Alda-1 attenuates lung ischemia-reperfusion injury by reducing 4-hydroxy-2-nonenal in alveolar epithelial cells

Critical Care Medicine

Volumn 44, Issue 7, 2016, Pages e544-e552

  Ding, Jie ^a,b   Zhang, Quanyi ^a,b   Luo, Qipeng ^a,b   Ying, Yongquan ^a,b   Liu, Yiwei ^a,b   Li, Yinan ^a,b   Wei, Wei ^a,b   Yan, Fuxia ^a,b   Zhang, Hao ^a,b  

^a FUWAI HOSPITAL   (China)

^b PEKING UNION MEDICAL COLLEGE   (China)

Author keywords

4 hydroxy 2 nonenal; alda 1; epithelial cells; lung injury; pulmonary alveoli; reperfusion injury

Indexed keywords

4 HYDROXYNONENAL; ALDA 1; ALDEHYDE DEHYDROGENASE ISOENZYME 2; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1BETA; INTERLEUKIN 6; MALONALDEHYDE; MYELOPEROXIDASE; SURFACTANT PROTEIN C; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; 1,3 BENZODIOXOLE DERIVATIVE; 4-HYDROXY-2-NONENAL; ALDEHYDE; BENZAMIDE DERIVATIVE; N-(1,3-BENZODIOXOL-5-YLMETHYL)-2,6-DICHLOROBENZAMIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CAPILLARY ENDOTHELIAL CELL; CONTROLLED STUDY; ENZYME ACTIVITY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE; INFLAMMATION; LUNG ALVEOLUS EPITHELIUM CELL; LUNG INJURY; LUNG PARENCHYMA; MALE; NONHUMAN; PERMEABILITY BARRIER; PRIORITY JOURNAL; PROSPECTIVE STUDY; PULMONARY MICROVASCULAR ENDOTHELIAL CELL; RAT; REPERFUSION INJURY; SUPPLEMENTATION; TUNEL ASSAY; WESTERN BLOTTING; ANIMAL; CELL CULTURE; METABOLISM; SPRAGUE DAWLEY RAT;

ALDEHYDE DEHYDROGENASE, MITOCHONDRIAL; ALDEHYDES; ALVEOLAR EPITHELIAL CELLS; ANIMALS; BENZAMIDES; BENZODIOXOLES; CELLS, CULTURED; HUMANS; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY;

EID: 84954357138     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0000000000001563     Document Type: Article

References (40)

