메뉴 건너뛰기




Volumn 278, Issue 12, 2011, Pages 1980-1989

Tec family kinases Itk and Rlk/Txk in T lymphocytes: Cross-regulation of cytokine production and T-cell fates

Author keywords

cytokines; innate lymphocytes; Itk; PLZF; Rlk Txk; T helper cells; Th1; Th17; Th2; thymus

Indexed keywords

CALCIUM ION; CYTOKINE; INTERLEUKIN 2 INDUCIBLE T CELL KINASE; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOLIPASE C GAMMA; PROTEIN TYROSINE KINASE; RESTING LYMPHOCYTE KINASE; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

EID: 79958163806     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2011.08072.x     Document Type: Review
Times cited : (57)

References (44)
  • 2
    • 66449085077 scopus 로고    scopus 로고
    • Girls homozygous for an IL-2-inducible T cell kinase mutation that leads to protein deficiency develop fatal EBV-associated lymphoproliferation
    • Huck K, Feyen O, Niehues T, Ruschendorf F, Hubner N, Laws HJ, Telieps T, Knapp S, Wacker HH, Meindl A, et al. (2009) Girls homozygous for an IL-2-inducible T cell kinase mutation that leads to protein deficiency develop fatal EBV-associated lymphoproliferation. J Clin Invest 119, 1350-1358.
    • (2009) J Clin Invest , vol.119 , pp. 1350-1358
    • Huck, K.1    Feyen, O.2    Niehues, T.3    Ruschendorf, F.4    Hubner, N.5    Laws, H.J.6    Telieps, T.7    Knapp, S.8    Wacker, H.H.9    Meindl, A.10
  • 4
    • 33745896226 scopus 로고    scopus 로고
    • Skewed Th1 responses caused by excessive expression of Txk, a member of the Tec family of tyrosine kinases, in patients with Behcet's disease
    • Suzuki N, Nara K, &, Suzuki T, (2006) Skewed Th1 responses caused by excessive expression of Txk, a member of the Tec family of tyrosine kinases, in patients with Behcet's disease. Clin Med Res 4, 147-151. (Pubitemid 44047369)
    • (2006) Clinical Medicine and Research , vol.4 , Issue.2 , pp. 147-151
    • Suzuki, N.1    Nara, K.2    Suzuki, T.3
  • 6
    • 34249854024 scopus 로고    scopus 로고
    • SLP-76 mediates and maintains activation of the Tec family kinase ITK via the T cell antigen receptor-induced association between SLP-76 and ITK
    • DOI 10.1073/pnas.0609771104
    • Bogin Y, Ainey C, Beach D, &, Yablonski D, (2007) SLP-76 mediates and maintains activation of the Tec family kinase ITK via the T cell antigen receptor-induced association between SLP-76 and ITK. Proc Natl Acad Sci USA 104, 6638-6643, doi:0609771104 [pii]. (Pubitemid 47175553)
    • (2007) Proceedings of the National Academy of Sciences of the United States of America , vol.104 , Issue.16 , pp. 6638-6643
    • Bogin, Y.1    Ainey, C.2    Beach, D.3    Yablonski, D.4
  • 7
    • 1542284064 scopus 로고    scopus 로고
    • Expression and Function of Tec, Itk, and Btk in Lymphocytes: Evidence for a Unique Role for Tec
    • DOI 10.1128/MCB.24.6.2455-2466.2004
    • Tomlinson MG, Kane LP, Su J, Kadlecek TA, Mollenauer MN, &, Weiss A, (2004) Expression and function of Tec, Itk, and Btk in lymphocytes: evidence for a unique role for Tec. Mol Cell Biol 24, 2455-2466. (Pubitemid 38326000)
    • (2004) Molecular and Cellular Biology , vol.24 , Issue.6 , pp. 2455-2466
    • Tomlinson, M.G.1    Kane, L.P.2    Su, J.3    Kadlecek, T.A.4    Mollenauer, M.N.5    Weiss, A.6
  • 10
    • 77952313777 scopus 로고    scopus 로고
    • Differentiation of effector CD4 T cell populations
    • Zhu J, Yamane H, &, Paul WE, (2010) Differentiation of effector CD4 T cell populations. Annu Rev Immunol 28, 445-489, doi:.
