Mitochondrion-targeted peptide SS-31 inhibited oxidized low-density lipoproteins-induced foam cell formation through both ros scavenging and inhibition of cholesterol influx in RAW264.7 cells

Molecules

Volumn 20, Issue 12, 2015, Pages 21287-21297

  Hao, Shuangying ^a   Ji, Jiajie ^b   Zhao, Hongting ^a   Shang, Longcheng ^a   Wu, Jing ^a   Li, Huihui ^a   Qiao, Tong ^b   Li, Kuanyu ^a   McPhee, Derek J ^c  

^a MEDICAL SCHOOL OF NANJING UNIVERSITY   (China)

^b THE AFFILIATED DRUM TOWER HOSPITAL OF NANJING UNIVERSITY MEDICAL SCHOOL   (China)

^c NONE

Author keywords

CD36; Foam cells; Inflammation; Lipid accumulation; Macrophage; Oxidative stress; Ss 31

Indexed keywords

ARGINYL-2,'6'-DIMETHYLTYROSYL-LYSYL-PHENYLALANINAMIDE; CHOLESTEROL; LOW DENSITY LIPOPROTEIN; OLIGOPEPTIDE; OXIDIZED LOW DENSITY LIPOPROTEIN; REACTIVE OXYGEN METABOLITE;

ANIMAL; CYTOLOGY; DRUG EFFECTS; FOAM CELL; HUMAN; MACROPHAGE; METABOLISM; MITOCHONDRION; MOUSE; RAW 264.7 CELL LINE; SECRETION (PROCESS); TRANSPORT AT THE CELLULAR LEVEL;

ANIMALS; BIOLOGICAL TRANSPORT; CHOLESTEROL; FOAM CELLS; HUMANS; LIPOPROTEINS, LDL; MACROPHAGES; MICE; MITOCHONDRIA; OLIGOPEPTIDES; RAW 264.7 CELLS; REACTIVE OXYGEN SPECIES;

EID: 84954338814     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules201219764     Document Type: Article

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