3,4-Dihydroxy-benzohydroxamic acid (Didox) suppresses pro-inflammatory profiles and oxidative stress in TLR4-activated RAW264.7 murine macrophages

Chemico-Biological Interactions

Volumn 233, Issue , 2015, Pages 95-105

  Matsebatlela, Thabe M ^a   Anderson, Amy L ^b   Gallicchio, Vincent S ^b   Elford, Howard ^c   Rice, Charles D ^b  

^a UNIVERSITY OF LIMPOPO   (South Africa)

^b CLEMSON UNIVERSITY   (United States)

^c Molecules for Health   (United States)

Author keywords

Didox; Inflammation; iNOS; Oxidative stress; RAW264.7 cells; TLR 4

Indexed keywords

3,4 DIHYDROXYBENZOHYDROXAMIC ACID; CATALASE; COPPER ZINC SUPEROXIDE DISMUTASE; CYCLOOXYGENASE 2; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MESSENGER RNA; NITRIC OXIDE; REACTIVE OXYGEN METABOLITE; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; 3,4-DIHYDROXYBENZOHYDROXAMIC ACID; ANTIINFLAMMATORY AGENT; HYDROXAMIC ACID; SCAVENGER; SUPEROXIDE DISMUTASE;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CELL ACTIVATION; CELL LINE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG ACTIVITY; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; GENE EXPRESSION; IMMUNOBLOTTING; MACROPHAGE; MOUSE; NONHUMAN; OXIDATIVE STRESS; QUANTITATIVE ANALYSIS; RAW 264.7 CELL LINE; REAL TIME POLYMERASE CHAIN REACTION; SOD1 GENE; ANIMAL; DOWN REGULATION; DRUG EFFECTS; GENETICS; IMMUNOLOGY; METABOLISM; UPREGULATION;

MURINAE;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CATALASE; CELL LINE; CYCLOOXYGENASE 2; DOWN-REGULATION; FREE RADICAL SCAVENGERS; HYDROXAMIC ACIDS; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; NITRIC OXIDE SYNTHASE TYPE II; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; SUPEROXIDE DISMUTASE; TOLL-LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 84926641942     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2015.03.027     Document Type: Article

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