Neutrophil extracellular traps regulate IL-1β-mediated inflammation in familial Mediterranean fever

Annals of the Rheumatic Diseases

Volumn 75, Issue 1, 2016, Pages 269-277

  Apostolidou, Eirini ^a,b   Skendros, Panagiotis ^a,b   Kambas, Konstantinos ^a   Mitroulis, Ioannis ^c   Konstantinidis, Theocharis ^a   Chrysanthopoulou, Akrivi ^a   Nakos, Konstantinos ^a   Tsironidou, Victoria ^a   Koffa, Maria ^a   Boumpas, Dimitrios T ^d,e   Ritis, Konstantinos ^a,b  

^a DEMOCRITUS UNIVERSITY OF THRACE   (Greece)

^b DEMOCRITUS UNIVERSITY OF THRACE   (Greece)

^c DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^d UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^e BIOMEDICAL RESEARCH FOUNDATION   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFLAMMATORY AGENT; COLCHICINE; DEOXYRIBONUCLEASE I; INTERLEUKIN 1BETA;

ADULT; AUTOPHAGY; BIOSYNTHESIS; CASE CONTROL STUDY; DRUG EFFECTS; EXTRACELLULAR TRAP; FAMILIAL MEDITERRANEAN FEVER; FEEDBACK SYSTEM; FEMALE; HUMAN; IMMUNOLOGY; MALE; MIDDLE AGED; NEUTROPHIL; REMISSION; YOUNG ADULT;

ADULT; ANTI-INFLAMMATORY AGENTS; AUTOPHAGY; CASE-CONTROL STUDIES; COLCHICINE; DEOXYRIBONUCLEASE I; EXTRACELLULAR TRAPS; FAMILIAL MEDITERRANEAN FEVER; FEEDBACK, PHYSIOLOGICAL; FEMALE; HUMANS; INTERLEUKIN-1BETA; MALE; MIDDLE AGED; NEUTROPHILS; REMISSION INDUCTION; YOUNG ADULT;

EID: 84954243529     PISSN: 00034967     EISSN: 14682060     Source Type: Journal    
DOI: 10.1136/annrheumdis-2014-205958     Document Type: Article

References (54)