    • (2010) Annu Rev Immunol , vol.28 , pp. 445-489
    • Zhu, J.1    Yamane, H.2    Paul, W.E.3
  • 11
    • 77649220954 scopus 로고    scopus 로고
    • Mechanisms underlying lineage commitment and plasticity of helper CD4+ T cells
    • doi:327/5969/1098 [pii].
    • O'Shea JJ, &, Paul WE, (2010) Mechanisms underlying lineage commitment and plasticity of helper CD4+ T cells. Science 327, 1098-1102, doi:327/5969/1098 [pii].
    • (2010) Science , vol.327 , pp. 1098-1102
    • O'Shea, J.J.1    Paul, W.E.2
  • 12
    • 0030963614 scopus 로고    scopus 로고
    • + T cell responses: The alternative approaches
    • DOI 10.1146/annurev.immunol.15.1.297
    • Constant SL, &, Bottomly K, (1997) Induction of Th1 and Th2 CD4+ T cell responses: the alternative approaches. Annu Rev Immunol 15, 297-322, doi:. (Pubitemid 27169283)
    • (1997) Annual Review of Immunology , vol.15 , pp. 297-322
    • Constant, S.L.1    Bottomly, K.2
  • 15
    • 0038557038 scopus 로고    scopus 로고
    • Attenuation of immunological symptoms of allergic asthma in mice lacking the tyrosine kinase ITK
    • Mueller C, &, August A, (2003) Attenuation of immunological symptoms of allergic asthma in mice lacking the tyrosine kinase ITK. J Immunol 170, 5056.
    • (2003) J Immunol , vol.170 , pp. 5056
    • Mueller, C.1    August, A.2
  • 16
    • 3142686560 scopus 로고    scopus 로고
    • Signaling through Itk promotes T helper 2 differentiation via negative regulation of T-bet
    • DOI 10.1016/j.immuni.2004.06.009, PII S1074761304001700
    • Miller AT, Wilcox HM, Lai Z, &, Berg LJ, (2004) Signaling through Itk promotes T helper 2 differentiation via negative regulation of T-bet. Immunity 21, 67-80. (Pubitemid 38925268)
    • (2004) Immunity , vol.21 , Issue.1 , pp. 67-80
    • Miller, A.T.1    Wilcox, H.M.2    Lai, Z.3    Berg, L.J.4
  • 17
    • 33646053861 scopus 로고    scopus 로고
    • + T cells to exert, but not gain, Th2 effector function
    • Au-Yeung BB, Katzman SD, &, Fowell DJ, (2006) Cutting edge: Itk-dependent signals required for CD4+ T cells to exert, but not gain, Th2 effector function. J Immunol 176, 3895-3899. (Pubitemid 44264364)
    • (2006) Journal of Immunology , vol.176 , Issue.7 , pp. 3895-3899
    • Au-Yeung, B.B.1    Katzman, S.D.2    Fowell, D.J.3
  • 18
    • 0032743460 scopus 로고    scopus 로고
    • Txk, a nonreceptor tyrosine kinase of the Tec family, is expressed in T helper type 1 cells and regulates interferon γ production in human T lymphocytes
    • DOI 10.1084/jem.190.8.1147
    • Kashiwakura J, Suzuki N, Nagafuchi H, Takeno M, Takeba Y, Shimoyama Y, &, Sakane T, (1999) Txk, a nonreceptor tyrosine kinase of the Tec family, is expressed in T helper type 1 cells and regulates interferon gamma production in human T lymphocytes. J Exp Med 190, 1147-1154. (Pubitemid 29496507)
    • (1999) Journal of Experimental Medicine , vol.190 , Issue.8 , pp. 1147-1154
    • Kashiwakura, J.-I.1    Suzuki, N.2    Nagafuchi, H.3    Takeno, M.4    Takeba, Y.5    Shimoyama, Y.6    Sakane, T.7
  • 20
    • 70350135638 scopus 로고    scopus 로고
    • ITK inhibitors in inflammation and immune-mediated disorders
    • Sahu N, &, August A, (2009) ITK inhibitors in inflammation and immune-mediated disorders. Curr Top Med Chem 9, 690-703.
    • (2009) Curr Top Med Chem , vol.9 , pp. 690-703
    • Sahu, N.1    August, A.2
  • 22
    • 70349743977 scopus 로고    scopus 로고
    • Differential expression of interleukin-17A and -17F is coupled to T cell receptor signaling via inducible T cell kinase
    • doi:S1074-7613(09)00413-0 [pii].