1. Apostolakis E, Filos KS, Koletsis E, et al. Lung dysfunction following cardiopulmonary bypass. J Card Surg 2010; 25:47-55
2. Weyker PD, Webb CA, Kiamanesh D, et al. Lung ischemia reperfusion injury: A bench-To-bedside review. Semin Cardiothorac Vasc Anesth 2013; 17:28-43
3. den Hengst WA, Gielis JF, Lin JY, et al. Lung ischemia-reperfusion injury: A molecular and clinical view on a complex pathophysiological process. Am J Physiol Heart Circ Physiol 2010; 299:H1283-H1299
4. Hill BG, Bhatnagar A. Beyond reactive oxygen species: Aldehydes as arbitrators of alarm and adaptation. Circ Res 2009; 105:1044-1046
5. Chen CH, Sun L, Mochly-Rosen D. Mitochondrial aldehyde dehydrogenase and cardiac diseases. Cardiovasc Res 2010; 88:51-57
6. Gong D, Zhang H, Hu S. Mitochondrial aldehyde dehydrogenase 2 activation and cardioprotection. J Mol Cell Cardiol 2013; 55:58-63
7. Chen CH, Budas GR, Churchill EN, et al. Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart. Science 2008; 321:1493-1495
8. Perez-Miller S, Younus H, Vanam R, et al. Alda-1 is an agonist and chemical chaperone for the common human aldehyde dehydrogenase 2 variant. Nat Struct Mol Biol 2010; 17:159-164
9. Gong D, Zhang Y, Zhang H, et al. Aldehyde dehydrogenase-2 activation during cardioplegic arrest enhances the cardioprotection against myocardial ischemia-reperfusion injury. Cardiovasc Toxicol 2012; 12:350-358
10. Fu SH, Zhang HF, Yang ZB, et al. Alda-1 reduces cerebral ischemia/reperfusion injury in rat through clearance of reactive aldehydes. Naunyn Schmiedebergs Arch Pharmacol 2014; 387:87-94
11. Guo JM, Liu AJ, Zang P, et al. ALDH2 protects against stroke by clearing 4-HNE. Cell Res 2013; 23:915-930
12. Schlensak C, Doenst T, Preusser S, et al. Cardiopulmonary bypass reduction of bronchial blood flow: A potential mechanism for lung injury in a neonatal pig model. J Thorac Cardiovasc Surg 2002; 123:1199-1205
13. Liu Y, Wang Q, Zhu X, et al. Pulmonary artery perfusion with protective solution reduces lung injury after cardiopulmonary bypass. Ann Thorac Surg 2000; 69:1402-1407
14. Suzuki T. Additional lung-protective perfusion techniques during cardiopulmonary bypass. Ann Thorac Cardiovasc Surg 2010; 16:150-155
15. Fan X, Liu Y, Wang Q, et al. Lung perfusion with clarithromycin ameliorates lung function after cardiopulmonary bypass. Ann Thorac Surg 2006; 81:896-901
16. Zhu W, Chen J, Cong X, et al. Hypoxia and serum deprivation-induced apoptosis in mesenchymal stem cells. Stem Cells 2006; 24:416-425
17. Chiang CH, Chuang CH, Liu SL. Apocynin attenuates ischemiareperfusion lung injury in an isolated and perfused rat lung model. Transl Res 2011; 158:17-29
18. Drake R, Gaar KA, Taylor AE. Estimation of the filtration coefficient of pulmonary exchange vessels. Am J Physiol 1978; 234:H266-H274
19. Schlensak C, Doenst T, Preusser S, et al. Bronchial artery perfusion during cardiopulmonary bypass does not prevent ischemia of the lung in piglets: Assessment of bronchial artery blood flow with fluorescent microspheres. Eur J Cardiothorac Surg 2001; 19:326-331
20. Apostolakis EE, Koletsis EN, Baikoussis NG, et al. Strategies to prevent intraoperative lung injury during cardiopulmonary bypass. J Cardiothorac Surg 2010; 5:1
21. de Perrot M, Liu M, Waddell TK, et al. Ischemia-reperfusion-induced lung injury. Am J Respir Crit Care Med 2003; 167:490-511
22. Al-Mehdi AB, Shuman H, Fisher AB. Intracellular generation of reactive oxygen species during nonhypoxic lung ischemia. Am J Physiol 1997; 272:L294-L300
23. Forman HJ, Thomas MJ. Oxidant production and bactericidal activity of phagocytes. Annu Rev Physiol 1986; 48:669-680
24. Yoon M, Madden MC, Barton HA. Developmental expression of aldehyde dehydrogenase in rat: A comparison of liver and lung development. Toxicol Sci 2006; 89:386-398
25. Stewart MJ, Malek K, Crabb DW. Distribution of messenger RNAs for aldehyde dehydrogenase 1, aldehyde dehydrogenase 2, and aldehyde dehydrogenase 5 in human tissues. J Investig Med 1996; 44:42-46
26. Petersen DR, Doorn JA. Reactions of 4-hydroxynonenal with proteins and cellular targets. Free Radic Biol Med 2004; 37:937-945
27. Yoval-Sánchez B, Rodríguez-Zavala JS. Differences in susceptibility to inactivation of human aldehyde dehydrogenases by lipid peroxidation byproducts. Chem Res Toxicol 2012; 25:722-729
28. Doorn JA, Hurley TD, Petersen DR. Inhibition of human mitochondrial aldehyde dehydrogenase by 4-hydroxynon-2-enal and 4-oxonon-2-enal. Chem Res Toxicol 2006; 19:102-110
29. Fischer S, Cassivi SD, Xavier AM, et al. Cell death in human lung transplantation: Apoptosis induction in human lungs during ischemia and after transplantation. Ann Surg 2000; 231:424-431
30. Signorelli S, Jennings P, Leonard MO, et al. Differential effects of hypoxic stress in alveolar epithelial cells and microvascular endothelial cells. Cell Physiol Biochem 2010; 25:135-144
31. Ho YS, Liou HB, Lin JK, et al. Lipid peroxidation and cell death mechanisms in pulmonary epithelial cells induced by peroxynitrite and nitric oxide. Arch Toxicol 2002; 76:484-493
32. Endo J, Sano M, Katayama T, et al. Metabolic remodeling induced by mitochondrial aldehyde stress stimulates tolerance to oxidative stress in the heart. Circ Res 2009; 105:1118-1127
33. Zhang H, Gong DX, Zhang YJ, et al. Effect of mitochondrial aldehyde dehydrogenase-2 genotype on cardioprotection in patients with congenital heart disease. Eur Heart J 2012; 33:1606-1614
34. Vaporidi K, Tsatsanis C, Georgopoulos D, et al. Effects of hypoxia and hypercapnia on surfactant protein expression proliferation and apoptosis in A549 alveolar epithelial cells. Life Sci 2005; 78:284-293
35. Aoki T, Suzuki Y, Nishio K, et al. Role of CD18-ICAM-1 in the entrapment of stimulated leukocytes in alveolar capillaries of perfused rat lungs. Am J Physiol 1997; 273:H2361-H2371
36. Fisher AB, Al-Mehdi AB, Manevich Y. Shear stress and endothelial cell activation. Crit Care Med 2002; 30:S192-S197
37. Wendel M, Giessmann U, Behrend P, et al. Inflammatory-Activated microvascular endothelial cells regulate interleukin-8 and monocyte chemoattractant protein-1 expression of A549 cells in a paracrine fashion. Exp Lung Res 2008; 34:85-100
38. Mulligan MS, Vaporciyan AA, Miyasaka M, et al. Tumor necrosis factor alpha regulates in vivo intrapulmonary expression of ICAM-1. Am J Pathol 1993; 142:1739-1749
39. Hermanns MI, Unger RE, Kehe K, et al. Lung epithelial cell lines in coculture with human pulmonary microvascular endothelial cells: Development of an alveolo-capillary barrier in vitro. Lab Invest 2004; 84:736-752
40. Beretta M, Gorren AC, Wenzl MV, et al. Characterization of the East Asian variant of aldehyde dehydrogenase-2: Bioactivation of nitroglycerin and effects of Alda-1. J Biol Chem 2010; 285:943-952