Alda-1 reduces cerebral ischemia/reperfusion injury in rat through clearance of reactive aldehydes

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 387, Issue 1, 2014, Pages 87-94

  Fu, Si Hai ^a   Zhang, Hong Feng ^a   Yang, Zhong Bao ^a   Li, Ting Bo ^a   Liu, Bin ^a   Lou, Zheng ^a   Ma, Qi Lin ^a   Luo, Xiu Ju ^a   Peng, Jun ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Alda 1; Aldehyde dehydrogenase 2; Brain; Ischemia reperfusion; Reactive aldehydes

Indexed keywords

4 HYDROXYNONENAL; ALDEHYDE; ALDEHYDE DEHYDROGENASE ISOENZYME 2; CASPASE 3; MALONALDEHYDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; BRAIN TISSUE; CONTROLLED STUDY; DRUG MEGADOSE; ENZYME ACTIVATION; ENZYME ACTIVITY; LOW DRUG DOSE; MALE; MORTALITY; NONHUMAN; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY;

ALDEHYDE DEHYDROGENASE; ALDEHYDES; ANIMALS; BENZAMIDES; BENZODIOXOLES; BRAIN ISCHEMIA; MALE; METABOLIC CLEARANCE RATE; MITOCHONDRIAL PROTEINS; NEUROPROTECTIVE AGENTS; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY;

EID: 84891617201     PISSN: 00281298     EISSN: 14321912     Source Type: Journal    
DOI: 10.1007/s00210-013-0922-8     Document Type: Article

References (26)