1. Shohat M, Halpern GJ. Familial Mediterranean fever - a review. Genet Med 2011;13:487-98.
2. Yenokyan G, Armenian HK. Triggers for attacks in familial Mediterranean fever: application of the case-crossover design. Am J Epidemiol 2012;175:1054-61.
3. French FMF Consortium. A candidate gene for familial Mediterranean fever. Nat Genet 1997;17:25-31.
4. Ancient missense mutations in a new member of the RoRet gene family are likely to cause familial Mediterranean fever. The International FMF Consortium. Cell 1997;90:797-807.
5. Yu JW, Wu J, Zhang Z, et al. Cryopyrin and pyrin activate caspase-1, but not NF-kappaB, via ASC oligomerization. Cell Death Differ 2006;13:236-49.
6. Chae JJ, Wood G, Masters SL, et al. The B30.2 domain of pyrin, the familial Mediterranean fever protein, interacts directly with caspase-1 to modulate IL-1beta production. Proc Natl Acad Sci USA 2006;103:9982-7.
7. Papin S, Cuenin S, Agostini L, et al. The SPRY domain of Pyrin, mutated in familial Mediterranean fever patients, interacts with inflammasome components and inhibits proIL-1beta processing. Cell Death Differ 2007;14:1457-66.
8. Mitroulis I, Skendros P, Ritis K. Targeting IL-1beta in disease; the expanding role of NLRP3 inflammasome. Eur J Intern Med 2010;21:157-63.
9. Dinarello CA, van der Meer JW. Treating inflammation by blocking interleukin-1 in humans. Semin Immunol 2013;25:469-84.
10. Manukyan G, Petrek M, Kriegova E, et al. Activated phenotype of circulating neutrophils in familial Mediterranean fever. Immunobiology 2013;218:892-8.
11. Brinkmann V, Reichard U, Goosmann C, et al. Neutrophil extracellular traps kill bacteria. Science 2004;303:1532-5.
12. Branzk N, Papayannopoulos V. Molecular mechanisms regulating NETosis in infection and disease. Semin Immunopathol 2013;35:513-30.
13. Remijsen Q, Vanden Berghe T, Wirawan E, et al. Neutrophil extracellular trap cell death requires both autophagy and superoxide generation. Cell Res 2011;21:290-304.
14. Mitroulis I, Kambas K, Chrysanthopoulou A, et al. Neutrophil extracellular trap formation is associated with IL-1β and autophagy-related signaling in gout. PLoS ONE 2011;6:e29318.
15. Mitroulis I, Kourtzelis I, Kambas K, et al. Evidence for the involvement of mTOR inhibition and basal autophagy in familial Mediterranean fever phenotype. Hum Immunol 2011;72:135-8.
16. Bachetti T, Chiesa S, Castagnola P. Autophagy contributes to inflammation in patients with TNFR-associated periodic syndrome (TRAPS). Ann Rheum Dis 2013;72:1044-52.
17. Giaglis S, Papadopoulos V, Kambas K, et al. MEFV alterations and population genetics analysis in a large cohort of Greek patients with familial Mediterranean fever. Clin Genet 2007;71:458-67.
18. Saffarzadeh M, Juenemann C, Queisser MA, et al. Neutrophil extracellular traps directly induce epithelial and endothelial cell death: a predominant role of histones. PLoS ONE 2012;7:e32366.
19. Kambas K, Mitroulis I, Apostolidou E, et al. Autophagy mediates the delivery of thrombogenic tissue factor to neutrophil extracellular traps in human sepsis. PLoS ONE 2012;7:e45427.
20. Caudrillier A, Kessenbrock K, Gilliss BM, et al. Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury. J Clin Invest 2012;122:2661-71.
21. Chrysanthopoulou A, Mitroulis I, Kambas K, et al. Tissue factor-thrombin signaling enhances the fibrotic activity of myofibroblasts in systemic sclerosis through upregulation of endothelin receptor A. Arthritis Rheum 2011;63:3586-97.
22. Mitroulis I, Skendros P, Oikonomou A, et al. The efficacy of canakinumab in the treatment of a patient with familial Mediterranean fever and longstanding destructive arthritis. Ann Rheum Dis 2011;70:1347-8.
23. Soriano A, Verecchia E, Afeltra A, et al. IL-1β biological treatment of familial Mediterranean fever. Clin Rev Allergy Immunol 2013;45:117-30.
24. Greten FR, Arkan MC, Bollrath J, et al. NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta. Cell 2007;130:918-31.
25. Guma M, Ronacher L, Liu-Bryan R, et al. Caspase 1-independent activation of interleukin-1beta in neutrophil-predominant inflammation. Arthritis Rheum 2009;60:3642-50.
26. Mankan AK, Dau T, Jenne D, et al. The NLRP3/ASC/Caspase-1 axis regulates IL-1β processing in neutrophils. Eur J Immunol 2012;42:710-15.
27. Bakele M, Joos M, Burdi S, et al. Localization and functionality of the inflammasome in neutrophils. J Biol Chem 2014;289:5320-9.
