Degradation of neutrophil extracellular traps co-varies with disease activity in patients with systemic lupus erythematosus

Arthritis Research and Therapy

Volumn 15, Issue 4, 2013, Pages

  Leffler, Jonatan ^a   Gullstrand, Birgitta ^a   Jönsen, Andreas ^b   Nilsson, Jan Åke ^b   Martin, Myriam ^a   Blom, Anna M ^a   Bengtsson, Anders A ^b  

^a LUND UNIVERSITY   (Sweden)

^b LUND UNIVERSITY   (Sweden)

Author keywords

degradation; glomerulonephritis; neutrophil extracellular traps; prospective study; Systemic lupus erythematosus

Indexed keywords

DNA; DNA ANTIBODY; HISTONE ANTIBODY;

ALOPECIA; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DISEASE ACTIVITY; DISEASE COURSE; FEMALE; FEVER; GLOMERULONEPHRITIS; HUMAN; MAJOR CLINICAL STUDY; MALE; NEUTROPHIL; NEUTROPHIL EXTRACELLULAR TRAP; PHENOTYPE; PROSPECTIVE STUDY; PROTEIN DEGRADATION; SERUM; SYSTEMIC LUPUS ERYTHEMATOSUS; ADOLESCENT; ADULT; AGED; COMPLICATION; EXTRACELLULAR TRAP; IMMUNOLOGY; METABOLISM; MIDDLE AGED; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; EXTRACELLULAR TRAPS; FEMALE; HUMANS; LUPUS ERYTHEMATOSUS, SYSTEMIC; MALE; MIDDLE AGED; YOUNG ADULT;

EID: 84893111758     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar4264     Document Type: Article

References (26)