1. Abarikwu SO, Pant AB, Farombi EO (2012) 4-Hydroxynonenal induces mitochondrial-mediated apoptosis and oxidative stress in SH-SY5Y human neuronal cells. Basic Clin Pharmacol Toxicol 110:441-448
2. Brouns R, De Deyn PP (2009) The complexity of neurobiological processes in acute ischemic stroke. Clin Neurol Neurosurg 111:483-495
3. Carbone DL, Doorn JA, Kiebler Z, Ickes BR, Petersen DR (2005) Modification of heat shock protein 90 by 4-hydroxynonenal in a rat model of chronic alcoholic liver disease. J Pharmacol Exp Ther 315:8-15
4. Chen CH, Budas GR, Churchill EN, Disatnik MH, Hurley TD, Mochly-Rosen D (2008) Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart. Science 321:1493-1495
5. Chen H, Yoshioka H, Kim GS, Jung JE, Okami N, Sakata H, Maier CM, Narasimhan P, Goeders CE, Chan PH (2011) Oxidative stress in ischemic brain damage: mechanisms of cell death and potential molecular targets for neuroprotection. Antioxid Redox Signal 14:1505-1517
6. Cheng CY, Su SY, Tang NY, Ho TY, Chiang SY, Hsieh CL (2008) Ferulic acid provides neuroprotection against oxidative stress-related apoptosis after cerebral ischemia/reperfusion injury by inhibiting ICAM-1 mRNA expression in rats. Brain Res 1209:136-150
7. Cheng J, Wang F, Yu DF, Wu PF, Chen JG (2011) The cytotoxic mechanism of malondialdehyde and protective effect of carnosine via protein cross-linking/mitochondrial dysfunction/reactive oxygen species/MAPK pathway in neurons. Eur J Pharmacol 650:184-194
8. Cherubini A, Ruggiero C, Polidori MC, Mecocci P (2005) Potential markers of oxidative stress in stroke. Free Radic Biol Med 39:841-852
9. Firuzi O, Miri R, Tavakkoli M, Saso L (2011) Antioxidant therapy: current status and future prospects. Curr Med Chem 18:3871-3888
10. Glatt H, Rost K, Frank H, Seidel A, Kollock R (2008) Detoxification of promutagenic aldehydes derived from methylpyrenes by human aldehyde dehydrogenases ALDH2 and ALDH3A1. Arch Biochem Biophys 477:196-205
11. Grotta J (2012) Timing of thrombolysis for acute ischemic stroke: "timing is everything" or "everyone is different". Ann N Y Acad Sci 1268:141-144
12. Guo JM, Liu AJ, Zang P, Dong WZ, Ying L, Wang W, Xu P, Song XR, Cai J, Zhang SQ, Duan JL, Mehta JL, Su DF (2013) ALDH2 protects against stroke by clearing 4-HNE. Cell Res 23:915-930
13. Higashi Y (2009) Edaravone for the treatment of acute cerebral infarction: role of endothelium-derived nitric oxide and oxidative stress. Expert Opin Pharmacother 10:323-331
14. Ho YS, Liou HB, Lin JK, Jeng JH, Pan MH, Lin YP, Guo HR, Ho SY, Lee CC, Wang YJ (2002) Lipid peroxidation and cell death mechanisms in pulmonary epithelial cells induced by peroxynitrite and nitric oxide. Arch Toxicol 76:484-493
15. Jung JE, Kim GS, Chen H, Maier CM, Narasimhan P, Song YS, Niizuma K, Katsu M, Okami N, Yoshioka H, Sakata H, Goeders CE, Chan PH (2010) Reperfusion and neurovascular dysfunction in stroke: from basic mechanisms to potential strategies for neuroprotection. Mol Neurobiol 41:172-179
16. Nakase T, Yoshioka S, Suzuki A (2011) Free radical scavenger, edaravone, reduces the lesion size of lacunar infarction in human brain ischemic stroke. BMC Neurol 11:39
17. Pan J, Konstas AA, Bateman B, Ortolano GA, Pile-Spellman J (2007) Reperfusion injury following cerebral ischemia: pathophysiology, MR imaging, and potential therapies. Neuroradiology 49:93-102
18. Roth C, Reith W, Walter S, Behnke S, Kettner M, Viera J, Yilmaz U, Alexandrou M, Politi M, Kostopoulos P, Korner H, Krick C, Haass A, Fassbender K, Papanagiotou P (2013) Mechanical recanalization with flow restoration in acute ischemic stroke: the ReFlow (mechanical recanalization with flow restoration in acute ischemic stroke) study. JACC Cardiovasc Interv 6:386-391
19. Sallar AM, Williams PB, Omishakin AM, Lloyd DP (2010) Stroke prevention: awareness of risk factors for stroke among African American residents in the Mississippi delta region. J Natl Med Assoc 102:84-94
20. Schabitz WR, Schade H, Heiland S, Kollmar R, Bardutzky J, Henninger N, Muller H, Carl U, Toyokuni S, Sommer C, Schwab S (2004) Neuroprotection by hyperbaric oxygenation after experimental focal cerebral ischemia monitored by MRI. Stroke 35:1175-1179
21. Slemmer JE, Shacka JJ, Sweeney MI, Weber JT (2008) Antioxidants and free radical scavengers for the treatment of stroke, traumatic brain injury and aging. Curr Med Chem 15:404-414
22. Sun A, Ren J (2013) ALDH2, a novel protector against stroke? Cell Res 23:874-875
23. Vaishnav RA, Singh IN, Miller DM, Hall ED (2010) Lipid peroxidation-derived reactive aldehydes directly and differentially impair spinal cord and brain mitochondrial function. J Neurotrauma 27:1311-1320
24. Vasiliou V, Nebert DW (2005) Analysis and update of the human aldehyde dehydrogenase (ALDH) gene family. Hum Genomics 2:138-143
25. Watanabe T, Tahara M, Todo S (2008) The novel antioxidant edaravone: from bench to bedside. Cardiovasc Ther 26:101-114
26. Yajima D, Motani H, Hayakawa M, Sato Y, Sato K, Iwase H (2009) The relationship between cell membrane damage and lipid peroxidation under the condition of hypoxia-reoxygenation: analysis of the mechanism using antioxidants and electron transport inhibitors. Cell Biochem Funct 27:338-343