    • Gomez-Rodriguez J, Sahu N, Handon R, Davidson TS, Anderson SM, Kirby MR, August A, &, Schwartzberg PL, (2009) Differential expression of interleukin-17A and -17F is coupled to T cell receptor signaling via inducible T cell kinase. Immunity 31, 587-597, doi:S1074-7613(09)00413-0 [pii].
    • (2009) Immunity , vol.31 , pp. 587-597
    • Gomez-Rodriguez, J.1    Sahu, N.2    Handon, R.3    Davidson, T.S.4    Anderson, S.M.5    Kirby, M.R.6    August, A.7    Schwartzberg, P.L.8
  • 23
    • 33745969458 scopus 로고    scopus 로고
    • + T Cells
    • DOI 10.1016/j.immuni.2006.05.012, PII S1074761306003074
    • Atherly LO, Lucas JA, Felices M, Yin CC, Reiner SL, &, Berg LJ, (2006) The Tec family tyrosine kinases Itk and Rlk regulate the development of conventional CD8+ T cells. Immunity 25, 79-91. (Pubitemid 44066834)
    • (2006) Immunity , vol.25 , Issue.1 , pp. 79-91
    • Atherly, L.O.1    Lucas, J.A.2    Felices, M.3    Yin, C.C.4    Reiner, S.L.5    Berg, L.J.6
  • 26
    • 35348835445 scopus 로고    scopus 로고
    • + T cells with innate function selectively develop in the absence of active Itk
    • DOI 10.1002/eji.200737311
    • Hu J, Sahu N, Walsh E, &, August A, (2007) Memory phenotype CD8+ T cells with innate function selectively develop in the absence of active Itk. Eur J Immunol 37, 2892-2899, doi:. (Pubitemid 47578308)
    • (2007) European Journal of Immunology , vol.37 , Issue.10 , pp. 2892-2899
    • Hu, J.1    Sahu, N.2    Walsh, E.3    August, A.4
  • 28
    • 36048946331 scopus 로고    scopus 로고
    • Requirements for Selection of Conventional and Innate T Lymphocyte Lineages
    • DOI 10.1016/j.immuni.2007.09.012, PII S1074761307005006
    • Horai R, Mueller KL, Handon RA, Cannons JL, Anderson SM, Kirby MR, &, Schwartzberg PL, (2007) Requirements for selection of conventional and innate T lymphocyte lineages. Immunity 27, 775-785, doi:S1074-7613(07)00500-6 [pii]. (Pubitemid 350102265)
    • (2007) Immunity , vol.27 , Issue.5 , pp. 775-785
    • Horai, R.1    Mueller, K.L.2    Handon, R.A.3    Cannons, J.L.4    Anderson, S.M.5    Kirby, M.R.6    Schwartzberg, P.L.7
  • 29
    • 34249693078 scopus 로고    scopus 로고
    • + T-cell development
    • DOI 10.1038/nri2091, PII NRI2091
    • Berg LJ, (2007) Signalling through TEC kinases regulates conventional versus innate CD8(+) T-cell development. Nat Rev 7, 479-485, doi:nri2091 [pii]. (Pubitemid 46834846)
    • (2007) Nature Reviews Immunology , vol.7 , Issue.6 , pp. 479-485
    • Berg, L.J.1
  • 30
    • 36049012716 scopus 로고    scopus 로고
    • Homotypic Interactions Mediated by Slamf1 and Slamf6 Receptors Control NKT Cell Lineage Development
    • DOI 10.1016/j.immuni.2007.08.020, PII S1074761307004931
    • Griewank K, Borowski C, Rietdijk S, Wang N, Julien A, Wei DG, Mamchak AA, Terhorst C, &, Bendelac A, (2007) Homotypic interactions mediated by Slamf1 and Slamf6 receptors control NKT cell lineage development. Immunity 27, 751-762, doi:S1074-7613(07)00493-1 [pii]. (Pubitemid 350102258)
    • (2007) Immunity , vol.27 , Issue.5 , pp. 751-762
    • Griewank, K.1    Borowski, C.2    Rietdijk, S.3    Wang, N.4    Julien, A.5    Wei, D.G.6    Mamchak, AlushaA.7    Terhorst, C.8    Bendelac, A.9
  • 31
    • 58149099175 scopus 로고    scopus 로고
    • SLAM receptors and SAP influence lymphocyte interactions, development and function
    • doi:nri2456 [pii].