28. Dinarello CA, Ikejima T, Warner SJ, et al. Interleukin 1 induces interleukin 1. I. Induction of circulating interleukin 1 in rabbits in vivo and in human mononuclear cells in vitro. J Immunol 1987;139:1902-10.
29. Dalton BJ, Connor JR, Johnson WJ. Interleukin-1 induces interleukin-1 alpha and interleukin-1 beta gene expression in synovial fibroblasts and peripheral blood monocytes. Arthritis Rheum 1989;32:279-87.
30. Toda Y, Tsukada J, Misago M, et al. Autocrine induction of the human pro-IL-1beta gene promoter by IL-1beta in monocytes. J Immunol 2002;168:1984-91.
31. Tadie JM, Bae HB, Jiang S, et al. HMGB1 promotes neutrophil extracellular trap formation through interactions with Toll-like receptor 4. Am J Physiol Lung Cell Mol Physiol 2013;304:L342-9.
32. Neeli I, Dwivedi N, Khan S, et al. Regulation of extracellular chromatin release from neutrophils. J Innate Immun 2009;1:194-201.
33. Wang Y, Li M, Stadler S, et al. Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation. J Cell Biol 2009;184:205-13.
34. Hakkim A, Fürnrohr BG, Amann K, et al. Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis. Proc Natl Acad Sci USA 2010;107:9813-18.
35. Leffler J, Martin M, Gullstrand B, et al. Neutrophil extracellular traps that are not degraded in systemic lupus erythematosus activate complement exacerbating the disease. J Immunol 2012;188:3522-31.
36. Leffler J, Gullstrand B, Jönsen A, et al. Degradation of neutrophil extracellular traps co-varies with disease activity in patients with systemic lupus erythematosus. Arthritis Res Ther 2013;15:R84.
37. Chrysanthopoulou A, Mitroulis I, Apostolidou E, et al. Neutrophil extracellular traps promote differentiation and function of fibroblasts. J Pathol 2014;233:294-307.
38. Roubille F, Kritikou E, Busseuil D, et al. Colchicine: an old wine in a new bottle? Antiinflamm Antiallergy Agents Med Chem 2013;12:14-23.
39. Stack J, Ryan J, McCarthy G. Colchicine: new insights to an old drug. Am J Ther 2013. Published Online First 4 Oct 2013. doi: 10.1097/01.mjt.0000433937.07244.e1.
40. Itakura A, McCarty OJ. Pivotal role for the mTOR pathway in the formation of neutrophil extracellular traps via regulation of autophagy. Am J Physiol Cell Physiol 2013;305:C348-54.
41. Chae JJ, Cho YH, Lee GS, et al. Gain-of-function Pyrin mutations induce NLRP3 protein-independent interleukin-1β activation and severe autoinflammation in mice. Immunity 2011;34:755-68.
42. Omenetti A, Carta S, Delfino L, et al. Increased NLRP3-dependent interleukin 1β secretion in patients with familial Mediterranean fever: correlation with MEFV genotype. Ann Rheum Dis 2014;73:462-9.
43. Gang N, Drenth JP, Langevitz P, et al. Activation of the cytokine network in familial Mediterranean fever. J Rheumatol 1999;26:890-7.
44. Manukyan GP, Ghazaryan KA, Ktsoyan ZhA, et al. Cytokine profile of Armenian patients with Familial Mediterranean fever. Clin Biochem 2008;41:920-2.
45. Ching JK, Ju JS, Pittman SK, et al. Increased autophagy accelerates colchicine-induced muscle toxicity. Autophagy 2013;9:2115-25.
46. Klionsky DJ, Abdalla FC, Abeliovich H, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 2012;8: 445-544.
47. Farrera C, Fadeel B. Macrophage clearance of neutrophil extracellular traps is a silent process. J Immunol 2013;191:2647-56.
48. Fuchs TA, Brill A, Duerschmied D, et al. Extracellular DNA traps promote thrombosis. Proc Natl Acad Sci USA 2010;107:15880-5.
49. Thomas GM, Carbo C, Curtis BR, et al. Extracellular DNA traps are associated with the pathogenesis of TRALI in humans and mice. Blood 2012;119: 6335-43.
50. Papayannopoulos V, Staab D, Zychlinsky A. Neutrophil elastase enhances sputum solubilization in cystic fibrosis patients receiving DNase therapy. PLoS ONE 2011;6: e28526.
51. Joosten LA, Netea MG, Fantuzzi G, et al. Inflammatory arthritis in caspase 1 gene-deficient mice: contribution of proteinase 3 to caspase 1-independent production of bioactive interleukin-1beta. Arthritis Rheum 2009;60:3651-62.
52. Marques-da-Silva C, Chaves MM, Castro NG, et al. Colchicine inhibits cationic dye uptake induced by ATP in P2X2 and P2X7 receptor-expressing cells: implications for its therapeutic action. Br J Pharmacol 2011;163:912-26.
53. Takenouchi T, Iwamaru Y, Sugama S, et al. Lysophospholipids and ATP mutually suppress maturation and release of IL-1 beta in mouse microglial cells using a Rho-dependent pathway. J Immunol 2008;180:7827-39.
54. Martinon F, Pétrilli V, Mayor A, et al. Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature 2006;440:237-41.