Inflammation and thrombosis: The clot thickens

Circulation

Volumn 103, Issue 13, 2001, Pages 1718-1720

  Libby, Peter ^a   Simon, Daniel I ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Atherosclerosis; Editorials; Growth substances; Inflammation; Platelets; Thrombosis

Indexed keywords

ANTICOAGULANT AGENT; ANTIINFLAMMATORY AGENT; AUTACOID; GLYCOPROTEIN GP 39; NITRIC OXIDE; PLATELET DERIVED GROWTH FACTOR; RANTES; THROMBOCYTE FACTOR 4; THROMBOSPONDIN; TRANSFORMING GROWTH FACTOR BETA;

ANTICOAGULANT THERAPY; ARTERY ENDOTHELIUM; BLOOD CLOTTING; EDITORIAL; HUMAN; INFLAMMATION; LEUKOCYTE; PRIORITY JOURNAL; SEPTIC SHOCK; THROMBOCYTE; THROMBOGENESIS; THROMBOSIS; VASCULAR DISEASE;

EID: 0035799341     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.103.13.1718     Document Type: Editorial

References (16)

1. Localization of tissue factor in the normal vessel wall and in the atherosclerotic plaque
2. Tissue factor mRNA in THP-1 monocytic cells is regulated at both transcriptional and posttranscriptional levels in response to lipopolysaccharide
3. Activation of monocyte/macrophage functions related to acute atheroma complication by ligation of CD40: Induction of collagenase, stromelysin, and tissue factor
4. Functional CD 40 ligand is expressed on human vascular endothelial cells, smooth muscle cells, and macrophages: Implications for CD40-CD40 ligand signaling in atherosclerosis
5. Tissue factor expression in human arterial smooth muscle cells: TF is present in three cellular pools after growth factor stimulation
6. CD40 ligation induces tissue factor expression in human vascular smooth muscle cells
7. Thrombin potently induces cytokine production by human vascular smooth muscle cells but not in mononuclear phagocytes
8. Proliferating or interleukin 1-activated human vascular smooth muscle cells secrete copious interleukin 6
9. The stromal cell-derived factor-1 chemokine is a potent platelet agonist highly expressed in atherosclerotic plaques
10. CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells
11. RANTES deposition by platelets triggers monocyte arrest on inflamed and atherosclerotic endothelium
12. MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions
13. A juxtacrine mechanism for neutrophil adhesion on platelets involves platelet-activating factor and a selectin-dependent activation process
14. Platelet glycoprotein Ib alpha is a counterreceptor for the leukocyte integrin Mac-1 (CD11b/CD18)
15. Increased neutrophil-platelet adhesion in patients with unstable angina
16. Increased platelet reactivity and circulating monocyte-platelet aggregates in patients with stable coronary artery disease