    • Schwartzberg PL, Mueller KL, Qi H, &, Cannons JL, (2009) SLAM receptors and SAP influence lymphocyte interactions, development and function. Nat Rev 9, 39-46, doi:nri2456 [pii].
    • (2009) Nat Rev , vol.9 , pp. 39-46
    • Schwartzberg, P.L.1    Mueller, K.L.2    Qi, H.3    Cannons, J.L.4
  • 32
    • 45549105834 scopus 로고    scopus 로고
    • Naive and innate memory phenotype CD4+ T cells have different requirements for active Itk for their development
    • doi:180/10/6544 [pii].
    • Hu J, &, August A, (2008) Naive and innate memory phenotype CD4+ T cells have different requirements for active Itk for their development. J Immunol 180, 6544-6552, doi:180/10/6544 [pii].
    • (2008) J Immunol , vol.180 , pp. 6544-6552
    • Hu, J.1    August, A.2
  • 33
    • 77954954319 scopus 로고    scopus 로고
    • T cells expressing the transcription factor PLZF regulate the development of memory-like CD8+ T cells
    • doi:ni.1898 [pii].
    • Weinreich MA, Odumade OA, Jameson SC, &, Hogquist KA, (2010) T cells expressing the transcription factor PLZF regulate the development of memory-like CD8+ T cells. Nat Immunol 11, 709-716, doi:ni.1898 [pii].
    • (2010) Nat Immunol , vol.11 , pp. 709-716
    • Weinreich, M.A.1    Odumade, O.A.2    Jameson, S.C.3    Hogquist, K.A.4
  • 35
    • 50049084627 scopus 로고    scopus 로고
    • The BTB-zinc finger transcriptional regulator PLZF controls the development of invariant natural killer T cell effector functions
    • doi:ni.1641 [pii].
    • Kovalovsky D, Uche OU, Eladad S, Hobbs RM, Yi W, Alonzo E, Chua K, Eidson M, Kim HJ, Im JS, et al. (2008) The BTB-zinc finger transcriptional regulator PLZF controls the development of invariant natural killer T cell effector functions. Nat Immunol 9, 1055-1064, doi:ni.1641 [pii].
    • (2008) Nat Immunol , vol.9 , pp. 1055-1064
    • Kovalovsky, D.1    Uche, O.U.2    Eladad, S.3    Hobbs, R.M.4    Yi, W.5    Alonzo, E.6    Chua, K.7    Eidson, M.8    Kim, H.J.9    Im, J.S.10
  • 36
    • 51349121407 scopus 로고    scopus 로고
    • The transcription factor PLZF directs the effector program of the NKT cell lineage
    • doi:S1074-7613(08)00337-3 [pii].
    • Savage AK, Constantinides MG, Han J, Picard D, Martin E, Li B, Lantz O, &, Bendelac A, (2008) The transcription factor PLZF directs the effector program of the NKT cell lineage. Immunity 29, 391-403, doi:S1074-7613(08)00337-3 [pii].
    • (2008) Immunity , vol.29 , pp. 391-403
    • Savage, A.K.1    Constantinides, M.G.2    Han, J.3    Picard, D.4    Martin, E.5    Li, B.6    Lantz, O.7    Bendelac, A.8
  • 37
    • 68249134207 scopus 로고    scopus 로고
    • KLF2 transcription-factor deficiency in T cells results in unrestrained cytokine production and upregulation of bystander chemokine receptors
    • doi:S1074-7613(09)00279-9 [pii].
    • Weinreich MA, Takada K, Skon C, Reiner SL, Jameson SC, &, Hogquist KA, (2009) KLF2 transcription-factor deficiency in T cells results in unrestrained cytokine production and upregulation of bystander chemokine receptors. Immunity 31, 122-130, doi:S1074-7613(09)00279-9 [pii].