1. Shao WH, Cohen PL. Disturbances of apoptotic cell clearance in systemic lupus erythematosus. Arthritis Res Ther 2011, 13:202. 10.1186/ar3535, 3157636, 21371352.
2. Munoz LE, Gaipl US, Franz S, Sheriff A, Voll RE, Kalden JR, Herrmann M. SLE--a disease of clearance deficiency?. Rheumatology 2005, 44:1101-1107. 10.1093/rheumatology/keh693, 15928001.
3. Herrmann M, Voll RE, Zoller OM, Hagenhofer M, Ponner BB, Kalden JR. Impaired phagocytosis of apoptotic cell material by monocyte-derived macrophages from patients with systemic lupus erythematosus. Arthritis Rheum 1998, 41:1241-1250. 10.1002/1529-0131(199807)41:7<1241::AID-ART15>3.0.CO;2-H, 9663482.
4. Casciola-Rosen LA, Anhalt G, Rosen A. Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes. J Exp Med 1994, 179:1317-1330. 10.1084/jem.179.4.1317, 2191465, 7511686.
5. Harley IT, Kaufman KM, Langefeld CD, Harley JB, Kelly JA. Genetic susceptibility to SLE: new insights from fine mapping and genome-wide association studies. Nat Rev Genet 2009, 10:285-290. 10.1038/nrg2571, 2737697, 19337289.
6. Brinkmann V, Reichard U, Goosmann C, Fauler B, Uhlemann Y, Weiss DS, Weinrauch Y, Zychlinsky A. Neutrophil extracellular traps kill bacteria. Science 2004, 303:1532-1535. 10.1126/science.1092385, 15001782.
7. Hakkim A, Furnrohr BG, Amann K, Laube B, Abed UA, Brinkmann V, Herrmann M, Voll RE, Zychlinsky A. Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis. Proc Natl Acad Sci USA 2010, 107:9813-9818. 10.1073/pnas.0909927107, 2906830, 20439745.
8. Leffler J, Martin M, Gullstrand B, Tyden H, Lood C, Truedsson L, Bengtsson AA, Blom AM. Neutrophil extracellular traps that are not degraded in systemic lupus erythematosus activate complement exacerbating the disease. J Immunol 2012, 188:3522-3531. 10.4049/jimmunol.1102404, 22345666.
9. Lande R, Ganguly D, Facchinetti V, Frasca L, Conrad C, Gregorio J, Meller S, Chamilos G, Sebasigari R, Riccieri V, Bassett R, Amuro H, Fukuhara S, Ito T, Liu YJ, Gilliet M. Neutrophils activate plasmacytoid dendritic cells by releasing self-DNA-peptide complexes in systemic lupus erythematosus. Sci Transl Med 2011, 3:73ra19. 10.1126/scitranslmed.3001180, 3399524, 21389263.
10. Villanueva E, Yalavarthi S, Berthier CC, Hodgin JB, Khandpur R, Lin AM, Rubin CJ, Zhao W, Olsen SH, Klinker M, Shealy D, Denny MF, Plumas J, Chaperot L, Kretzler M, Bruce AT, Kaplan MJ. Netting neutrophils induce endothelial damage, infiltrate tissues, and expose immunostimulatory molecules in systemic lupus erythematosus. J Immunol 2011, 187:538-552. 10.4049/jimmunol.1100450, 3119769, 21613614.
11. Chitrabamrung S, Rubin RL, Tan EM. Serum deoxyribonuclease I and clinical activity in systemic lupus erythematosus. Rheumatol Int 1981, 1:55-60. 10.1007/BF00541153, 6287560.
12. Lachmann PJ. Lupus and desoxyribonuclease. Lupus 2003, 12:202-206. 10.1191/0961203303lu357xx, 12708782.
13. Eulitz D, Mannherz HG. Inhibition of deoxyribonuclease I by actin is to protect cells from premature cell death. Apoptosis 2007, 12:1511-1521. 10.1007/s10495-007-0078-4, 17468836.
14. Yeh TM, Chang HC, Liang CC, Wu JJ, Liu MF. Deoxyribonuclease-inhibitory antibodies in systemic lupus erythematosus. J Biomed Sci 2003, 10:544-551. 10.1007/BF02256116, 12928595.
15. Tan EM, Cohen AS, Fries JF, Masi AT, McShane DJ, Rothfield NF, Schaller JG, Talal N, Winchester RJ. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1982, 25:1271-1277. 10.1002/art.1780251101, 7138600.
16. Gladman DD, Ibanez D, Urowitz MB. Systemic lupus erythematosus disease activity index 2000. J Rheumatol 2002, 29:288-291.
17. Brinkmann V, Laube B, Abu Abed U, Goosmann C, Zychlinsky A. Neutrophil extracellular traps: how to generate and visualize them. J Vis Exp 2010
18. Gullstrand B, Lefort MH, Tyden H, Jonsen A, Lood C, Johansson A, Jacobsen S, Truedsson L, Bengtsson AA. Combination of autoantibodies against different histone proteins influences complement-dependent phagocytosis of necrotic cell material by polymorphonuclear leukocytes in systemic lupus erythematosus. J Rheumatol 2012, 39:1619-1627. 10.3899/jrheum.111511, 22753651.
19. Gault MH, Longerich LL, Harnett JD, Wesolowski C. Predicting glomerular function from adjusted serum creatinine. Nephron 1992, 62:249-256. 10.1159/000187054, 1436333.
20. Sorice M, Circella A, Misasi R, Pittoni V, Garofalo T, Cirelli A, Pavan A, Pontieri GM, Valesini G. Cardiolipin on the surface of apoptotic cells as a possible trigger for antiphospholipids antibodies. Clin Exp Immunol 2000, 122:277-284. 10.1046/j.1365-2249.2000.01353.x, 1905767, 11091286.
21. Valentijn RM, van Overhagen H, Hazevoet HM, Hermans J, Cats A, Daha MR, van Es LA. The value of complement and immune complex determinations in monitoring disease activity in patients with systemic lupus erythematosus. Arthritis Rheum 1985, 28:904-913. 10.1002/art.1780280810, 4026886.
22. Lachmann PJ. Allergic reactions, connective tissue, and disease. Sci Basis Med Annu Rev 1967, 36-58.
23. Davis JC, Manzi S, Yarboro C, Rairie J, McInnes I, Averthelyi D, Sinicropi D, Hale VG, Balow J, Austin H, Boumpas DT, Klippel JH. Recombinant human Dnase I (rhDNase) in patients with lupus nephritis. Lupus 1999, 8:68-76. 10.1191/096120399678847380, 10025601.
24. Pan CQ, Dodge TH, Baker DL, Prince WS, Sinicropi DV, Lazarus RA. Improved potency of hyperactive and actin-resistant human DNase I variants for treatment of cystic fibrosis and systemic lupus erythematosus. J Biol Chem 1998, 273:18374-18381. 10.1074/jbc.273.29.18374, 9660804.
25. Macanovic M, Sinicropi D, Shak S, Baughman S, Thiru S, Lachmann PJ. The treatment of systemic lupus erythematosus (SLE) in NZB/W F1 hybrid mice; studies with recombinant murine DNase and with dexamethasone. Clin Exp Immunol 1996, 106:243-252. 10.1046/j.1365-2249.1996.d01-839.x, 2200591, 8918569.
26. Jones AP, Wallis CE. Recombinant human deoxyribonuclease for cystic fibrosis. Cochrane Database Syst Rev 2003, CD001127.