Inhibition of the kinase ITK in a mouse model of asthma reduces cell death and fails to inhibit the inflammatory response

Science Signaling

Volumn 8, Issue 405, 2015, Pages

  Sun, Yonglian ^a   Peng, Ivan ^a   Webster, Joshua D ^a   Suto, Eric ^a   Lesch, Justin ^a   Wu, Xiumin ^a   Senger, Kate ^a   Francis, George ^a   Barrett, Kathy ^a   Collier, Jenna L ^a   Burch, Jason D ^a   Zhou, Meijuan ^a   Chen, Yuan ^a   Chan, Connie ^a   Eastham Anderson, Jeff ^a   Ngu, Hai ^a   Li, Olga ^a   Staton, Tracy ^a   Havnar, Charles ^a   Jaochico, Allan ^a   Jackman, Janet ^a   Jeet, Surinder ^a   Riol Blanco, Lorena ^a   Wu, Lawren C ^a   Choy, David F ^a   Arron, Joseph R ^a   McKenzie, Brent S ^a   Ghilardi, Nico ^a   Ismaili, Moulay Hicham Alaoui ^a   Pei, Zhonghua ^a   Devoss, Jason ^a   Austin, Cary D ^a   Lee, Wyne P ^a   Zarrin, Ali A ^a   more..

^a GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; INTERLEUKIN 2; INTERLEUKIN 2 INDUCIBLE T CELL KINASE; PHOSPHOLIPASE C GAMMA1; PROTEIN TYROSINE KINASE; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG; CYTOKINE; EMT PROTEIN-TYROSINE KINASE; PHOSPHOLIPASE C GAMMA; PLCG1 PROTEIN, MOUSE; PROTEIN KINASE INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTHMA; BRONCHOALVEOLAR LAVAGE FLUID; CELL DEATH; CELL HYPERPLASIA; CONTROLLED STUDY; CYTOKINE RELEASE; FEMALE; HUMAN; HUMAN CELL; INHIBITION KINETICS; MOUSE; NONHUMAN; PNEUMONIA; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RESPIRATORY TRACT ALLERGY; RESPIRATORY TRACT INFLAMMATION; SIGNAL TRANSDUCTION; TH2 CELL; WILD TYPE; ANIMAL; ANTAGONISTS AND INHIBITORS; BAGG ALBINO MOUSE; DISEASE MODEL; DRUG EFFECTS; GENETICS; IMMUNOLOGY; INFLAMMATION; KNOCKOUT MOUSE; PATHOLOGY;

ANIMALS; ASTHMA; CELL DEATH; CYTOKINES; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; INFLAMMATION; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; PHOSPHOLIPASE C GAMMA; PROTEIN KINASE INHIBITORS; PROTEIN-TYROSINE KINASES; TH2 CELLS;

EID: 84954320577     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.aab0949     Document Type: Article

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