: Endothelial nitric oxide synthase targeting to caveolae. Specific interactions with caveolin isoforms in cardiac myocytes and endothelial cells. J Biol Chem 271: 22810-22814, 1996