    • (2009) Immunity , vol.31 , pp. 122-130
    • Weinreich, M.A.1    Takada, K.2    Skon, C.3    Reiner, S.L.4    Jameson, S.C.5    Hogquist, K.A.6
  • 38
    • 77955920553 scopus 로고    scopus 로고
    • SAP protein-dependent natural killer T-like cells regulate the development of CD8(+) T cells with innate lymphocyte characteristics
    • Verykokakis M, Boos MD, Bendelac A, &, Kee BL, (2010) SAP protein-dependent natural killer T-like cells regulate the development of CD8(+) T cells with innate lymphocyte characteristics. Immunity 33, 203-215.
    • (2010) Immunity , vol.33 , pp. 203-215
    • Verykokakis, M.1    Boos, M.D.2    Bendelac, A.3    Kee, B.L.4
  • 39
    • 0036499182 scopus 로고    scopus 로고
    • Defective Fas ligand expression and activation-induced cell death in the absence of IL-2-inducible T cell kinase
    • Miller AT, &, Berg LJ, (2002) Defective Fas ligand expression and activation-induced cell death in the absence of IL-2-inducible T cell kinase. J Immunol 168, 2163-2172. (Pubitemid 34171815)
    • (2002) Journal of Immunology , vol.168 , Issue.5 , pp. 2163-2172
    • Miller, A.T.1    Berg, L.J.2
  • 40
    • 79958137465 scopus 로고    scopus 로고
    • Tec family kinases: Itk signaling and the development of NKT αβ and γδ T cells
    • Qi Q, Kannan AK, &, August A, (2011) Tec family kinases: Itk signaling and the development of NKT αβ and γδ T cells. FEBS J 278, 1970-71979.
    • (2011) FEBS J , vol.278 , pp. 1970-71979
    • Qi, Q.1    Kannan, A.K.2    August, A.3
  • 41
    • 66249138887 scopus 로고    scopus 로고
    • Tec kinase Itk in gammadeltaT cells is pivotal for controlling IgE production in vivo
    • doi:0808459106 [pii].
    • Felices M, Yin CC, Kosaka Y, Kang J, &, Berg LJ, (2009) Tec kinase Itk in gammadeltaT cells is pivotal for controlling IgE production in vivo. Proc Natl Acad Sci USA 106, 8308-8313, doi:0808459106 [pii].
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 8308-8313
    • Felices, M.1    Yin, C.C.2    Kosaka, Y.3    Kang, J.4    Berg, L.J.5
  • 42
    • 70149110081 scopus 로고    scopus 로고
    • Enhanced development of CD4+ gammadelta T cells in the absence of Itk results in elevated IgE production
    • doi:blood-2008-12-196345 [pii].
    • Qi Q, Xia M, Hu J, Hicks E, Iyer A, Xiong N, &, August A, (2009) Enhanced development of CD4+ gammadelta T cells in the absence of Itk results in elevated IgE production. Blood 114, 564-571, doi:blood-2008-12-196345 [pii].
    • (2009) Blood , vol.114 , pp. 564-571
    • Qi, Q.1    Xia, M.2    Hu, J.3    Hicks, E.4    Iyer, A.5    Xiong, N.6    August, A.7
  • 43
    • 0036721616 scopus 로고    scopus 로고
    • NK T cell precursors exhibit differential cytokine regulation and require Itk for efficient maturation
    • Gadue P, &, Stein PL, (2002) NK T cell precursors exhibit differential cytokine regulation and require Itk for efficient maturation. J Immunol 169, 2397-2406. (Pubitemid 34920982)
    • (2002) Journal of Immunology , vol.169 , Issue.5 , pp. 2397-2406
    • Gadue, P.1    Stein, P.L.2
  • 44
    • 68149108582 scopus 로고    scopus 로고
    • TCR-inducible PLZF transcription factor required for innate phenotype of a subset of gammadelta T cells with restricted TCR diversity
    • doi:0903895106 [pii].
    • Kreslavsky T, Savage AK, Hobbs R, Gounari F, Bronson R, Pereira P, Pandolfi PP, Bendelac A, &, von Boehmer H, (2009) TCR-inducible PLZF transcription factor required for innate phenotype of a subset of gammadelta T cells with restricted TCR diversity. Proc Natl Acad Sci USA 106, 12453-12458, doi:0903895106 [pii].
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 12453-12458
    • Kreslavsky, T.1    Savage, A.K.2    Hobbs, R.3    Gounari, F.4    Bronson, R.5    Pereira, P.6    Pandolfi, P.P.7    Bendelac, A.8    Von Boehmer, H.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.